{"id":"https://openalex.org/W20468255","doi":null,"title":"Inhibition of bleomycin-induced pulmonary fibrosis by nordihydroguaiaretic acid. The role of alveolar macrophage activation and mediator production.","display_name":"Inhibition of bleomycin-induced pulmonary fibrosis by nordihydroguaiaretic acid. The role of alveolar macrophage activation and mediator production.","publication_year":1986,"publication_date":"1986-08-01","ids":{"openalex":"https://openalex.org/W20468255","mag":"20468255","pmid":"https://pubmed.ncbi.nlm.nih.gov/2426952","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888290"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1888290","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888290","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888290","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077346838","display_name":"Sem Hin Phan","orcid":"https://orcid.org/0000-0002-3711-2159","observed_orcids":["https://orcid.org/0000-0002-3711-2159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S H Phan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004928457","display_name":"Steven L. Kunkel","orcid":"https://orcid.org/0000-0002-5738-6341","observed_orcids":["https://orcid.org/0000-0002-5738-6341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S L Kunkel","raw_affiliation_strings":["Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.4522,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.96606623,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"124","issue":"2","first_page":"343","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bleomycin","display_name":"bleomycin","score":0.8820000290870667},{"id":"https://openalex.org/keywords/nordihydroguaiaretic-acid","display_name":"nordihydroguaiaretic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipoxygenase-inhibition","display_name":"lipoxygenase inhibition","score":0.8420000076293945},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.8939999938011169},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.9559999704360962},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9459999799728394}],"concepts":[{"id":"https://openalex.org/C2776889390","wikidata":"https://www.wikidata.org/wiki/Q7050774","display_name":"Nordihydroguaiaretic acid","level":4,"score":0.9448198080062866},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.8055635094642639},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.764754056930542},{"id":"https://openalex.org/C2778012055","wikidata":"https://www.wikidata.org/wiki/Q448687","display_name":"Alveolar macrophage","level":4,"score":0.6488297581672668},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5539794564247131},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5069025158882141},{"id":"https://openalex.org/C2778543330","wikidata":"https://www.wikidata.org/wiki/Q191341","display_name":"Pulmonary alveolus","level":4,"score":0.4698787033557892},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44364067912101746},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4275248646736145},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4236503541469574},{"id":"https://openalex.org/C2780857362","wikidata":"https://www.wikidata.org/wiki/Q1827455","display_name":"Lipoxygenase","level":3,"score":0.3608492612838745},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32375478744506836},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3208996653556824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28720852732658386},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.26917117834091187},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2012452781200409},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.09161120653152466},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07373303174972534},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002396","descriptor_name":"Catechols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008808","descriptor_name":"Mice, Inbred CBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009637","descriptor_name":"Masoprocol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1888290","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888290","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:2426952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2426952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:20468255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2426952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1888290","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888290","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W4791821","https://openalex.org/W28829384","https://openalex.org/W51309640","https://openalex.org/W57738156","https://openalex.org/W221107747","https://openalex.org/W306251667","https://openalex.org/W1224002455","https://openalex.org/W1263945336","https://openalex.org/W1499341710","https://openalex.org/W1535953403","https://openalex.org/W1550447653","https://openalex.org/W1552275448","https://openalex.org/W1557310960","https://openalex.org/W1571254150","https://openalex.org/W1604292228","https://openalex.org/W1676695400","https://openalex.org/W1802671208","https://openalex.org/W1820131076","https://openalex.org/W1837837142","https://openalex.org/W1869376589","https://openalex.org/W1969321901","https://openalex.org/W1984882172","https://openalex.org/W1991260449","https://openalex.org/W1991663972","https://openalex.org/W1993378025","https://openalex.org/W1994110238","https://openalex.org/W2015211989","https://openalex.org/W2016530154","https://openalex.org/W2023265161","https://openalex.org/W2032074633","https://openalex.org/W2035306112","https://openalex.org/W2038468255","https://openalex.org/W2040576190","https://openalex.org/W2046362689","https://openalex.org/W2055583690","https://openalex.org/W2057190561","https://openalex.org/W2061278134","https://openalex.org/W2063586607","https://openalex.org/W2067177821","https://openalex.org/W2068660301","https://openalex.org/W2071264144","https://openalex.org/W2084902432","https://openalex.org/W2099780759","https://openalex.org/W2112138377","https://openalex.org/W2121844839","https://openalex.org/W2144266362","https://openalex.org/W2159069239","https://openalex.org/W2165720865","https://openalex.org/W2187043740","https://openalex.org/W2405003887","https://openalex.org/W2410125802"],"related_works":["https://openalex.org/W6977362549","https://openalex.org/W2586241184","https://openalex.org/W2061278134","https://openalex.org/W2253593857","https://openalex.org/W7096415059","https://openalex.org/W3156736372","https://openalex.org/W2157628349","https://openalex.org/W3094749815","https://openalex.org/W2069046498","https://openalex.org/W2089492050"],"abstract_inverted_index":{"The":[0,82,289,315],"role":[1,16],"of":[2,8,24,28,34,52,93,112,117,121,136,150,170,180,189,245,251,271,278,280,291,299,306,311],"alveolar":[3,137,153,208,300],"macrophage":[4,171,178,209,260,301,321],"activation":[5],"and":[6,77,213,232,274,303],"release":[7],"mediators":[9],"remains":[10],"unclear.":[11],"In":[12,96,200],"this":[13,15,109,160,168,219,230,243,287,292],"study,":[14],"is":[17,225],"examined":[18],"with":[19,108,167],"respect":[20],"to":[21,45,146,325],"the":[22,32,98,115,134,266,275,297,309],"effects":[23],"relatively":[25],"selective":[26],"inhibitors":[27],"arachidonate":[29,328],"metabolism":[30],"on":[31],"pathogenesis":[33,310],"pulmonary":[35,47,60,123,246,313],"fibrosis.":[36,48,124,247,314],"CBA/J":[37],"mice":[38],"were":[39],"administered":[40],"bleomycin":[41,190,202],"(0.037":[42],"units)":[43],"endotracheally":[44],"induce":[46],"Daily":[49],"intraperitoneal":[50],"injections":[51],"a":[53,63,91,128,163,187,205,236],"lipoxygenase":[54],"inhibitor,":[55,100],"nordihydroguaiaretic":[56],"acid":[57],"(NDGA)":[58],"inhibited":[59,159,196],"fibrosis":[61],"in":[62,133,162,176,207,229,242,258,283,286,308],"dose-dependent":[64,164],"manner":[65],"(15-25":[66],"mg/kg":[67],"body":[68],"weight),":[69],"as":[70,186],"assessed":[71],"by":[72,197,327],"both":[73,320],"lung":[74,79],"collagen":[75],"synthesis":[76],"total":[78,151],"hydroxyproline":[80],"content.":[81],"less":[83],"specific":[84],"inhibitor":[85],"BW755c":[86],"was":[87,104,114,173,194,253],"also":[88,195,317],"effective":[89],"at":[90,240],"dose":[92],"25":[94],"mg/kg.":[95],"contrast,":[97,201],"cyclooxygenase":[99,269],"ibuprofen":[101],"(15":[102],"mg/kg),":[103],"completely":[105],"ineffective.":[106],"Correlated":[107],"antifibrogenic":[110,249],"activity":[111,185,250],"NDGA":[113,198,214,252,272],"inhibition":[116,273],"several":[118],"other":[119],"parameters":[120,322],"bleomycin-induced":[122,312],"Bleomycin":[125],"treatment":[126,203,215],"caused":[127,204],"greater":[129],"than":[130],"threefold":[131],"increase":[132,161,175,193],"percentage":[135],"macrophages":[138],"expressing":[139],"Ia":[140],"antigen":[141],"(from":[142],"7.7%":[143],"+/-":[144,148],"1.07%":[145],"29.9%":[147],"4.16%":[149],"recoverable":[152],"macrophages).":[154],"NDGA,":[155],"but":[156],"not":[157,217],"ibuprofen,":[158],"manner.":[165],"Associated":[166],"indication":[169],"stimulation":[172,302],"an":[174],"spontaneous":[177,259],"production":[179,305],"fibroblast":[181],"growth":[182],"factor":[183],"(MDGF)":[184],"result":[188],"instillation.":[191],"This":[192,248],"treatment.":[199],"reduction":[206,257],"interleukin-1":[210],"(IL-1)":[211],"production,":[212,263],"did":[216],"alter":[218],"reduction,":[220],"which":[221,264],"suggests":[222,265],"that":[223,233,319],"MDGF":[224,234,307],"separate":[226],"from":[227],"IL-1":[228],"case,":[231],"played":[235],"more":[237],"dominant":[238],"role,":[239],"least":[241],"model":[244],"accomplished":[254],"without":[255],"any":[256],"prostaglandin":[261],"(PG)E2":[262],"selectivity":[267],"(versus":[268],"pathway)":[270],"relative":[276],"lack":[277],"importance":[279,298],"macrophage-derived":[281],"PGE2":[282],"modulating":[284],"fibrogenesis":[285],"model.":[288],"results":[290],"study":[293],"have":[294],"thus":[295],"demonstrated":[296],"increased":[304],"data":[316],"suggest":[318],"are":[323],"subject":[324],"regulation":[326],"metabolites.":[329]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}