{"id":"https://openalex.org/W2046708347","doi":"https://doi.org/10.1016/0024-3205(91)90580-5","title":"Rat growth hormone-releasing factor stimulates cyclic GMP formation and phosphatidylinositol metabolism in the median eminence","display_name":"Rat growth hormone-releasing factor stimulates cyclic GMP formation and phosphatidylinositol metabolism in the median eminence","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2046708347","doi":"https://doi.org/10.1016/0024-3205(91)90580-5","mag":"2046708347","pmid":"https://pubmed.ncbi.nlm.nih.gov/1675756"},"language":"en","primary_location":{"id":"doi:10.1016/0024-3205(91)90580-5","doi":"https://doi.org/10.1016/0024-3205(91)90580-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0024-3205(91)90580-5","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087226030","display_name":"M. Cecilia Aguila","orcid":"https://orcid.org/0009-0008-7829-5191","observed_orcids":["https://orcid.org/0009-0008-7829-5191"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.Cecilia Aguila","raw_affiliation_strings":["Department of Physiology, University of Texas Southwestern Medical Center, Dallas 75235-9040"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Texas Southwestern Medical Center, Dallas 75235-9040","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110476474","display_name":"Gary D. Snyder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary D. Snyder","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Iowa, College of Medicine, Building MRF, Room 466, Iowa City, Iowa 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Iowa, College of Medicine, Building MRF, Room 466, Iowa City, Iowa 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069185819","display_name":"Samuel M. McCann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel M. McCann","raw_affiliation_strings":["Department of Physiology, Neuropeptide Division, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75235-9040, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Neuropeptide Division, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75235-9040, USA","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":0.9001,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.73210886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"49","issue":"1","first_page":"67","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.03350000083446503,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone-releasing-hormone","display_name":"growth hormone-releasing hormone","score":0.9769999980926514},{"id":"https://openalex.org/keywords/somatostatin-release","display_name":"somatostatin release","score":0.8379999995231628},{"id":"https://openalex.org/keywords/median-eminence","display_name":"median eminence","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.8560000061988831},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.7739999890327454},{"id":"https://openalex.org/keywords/phosphoinositide-metabolism","display_name":"phosphoinositide metabolism","score":0.9929999709129333},{"id":"https://openalex.org/keywords/inositol-phosphates","display_name":"inositol phosphates","score":0.9760000109672546},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9670000076293945},{"id":"https://openalex.org/keywords/growth-hormone-regulation","display_name":"growth hormone regulation","score":0.47099998593330383},{"id":"https://openalex.org/keywords/receptor-signaling","display_name":"receptor signaling","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8441139459609985},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8298221826553345},{"id":"https://openalex.org/C2779067335","wikidata":"https://www.wikidata.org/wiki/Q1337712","display_name":"Median eminence","level":3,"score":0.7744989395141602},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.7700546979904175},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.6858896613121033},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.586266815662384},{"id":"https://openalex.org/C2778524494","wikidata":"https://www.wikidata.org/wiki/Q967433","display_name":"Cyclic nucleotide","level":4,"score":0.5713539123535156},{"id":"https://openalex.org/C2778618036","wikidata":"https://www.wikidata.org/wiki/Q2878809","display_name":"Inositol phosphate","level":4,"score":0.5200038552284241},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.5184918642044067},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5011556148529053},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4606457054615021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35687142610549927},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.35036754608154297},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.28607165813446045},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.2829575538635254},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22095444798469543},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1407063901424408},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08956369757652283},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007295","descriptor_name":"Inositol Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008473","descriptor_name":"Median Eminence","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015290","descriptor_name":"Second Messenger Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0024-3205(91)90580-5","doi":"https://doi.org/10.1016/0024-3205(91)90580-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0024-3205(91)90580-5","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},{"id":"pmid:1675756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1675756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W28046080","https://openalex.org/W1534361617","https://openalex.org/W1900029203","https://openalex.org/W2027704731","https://openalex.org/W2029072064","https://openalex.org/W2029604573","https://openalex.org/W2038486946","https://openalex.org/W2043396432","https://openalex.org/W2068990274","https://openalex.org/W2092360966","https://openalex.org/W2129188677","https://openalex.org/W2154588586","https://openalex.org/W2165599173","https://openalex.org/W2169184394","https://openalex.org/W2238525991","https://openalex.org/W2505806687"],"related_works":["https://openalex.org/W2109658409","https://openalex.org/W2102332304","https://openalex.org/W2064075279","https://openalex.org/W1995812525","https://openalex.org/W2014000313","https://openalex.org/W2095351375","https://openalex.org/W2144743522","https://openalex.org/W1479999619","https://openalex.org/W2036961586","https://openalex.org/W2025379242"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}