{"id":"https://openalex.org/W2046848792","doi":"https://doi.org/10.2174/157340106778017878","title":"Role of Dietary Xenobiotics-Gene Interactions in Carcinogenesis: Protective Effects of Nutritional Factors","display_name":"Role of Dietary Xenobiotics-Gene Interactions in Carcinogenesis: Protective Effects of Nutritional Factors","publication_year":2006,"publication_date":"2006-08-01","ids":{"openalex":"https://openalex.org/W2046848792","doi":"https://doi.org/10.2174/157340106778017878","mag":"2046848792"},"language":"en","primary_location":{"id":"doi:10.2174/157340106778017878","doi":"https://doi.org/10.2174/157340106778017878","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157340106778017878","pdf_url":null,"source":{"id":"https://openalex.org/S33754043","display_name":"Current Nutrition & Food Science","issn_l":"1573-4013","issn":["1573-4013","2212-3881"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Nutrition & Food Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112386626","display_name":"Donato F. Romagnolo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donato Romagnolo","raw_affiliation_strings":["Nutritional Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109159036","display_name":"Stephanie C. Degner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Degner","raw_affiliation_strings":["University of Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103255722","display_name":"Michael Quentin Kemp","orcid":"https://orcid.org/0000-0002-2910-452X","observed_orcids":["https://orcid.org/0000-0002-2910-452X"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Kemp","raw_affiliation_strings":["University of Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001096479","display_name":"Jennifer K. Hockings","orcid":"https://orcid.org/0000-0001-9864-205X","observed_orcids":["https://orcid.org/0000-0001-9864-205X"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Hockings","raw_affiliation_strings":["University of Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084037167","display_name":"Ornella I. Selmin","orcid":"https://orcid.org/0000-0003-3992-7834","observed_orcids":["https://orcid.org/0000-0003-3992-7834"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ornella Selmin","raw_affiliation_strings":["Nutritional Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutritional Sciences","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5007,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.66612289,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"3","first_page":"205","last_page":"214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.16269999742507935,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nutrient-interactions","display_name":"nutrient interactions","score":0.38600000739097595},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7509999871253967},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.9290000200271606},{"id":"https://openalex.org/keywords/dioxins","display_name":"dioxins","score":1.0},{"id":"https://openalex.org/keywords/chlorinated-hydrocarbons","display_name":"chlorinated hydrocarbons","score":0.9879999756813049},{"id":"https://openalex.org/keywords/aromatic-hydrocarbon-receptor","display_name":"aromatic hydrocarbon receptor","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9369999766349792},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8519999980926514},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.890999972820282},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.7329999804496765},{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.796999990940094},{"id":"https://openalex.org/keywords/alpha-naphthoflavone","display_name":"alpha-naphthoflavone","score":0.9629999995231628},{"id":"https://openalex.org/keywords/fatty-acids","display_name":"fatty acids","score":0.6050000190734863},{"id":"https://openalex.org/keywords/conjugated-linoleic-acid","display_name":"conjugated linoleic acid","score":0.9580000042915344},{"id":"https://openalex.org/keywords/omega-3-polyunsaturated-fatty-acids","display_name":"omega-3 polyunsaturated fatty acids","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7480000257492065},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C115448650","wikidata":"https://www.wikidata.org/wiki/Q409205","display_name":"Xenobiotic","level":3,"score":0.7332661151885986},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.7309376001358032},{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.6584665775299072},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5475141406059265},{"id":"https://openalex.org/C2779780233","wikidata":"https://www.wikidata.org/wiki/Q56696202","display_name":"Conjugated linoleic acid","level":4,"score":0.5407931208610535},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5226219296455383},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5018532276153564},{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.4704659879207611},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.44818544387817383},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.422113299369812},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4187315106391907},{"id":"https://openalex.org/C2780809830","wikidata":"https://www.wikidata.org/wiki/Q407426","display_name":"Linoleic acid","level":3,"score":0.3599892556667328},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32585084438323975},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2959628701210022},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.29309791326522827},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.21548870205879211}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/157340106778017878","doi":"https://doi.org/10.2174/157340106778017878","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157340106778017878","pdf_url":null,"source":{"id":"https://openalex.org/S33754043","display_name":"Current Nutrition & Food Science","issn_l":"1573-4013","issn":["1573-4013","2212-3881"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Nutrition & Food Science","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2099216178","https://openalex.org/W126720373","https://openalex.org/W2263221693","https://openalex.org/W1995084981","https://openalex.org/W2917583528","https://openalex.org/W4226014545","https://openalex.org/W2345562910","https://openalex.org/W2911751515","https://openalex.org/W560649973","https://openalex.org/W2969659341"],"abstract_inverted_index":{"In":[0],"this":[1],"paper,":[2],"we":[3,225],"discuss":[4],"how":[5],"interactions":[6],"between":[7],"dietary":[8,185,196],"xenobiotics":[9],"and":[10,55,70,97,109,131,155,191,209,240],"nutrients":[11],"influence":[12,201],"cancer":[13,205],"risk":[14,203],"by":[15,68,206],"modulating":[16],"overlapping":[17],"biochemical":[18],"pathways":[19],"leading":[20],"to":[21,46,84,114,144,147],"repression":[22],"of":[23,28,44,61,75,91,101,118,128,133,139,151,159,173,184,204,221,237],"tumor":[24,29,103],"suppressor":[25,104],"genes,":[26],"activation":[27,60,158,172],"promoters,":[30],"or":[31,212],"both.":[32],"Epidemiologic":[33],"studies":[34],"in":[35,93,125,189,230,247],"humans":[36],"suggested":[37],"that":[38,88,167],"diet":[39],"is":[40],"an":[41],"important":[42],"vehicle":[43],"exposure":[45],"various":[47],"xenobiotics,":[48],"including":[49,78,153],"polycyclic":[50],"aromatic":[51,63],"hydrocarbons":[52,57],"(PAHs),":[53],"dioxins,":[54],"chlorinated":[56],"(CHs).":[58],"The":[59,137],"the":[62,73,94,99,102,116,126,149,160,171,174,202,219,234],"hydrocarbon":[64],"receptor":[65],"(AhR)":[66],"pathway":[67,176],"PAHs":[69,83,108],"dioxins":[71,110],"stimulates":[72],"expression":[74,100,117,150,220],"several":[76],"genes":[77],"cytochrome":[79],"P450s,":[80],"which":[81,179],"metabolize":[82],"highly":[85],"mutagenic":[86],"compounds":[87],"cause":[89],"fixation":[90],"mutations":[92],"p53":[95],"gene":[96,248],"repress":[98],"gene,":[105],"BRCA-1.":[106],"Conversely,":[107],"have":[111],"been":[112,142],"shown":[113],"activate":[115,148],"cyclooxygenase-2":[119],"(COX-2),":[120],"whose":[121],"protein":[122],"product":[123],"participates":[124],"production":[127],"reactive":[129],"PAH-metabolites":[130],"synthesis":[132],"proinflammatory":[134],"prostaglandins":[135],"(PGs).":[136],"carcinogenicity":[138],"CHs":[140],"has":[141],"attributed":[143],"their":[145],"ability":[146],"oncogenes":[152],"c-myc,":[154],"fatty":[156,197,256],"acid":[157,216],"peroxisome":[161],"proliferator-activated":[162],"receptor-\u03b1":[163],"(PPAR\u03b1).":[164],"Dietary":[165,251],"components":[166],"may":[168,199],"protect":[169],"against":[170,244],"AhR":[175],"include":[177],"flavonoids,":[178],"comprise":[180],"a":[181],"large":[182],"family":[183],"phenolic":[186],"phytochemicals":[187],"found":[188],"fruits":[190],"vegetables.":[192],"Nutrients":[193],"such":[194],"as":[195],"acids":[198],"differentially":[200],"inducing":[207],"(linoleic":[208],"arachidonic":[210],"acid)":[211],"repressing":[213],"(conjugated":[214],"linoleic":[215],"(CLA);":[217],"n-3PUFA)":[218],"COX-":[222],"2.":[223],"Finally,":[224],"present":[226],"original":[227],"findings":[228],"produced":[229],"our":[231],"laboratory":[232],"documenting":[233],"protective":[235],"effects":[236],"natural":[238],"(genestein)":[239],"synthetic":[241],"(\u03b1-naphthoflavone)":[242],"flavonoids":[243],"PAH-induced":[245],"changes":[246],"expression.":[249],"Keywords:":[250],"carcinogens,":[252],"BRCA-1,":[253],"p53,":[254],"COX-2,":[255],"acids,":[257],"polyphenols":[258]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}