{"id":"https://openalex.org/W2046861415","doi":"https://doi.org/10.1002/jnr.21074","title":"Lack of neprilysin suffices to generate murine amyloid\u2010like deposits in the brain and behavioral deficit in vivo","display_name":"Lack of neprilysin suffices to generate murine amyloid\u2010like deposits in the brain and behavioral deficit in vivo","publication_year":2006,"publication_date":"2006-09-22","ids":{"openalex":"https://openalex.org/W2046861415","doi":"https://doi.org/10.1002/jnr.21074","mag":"2046861415","pmid":"https://pubmed.ncbi.nlm.nih.gov/16998901"},"language":"en","primary_location":{"id":"doi:10.1002/jnr.21074","doi":"https://doi.org/10.1002/jnr.21074","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jnr.21074","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049569986","display_name":"Rime Madani","orcid":"https://orcid.org/0009-0002-1879-2483","observed_orcids":["https://orcid.org/0009-0002-1879-2483"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Rime Madani","raw_affiliation_strings":["Institute of Anatomy, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106477982","display_name":"Rapha\u00ebl Poirier","orcid":"https://orcid.org/0009-0002-3968-2734","observed_orcids":["https://orcid.org/0009-0002-3968-2734"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Raphael Poirier","raw_affiliation_strings":["Division of Psychiatry Research, University of Zurich, Zurich, Switzerland","The first two authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Psychiatry Research, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"The first two authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009427739","display_name":"David Paul Wolfer","orcid":"https://orcid.org/0000-0002-5957-1401","observed_orcids":["https://orcid.org/0000-0002-5957-1401"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"David P. Wolfer","raw_affiliation_strings":["Institute of Anatomy, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026047312","display_name":"Hans Welzl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hans Welzl","raw_affiliation_strings":["Institute of Anatomy, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017134924","display_name":"Peter Groscurth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Peter Groscurth","raw_affiliation_strings":["Institute of Anatomy, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009101953","display_name":"Hans\u2010Peter Lipp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hans\u2010Peter Lipp","raw_affiliation_strings":["Institute of Anatomy, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113749473","display_name":"Bao Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bao Lu","raw_affiliation_strings":["Pulmonary Division, Children's Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Division, Children's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066449138","display_name":"Mohammed El Mouedden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137982388","display_name":"Janssen (Belgium)","ror":"https://ror.org/04yzcpd71","country_code":"BE","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I137982388"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Mohammed El Mouedden","raw_affiliation_strings":["CNS-Pain and Alzheimer, Janssen Pharmaceutica, Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNS-Pain and Alzheimer, Janssen Pharmaceutica, Beerse, Belgium","institution_ids":["https://openalex.org/I137982388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016090292","display_name":"Marc H. Mercken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137982388","display_name":"Janssen (Belgium)","ror":"https://ror.org/04yzcpd71","country_code":"BE","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I137982388"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Marc Mercken","raw_affiliation_strings":["CNS-Pain and Alzheimer, Janssen Pharmaceutica, Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNS-Pain and Alzheimer, Janssen Pharmaceutica, Beerse, Belgium","institution_ids":["https://openalex.org/I137982388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109156775","display_name":"Roger M. Nitsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Roger M. Nitsch","raw_affiliation_strings":["Division of Psychiatry Research, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Psychiatry Research, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030075900","display_name":"M. Hasan Mohajeri","orcid":"https://orcid.org/0000-0002-2112-6281","observed_orcids":["https://orcid.org/0000-0002-2112-6281"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"M. Hasan Mohajeri","raw_affiliation_strings":["Division of Psychiatry Research, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Psychiatry Research, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5030075900"],"corresponding_institution_ids":["https://openalex.org/I202697423"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":1.5098,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.78865337,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"84","issue":"8","first_page":"1871","last_page":"1878"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neprilysin","display_name":"neprilysin","score":0.9539999961853027},{"id":"https://openalex.org/keywords/amyloid-beta-deposition","display_name":"amyloid-beta deposition","score":0.8100000023841858},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9490000009536743},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.9409999847412109},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8230000138282776},{"id":"https://openalex.org/keywords/conditioned-taste-aversion","display_name":"conditioned taste aversion","score":0.9760000109672546},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.6660000085830688},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C104826730","wikidata":"https://www.wikidata.org/wiki/Q414232","display_name":"Neprilysin","level":3,"score":0.986153244972229},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6717686057090759},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.565534234046936},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.452208012342453},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44494912028312683},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.42495793104171753},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4226440191268921},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4183773398399353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35815000534057617},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3207697868347168},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25622159242630005},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2198544442653656},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.19867730140686035},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19552013278007507},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10920798778533936},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001362","descriptor_name":"Avoidance Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003216","descriptor_name":"Conditioning, Operant","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014868","descriptor_name":"Water Deprivation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015260","descriptor_name":"Neprilysin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/jnr.21074","doi":"https://doi.org/10.1002/jnr.21074","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jnr.21074","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},{"id":"pmid:16998901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16998901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroscience research","raw_type":"Journal Article"},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/62131","doi":null,"is_oa":false,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/62131","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Madani, R., Poirier, R., Wolfer, D. P., Welzl, H., Groscurth, P., Lipp, H. P., Lu, B., El Mouedden, M., Mercken, M., Nitsch, R. M., & Mohajeri, M. H. (2006). Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivo. Journal of Neuroscience Research, 84, 1871\u20131878. https://doi.org/10.1002/jnr.21074","raw_type":"Journal Article"},{"id":"pmh:oai:www.zora.uzh.ch:49390","doi":null,"is_oa":false,"landing_page_url":"https://www.zora.uzh.ch/49390","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Madani, R; Poirier, R; Wolfer, D P; Welzl, H; Groscurth, P; Lipp, H P; Lu, B; El Mouedden, M; Mercken, M; Nitsch, R M; Mohajeri, M H (2006). Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral deficit in vivo. Journal of Neuroscience Research, 84(8):1871-1878.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1502136522","https://openalex.org/W1584834830","https://openalex.org/W1621971853","https://openalex.org/W1912490196","https://openalex.org/W1929267935","https://openalex.org/W1965275873","https://openalex.org/W1966399026","https://openalex.org/W1967408430","https://openalex.org/W1967794260","https://openalex.org/W1971855284","https://openalex.org/W1975963996","https://openalex.org/W1976128767","https://openalex.org/W1979912064","https://openalex.org/W1988071597","https://openalex.org/W1995426930","https://openalex.org/W1995650022","https://openalex.org/W1998208719","https://openalex.org/W1999319209","https://openalex.org/W2009333666","https://openalex.org/W2010773967","https://openalex.org/W2011780779","https://openalex.org/W2015708455","https://openalex.org/W2016893056","https://openalex.org/W2017956681","https://openalex.org/W2019644389","https://openalex.org/W2020951538","https://openalex.org/W2029205666","https://openalex.org/W2029532449","https://openalex.org/W2030011352","https://openalex.org/W2041256706","https://openalex.org/W2046213286","https://openalex.org/W2048975745","https://openalex.org/W2075140331","https://openalex.org/W2081342701","https://openalex.org/W2082452187","https://openalex.org/W2084385125","https://openalex.org/W2086422907","https://openalex.org/W2092788481","https://openalex.org/W2095727654","https://openalex.org/W2096410114","https://openalex.org/W2101738438","https://openalex.org/W2117983251","https://openalex.org/W2121511337","https://openalex.org/W2122065036","https://openalex.org/W2148191687","https://openalex.org/W2150999725","https://openalex.org/W2153966730","https://openalex.org/W2197519625","https://openalex.org/W2401135841"],"related_works":["https://openalex.org/W2078717887","https://openalex.org/W2030011352","https://openalex.org/W1131579344","https://openalex.org/W2028228469","https://openalex.org/W1972565866","https://openalex.org/W3022811889","https://openalex.org/W2125277088","https://openalex.org/W1976981142","https://openalex.org/W3021575418","https://openalex.org/W2114160207"],"abstract_inverted_index":{"Accumulation":[0],"of":[1,14,29,56,60,68,73,116,138,165,175],"the":[2,7,54,66,136,159],"beta-amyloid":[3],"peptide":[4],"(Abeta)":[5],"in":[6,37,47,76,81,112,119,158,168],"brain":[8,106,160],"is":[9,152],"a":[10,31,126],"major":[11,32],"pathological":[12],"hallmark":[13],"Alzheimer's":[15],"disease":[16],"(AD),":[17],"leading":[18],"to":[19,53,64,114,163],"synaptic":[20],"dysfunction,":[21],"neuronal":[22,117],"death,":[23],"and":[24,40,78,90,103,109,161,178],"memory":[25],"impairment.":[26],"The":[27,58],"levels":[28,102],"neprilysin,":[30],"Abeta-degrading":[33],"enzyme,":[34],"are":[35],"decreased":[36],"AD":[38],"brains":[39,77],"during":[41],"aging.":[42],"Because":[43],"neprilysin":[44,69,150],"cleaves":[45],"Abeta":[46,75,107,156],"vivo,":[48],"its":[49],"down-regulation":[50],"may":[51],"contribute":[52],"pathophysiology":[55],"AD.":[57],"aim":[59],"this":[61],"study":[62],"was":[63],"assess":[65],"consequences":[67],"deficiency":[70,151],"on":[71,87],"accumulation":[72,157],"murine":[74],"associated":[79,153],"pathologies":[80],"vivo":[82,169],"by":[83],"investigating":[84],"neprilysin-deficient":[85,94,123],"mice":[86,95,124],"biochemical,":[88],"morphological,":[89],"behavioral":[91,180],"levels.":[92],"Aged":[93],"expressed":[96],"physiological":[97,146],"amyloid":[98],"precursor":[99],"protein":[100],"(APP)":[101],"exhibited":[104],"elevated":[105],"concentrations":[108],"amyloid-like":[110,166],"deposits":[111],"addition":[113],"signs":[115,174],"degeneration":[118],"their":[120],"brains.":[121],"Behaviorally,":[122],"acquired":[125],"significantly":[127],"weaker":[128],"conditioned":[129],"taste":[130],"aversion":[131,137],"that":[132],"extinguished":[133],"faster":[134],"than":[135],"age-matched":[139],"controls.":[140],"Our":[141],"data":[142],"establish":[143],"that,":[144],"under":[145],"APP":[147],"expression":[148],"levels,":[149],"with":[154,173,179],"increased":[155],"leads":[162],"deposition":[164],"structures":[167],"as":[170,172],"well":[171],"AD-like":[176],"pathology":[177],"deficits.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}