{"id":"https://openalex.org/W2046775136","doi":"https://doi.org/10.1177/0885328209351136","title":"Preparation of Magnetic Iron Oxide Nanoparticles for Hyperthermia of Cancer in a FeCl 2 -NaNO 3 -NaOH Aqueous System","display_name":"Preparation of Magnetic Iron Oxide Nanoparticles for Hyperthermia of Cancer in a FeCl 2 -NaNO 3 -NaOH Aqueous System","publication_year":2010,"publication_date":"2010-03-05","ids":{"openalex":"https://openalex.org/W2046775136","doi":"https://doi.org/10.1177/0885328209351136","mag":"2046775136","pmid":"https://pubmed.ncbi.nlm.nih.gov/20207773"},"language":"en","primary_location":{"id":"doi:10.1177/0885328209351136","doi":"https://doi.org/10.1177/0885328209351136","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0885328209351136","pdf_url":null,"source":{"id":"https://openalex.org/S89326922","display_name":"Journal of Biomaterials Applications","issn_l":"0885-3282","issn":["0885-3282","1530-8022"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomaterials Applications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101962258","display_name":"Zhixia Li","orcid":"https://orcid.org/0000-0001-8834-4649","observed_orcids":["https://orcid.org/0000-0001-8834-4649","https://orcid.org/0009-0004-2386-583X"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Zhixia Li","raw_affiliation_strings":["Graduate School of Biomedical Engineering, Tohoku University Sendai 980-8579, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Engineering, Tohoku University Sendai 980-8579, Japan,","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062017208","display_name":"Masakazu Kawashita","orcid":"https://orcid.org/0000-0002-4329-9001","observed_orcids":["https://orcid.org/0000-0002-4329-9001"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masakazu Kawashita","raw_affiliation_strings":["Graduate School of Biomedical Engineering, Tohoku University Sendai 980-8579, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Engineering, Tohoku University Sendai 980-8579, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057569242","display_name":"Norio Araki","orcid":"https://orcid.org/0009-0003-8853-7936","observed_orcids":["https://orcid.org/0009-0003-8853-7936"]},"institutions":[{"id":"https://openalex.org/I3017590076","display_name":"Kyoto Medical Center","ror":"https://ror.org/045kb1d14","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3017590076","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norio Araki","raw_affiliation_strings":["National Hospital Organization Kyoto Medical Center Kyoto 612-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Hospital Organization Kyoto Medical Center Kyoto 612-8555, Japan","institution_ids":["https://openalex.org/I3017590076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041142405","display_name":"Michihide Mitsumori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michihide Mitsumori","raw_affiliation_strings":["Graduate School of Medicine, Kyoto University Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Medicine, Kyoto University Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015259799","display_name":"Masahiro Hiraoka","orcid":"https://orcid.org/0000-0002-7639-569X","observed_orcids":["https://orcid.org/0000-0002-7639-569X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Hiraoka","raw_affiliation_strings":["Graduate School of Medicine, Kyoto University Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Medicine, Kyoto University Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111647247","display_name":"Masaaki Doi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Doi","raw_affiliation_strings":["Graduate School of Engineering, Tohoku University Sendai 980-8579, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Engineering, Tohoku University Sendai 980-8579, Japan","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101962258"],"corresponding_institution_ids":["https://openalex.org/I201537933"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.6719,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.81341603,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"25","issue":"7","first_page":"643","last_page":"661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12405","display_name":"Characterization and Applications of Magnetic Nanoparticles","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10922","display_name":"Magnetic Properties and Synthesis of Ferrites","score":0.03610000014305115,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11786","display_name":"Geomagnetism and Paleomagnetism Studies","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1908","display_name":"Geophysics"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/magnetic-iron-oxide-nanoparticles","display_name":"magnetic iron oxide nanoparticles","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.7350000143051147},{"id":"https://openalex.org/keywords/magnetite","display_name":"magnetite","score":0.8730000257492065},{"id":"https://openalex.org/keywords/maghemite","display_name":"maghemite","score":0.9980000257492065},{"id":"https://openalex.org/keywords/reaction-mechanism","display_name":"reaction mechanism","score":0.6430000066757202},{"id":"https://openalex.org/keywords/molar-ratio-effects","display_name":"molar ratio effects","score":0.7900000214576721},{"id":"https://openalex.org/keywords/nanoparticle-size-control","display_name":"nanoparticle size control","score":0.6890000104904175},{"id":"https://openalex.org/keywords/alternating-magnetic-field-heating","display_name":"alternating magnetic field heating","score":0.8119999766349792},{"id":"https://openalex.org/keywords/agar-phantom","display_name":"agar phantom","score":0.7149999737739563},{"id":"https://openalex.org/keywords/heating-efficiency","display_name":"heating efficiency","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6890845894813538},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.6670199632644653},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6547839641571045},{"id":"https://openalex.org/C87023908","wikidata":"https://www.wikidata.org/wiki/Q3870166","display_name":"Magnetic nanoparticles","level":3,"score":0.6079157590866089},{"id":"https://openalex.org/C2780357685","wikidata":"https://www.wikidata.org/wiki/Q154357","display_name":"Nano-","level":2,"score":0.5389028787612915},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.4843657910823822},{"id":"https://openalex.org/C2778889443","wikidata":"https://www.wikidata.org/wiki/Q6073014","display_name":"Iron oxide nanoparticles","level":3,"score":0.48150691390037537},{"id":"https://openalex.org/C2780838151","wikidata":"https://www.wikidata.org/wiki/Q564872","display_name":"Magnetic hyperthermia","level":4,"score":0.44823262095451355},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.44492438435554504},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.4378674030303955},{"id":"https://openalex.org/C2777697756","wikidata":"https://www.wikidata.org/wiki/Q721849","display_name":"Iron oxide","level":2,"score":0.4326012432575226},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.429416298866272},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2240297794342041},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.1587393581867218},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1416986584663391},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.13087165355682373},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0857592225074768},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/0885328209351136","doi":"https://doi.org/10.1177/0885328209351136","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0885328209351136","pdf_url":null,"source":{"id":"https://openalex.org/S89326922","display_name":"Journal of Biomaterials Applications","issn_l":"0885-3282","issn":["0885-3282","1530-8022"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomaterials Applications","raw_type":"journal-article"},{"id":"pmid:20207773","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20207773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomaterials applications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327420","display_name":"Kazuchika Okura Memorial Foundation","ror":"https://ror.org/05r5jkq07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W17595272","https://openalex.org/W1670488220","https://openalex.org/W1968317672","https://openalex.org/W1976931754","https://openalex.org/W1984129864","https://openalex.org/W1988588174","https://openalex.org/W1988975807","https://openalex.org/W1992035534","https://openalex.org/W1992595685","https://openalex.org/W1995459860","https://openalex.org/W1995843690","https://openalex.org/W1998829244","https://openalex.org/W2001837470","https://openalex.org/W2005502902","https://openalex.org/W2016488018","https://openalex.org/W2017000730","https://openalex.org/W2017985531","https://openalex.org/W2022037160","https://openalex.org/W2025988053","https://openalex.org/W2028247401","https://openalex.org/W2028648188","https://openalex.org/W2030663808","https://openalex.org/W2030817491","https://openalex.org/W2031147516","https://openalex.org/W2036088849","https://openalex.org/W2036638238","https://openalex.org/W2038754814","https://openalex.org/W2039985275","https://openalex.org/W2043089980","https://openalex.org/W2045536980","https://openalex.org/W2049424269","https://openalex.org/W2062817069","https://openalex.org/W2064670842","https://openalex.org/W2068141018","https://openalex.org/W2082917454","https://openalex.org/W2086328136","https://openalex.org/W2088197039","https://openalex.org/W2093718909","https://openalex.org/W2106869695","https://openalex.org/W2112169227","https://openalex.org/W2134126872","https://openalex.org/W2134723899","https://openalex.org/W2464239779"],"related_works":["https://openalex.org/W1670488220","https://openalex.org/W7220953896","https://openalex.org/W2406502147","https://openalex.org/W4309686434","https://openalex.org/W3095581468","https://openalex.org/W6946134232","https://openalex.org/W3084658749","https://openalex.org/W2910525725","https://openalex.org/W7120372452","https://openalex.org/W2569843720"],"abstract_inverted_index":{"Magnetic":[0],"iron":[1],"oxide":[2],"nanoparticles":[3,58],"(MIONPs)":[4],"were":[5,77,105],"synthesized":[6],"in":[7,24,83,93,101,132],"a":[8,89,138],"FeCl\u2082-NaNO\u2083-NaOH":[9],"aqueous":[10],"system":[11],"under":[12,107,158],"various":[13],"initial":[14,32],"Fe(2+)/NO\u207b\u2083":[15,42],"molar":[16,21,33,44],"ratios":[17,22],"(\u03b1)":[18],"and":[19,64,72],"Fe(2+)/OH-":[20],"(\u03b2)":[23],"order":[25,82],"to":[26,53,88,151],"clarify":[27],"the":[28,31,38,54,81,98,121,125,133,162],"effects":[29],"of":[30,35,46,56,61,97,120,140],"ratio":[34,45],"reactants":[36],"on":[37],"reaction":[39],"mechanism.":[40],"The":[41,67,92,116],"/OH(-)":[43],"3":[47],":":[48,50],"1":[49],"5":[51],"led":[52],"formation":[55],"magnetic":[57,110],"mainly":[59],"composed":[60],"magnetite":[62],"(Fe\u2083O\u2084)":[63],"maghemite":[65],"(\u03b3-Fe\u2082O\u2083).":[66],"36":[68,126],"nm":[69,74,127],"sized":[70,75,128],"\u03b3-Fe\u2082O\u2083":[71,129],"413":[73],"Fe\u2083O\u2084":[76],"obtained":[78],"by":[79],"changing":[80],"which":[84],"NaNO\u2083":[85],"was":[86,130],"added":[87],"NaOH":[90],"solution.":[91],"vitro":[94],"heat":[95],"generations":[96],"resulting":[99],"MIONPs":[100,153],"an":[102,108],"agar":[103,122],"phantom":[104,123],"measured":[106],"alternating":[109],"field":[111],"(100":[112],"kHz,":[113],"23.9":[114],"kA/m).":[115],"temperature":[117],"rise":[118],"(\u0394T)":[119],"for":[124],"55\u00b0C":[131],"first":[134],"140":[135],"s,":[136],"with":[137,154],"concentration":[139],"58":[141],"mg":[142],"Fe/mL.":[143],"Our":[144],"results":[145],"showed":[146],"that":[147],"it":[148],"is":[149],"possible":[150],"prepare":[152],"high":[155],"heating":[156],"efficiencies":[157],"optimal":[159],"conditions":[160],"using":[161],"present":[163],"method.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}