{"id":"https://openalex.org/W2046851622","doi":"https://doi.org/10.1016/j.antiviral.2007.01.024","title":"Synthesis and Antiviral Activity of 1-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]-5-Azacytosine and its Ester Prodrugs","display_name":"Synthesis and Antiviral Activity of 1-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]-5-Azacytosine and its Ester Prodrugs","publication_year":2007,"publication_date":"2007-02-23","ids":{"openalex":"https://openalex.org/W2046851622","doi":"https://doi.org/10.1016/j.antiviral.2007.01.024","mag":"2046851622"},"language":"en","primary_location":{"id":"doi:10.1016/j.antiviral.2007.01.024","doi":"https://doi.org/10.1016/j.antiviral.2007.01.024","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.antiviral.2007.01.024","pdf_url":null,"source":{"id":"https://openalex.org/S137372404","display_name":"Antiviral Research","issn_l":"0166-3542","issn":["0166-3542","1872-9096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024818475","display_name":"Marcela Kre\u010dmerov\u00e1","orcid":"https://orcid.org/0000-0001-7780-1795","observed_orcids":["https://orcid.org/0000-0001-7780-1795"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210145889","display_name":"Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry","ror":"https://ror.org/04nfjn472","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"M KRECMEROVA","raw_affiliation_strings":["Gilead Sciences & IOCB Research Centre, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences & IOCB Research Centre, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111746439","display_name":"Anton\u0131\u0301n Hol\u00fd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210145889","display_name":"Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry","ror":"https://ror.org/04nfjn472","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"A HOLY","raw_affiliation_strings":["Gilead Sciences & IOCB Research Centre, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences & IOCB Research Centre, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057460293","display_name":"A. P\u00edskala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210145889","display_name":"Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry","ror":"https://ror.org/04nfjn472","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"A PISKALA","raw_affiliation_strings":["Gilead Sciences & IOCB Research Centre, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences & IOCB Research Centre, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030479730","display_name":"Graciela Andre\u00ef","orcid":"https://orcid.org/0000-0003-2609-4896","observed_orcids":["https://orcid.org/0000-0003-2609-4896"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"G ANDREI","raw_affiliation_strings":["Rega institute for Medical Research, Katholieke Universiteit Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega institute for Medical Research, Katholieke Universiteit Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085228034","display_name":"Robert Snoeck","orcid":"https://orcid.org/0000-0002-7586-5434","observed_orcids":["https://orcid.org/0000-0002-7586-5434"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"R SNOECK","raw_affiliation_strings":["Rega institute for Medical Research, Katholieke Universiteit Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega institute for Medical Research, Katholieke Universiteit Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081640914","display_name":"Lieve M. J. Naesens","orcid":"https://orcid.org/0000-0001-9742-9302","observed_orcids":["https://orcid.org/0000-0001-9742-9302"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"L NAESENS","raw_affiliation_strings":["Rega institute for Medical Research, Katholieke Universiteit Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega institute for Medical Research, Katholieke Universiteit Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089010495","display_name":"Johan H. Neyts","orcid":"https://orcid.org/0000-0002-0033-7514","observed_orcids":["https://orcid.org/0000-0002-0033-7514"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J NEYTS","raw_affiliation_strings":["Rega institute for Medical Research, Katholieke Universiteit Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega institute for Medical Research, Katholieke Universiteit Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038319371","display_name":"Jan M. Balzarini","orcid":"https://orcid.org/0000-0003-2240-3321","observed_orcids":["https://orcid.org/0000-0003-2240-3321","https://orcid.org/0000-0003-1144-1808"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J BALZARINI","raw_affiliation_strings":["Rega institute for Medical Research, Katholieke Universiteit Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega institute for Medical Research, Katholieke Universiteit Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040662398","display_name":"Erik De Clercq","orcid":"https://orcid.org/0000-0002-2985-8890","observed_orcids":["https://orcid.org/0000-0002-2985-8890"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"E DECLERCQ","raw_affiliation_strings":["Rega institute for Medical Research, Katholieke Universiteit Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega institute for Medical Research, Katholieke Universiteit Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4160,"currency":"USD","value_usd":4160},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11342714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"3","first_page":"A33","last_page":"A33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ester-prodrugs","display_name":"ester prodrugs","score":0.6990000009536743},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.781000018119812},{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.7570000290870667},{"id":"https://openalex.org/keywords/hiv-reverse-transcriptase-inhibitors","display_name":"HIV reverse transcriptase inhibitors","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.8310329914093018},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5882235765457153},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.49648910760879517},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07297727465629578}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.antiviral.2007.01.024","doi":"https://doi.org/10.1016/j.antiviral.2007.01.024","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.antiviral.2007.01.024","pdf_url":null,"source":{"id":"https://openalex.org/S137372404","display_name":"Antiviral Research","issn_l":"0166-3542","issn":["0166-3542","1872-9096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2060403953","https://openalex.org/W2297077467","https://openalex.org/W2012183448","https://openalex.org/W2071422694","https://openalex.org/W7131994648","https://openalex.org/W2277532264","https://openalex.org/W7132702417","https://openalex.org/W2003573475","https://openalex.org/W2967822852","https://openalex.org/W2033527014"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2016-06-24T00:00:00"}
