{"id":"https://openalex.org/W2046690219","doi":"https://doi.org/10.1159/000169029","title":"Serum Bicarbonate Is an Independent Determinant of Protein Catabolic Rate in Chronic Hemodialysis","display_name":"Serum Bicarbonate Is an Independent Determinant of Protein Catabolic Rate in Chronic Hemodialysis","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2046690219","doi":"https://doi.org/10.1159/000169029","mag":"2046690219","pmid":"https://pubmed.ncbi.nlm.nih.gov/8886174"},"language":"en","primary_location":{"id":"doi:10.1159/000169029","doi":"https://doi.org/10.1159/000169029","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000169029","pdf_url":null,"source":{"id":"https://openalex.org/S106979888","display_name":"American Journal of Nephrology","issn_l":"0250-8095","issn":["0250-8095","1421-9670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053658081","display_name":"Bahar Bastani","orcid":"https://orcid.org/0000-0002-2138-4248","observed_orcids":["https://orcid.org/0000-0002-2138-4248"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bahar Bastani","raw_affiliation_strings":["Division of Nephrology, St. Louis University Health Sciences Center, MO 63110, USA","Division of Nephrology, St. Louis University Health Sciences Center, St. Louis, Mo., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, St. Louis University Health Sciences Center, MO 63110, USA","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Division of Nephrology, St. Louis University Health Sciences Center, St. Louis, Mo., USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010984918","display_name":"Mary McNeely","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary McNeely","raw_affiliation_strings":["Division of Nephrology, St. Louis University Health Sciences Center, St. Louis, Mo., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, St. Louis University Health Sciences Center, St. Louis, Mo., USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024714006","display_name":"Paul G. Schmitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul G. Schmitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3877,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.88623693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"16","issue":"5","first_page":"382","last_page":"385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.6015999913215637,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.6015999913215637,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.38960000872612,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-bicarbonate","display_name":"serum bicarbonate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-catabolic-rate","display_name":"protein catabolic rate","score":0.8650000095367432},{"id":"https://openalex.org/keywords/maintenance-hemodialysis","display_name":"maintenance hemodialysis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/metabolic-acidosis","display_name":"metabolic acidosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/protein-kinetics","display_name":"protein kinetics","score":0.8140000104904175},{"id":"https://openalex.org/keywords/serum-albumin","display_name":"serum albumin","score":0.7269999980926514},{"id":"https://openalex.org/keywords/urea-nitrogen","display_name":"urea nitrogen","score":0.7379999756813049},{"id":"https://openalex.org/keywords/dialysis-adequacy","display_name":"dialysis adequacy","score":0.7360000014305115},{"id":"https://openalex.org/keywords/nonlinear-relationship","display_name":"nonlinear relationship","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.8338305354118347},{"id":"https://openalex.org/C2779246250","wikidata":"https://www.wikidata.org/wiki/Q1598200","display_name":"Metabolic acidosis","level":2,"score":0.7573477625846863},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.7360618710517883},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.719454824924469},{"id":"https://openalex.org/C2781112554","wikidata":"https://www.wikidata.org/wiki/Q409202","display_name":"Bicarbonate","level":2,"score":0.7030021548271179},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6913392543792725},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6601522564888},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.6149094700813293},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.48481932282447815},{"id":"https://openalex.org/C197683979","wikidata":"https://www.wikidata.org/wiki/Q14876077","display_name":"Protein catabolism","level":3,"score":0.4634333550930023},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.4579114317893982},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2917076349258423},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2301824986934662},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18606388568878174},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.1283615529537201}],"mesh":[{"descriptor_ui":"D001639","descriptor_name":"Bicarbonates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001806","descriptor_name":"Blood Urea Nitrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000169029","doi":"https://doi.org/10.1159/000169029","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000169029","pdf_url":null,"source":{"id":"https://openalex.org/S106979888","display_name":"American Journal of Nephrology","issn_l":"0250-8095","issn":["0250-8095","1421-9670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Nephrology","raw_type":"journal-article"},{"id":"pmid:8886174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8886174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of nephrology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2414855668","https://openalex.org/W2806651409","https://openalex.org/W2065230531","https://openalex.org/W2361131254","https://openalex.org/W7073791050","https://openalex.org/W2563755463","https://openalex.org/W2159227414","https://openalex.org/W1597991568","https://openalex.org/W2015821337","https://openalex.org/W2114865784"],"abstract_inverted_index":{"Serum":[0],"bicarbonate":[1],"is":[2],"an":[3,21,67],"independent":[4,68],"determinant":[5],"of":[6,56,60,72,81,96],"protein":[7,24,38,126,160],"catabolic":[8,25,39],"rate":[9,40],"in":[10,23,48,128,145,153,162],"chronic":[11,50,167],"hemodialysis.":[12,132,168],"Recent":[13],"biochemical":[14],"studies":[15],"suggest":[16],"that":[17,121,151],"metabolic":[18,122],"acidosis":[19,123],"induces":[20],"increase":[22],"rate.":[26],"Therefore,":[27],"we":[28],"retrospectively":[29],"examined":[30],"the":[31,82,94,97],"relationship":[32,87,135],"between":[33,88],"serum":[34,46,89,112],"total":[35],"CO2,":[36],"normalized":[37],"(NPCR),":[41],"midweek":[42],"BUN,":[43],"KT/V,":[44],"and":[45,69,91],"albumin":[47],"70":[49],"hemodialysis":[51],"patients":[52,129,164],"over":[53],"a":[54,85,156],"period":[55],"4-6":[57],"months":[58],"(total":[59],"270":[61],"determinations).":[62],"Multiple":[63],"regression":[64,98],"analysis":[65,80,149],"indicated":[66,84],"inverse":[70],"association":[71],"tCO2":[73,154],"with":[74],"NPCR":[75],"(p":[76],"<":[77,114],"0.0001).":[78],"Subsequent":[79],"data":[83],"nonlinear":[86],"CO2":[90,113],"NPCR.":[92],"Indeed,":[93],"slope":[95],"abruptly":[99],"increased":[100],"from":[101],"-0.015":[102],"+/-":[103,107],"0.005":[104],"to":[105,137,142],"-0.108":[106],"0.032":[108],"when":[109],"analyzed":[110],"for":[111],"or":[115],"=":[116],"15":[117],"mEq/l.":[118],"We":[119],"conclude":[120],"may":[124],"modulate":[125],"kinetics":[127],"receiving":[130],"maintenance":[131],"Moreover,":[133],"this":[134,148],"appears":[136],"be":[138],"exaggerated":[139],"at":[140],"moderate":[141],"severe":[143],"reductions":[144],"tCO2.":[146],"Thus,":[147],"suggests":[150],"decreases":[152],"have":[155],"detrimental":[157],"effect":[158],"on":[159,166],"catabolism":[161],"stable":[163],"maintained":[165]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
