{"id":"https://openalex.org/W2046582250","doi":"https://doi.org/10.1186/1741-7015-9-2","title":"Differential endothelial cell gene expression by African Americans versusCaucasian Americans: a possible contribution to health disparity in vascular disease and cancer","display_name":"Differential endothelial cell gene expression by African Americans versusCaucasian Americans: a possible contribution to health disparity in vascular disease and cancer","publication_year":2011,"publication_date":"2011-01-11","ids":{"openalex":"https://openalex.org/W2046582250","doi":"https://doi.org/10.1186/1741-7015-9-2","mag":"2046582250","pmid":"https://pubmed.ncbi.nlm.nih.gov/21223544","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3029215"},"language":"en","primary_location":{"id":"doi:10.1186/1741-7015-9-2","doi":"https://doi.org/10.1186/1741-7015-9-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1741-7015-9-2","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/1741-7015-9-2","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/1741-7015-9-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011982597","display_name":"Peng Wei","orcid":"https://orcid.org/0000-0001-7758-6116","observed_orcids":["https://orcid.org/0000-0001-7758-6116"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Wei","raw_affiliation_strings":["Vascular Biology Center, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Biology Center, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046318545","display_name":"Liming Chang Milbauer","orcid":"https://orcid.org/0000-0002-9286-699X","observed_orcids":["https://orcid.org/0000-0002-9286-699X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LC Milbauer","raw_affiliation_strings":["Division of Hematology-Oncology-Transplantation, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA","Vascular Biology Center, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology-Transplantation, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Vascular Biology Center, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049525448","display_name":"Judy Enenstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Enenstein","raw_affiliation_strings":["Division of Hematology-Oncology-Transplantation, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA","Vascular Biology Center, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology-Transplantation, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Vascular Biology Center, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090785817","display_name":"Julia Nguyen","orcid":"https://orcid.org/0009-0009-4715-5150","observed_orcids":["https://orcid.org/0009-0009-4715-5150"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Nguyen","raw_affiliation_strings":["Division of Hematology-Oncology-Transplantation, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA","Vascular Biology Center, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology-Transplantation, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Vascular Biology Center, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018997928","display_name":"Wei Pan","orcid":"https://orcid.org/0000-0002-1159-0582","observed_orcids":["https://orcid.org/0000-0002-1159-0582"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W Pan","raw_affiliation_strings":["Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112820782","display_name":"RP Hebbel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"RP Hebbel","raw_affiliation_strings":["Division of Hematology-Oncology-Transplantation, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA","Vascular Biology Center, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology-Transplantation, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Vascular Biology Center, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112820782"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":11.9608,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.97959386,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"2","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12749","display_name":"Race, Genetics, and Society","score":0.5253999829292297,"subfield":{"id":"https://openalex.org/subfields/3314","display_name":"Anthropology"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T12749","display_name":"Race, Genetics, and Society","score":0.5253999829292297,"subfield":{"id":"https://openalex.org/subfields/3314","display_name":"Anthropology"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.19339999556541443,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.03999999910593033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-cell-gene-expression","display_name":"endothelial cell gene expression","score":0.9100000262260437},{"id":"https://openalex.org/keywords/african-americans","display_name":"African Americans","score":0.9240000247955322},{"id":"https://openalex.org/keywords/white-americans","display_name":"White Americans","score":0.9649999737739563},{"id":"https://openalex.org/keywords/health-disparities","display_name":"health disparities","score":0.8240000009536743},{"id":"https://openalex.org/keywords/blood-outgrowth-endothelial-cells","display_name":"blood outgrowth endothelial cells","score":0.925000011920929},{"id":"https://openalex.org/keywords/shear-stress-response","display_name":"shear stress response","score":0.9010000228881836},{"id":"https://openalex.org/keywords/phosphoserine-phosphatase","display_name":"phosphoserine phosphatase","score":0.6539999842643738},{"id":"https://openalex.org/keywords/sos1","display_name":"SOS1","score":0.7300000190734863},{"id":"https://openalex.org/keywords/autocrine-motility-factor-receptor","display_name":"AMFR","score":0.9810000061988831},{"id":"https://openalex.org/keywords/fgfr3","display_name":"FGFR3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/arvcf","display_name":"ARVCF","score":0.8360000252723694},{"id":"https://openalex.org/keywords/eif4b","display_name":"eIF4B","score":0.9919999837875366},{"id":"https://openalex.org/keywords/genetic-ancestry","display_name":"genetic ancestry","score":0.5070000290870667},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7570000290870667},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.6380000114440918},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.5440000295639038},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9750000238418579}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6450865268707275},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.6010750532150269},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5824731588363647},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5823328495025635},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5453405380249023},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5175182819366455},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5047625303268433},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48111289739608765},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4565342366695404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3858755826950073},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3589850664138794},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2489665448665619}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001741","descriptor_name":"Black or African American","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014652","descriptor_name":"Vascular Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D014652","descriptor_name":"Vascular Diseases","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D014652","descriptor_name":"Vascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1741-7015-9-2","doi":"https://doi.org/10.1186/1741-7015-9-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1741-7015-9-2","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/1741-7015-9-2","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3029215","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3029215","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Med","raw_type":"Text"},{"id":"pmid:21223544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21223544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medicine","raw_type":"Comparative Study"},{"id":"pmh:oai:doaj.org/article:3c8bef7202764bcca3bac6e381556a9a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3c8bef7202764bcca3bac6e381556a9a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medicine, Vol 9, Iss 1, p 2 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1741-7015-9-2","doi":"https://doi.org/10.1186/1741-7015-9-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1741-7015-9-2","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/1741-7015-9-2","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854},{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.7390999794006348}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1421860442","display_name":null,"funder_award_id":"P01-HL055552","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4794016299","display_name":"Vascular Pathobiology of Sickle Cell Disease","funder_award_id":"5p01hl055552-15","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G696249762","display_name":null,"funder_award_id":"P01 HL55552","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7704716642","display_name":null,"funder_award_id":"P01 HL68970","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000107826","display_name":null,"funder_award_id":"HL-55552","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2046582250.pdf","grobid_xml":"https://content.openalex.org/works/W2046582250.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W123313388","https://openalex.org/W140081794","https://openalex.org/W188045412","https://openalex.org/W1506915389","https://openalex.org/W1518815626","https://openalex.org/W1549774650","https://openalex.org/W1561592301","https://openalex.org/W1571324662","https://openalex.org/W1834747511","https://openalex.org/W1848925057","https://openalex.org/W1953758512","https://openalex.org/W1963542565","https://openalex.org/W1964220568","https://openalex.org/W1964895626","https://openalex.org/W1966225115","https://openalex.org/W1971447739","https://openalex.org/W1977332535","https://openalex.org/W1977480665","https://openalex.org/W1981949501","https://openalex.org/W1998224034","https://openalex.org/W1999216047","https://openalex.org/W1999956350","https://openalex.org/W2001036195","https://openalex.org/W2001115778","https://openalex.org/W2002395285","https://openalex.org/W2003338204","https://openalex.org/W2008079184","https://openalex.org/W2013890168","https://openalex.org/W2018550467","https://openalex.org/W2019441496","https://openalex.org/W2022106459","https://openalex.org/W2029271213","https://openalex.org/W2034781152","https://openalex.org/W2035375602","https://openalex.org/W2036999836","https://openalex.org/W2044002866","https://openalex.org/W2047550265","https://openalex.org/W2049466721","https://openalex.org/W2057121401","https://openalex.org/W2060151548","https://openalex.org/W2060903906","https://openalex.org/W2064371891","https://openalex.org/W2065692926","https://openalex.org/W2068525568","https://openalex.org/W2075522396","https://openalex.org/W2077358124","https://openalex.org/W2083380010","https://openalex.org/W2092509345","https://openalex.org/W2095310139","https://openalex.org/W2097325658","https://openalex.org/W2098126226","https://openalex.org/W2101177673","https://openalex.org/W2101633780","https://openalex.org/W2102714321","https://openalex.org/W2105902511","https://openalex.org/W2106498117","https://openalex.org/W2111165451","https://openalex.org/W2116811581","https://openalex.org/W2120865735","https://openalex.org/W2124830606","https://openalex.org/W2126612686","https://openalex.org/W2127074707","https://openalex.org/W2130188982","https://openalex.org/W2130410032","https://openalex.org/W2131734780","https://openalex.org/W2134270369","https://openalex.org/W2136159134","https://openalex.org/W2147107152","https://openalex.org/W2149117402","https://openalex.org/W2150228788","https://openalex.org/W2151959508","https://openalex.org/W2156131212","https://openalex.org/W2157795344","https://openalex.org/W2158273923","https://openalex.org/W2161334993","https://openalex.org/W2161874576","https://openalex.org/W2165914315","https://openalex.org/W2169481132","https://openalex.org/W2170989872","https://openalex.org/W3136389637","https://openalex.org/W4294107304"],"related_works":["https://openalex.org/W2009346773","https://openalex.org/W2259856999","https://openalex.org/W2111154266","https://openalex.org/W2783328313","https://openalex.org/W2989860147","https://openalex.org/W1991737772","https://openalex.org/W2120004578","https://openalex.org/W2011063780","https://openalex.org/W4414937141","https://openalex.org/W7095202446"],"abstract_inverted_index":{"BACKGROUND:":[0],"Health":[1],"disparities":[2],"and":[3,44,66,80,93,102,192,274,282,301,326,358,361],"the":[4,20,26,29,38,136,157,175,211,219,255,291,347],"high":[5],"prevalence":[6],"of":[7,28,41,74,107,112,121,140,215,241,254,271,293,331],"cardiovascular":[8,42],"disease":[9,43,298,333,356],"continue":[10],"to":[11,37,51,60,89,131,329,345],"be":[12,33,278,342],"perplexing":[13],"worldwide":[14],"health":[15],"challenges.":[16],"This":[17],"study":[18],"addresses":[19],"possibility":[21],"that":[22,125,250,313],"genetic":[23,314],"differences":[24],"affecting":[25],"biology":[27,227,325],"vascular":[30,275,297],"endothelium":[31],"could":[32,320,341],"a":[34,170,268],"factor":[35],"contributing":[36],"increased":[39],"burden":[40,334],"cancer":[45,302],"among":[46,335],"African":[47],"Americans":[48,53],"(AA)":[49],"compared":[50],"Caucasian":[52],"(CA).":[54],"METHODS:":[55],"From":[56],"self-identified,":[57],"healthy,":[58],"20":[59],"29-year-old":[61],"AA":[62,186,194,233,281],"(n":[63,68],"=":[64,69,145],"21)":[65],"CA":[67],"17),":[70],"we":[71,223],"established":[72],"cultures":[73],"blood":[75],"outgrowth":[76],"endothelial":[77,132,263,272,294,323],"cells":[78,295],"(BOEC)":[79],"applied":[81],"microarray":[82],"profiling.":[83],"BOEC":[84],"have":[85,259,287],"never":[86],"been":[87],"exposed":[88],"in":[90,153,262,296],"vivo":[91],"influences,":[92],"their":[94],"gene":[95,123],"expression":[96,111,120,242],"reflects":[97],"culture":[98],"conditions":[99],"(meticulously":[100],"controlled)":[101],"donor":[103],"genetics.":[104],"Significance":[105],"Analysis":[106,118],"Microarray":[108],"identified":[109,224],"differential":[110],"single":[113,148],"genes.":[114],"Gene":[115],"Set":[116],"Enrichment":[117],"examined":[119],"pre-determined":[122],"sets":[124],"survey":[126],"nine":[127],"biological":[128,220],"systems":[129,221],"relevant":[130],"biology.":[133,264],"RESULTS:":[134],"At":[135],"highly":[137],"stringent":[138,213],"threshold":[139,214],"False":[141],"Discovery":[142],"Rate":[143],"(FDR)":[144],"0,":[146],"31":[147],"genes":[149,183,248,256],"were":[150,207],"differentially":[151,208],"expressed":[152,209],"AA.":[154,336],"PSPH":[155,176],"exhibited":[156],"greatest":[158],"fold-change":[159],"(AA":[160,243],">":[161,187,244],"CA),":[162],"but":[163],"this":[164],"was":[165],"entirely":[166],"accounted":[167],"for":[168,185,193,204,232,246,290],"by":[169],"homolog":[171],"(PSPHL)":[172],"hidden":[173],"within":[174,249],"probe":[177],"set.":[178],"Among":[179],"other":[180],"significantly":[181,230],"different":[182,231,279],"were:":[184],"CA,":[188,196,235],"SOS1,":[189],"AMFR,":[190],"FGFR3;":[191],"<":[195],"ARVCF,":[197],"BIN3,":[198],"EIF4B.":[199],"Many":[200,253],"more":[201],"(221":[202],"transcripts":[203],"204":[205],"genes)":[206],"at":[210],"less":[212],"FDR":[216],"<.05.":[217],"Using":[218],"approach,":[222],"shear":[225],"response":[226],"as":[228],"being":[229],"versus":[234],"showing":[236],"an":[237],"apparent":[238],"tonic":[239],"increase":[240],"CA)":[245],"46/157":[247],"system.":[251],"CONCLUSIONS:":[252],"implicated":[257],"here":[258,340],"substantial":[260],"roles":[261],"Shear":[265],"stress":[266],"response,":[267],"critical":[269],"regulator":[270],"function":[273,360],"homeostasis,":[276],"may":[277],"between":[280,349],"CA.":[283],"These":[284],"results":[285],"potentially":[286],"direct":[288],"implications":[289],"role":[292],"(hypertension,":[299],"stroke)":[300],"(via":[303],"angiogenesis).":[304],"Also,":[305],"they":[306],"are":[307],"consistent":[308],"with":[309],"our":[310],"over-arching":[311],"hypothesis":[312],"influences":[315],"stemming":[316],"from":[317,351],"ancestral":[318],"continent-of-origin":[319],"impact":[321],"upon":[322],"cell":[324,359],"thereby":[327],"contribute":[328],"disparity":[330],"vascular-related":[332],"The":[337],"method":[338],"used":[339],"productively":[343],"employed":[344],"bridge":[346],"gap":[348],"information":[350],"structural":[352],"genomics":[353],"(for":[354],"example,":[355],"association)":[357],"pathophysiology.":[362]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}