{"id":"https://openalex.org/W2046564655","doi":"https://doi.org/10.1002/mrd.20416","title":"Differential response of cumulus cell-enclosed and denuded mouse oocytes in a meiotic induction model system","display_name":"Differential response of cumulus cell-enclosed and denuded mouse oocytes in a meiotic induction model system","publication_year":2005,"publication_date":"2005-12-16","ids":{"openalex":"https://openalex.org/W2046564655","doi":"https://doi.org/10.1002/mrd.20416","mag":"2046564655","pmid":"https://pubmed.ncbi.nlm.nih.gov/16362973"},"language":"en","primary_location":{"id":"doi:10.1002/mrd.20416","doi":"https://doi.org/10.1002/mrd.20416","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrd.20416","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Stephen M. Downs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102461120","display_name":"Marquette University","ror":"https://ror.org/04gr4te78","country_code":"US","type":"education","lineage":["https://openalex.org/I102461120"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen M. Downs","raw_affiliation_strings":["Biology Department, Marquette University, Milwaukee, Wisconsin, USA. Stephen.Downs@Marquette.edu","Biology Department Marquette University, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, Marquette University, Milwaukee, Wisconsin, USA. Stephen.Downs@Marquette.edu","institution_ids":["https://openalex.org/I102461120"]},{"raw_affiliation_string":"Biology Department Marquette University, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I102461120"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ryan Gilles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102461120","display_name":"Marquette University","ror":"https://ror.org/04gr4te78","country_code":"US","type":"education","lineage":["https://openalex.org/I102461120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Gilles","raw_affiliation_strings":["Biology Department, Marquette University, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, Marquette University, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I102461120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068842582","display_name":"Christopher VanDerhoef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102461120","display_name":"Marquette University","ror":"https://ror.org/04gr4te78","country_code":"US","type":"education","lineage":["https://openalex.org/I102461120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher VanDerhoef","raw_affiliation_strings":["Biology Department, Marquette University, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, Marquette University, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I102461120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020278379","display_name":"Peter G. Humpherson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter G. Humpherson","raw_affiliation_strings":["Biology Department, University of York, York, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, University of York, York, United Kingdom","institution_ids":["https://openalex.org/I52099693"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057703824","display_name":"Henry J. Leese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52099693","display_name":"University of York","ror":"https://ror.org/04m01e293","country_code":"GB","type":"education","lineage":["https://openalex.org/I52099693"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Henry J. Leese","raw_affiliation_strings":["Biology Department, University of York, York, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, University of York, York, United Kingdom","institution_ids":["https://openalex.org/I52099693"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I102461120"],"apc_list":{"value":4260,"currency":"USD","value_usd":4260},"apc_paid":null,"fwci":1.6833,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.81811039,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"73","issue":"3","first_page":"379","last_page":"389"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oocyte-maturation","display_name":"oocyte maturation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/meiotic-induction","display_name":"meiotic induction","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cumulus-cells","display_name":"cumulus cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/denuded-oocytes","display_name":"denuded oocytes","score":0.9459999799728394},{"id":"https://openalex.org/keywords/germinal-vesicle-breakdown","display_name":"germinal vesicle breakdown","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pyruvate","display_name":"pyruvate","score":0.9240000247955322},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.6980000138282776},{"id":"https://openalex.org/keywords/pyruvate-accumulation","display_name":"pyruvate accumulation","score":0.828000009059906},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.7080000042915344},{"id":"https://openalex.org/keywords/mouse-oocytes","display_name":"mouse oocytes","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.7746075391769409},{"id":"https://openalex.org/C2994119143","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Germinal vesicle","level":4,"score":0.7696535587310791},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.714903712272644},{"id":"https://openalex.org/C2781116151","wikidata":"https://www.wikidata.org/wiki/Q410305","display_name":"Hypoxanthine","level":3,"score":0.6141712069511414},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.49548447132110596},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4630216956138611},{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.4617500603199005},{"id":"https://openalex.org/C2778928357","wikidata":"https://www.wikidata.org/wiki/Q5194195","display_name":"Cumulus oophorus","level":4,"score":0.4421652853488922},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3311507999897003},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3070695996284485},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24818667769432068},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.2315090000629425},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.21737012267112732},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003994","descriptor_name":"Bucladesine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006080","descriptor_name":"Ovarian Follicle","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006080","descriptor_name":"Ovarian Follicle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006080","descriptor_name":"Ovarian Follicle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008540","descriptor_name":"Meiosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019271","descriptor_name":"Hypoxanthine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/mrd.20416","doi":"https://doi.org/10.1002/mrd.20416","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrd.20416","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},{"id":"pmid:16362973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16362973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular reproduction and development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G344564575","display_name":"Regulation of Mammalian Oocyte Maturation","funder_award_id":"R01HD040392","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6055639802","display_name":"MEIOTIC REGULATION IN MAMMALIAN OOCYTES","funder_award_id":"R15HD039172","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1783132194","https://openalex.org/W1963881210","https://openalex.org/W1964564069","https://openalex.org/W1964881942","https://openalex.org/W1968446974","https://openalex.org/W1969030895","https://openalex.org/W1971932969","https://openalex.org/W1973690432","https://openalex.org/W1974265269","https://openalex.org/W1978702490","https://openalex.org/W1981794598","https://openalex.org/W1982451630","https://openalex.org/W1983076004","https://openalex.org/W1985351973","https://openalex.org/W1987435381","https://openalex.org/W1991257353","https://openalex.org/W1997800433","https://openalex.org/W2001265103","https://openalex.org/W2007904803","https://openalex.org/W2030621462","https://openalex.org/W2034282657","https://openalex.org/W2040270754","https://openalex.org/W2043696894","https://openalex.org/W2047401461","https://openalex.org/W2049693640","https://openalex.org/W2053470850","https://openalex.org/W2054768130","https://openalex.org/W2060409303","https://openalex.org/W2070375223","https://openalex.org/W2074786429","https://openalex.org/W2079482444","https://openalex.org/W2080327931","https://openalex.org/W2083291133","https://openalex.org/W2088057711","https://openalex.org/W2089418877","https://openalex.org/W2092464908","https://openalex.org/W2092715440","https://openalex.org/W2094202638","https://openalex.org/W2099367586","https://openalex.org/W2100475231","https://openalex.org/W2100904501","https://openalex.org/W2109850843","https://openalex.org/W2116486339","https://openalex.org/W2122327017","https://openalex.org/W2122522938","https://openalex.org/W2123488059","https://openalex.org/W2126460557","https://openalex.org/W2128288344","https://openalex.org/W2132198130","https://openalex.org/W2135104064","https://openalex.org/W2135454248","https://openalex.org/W2141933025","https://openalex.org/W2143815750","https://openalex.org/W2148996094","https://openalex.org/W2149021404","https://openalex.org/W2149027079","https://openalex.org/W2152066164","https://openalex.org/W2152668934","https://openalex.org/W2154741864","https://openalex.org/W2159339694","https://openalex.org/W2162023197","https://openalex.org/W2181729942","https://openalex.org/W2263433144","https://openalex.org/W2265404956"],"related_works":["https://openalex.org/W1997800433","https://openalex.org/W2074582018","https://openalex.org/W1974249235","https://openalex.org/W2080327931","https://openalex.org/W2056522699","https://openalex.org/W2140503635","https://openalex.org/W2005528903","https://openalex.org/W2138059007","https://openalex.org/W2138773618","https://openalex.org/W2056462171"],"abstract_inverted_index":{"In":[0],"this":[1],"study":[2,287],"we":[3],"have":[4],"examined":[5],"the":[6,98,104,115,140,154,236,245,260,279],"effects":[7],"of":[8,38,66,83,87,100,201,204,232,247,263,270,282],"denuded":[9,25,283],"oocyte":[10],"coculture":[11,93,223,275,285],"with":[12,47,68,80,97,161,169,173],"dissociated":[13,71],"cumulus":[14,29],"cells":[15],"(CC)":[16],"or":[17,28,70,110,198],"intact":[18],"oocyte-CC":[19],"complexes":[20,69],"on":[21,85],"meiotic":[22,45,118,288],"resumption.":[23],"When":[24,107,124,163],"oocytes":[26,31],"(DO)":[27],"cell-enclosed":[30],"(CEO)":[32],"were":[33,126,188,254],"cultured":[34,127,189,214],"in":[35,44,129,182,190,208,235,244],"40-microl":[36],"drops":[37],"medium":[39,165,210],"under":[40,221],"oil,":[41],"and":[42,76,206,218,229,272,277],"held":[43],"arrest":[46],"4":[48],"mM":[49],"hypoxanthine":[50],"plus":[51],"25":[52],"microM":[53],"dbcAMP,":[54],"they":[55],"underwent":[56],"germinal":[57],"vesicle":[58],"breakdown":[59],"(GVB)":[60],"at":[61],"similar":[62],"frequencies":[63],"(34%-35%).":[64],"Coculture":[65],"DO":[67,84,174,213,253,271],"CCs":[72,101],"stimulated":[73],"maturation":[74,86,178,246],"(50%":[75],"61%":[77],"GVB,":[78],"respectively),":[79],"no":[81,117,196],"effect":[82,94,145,157,197,262],"cocultured":[88,122],"CEO":[89,125,187,258,273],"(32%":[90],"GVB).":[91],"This":[92,156],"was":[95,112,158,166,194,227],"increased":[96,199],"number":[99,133],"added":[102],"to":[103,136,176,241,259,274,286],"culture":[105,172,181],"drop.":[106],"either":[108,195],"glucose":[109,150,205,217,226],"glutamine":[111,152],"eliminated":[113],"from":[114,121,134,153],"medium,":[116,192,237],"induction":[119],"resulted":[120],"CCs.":[123],"alone":[128,215],"microdrops,":[130],"increasing":[131],"their":[132],"10":[135],"50":[137],"significantly":[138],"lowered":[139],"percentage":[141],"resuming":[142],"maturation,":[143],"an":[144,242],"also":[146],"reduced":[147],"by":[148],"removing":[149],"and/or":[151],"medium.":[155],"not":[159],"observed":[160],"DO.":[162,248],"inhibitory":[164],"conditioned":[167,191],"overnight":[168],"complexes,":[170],"subsequent":[171],"led":[175,240],"higher":[177],"percentages":[179],"than":[180,257],"unconditioned":[183],"medium;":[184],"however,":[185],"when":[186],"there":[193],"inhibition":[200],"maturation.":[202],"Assay":[203],"pyruvate":[207,233],"spent":[209],"showed":[211,251],"that":[212,239,252],"consumed":[216,228],"pyruvate,":[219],"but":[220],"CC":[222],"conditions":[224,276],"more":[225,255],"significant":[230],"amounts":[231],"accumulated":[234],"changes":[238],"increase":[243],"Further":[249],"experiments":[250],"sensitive":[256],"meiosis-inducing":[261],"pyruvate.":[264],"These":[265],"results":[266],"demonstrate":[267],"different":[268],"responsiveness":[269],"question":[278],"physiological":[280],"relevance":[281],"oocyte/CC":[284],"induction.":[289]},"counts_by_year":[{"year":2018,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
