{"id":"https://openalex.org/W2046763552","doi":"https://doi.org/10.1038/jcbfm.1994.49","title":"Temperature Dependent Change of Apparent Diffusion Coefficient of Water in Normal and Ischemic Brain of Rats","display_name":"Temperature Dependent Change of Apparent Diffusion Coefficient of Water in Normal and Ischemic Brain of Rats","publication_year":1994,"publication_date":"1994-05-01","ids":{"openalex":"https://openalex.org/W2046763552","doi":"https://doi.org/10.1038/jcbfm.1994.49","mag":"2046763552","pmid":"https://pubmed.ncbi.nlm.nih.gov/8163580"},"language":"en","primary_location":{"id":"doi:10.1038/jcbfm.1994.49","doi":"https://doi.org/10.1038/jcbfm.1994.49","is_oa":true,"landing_page_url":"https://doi.org/10.1038/jcbfm.1994.49","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1994.49?download=true","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1994.49?download=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028025164","display_name":"Yasuhiro Hasegawa","orcid":"https://orcid.org/0000-0003-3200-376X","observed_orcids":["https://orcid.org/0000-0003-3200-376X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasuhiro Hasegawa","raw_affiliation_strings":["Department of Neurology, The Medical Center of Central Massachusetts-Memorial, Worcester, Massachusetts, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Medical Center of Central Massachusetts-Memorial, Worcester, Massachusetts, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006786561","display_name":"Lawrence L. Latour","orcid":"https://orcid.org/0000-0001-6160-5263","observed_orcids":["https://orcid.org/0000-0001-6160-5263"]},"institutions":[{"id":"https://openalex.org/I107077323","display_name":"Worcester Polytechnic Institute","ror":"https://ror.org/05ejpqr48","country_code":"US","type":"education","lineage":["https://openalex.org/I107077323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence L. Latour","raw_affiliation_strings":["Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts, U.S.A","institution_ids":["https://openalex.org/I107077323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072837575","display_name":"Christopher H. Sotak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher H. Sotak","raw_affiliation_strings":["Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, U.S.A","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015046378","display_name":"Bernard J. Dardzinski","orcid":"https://orcid.org/0000-0001-7098-9131","observed_orcids":["https://orcid.org/0000-0001-7098-9131"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernard J. Dardzinski","raw_affiliation_strings":["Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, U.S.A","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036747513","display_name":"Marc Fisher","orcid":"https://orcid.org/0000-0002-6116-475X","observed_orcids":["https://orcid.org/0000-0002-6116-475X"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Fisher","raw_affiliation_strings":["Department of Neurology, The Medical Center of Central Massachusetts-Memorial, Worcester, Massachusetts, U.S.A","Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Medical Center of Central Massachusetts-Memorial, Worcester, Massachusetts, U.S.A","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts, U.S.A","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":8.0146,"has_fulltext":true,"cited_by_count":90,"citation_normalized_percentile":{"value":0.97727073,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"3","first_page":"383","last_page":"390"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.614300012588501,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.614300012588501,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.34450000524520874,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apparent-diffusion-coefficient","display_name":"apparent diffusion coefficient","score":0.9919999837875366},{"id":"https://openalex.org/keywords/water-diffusion","display_name":"water diffusion","score":0.7590000033378601},{"id":"https://openalex.org/keywords/brain-temperature","display_name":"brain temperature","score":0.9449999928474426},{"id":"https://openalex.org/keywords/body-temperature","display_name":"body temperature","score":0.7089999914169312},{"id":"https://openalex.org/keywords/focal-cerebral-ischemia","display_name":"focal cerebral ischemia","score":0.9679999947547913},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.9559999704360962},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.7950000166893005},{"id":"https://openalex.org/keywords/diffusion-weighted-imaging","display_name":"diffusion-weighted imaging","score":0.6940000057220459},{"id":"https://openalex.org/keywords/brain-temperature-monitoring","display_name":"brain temperature monitoring","score":0.5210000276565552},{"id":"https://openalex.org/keywords/rat-brain","display_name":"rat brain","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C70816921","wikidata":"https://www.wikidata.org/wiki/Q258852","display_name":"Effective diffusion coefficient","level":3,"score":0.7409924268722534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5293090343475342},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5186699628829956},{"id":"https://openalex.org/C16643434","wikidata":"https://www.wikidata.org/wiki/Q898642","display_name":"Temperature coefficient","level":2,"score":0.4659610390663147},{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.45590442419052124},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3448232114315033},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3320603370666504},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3320586681365967},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.13518333435058594},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1258947253227234},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.08616220951080322},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001831","descriptor_name":"Body Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013821","descriptor_name":"Thermometers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/jcbfm.1994.49","doi":"https://doi.org/10.1038/jcbfm.1994.49","is_oa":true,"landing_page_url":"https://doi.org/10.1038/jcbfm.1994.49","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1994.49?download=true","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:8163580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8163580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.umassmed.edu:neuro_pp-1133","doi":null,"is_oa":false,"landing_page_url":"http://www.nature.com/jcbfm/journal/v14/n3/abs/jcbfm199449a.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurology Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1038/jcbfm.1994.49","doi":"https://doi.org/10.1038/jcbfm.1994.49","is_oa":true,"landing_page_url":"https://doi.org/10.1038/jcbfm.1994.49","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1994.49?download=true","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2046763552.pdf","grobid_xml":"https://content.openalex.org/works/W2046763552.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1969291097","https://openalex.org/W1970231623","https://openalex.org/W1972155682","https://openalex.org/W1973406593","https://openalex.org/W1978428462","https://openalex.org/W2000327465","https://openalex.org/W2001446879","https://openalex.org/W2004220886","https://openalex.org/W2008111159","https://openalex.org/W2022593257","https://openalex.org/W2026044579","https://openalex.org/W2030591899","https://openalex.org/W2034524677","https://openalex.org/W2043151182","https://openalex.org/W2056878394","https://openalex.org/W2071665004","https://openalex.org/W2080656191","https://openalex.org/W2089026118","https://openalex.org/W2091835099","https://openalex.org/W2098748526","https://openalex.org/W2106552966","https://openalex.org/W2112505121","https://openalex.org/W2115805659","https://openalex.org/W2118414643","https://openalex.org/W2129841144","https://openalex.org/W2140099191","https://openalex.org/W2142040044","https://openalex.org/W2146638685"],"related_works":["https://openalex.org/W2064274930","https://openalex.org/W2038736018","https://openalex.org/W4210565167","https://openalex.org/W2169991153","https://openalex.org/W2105084991","https://openalex.org/W2956129576","https://openalex.org/W2208898199","https://openalex.org/W2414213520","https://openalex.org/W7095659770","https://openalex.org/W2056127726"],"abstract_inverted_index":{"To":[0],"identify":[1],"the":[2,7,17,44,54,96,121,133,143,157,166,187],"temperature":[3,36,63,72,94,97,145,155],"dependent":[4],"change":[5],"of":[6,12,20,29,34,83,115,120,189],"apparent":[8],"diffusion":[9],"coefficient":[10],"(ADC)":[11],"water":[13,40],"in":[14,64,110,156,178,183],"brain":[15,23,86,104,111,154,172,193],"tissue,":[16],"ADC":[18,87,105,128,150,173],"values":[19,88,106,151],"normal":[21,84],"rat":[22],"were":[24,67,129,162],"measured":[25],"over":[26,70,95],"a":[27,38,71],"range":[28,73,98],"body":[30,93,144],"temperatures":[31],"with":[32,92],"monitoring":[33],"head":[35],"using":[37,50,132],"small":[39],"reference":[41],"implanted":[42,52],"under":[43],"temporalis":[45,57],"muscle.":[46],"An":[47],"initial":[48],"experiment":[49],"thermocouples":[51],"into":[53],"cortex,":[55],"caudate-putamen,":[56],"muscle,":[58],"and":[59,118,152,159],"rectum":[60],"demonstrated":[61],"that":[62,103,171],"all":[65],"regions":[66],"highly":[68],"correlated":[69],"from":[74],"33":[75],"to":[76,185],"39":[77],"degrees":[78,100,148],"C.":[79,149],"In":[80],"another":[81],"group":[82],"rats,":[85],"varied":[89],"almost":[90],"uniformly":[91],"33-39":[99],"C,":[101],"implying":[102],"accurately":[107],"reflect":[108],"changes":[109],"temperature.":[112,194],"The":[113],"effects":[114,188],"focal":[116],"ischemia":[117],"administration":[119],"noncompetitive":[122],"N-methyl-D-aspartate":[123],"(NMDA)":[124],"antagonist,":[125],"CNS-1102,":[126],"on":[127,192],"also":[130],"examined,":[131],"suture":[134],"middle":[135],"cerebral":[136],"artery":[137],"(MCA)":[138],"occlusion":[139],"model":[140],"while":[141],"maintaining":[142],"at":[146],"37":[147],"therefore":[153],"nonischemic":[158],"ischemic":[160],"hemispheres":[161],"not":[163],"affected":[164],"by":[165],"drug.":[167],"These":[168],"experiments":[169],"suggest":[170],"measurement":[174],"could":[175],"be":[176],"useful":[177],"animal":[179],"studies":[180],"and,":[181],"potentially,":[182],"humans":[184],"assess":[186],"pharmacologic":[190],"intervention":[191]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
