{"id":"https://openalex.org/W2046907336","doi":"https://doi.org/10.1126/science.3952496","title":"Anti-Idiotypic Antibodies Bear the Internal Image of a Human Tumor Antigen","display_name":"Anti-Idiotypic Antibodies Bear the Internal Image of a Human Tumor Antigen","publication_year":1986,"publication_date":"1986-04-04","ids":{"openalex":"https://openalex.org/W2046907336","doi":"https://doi.org/10.1126/science.3952496","mag":"2046907336","pmid":"https://pubmed.ncbi.nlm.nih.gov/3952496"},"language":"en","primary_location":{"id":"doi:10.1126/science.3952496","doi":"https://doi.org/10.1126/science.3952496","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.3952496","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021976445","display_name":"Dorothee Herlyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorothee Herlyn","raw_affiliation_strings":["Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090059410","display_name":"Alonzo H. Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alonzo H. Ross","raw_affiliation_strings":["Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050328478","display_name":"Hilary Koprowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hilary Koprowski","raw_affiliation_strings":["Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I102322052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I102322052"],"apc_list":null,"apc_paid":null,"fwci":14.9237,"has_fulltext":false,"cited_by_count":125,"citation_normalized_percentile":{"value":0.99325008,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"232","issue":"4746","first_page":"100","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-idiotypic-antibodies","display_name":"anti-idiotypic antibodies","score":0.9589999914169312},{"id":"https://openalex.org/keywords/inner-images","display_name":"internal image","score":0.5210000276565552},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.7059999704360962},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.6520000100135803},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.7929999828338623},{"id":"https://openalex.org/keywords/antibody-combining-site","display_name":"antibody combining site","score":0.5099999904632568},{"id":"https://openalex.org/keywords/anti-anti-idiotypic-antibodies","display_name":"anti-anti-idiotypic antibodies","score":0.8040000200271606},{"id":"https://openalex.org/keywords/antibody-specificity","display_name":"antibody specificity","score":0.3540000021457672},{"id":"https://openalex.org/keywords/antibody-avidity","display_name":"antibody avidity","score":0.7630000114440918},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.7265256643295288},{"id":"https://openalex.org/C74505204","wikidata":"https://www.wikidata.org/wiki/Q1047644","display_name":"Idiotype","level":4,"score":0.7176467180252075},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7053292989730835},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.685908317565918},{"id":"https://openalex.org/C2777991845","wikidata":"https://www.wikidata.org/wiki/Q2396793","display_name":"Isotype","level":4,"score":0.4980800151824951},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4742763936519623},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.4690704047679901},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45780134201049805},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.42212167382240295},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42151927947998047},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39897048473358154}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006041","descriptor_name":"Goats","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007130","descriptor_name":"Immunoglobulin Idiotypes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.3952496","doi":"https://doi.org/10.1126/science.3952496","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.3952496","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:3952496","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3952496","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2057109075","display_name":null,"funder_award_id":"CA 21124","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3471318205","display_name":null,"funder_award_id":"CA-10815","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8260184796","display_name":null,"funder_award_id":"CA-33490","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W148691341","https://openalex.org/W1533446346","https://openalex.org/W1991852370","https://openalex.org/W2011388275","https://openalex.org/W2027580030","https://openalex.org/W2037727282","https://openalex.org/W2041324679","https://openalex.org/W2044953793","https://openalex.org/W2047644188","https://openalex.org/W2054584972","https://openalex.org/W2059922001","https://openalex.org/W2072494626","https://openalex.org/W2080724710","https://openalex.org/W2082935876","https://openalex.org/W2085414514","https://openalex.org/W2098001605","https://openalex.org/W2109338036","https://openalex.org/W2123522897","https://openalex.org/W2128056949"],"related_works":["https://openalex.org/W2042710255","https://openalex.org/W2007924699","https://openalex.org/W2158770355","https://openalex.org/W2409127913","https://openalex.org/W2418384466","https://openalex.org/W2077068169","https://openalex.org/W1521429166","https://openalex.org/W1479792841","https://openalex.org/W2081999198","https://openalex.org/W2463537988"],"abstract_inverted_index":{"Goat":[0],"antibodies":[1],"to":[2,24,30,64,79,140],"idiotypes":[3],"(anti-idiotypic":[4],"antibodies;":[5],"Ab2)":[6],"that":[7,107],"recognize":[8],"an":[9],"idiotype":[10],"associated":[11],"with":[12,61],"the":[13,53,65,90,93,97,110,119,123,134],"combining":[14],"site":[15],"of":[16,41,48,71,112,122,137],"a":[17],"BALB/c":[18,32],"mouse":[19],"IgG2a":[20],"monoclonal":[21,37],"antibody":[22,39],"(Ab1)":[23],"human":[25],"gastric":[26],"carcinoma":[27],"were":[28],"used":[29],"immunize":[31],"mice":[33],"and":[34,52,59,92],"rabbits.":[35,88],"A":[36],"anti-anti-idiotypic":[38],"(Ab3)":[40],"IgG1":[42],"isotype":[43],"was":[44,76],"obtained":[45],"after":[46],"immunization":[47],"mice.":[49],"The":[50,69],"Ab3":[51,73,82,95],"Ab1":[54],"showed":[55],"identical":[56],"binding":[57],"specificities":[58],"bound":[60,96],"similar":[62],"avidities":[63],"same":[66,98],"tumor":[67],"antigen.":[68,125],"induction":[70],"Ab1-like":[72],"by":[74],"Ab2":[75,108,127],"not":[77],"restricted":[78],"mice,":[80],"since":[81],"could":[83],"also":[84],"be":[85],"induced":[86,109],"in":[87],"Both":[89],"mouse-":[91],"rabbit-derived":[94],"gastrointestinal":[99],"cancer-associated":[100],"antigen":[101],"as":[102],"Ab1.":[103],"These":[104],"findings":[105],"indicate":[106],"formation":[111],"antigen-specific":[113],"Ab3,":[114],"probably":[115],"because":[116],"it":[117],"bears":[118],"internal":[120],"image":[121],"tumor-associated":[124],"This":[126],"may":[128],"therefore":[129],"have":[130],"potential":[131],"for":[132],"modulating":[133],"immune":[135],"response":[136],"cancer":[138],"patients":[139],"their":[141],"tumors.":[142]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}