{"id":"https://openalex.org/W2046355896","doi":"https://doi.org/10.4103/0973-1296.117822","title":"Cytoprotective and antioxidant effects of phenolic compounds from Haberlea rhodopensis Friv. (Gesneriaceae)","display_name":"Cytoprotective and antioxidant effects of phenolic compounds from Haberlea rhodopensis Friv. (Gesneriaceae)","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2046355896","doi":"https://doi.org/10.4103/0973-1296.117822","mag":"2046355896","pmid":"https://pubmed.ncbi.nlm.nih.gov/24124280"},"language":"en","primary_location":{"id":"doi:10.4103/0973-1296.117822","doi":"https://doi.org/10.4103/0973-1296.117822","is_oa":true,"landing_page_url":"https://doi.org/10.4103/0973-1296.117822","pdf_url":"https://phcog.com/article/sites/default/files/PhcogMag-9-36-294.pdf","source":{"id":"https://openalex.org/S40318847","display_name":"Pharmacognosy Magazine","issn_l":"0973-1296","issn":["0973-1296","0976-4062"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacognosy Magazine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://phcog.com/article/sites/default/files/PhcogMag-9-36-294.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063893352","display_name":"Dimitrina Zheleva\u2010Dimitrova","orcid":"https://orcid.org/0000-0002-1952-9903","observed_orcids":["https://orcid.org/0000-0002-1952-9903"]},"institutions":[{"id":"https://openalex.org/I30147112","display_name":"Medical University of Sofia","ror":"https://ror.org/01n9zy652","country_code":"BG","type":"education","lineage":["https://openalex.org/I30147112"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Dimitrina Zheleva-Dimitrova","raw_affiliation_strings":["Departments of Pharmacology, Pharmacotherapy and Toxicology , and Pharmacognosy , Faculty of Pharmacy , Medical University of Sofi a , Dunav 2 Str. , Sofi a-1000 , Bulgaria,","Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, Dunav 2 Str., Sofia-1000, Bulgaria, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Pharmacotherapy and Toxicology , and Pharmacognosy , Faculty of Pharmacy , Medical University of Sofi a , Dunav 2 Str. , Sofi a-1000 , Bulgaria,","institution_ids":["https://openalex.org/I30147112"]},{"raw_affiliation_string":"Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, Dunav 2 Str., Sofia-1000, Bulgaria, Germany","institution_ids":["https://openalex.org/I30147112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065309317","display_name":"Paraskev T. Nedialkov","orcid":"https://orcid.org/0000-0001-5640-6120","observed_orcids":["https://orcid.org/0000-0001-5640-6120"]},"institutions":[{"id":"https://openalex.org/I30147112","display_name":"Medical University of Sofia","ror":"https://ror.org/01n9zy652","country_code":"BG","type":"education","lineage":["https://openalex.org/I30147112"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Paraskev Nedialkov","raw_affiliation_strings":["Departments of Pharmacology, Pharmacotherapy and Toxicology , and Pharmacognosy , Faculty of Pharmacy , Medical University of Sofi a , Dunav 2 Str. , Sofi a-1000 , Bulgaria,","Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, Dunav 2 Str., Sofia-1000, Bulgaria, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Pharmacotherapy and Toxicology , and Pharmacognosy , Faculty of Pharmacy , Medical University of Sofi a , Dunav 2 Str. , Sofi a-1000 , Bulgaria,","institution_ids":["https://openalex.org/I30147112"]},{"raw_affiliation_string":"Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, Dunav 2 Str., Sofia-1000, Bulgaria, Germany","institution_ids":["https://openalex.org/I30147112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076965703","display_name":"Magdalena Kondeva-Burdina","orcid":"https://orcid.org/0000-0001-6776-0870","observed_orcids":["https://orcid.org/0000-0001-6776-0870"]},"institutions":[{"id":"https://openalex.org/I30147112","display_name":"Medical University of Sofia","ror":"https://ror.org/01n9zy652","country_code":"BG","type":"education","lineage":["https://openalex.org/I30147112"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Magdalena Kondeva-Burdina","raw_affiliation_strings":["Department of Pharmacology, Pharmacotherapy and Toxicology, Medical University of Sofia, Dunav 2 Str., Sofia-1000, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Pharmacotherapy and Toxicology, Medical University of Sofia, Dunav 2 Str., Sofia-1000, Bulgaria","institution_ids":["https://openalex.org/I30147112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081375237","display_name":"Ulrich Girreser","orcid":"https://orcid.org/0000-0002-4535-3657","observed_orcids":["https://orcid.org/0000-0002-4535-3657"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich Girreser","raw_affiliation_strings":["Department of Pharmaceutical/Medicinal Chemistry , Institute of Pharmacy , Christian-Albrechts-University of Kiel , Gutenbergstr. 76 , 24118 Kiel , Germany","Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical/Medicinal Chemistry , Institute of Pharmacy , Christian-Albrechts-University of Kiel , Gutenbergstr. 76 , 24118 Kiel , Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023420686","display_name":"Mitka Mitcheva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30147112","display_name":"Medical University of Sofia","ror":"https://ror.org/01n9zy652","country_code":"BG","type":"education","lineage":["https://openalex.org/I30147112"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Mitka Mitcheva","raw_affiliation_strings":["Faculty of Pharmacy , Medical University of Sofi a , Dunav 2 Str. , Sofi a-1000 , Bulgaria","Department of Pharmacology, Pharmacotherapy and Toxicology, Medical University of Sofia, Dunav 2 Str., Sofia-1000, Bulgaria, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy , Medical University of Sofi a , Dunav 2 Str. , Sofi a-1000 , Bulgaria","institution_ids":["https://openalex.org/I30147112"]},{"raw_affiliation_string":"Department of Pharmacology, Pharmacotherapy and Toxicology, Medical University of Sofia, Dunav 2 Str., Sofia-1000, Bulgaria, Germany","institution_ids":["https://openalex.org/I30147112"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1600,"currency":"USD","value_usd":1600},"apc_paid":null,"fwci":3.0025,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.90480677,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":"36","first_page":"294","last_page":"294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.7178000211715698,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.7178000211715698,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.25540000200271606,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haberlea-rhodopensis","display_name":"Haberlea rhodopensis","score":1.0},{"id":"https://openalex.org/keywords/flavone-c-glycosides","display_name":"flavone C-glycosides","score":0.8769999742507935},{"id":"https://openalex.org/keywords/hispidulin","display_name":"hispidulin","score":0.7580000162124634},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.8899999856948853},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.8809999823570251},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8069999814033508},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.6179999709129333},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.7739999890327454},{"id":"https://openalex.org/keywords/natural-antioxidants","display_name":"natural antioxidants","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C2779795977","wikidata":"https://www.wikidata.org/wiki/Q156686","display_name":"Gesneriaceae","level":2,"score":0.9190390706062317},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.6806468963623047},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.547006368637085},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5273735523223877},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.266539990901947},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21817901730537415},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18709874153137207},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.10976186394691467}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4103/0973-1296.117822","doi":"https://doi.org/10.4103/0973-1296.117822","is_oa":true,"landing_page_url":"https://doi.org/10.4103/0973-1296.117822","pdf_url":"https://phcog.com/article/sites/default/files/PhcogMag-9-36-294.pdf","source":{"id":"https://openalex.org/S40318847","display_name":"Pharmacognosy Magazine","issn_l":"0973-1296","issn":["0973-1296","0976-4062"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacognosy Magazine","raw_type":"journal-article"},{"id":"pmid:24124280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24124280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacognosy magazine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2786831","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3793333","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3793333","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3793333","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacogn Mag","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4103/0973-1296.117822","doi":"https://doi.org/10.4103/0973-1296.117822","is_oa":true,"landing_page_url":"https://doi.org/10.4103/0973-1296.117822","pdf_url":"https://phcog.com/article/sites/default/files/PhcogMag-9-36-294.pdf","source":{"id":"https://openalex.org/S40318847","display_name":"Pharmacognosy Magazine","issn_l":"0973-1296","issn":["0973-1296","0976-4062"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacognosy Magazine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"sustainable_development_goals_aurora":[{"display_name":"Life below water","id":"https://metadata.un.org/sdg/14","score":0.8299999833106995}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2046355896.pdf","grobid_xml":"https://content.openalex.org/works/W2046355896.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W134532314","https://openalex.org/W1488214979","https://openalex.org/W1558631703","https://openalex.org/W1571764227","https://openalex.org/W1578665086","https://openalex.org/W1958467035","https://openalex.org/W2001312929","https://openalex.org/W2013644244","https://openalex.org/W2014239635","https://openalex.org/W2015801271","https://openalex.org/W2045312842","https://openalex.org/W2056420869","https://openalex.org/W2094411930","https://openalex.org/W2126060486","https://openalex.org/W2130682197","https://openalex.org/W2189456454","https://openalex.org/W2204240265","https://openalex.org/W2582767860"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487"],"abstract_inverted_index":{"BACKGROUND:":[0],"Haberlea":[1],"rhodopensis":[2,56,204],"Friv.":[3],"(Gesneriaceae)":[4],"is":[5],"a":[6,221],"rare":[7],"poikilohydric":[8],"endemic":[9],"and":[10,23,42,48,69,88,101,123,154,174,186,191,211],"preglacial":[11],"relict":[12],"growing":[13],"in":[14,107,131,177],"Balkan":[15],"Peninsula.":[16],"Previous":[17],"investigations":[18],"demonstrated":[19,166,205],"strong":[20],"antioxidant,":[21],"antimicrobial":[22],"antimutagenic":[24],"potential":[25],"of":[26,35,54,62,72,80,103,137,147,162],"alcoholic":[27],"extract":[28],"from":[29,51,202],"the":[30,52,167,184,195],"plant.":[31],"OBJECTIVE:":[32],"The":[33,60,115,135],"isolation":[34],"known":[36],"caffeoyl":[37],"phenylethanoid":[38],"glucoside":[39],"-":[40],"myconoside":[41,216],"flavone-C-glycosides":[43],"hispidulin":[44,46,49],"8-C-(2-O-syringoyl-\u03b2-glucopyranoside),":[45],"8-C-(6-O-acetyl-2-O-syringoyl-\u03b2-glucopyranoside),":[47],"8-C-(6-O-acetyl-\u03b2-glucopyranoside)":[50],"leaves":[53],"H.":[55,203],"was":[57,65,83,217],"carried":[58],"out.":[59],"aim":[61],"this":[63],"study":[64],"to":[66,219],"investigate":[67],"cyto-protective":[68],"antioxidant":[70,97,124,175,192],"effects":[71,125],"isolated":[73,81,132,201],"compounds.":[74],"MATERIALS":[75],"AND":[76],"METHODS:":[77],"Antioxidant":[78],"activity":[79,176,193],"substances":[82,141],"examined":[84],"using":[85],"1,1-diphenyl-2-picrylhydrazyl":[86],"(DPPH)":[87],"2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic":[89],"acid)":[90],"diammonium":[91],"salt":[92],"(ABTS)":[93],"radicals;":[94],"ferric":[95,112],"reducing":[96],"power":[98],"(FRAP)":[99],"assay":[100],"inhibition":[102],"lipid":[104,213],"peroxidation":[105],"(LPO)":[106],"linoleic":[108,178],"acid":[109,139,179],"system":[110,180],"by":[111],"thyocianate":[113],"method.":[114],"compounds":[116,200],"were":[117,142,158],"investigated":[118],"for":[119],"their":[120],"possible":[121],"protective":[122],"against":[126,194],"tert-butyl":[127],"hydroperoxide-induced":[128],"oxidative":[129],"stress":[130],"rat":[133],"hepatocytes.":[134],"levels":[136],"thiobarbituric":[138],"reactive":[140],"assayed":[143],"as":[144,160,181,183],"an":[145],"index":[146],"LPO.":[148],"Lactate":[149],"dehydrogenase":[150],"leakage,":[151],"cell":[152],"viability,":[153],"reduced":[155],"glutathione":[156],"depletion":[157],"used":[159],"signs":[161],"cytotoxicity.":[163],"RESULTS:":[164],"Myconoside":[165],"highest":[168,185],"DPPH":[169],"radical":[170,208],"scavenging,":[171],"ABTS,":[172],"FRAP,":[173],"well":[182],"statistically":[187],"most":[188],"significant":[189,206],"protection":[190],"toxic":[196],"agent.":[197],"CONCLUSION:":[198],"Phenolic":[199],"cytoprotective,":[207],"scavenging":[209],"potential,":[210],"inhibit":[212],"peroxidation,":[214],"moreover,":[215],"found":[218],"be":[220],"new":[222],"powerful":[223],"natural":[224],"antioxidant.":[225]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}