{"id":"https://openalex.org/W2046352516","doi":"https://doi.org/10.2337/diab.45.8.1121","title":"Major Histocompatibility Complex Class I\u2013Restricted Infiltration and Destruction of Pancreatic Islets by NOD Mouse-Derived \u03b2-Cell Cytotoxic CD8+ T-Cell Clones In Vivo","display_name":"Major Histocompatibility Complex Class I\u2013Restricted Infiltration and Destruction of Pancreatic Islets by NOD Mouse-Derived \u03b2-Cell Cytotoxic CD8+ T-Cell Clones In Vivo","publication_year":1996,"publication_date":"1996-08-01","ids":{"openalex":"https://openalex.org/W2046352516","doi":"https://doi.org/10.2337/diab.45.8.1121","mag":"2046352516","pmid":"https://pubmed.ncbi.nlm.nih.gov/8690161"},"language":"en","primary_location":{"id":"doi:10.2337/diab.45.8.1121","doi":"https://doi.org/10.2337/diab.45.8.1121","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.45.8.1121","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089185040","display_name":"Toshihiro Utsugi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Toshihiro Utsugi","raw_affiliation_strings":["Department of Microbiology and Infectious Diseases and Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary\u2008Calgary, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Infectious Diseases and Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary\u2008Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044000185","display_name":"Ji\u2010Won Yoon","orcid":"https://orcid.org/0000-0001-8537-2601","observed_orcids":["https://orcid.org/0000-0001-8537-2601"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ji-Won Yoon","raw_affiliation_strings":["Department of Microbiology and Infectious Diseases and Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary\u2008Calgary, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Infectious Diseases and Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary\u2008Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067076240","display_name":"Byung\u2010Ju Park","orcid":"https://orcid.org/0000-0003-3276-2416","observed_orcids":["https://orcid.org/0000-0003-3276-2416"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Byung-Ju Park","raw_affiliation_strings":["Department of Microbiology and Infectious Diseases and Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary\u2008Calgary, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Infectious Diseases and Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary\u2008Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070711619","display_name":"Minoru Imamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Minoru Imamura","raw_affiliation_strings":["Department of Microbiology and Infectious Diseases and Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary\u2008Calgary, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Infectious Diseases and Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary\u2008Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044434569","display_name":"Nuzhat Averill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nuzhat Averill","raw_affiliation_strings":["Department of Microbiology and Infectious Diseases and Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary\u2008Calgary, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Infectious Diseases and Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary\u2008Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111691008","display_name":"Shoji Kawazu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoji Kawazu","raw_affiliation_strings":["Department of Internal Medicine, Gunma University School of Medicine\u2008Gunma, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Gunma University School of Medicine\u2008Gunma, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024832913","display_name":"Pere Santamar\u00eda","orcid":"https://orcid.org/0000-0003-3469-1586","observed_orcids":["https://orcid.org/0000-0003-3469-1586"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Pere Santamaria","raw_affiliation_strings":["Department of Microbiology and Infectious Diseases and Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary\u2008Calgary, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Infectious Diseases and Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary\u2008Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6555,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.82577681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"45","issue":"8","first_page":"1121","last_page":"1131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.6940000057220459},{"id":"https://openalex.org/keywords/mhc-class-i-restriction","display_name":"MHC class I restriction","score":0.9190000295639038},{"id":"https://openalex.org/keywords/islet-transplantation","display_name":"islet transplantation","score":0.6150000095367432},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.7369999885559082},{"id":"https://openalex.org/keywords/nod-mice","display_name":"NOD mice","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.6869999766349792},{"id":"https://openalex.org/keywords/insulitis","display_name":"insulitis","score":0.4659999907016754},{"id":"https://openalex.org/keywords/h-2kd","display_name":"H-2Kd","score":0.5080000162124634},{"id":"https://openalex.org/keywords/h-2db","display_name":"H-2Db","score":0.7590000033378601},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.859000027179718},{"id":"https://openalex.org/keywords/t-cell-clones","display_name":"T cell clones","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.8126360177993774},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.8081868886947632},{"id":"https://openalex.org/C2778013207","wikidata":"https://www.wikidata.org/wiki/Q1961243","display_name":"NOD mice","level":4,"score":0.7904600501060486},{"id":"https://openalex.org/C55851684","wikidata":"https://www.wikidata.org/wiki/Q518390","display_name":"Nod","level":3,"score":0.6708892583847046},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6211787462234497},{"id":"https://openalex.org/C2779511750","wikidata":"https://www.wikidata.org/wiki/Q922215","display_name":"Insulitis","level":4,"score":0.5912531614303589},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.570482075214386},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.5278054475784302},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.47513774037361145},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4688098728656769},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.4682741165161133},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.4584594964981079},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.4262537360191345},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.29558026790618896},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2675461173057556},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.16934552788734436},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.142379492521286},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06673586368560791},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008212","descriptor_name":"Lymphocyte Depletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016381","descriptor_name":"Islets of Langerhans Transplantation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016381","descriptor_name":"Islets of Langerhans Transplantation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/diab.45.8.1121","doi":"https://doi.org/10.2337/diab.45.8.1121","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.45.8.1121","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"doi:10.2337/diabetes.45.8.1121","doi":"https://doi.org/10.2337/diabetes.45.8.1121","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diabetes.45.8.1121","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:8690161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8690161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4252338377","https://openalex.org/W2102852505","https://openalex.org/W2068926233","https://openalex.org/W2058344053","https://openalex.org/W2134412880","https://openalex.org/W1967625317","https://openalex.org/W2020206943","https://openalex.org/W2088190808","https://openalex.org/W2084899903","https://openalex.org/W1979953364"],"abstract_inverted_index":{"NOD":[0,11,84,96,289],"mouse-derived":[1],"beta-cell-specific":[2],"cytotoxic":[3,177],"T-cell":[4],"(beta-CTL)":[5],"clones":[6,94,161,214],"are":[7],"diabetogenic":[8],"in":[9,56,191,247],"adult":[10,288],"mice,":[12,90,290],"but":[13,205],"only":[14],"if":[15],"co-injected":[16],"with":[17],"splenic":[18],"CD4+":[19,135,189,267],"T-cells":[20,190,268],"from":[21,60,95,292],"diabetic":[22,76,233],"animals.":[23],"This":[24],"investigation":[25],"was":[26],"initiated":[27],"to":[28,269,273],"determine":[29],"whether":[30,47],"infiltration":[31,250],"of":[32,73,110,148,164,188,223,251,286],"pancreatic":[33,284],"islets":[34,59,253,285],"by":[35,254],"beta-CTL":[36,48,93,122,160,202,213],"is":[37,256],"a":[38,50,175],"major":[39],"histocompatibility":[40],"complex":[41],"(MHC)":[42],"class":[43,259],"I-restricted":[44,260],"response,":[45],"and":[46,134,136,139,162,277],"has":[49],"direct":[51],"cytopathic":[52],"effect":[53],"on":[54],"beta-cells":[55,246],"vivo.":[57],"Pancreatic":[58],"BALB/c":[61],"(H-2d)":[62],"or":[63,83,185,234],"B6":[64],"(H-2b)":[65],"mice":[66,97,102,118,156,172,198,231],"were":[67,98,215],"transplanted":[68],"under":[69],"the":[70,111,121,124,128,149,159,165,212,224,270],"renal":[71],"capsule":[72],"streptozotocin":[74],"(STZ)-induced":[75],"(NOD":[77,114,152,168,194,227],"x":[78,85,115,153,169,195,228],"BALB/c)":[79,116,170,196,229],"F1":[80,87,117,155,171,197,230],"(H-2Kd,":[81],"H-2Dd,b)":[82],"B6)":[86,154],"(H-2Kd,b,":[88],"H-2Db)":[89],"respectively.":[91],"H-2Kd-restricted":[92],"transfused":[99],"into":[100,127],"euglycemic":[101],"within":[103,142],"3":[104],"days":[105,219],"after":[106,220],"transplantation.":[107],"In":[108,145,209],"all":[109],"H-2d":[112,166,192,225],"islet-grafted":[113,151,167,193,226],"that":[119,240],"received":[120,158,174],"clones,":[123],"beta-CTLs":[125,243,255,263],"homed":[126],"grafts,":[129],"recruited":[130],"host":[131],"Mac-1+":[132],"cells":[133],"CD8+":[137],"T-cells,":[138],"caused":[140],"diabetes":[141,204],"7":[143],"days.":[144],"contrast,":[146,210],"none":[147,163,222],"H-2b":[150],"who":[157,173],"non-beta-cell":[176],"CTL":[178],"clone":[179],"(N":[180],"beta-CTL)":[181],"developed":[182,235],"graft":[183,236],"inflammation":[184],"diabetes.":[186],"Depletion":[187],"did":[199],"not":[200],"prevent":[201],"clone-induced":[203],"reduced":[206],"its":[207],"severity.":[208],"when":[211],"injected":[216],">":[217],"8":[218],"transplantation,":[221],"became":[232],"inflammation.":[237],"We":[238],"conclude":[239],"(1)":[241],"islet-derived":[242],"can":[244,264],"destroy":[245],"vivo;":[248],"(2)":[249],"grafted":[252],"an":[257],"MHC":[258],"response;":[261],"(3)":[262],"recruit":[265],"naive":[266],"site,":[271],"leading":[272],"further":[274],"beta-cell":[275],"damage;":[276],"(4)":[278],"revascularized":[279],"islet":[280],"grafts":[281],"are,":[282],"like":[283],"irradiated":[287],"\"sequestered\"":[291],"circulating":[293],"beta-CTLs.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}