{"id":"https://openalex.org/W2046759656","doi":"https://doi.org/10.1055/s-0030-1251100","title":"Activation of WNT/\u03b2-catenin signaling attenuates experimental emphysema","display_name":"Activation of WNT/\u03b2-catenin signaling attenuates experimental emphysema","publication_year":2010,"publication_date":"2010-03-01","ids":{"openalex":"https://openalex.org/W2046759656","doi":"https://doi.org/10.1055/s-0030-1251100","mag":"2046759656"},"language":"en","primary_location":{"id":"doi:10.1055/s-0030-1251100","doi":"https://doi.org/10.1055/s-0030-1251100","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0030-1251100","pdf_url":null,"source":{"id":"https://openalex.org/S111957458","display_name":"Pneumologie","issn_l":"0934-8387","issn":["0934-8387","1438-8790"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pneumologie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078261997","display_name":"M\u00e9lanie K\u00f6nigshoff","orcid":"https://orcid.org/0000-0001-9414-5128","observed_orcids":["https://orcid.org/0000-0001-9414-5128"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M K\u00f6nigshoff","raw_affiliation_strings":["Comprehensive Pneumology Center, HelmholtzZentrum M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Pneumology Center, HelmholtzZentrum M\u00fcnchen","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053293174","display_name":"Nikolaus Kneidinger","orcid":"https://orcid.org/0000-0001-7583-0453","observed_orcids":["https://orcid.org/0000-0001-7583-0453"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"N Kneidinger","raw_affiliation_strings":["University of Gie\u00dfen Lung Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Gie\u00dfen Lung Center","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100732300","display_name":"Ahmet Y\u0131ld\u0131r\u0131m","orcid":"https://orcid.org/0000-0002-8810-1302","observed_orcids":["https://orcid.org/0000-0002-8810-1302"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Yildirim","raw_affiliation_strings":["Comprehensive Pneumology Center, HelmholtzZentrum M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Pneumology Center, HelmholtzZentrum M\u00fcnchen","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088305308","display_name":"Rio Dumitrascu","orcid":"https://orcid.org/0000-0001-5721-2301","observed_orcids":["https://orcid.org/0000-0001-5721-2301"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R Dumitrascu","raw_affiliation_strings":["University of Gie\u00dfen Lung Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Gie\u00dfen Lung Center","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030309692","display_name":"RALPH THEO SCHERMULY","orcid":"https://orcid.org/0000-0002-5167-6970","observed_orcids":["https://orcid.org/0000-0002-5167-6970"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R Schermuly","raw_affiliation_strings":["University of Gie\u00dfen Lung Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Gie\u00dfen Lung Center","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009672774","display_name":"Oliver Eickelberg","orcid":"https://orcid.org/0000-0001-7170-0360","observed_orcids":["https://orcid.org/0000-0001-7170-0360"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"O Eickelberg","raw_affiliation_strings":["Comprehensive Pneumology Center, HelmholtzZentrum M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Pneumology Center, HelmholtzZentrum M\u00fcnchen","institution_ids":["https://openalex.org/I3018134672"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18047316,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"64","issue":"S 03","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9980000257492065},{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.8949999809265137},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/lithium-chloride","display_name":"lithium chloride","score":0.6790000200271606},{"id":"https://openalex.org/keywords/alveolar-epithelial-cells","display_name":"alveolar epithelial cells","score":0.7990000247955322},{"id":"https://openalex.org/keywords/elastase-induced-lung-injury","display_name":"elastase-induced lung injury","score":0.8119999766349792},{"id":"https://openalex.org/keywords/lung-repair","display_name":"lung repair","score":0.5640000104904175},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.8119999766349792},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.9349777698516846},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.6384556293487549},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5783455967903137},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.5502684712409973},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5038389563560486},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4803227484226227},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4766986072063446},{"id":"https://openalex.org/C2779324961","wikidata":"https://www.wikidata.org/wiki/Q1634046","display_name":"Beta-catenin","level":4,"score":0.46415600180625916},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4403952360153198},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.43592894077301025},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4077492654323578},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33449074625968933},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2670819163322449},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2575135827064514},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24910083413124084},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06849732995033264},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0030-1251100","doi":"https://doi.org/10.1055/s-0030-1251100","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0030-1251100","pdf_url":null,"source":{"id":"https://openalex.org/S111957458","display_name":"Pneumologie","issn_l":"0934-8387","issn":["0934-8387","1438-8790"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pneumologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1981037437","https://openalex.org/W6926237884","https://openalex.org/W2327478462","https://openalex.org/W2151888217","https://openalex.org/W2549557055","https://openalex.org/W2324948771","https://openalex.org/W6992011089","https://openalex.org/W1879934711","https://openalex.org/W2566898596","https://openalex.org/W2615675311"],"abstract_inverted_index":{"Rationale":[0],":":[1,22,47,96,177],"Chronic":[2],"obstructive":[3],"pulmonary":[4],"disease":[5],"is":[6,19],"a":[7,38,198,218],"devastating":[8],"and":[9,33,40,51,62,71,79,93,165,189,213],"poorly":[10],"understood":[11],"disease.":[12],"Currently,":[13],"no":[14],"causal":[15],"therapy":[16],"for":[17,222],"COPD":[18,32,61,113],"available.":[20],"Objectives":[21],"To":[23],"elucidate":[24],"the":[25,104],"impact":[26],"of":[27,53,76,153,168,201],"WNT/\u03b2-catenin":[28,54,77,98,126,131,144,179,202,215],"signaling":[29,55,78,99,121,127,132,180,203],"in":[30,43,58,83,87,90,103,107,128,135,185,193,204,210],"human":[31,60,108],"its":[34],"potential":[35],"role":[36,75,200],"as":[37,140,142,156,217],"preventive":[39,139],"therapeutic":[41,80,143,220],"target":[42],"experimental":[44,136,154],"emphysema.":[45,137,194,223],"Methods":[46],"The":[48,74],"expression,":[49],"localization":[50],"activity":[52],"were":[56,101],"assessed":[57,86],"12":[59,63],"transplant":[64],"donor":[65],"samples":[66],"using":[67],"quantitative":[68],"RT-PCR,":[69],"immunohistochemistry,":[70],"western":[72],"blotting.":[73],"modulation":[81],"thereof":[82],"vivo":[84,211],"was":[85,122,133],"elastase-induced":[88],"emphysema":[89],"mice.":[91],"Measurements":[92],"Main":[94,97],"Results":[95],"components":[100],"expressed":[102],"alveolar":[105,169,205],"epithelium":[106],"lung":[109],"tissue":[110,187],"derived":[111],"from":[112],"patients,":[114],"but":[115],"neither":[116],"differenzially":[117],"regulation":[118],"nor":[119],"active":[120],"detected,":[123],"suggesting":[124],"silenced":[125],"COPD.":[129],"Further,":[130],"downregulated":[134],"Importantly,":[138],"well":[141],"activation":[145,216],"by":[146,158],"lithium":[147],"chloride":[148],"led":[149],"to":[150,182],"an":[151],"attenuation":[152],"emphysema,":[155],"measured":[157],"decreased":[159],"airspace":[160],"enlargement,":[161],"reduced":[162],"collagen":[163],"content,":[164],"elevated":[166],"expression":[167],"epithelial":[170,206],"cell":[171,207],"marker":[172],"upon":[173],"WNT":[174],"activation.":[175],"Conclusion":[176],"Silenced":[178],"appears":[181],"be":[183],"involved":[184],"parenchymal":[186],"destruction":[188],"impaired":[190],"repair":[191,208],"capability":[192],"These":[195],"data":[196],"underline":[197],"crucial":[199],"mechanism":[209],",":[212],"suggest":[214],"suitable":[219],"approach":[221]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}