{"id":"https://openalex.org/W2046351261","doi":"https://doi.org/10.1158/1078-0432.ovca13-b48","title":"Abstract B48: Targeting chemo-resistance in CCNE1-amplified ovarian cancer","display_name":"Abstract B48: Targeting chemo-resistance in CCNE1-amplified ovarian cancer","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W2046351261","doi":"https://doi.org/10.1158/1078-0432.ovca13-b48","mag":"2046351261"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ovca13-b48","doi":"https://doi.org/10.1158/1078-0432.ovca13-b48","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ovca13-b48","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031246918","display_name":"Barbie Taylor\u2010Harding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbie Taylor-Harding","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067050751","display_name":"Hasmik Agadjanian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hasmik Agadjanian","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113810688","display_name":"Paul Joseph Aspuria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Joseph Aspuria","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takako Mizuno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takako Mizuno","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039227624","display_name":"Dong\u2010Joo Cheon","orcid":"https://orcid.org/0000-0002-6134-4902","observed_orcids":["https://orcid.org/0000-0002-6134-4902"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong-Joo Cheon","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075368929","display_name":"Sandra Or\u0161uli\u0107","orcid":"https://orcid.org/0000-0001-5119-8721","observed_orcids":["https://orcid.org/0000-0001-5119-8721"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Orsulic","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082993956","display_name":"Beth Y. Karlan","orcid":"https://orcid.org/0000-0002-9451-2933","observed_orcids":["https://orcid.org/0000-0002-9451-2933"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth Karlan","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055415378","display_name":"Christine Walsh","orcid":"https://orcid.org/0000-0002-0903-3971","observed_orcids":["https://orcid.org/0000-0002-0903-3971"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Walsh","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111144811","display_name":"Wolf Ruprecht Wiedemeyer","orcid":"https://orcid.org/0009-0004-2326-9659","observed_orcids":["https://orcid.org/0009-0004-2326-9659"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wolf Ruprecht Wiedemeyer","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1282927834"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"19_Supplement","first_page":"B48","last_page":"B48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.701200008392334,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.701200008392334,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.19850000739097595,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.05959999933838844,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclin-e1","display_name":"cyclin E1","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.8889999985694885},{"id":"https://openalex.org/keywords/high-grade-serous-ovarian-carcinoma","display_name":"high-grade serous ovarian cancer","score":0.8330000042915344},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7990000247955322},{"id":"https://openalex.org/keywords/platinum-resistance","display_name":"platinum resistance","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.7739999890327454},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.8370000123977661},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.8029999732971191},{"id":"https://openalex.org/keywords/dinaciclib","display_name":"dinaciclib","score":0.8339999914169312},{"id":"https://openalex.org/keywords/e2f-transcription","display_name":"E2F transcription","score":0.9169999957084656},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.9129999876022339},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7590000033378601},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.720576286315918},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.6063905358314514},{"id":"https://openalex.org/C2780360765","wikidata":"https://www.wikidata.org/wiki/Q5198275","display_name":"Cyclin E1","level":5,"score":0.5583091378211975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5487396121025085},{"id":"https://openalex.org/C11882975","wikidata":"https://www.wikidata.org/wiki/Q24781041","display_name":"Cyclin D","level":5,"score":0.48509395122528076},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.45665207505226135},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.40115413069725037},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.241389662027359},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23329448699951172}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.ovca13-b48","doi":"https://doi.org/10.1158/1078-0432.ovca13-b48","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ovca13-b48","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2333479828","https://openalex.org/W1524281614","https://openalex.org/W3021743961","https://openalex.org/W2103386635","https://openalex.org/W3169918843","https://openalex.org/W2015383124","https://openalex.org/W2469609186","https://openalex.org/W4392379956","https://openalex.org/W2484609088","https://openalex.org/W4409625711"],"abstract_inverted_index":{"Abstract":[0],"The":[1,120],"putative":[2],"oncogene":[3],"CCNE1":[4],"(cyclin":[5,66],"E1)":[6],"is":[7,39,251,265],"frequently":[8],"amplified":[9],"in":[10,96,149,179,185,266,307,321],"human":[11],"high-grade":[12],"serous":[13],"ovarian":[14,103,130,191,279,309],"cancer.":[15,310],"CCNE1-amplified":[16,102,129,278,308],"cancers":[17,104,131,280],"tend":[18],"to":[19,34,89,105,151,195,237,275,281,327],"be":[20,273],"wildtype":[21],"for":[22,43,198,218,253],"BRCA1":[23,70,136,182,231,254],"and":[24,26,32,59,71,94,119,145,162,183,206,232,256],"BRCA2":[25,72,184],"are":[27,73],"associated":[28],"with":[29,200],"shorter":[30],"survival":[31],"resistance":[33],"platinum-based":[35],"chemotherapy.":[36],"Cyclin":[37],"E1":[38,85,222,249],"an":[40,107],"activating":[41],"cofactor":[42],"cyclin-dependent":[44],"kinases":[45],"(CDK),":[46],"which":[47,216,264],"stimulate":[48],"cell":[49,193,241],"cycle":[50],"progression":[51],"through":[52],"phosphorylation":[53],"of":[54,62,77,135,155,181,190,220,230,314],"the":[55,315],"retinoblastoma":[56],"(RB)":[57],"protein":[58],"subsequent":[60],"induction":[61],"E2F":[63,78],"transcriptional":[64],"activity":[65],"E1-RB-E2F":[67],"signaling).":[68],"Since":[69],"known":[74],"target":[75],"genes":[76],"transcription":[79],"factors,":[80],"we":[81,126,141,166],"hypothesize":[82],"that":[83,128,168,247],"cyclin":[84,156,204,221,248],"signaling":[86,158,250],"actively":[87],"contributes":[88],"high":[90],"DNA":[91,212],"repair":[92],"capacity":[93],"chemo-resistance":[95,306],"a":[97,267],"BRCA1/2-dependent":[98],"manner.":[99],"We":[100],"predict":[101],"exhibit":[106],"\u201canti-BRCAness\u201d":[108],"phenotype.":[109],"In":[110],"two":[111],"independent":[112],"gene":[113],"expression":[114,255],"datasets,":[115],"generated":[116],"by":[117],"TCGA":[118],"Women's":[121],"Cancer":[122,323,338],"Program":[123],"at":[124],"Cedars-Sinai,":[125],"found":[127],"maintain":[132],"higher":[133],"levels":[134,229],"than":[137,239],"CCNE1-wildtype":[138],"tumors.":[139],"Moreover,":[140],"have":[142],"employed":[143],"genetic":[144],"pharmacological":[146,169],"targeting":[147],"approaches":[148],"order":[150],"assess":[152],"if":[153],"inhibition":[154],"E1-dependent":[157],"can":[159],"induce":[160],"BRCAness":[161],"restore":[163],"chemo-sensitivity.":[164],"Here,":[165],"show":[167],"CDK":[170],"inhibitors":[171],"(CDKi)":[172],"effectively":[173],"shut":[174],"down":[175],"E2F-mediated":[176],"transcription,":[177],"resulting":[178],"downregulation":[180],"CDKi-treated":[186],"cells.":[187],"Long-term":[188],"exposure":[189],"cancer":[192],"lines":[194],"CDKi":[196,260],"selected":[197],"cells":[199],"reduced":[201],"dependency":[202],"on":[203,319],"E1,":[205],"genomic":[207],"profiling":[208],"revealed":[209],"de":[210],"novo":[211],"copy":[213],"number":[214],"changes":[215],"compensate":[217],"loss":[219],"function.":[223],"Importantly,":[224],"CDKi-resistant":[225],"subclones":[226],"retained":[227],"lower":[228],"were":[233],"significantly":[234],"more":[235],"sensitive":[236],"cisplatin":[238],"parental":[240],"lines.":[242],"Collectively,":[243],"our":[244],"results":[245],"suggest":[246],"required":[252],"chemo-resistance.":[257],"Currently":[258],"available":[259],"such":[261],"as":[262],"Dinaciclib,":[263],"phase":[268],"3":[269],"clinical":[270],"trial,":[271],"may":[272],"useful":[274],"specifically":[276],"sensitize":[277],"cisplatin.":[282],"Citation":[283],"Format:":[284],"Barbie":[285],"Taylor-Harding,":[286],"Hasmik":[287],"Agadjanian,":[288],"Paul":[289],"Joseph":[290],"Aspuria,":[291],"Takako":[292],"Mizuno,":[293],"Dong-Joo":[294],"Cheon,":[295],"Sandra":[296],"Orsulic,":[297],"Beth":[298],"Karlan,":[299],"Christine":[300],"Walsh,":[301],"Wolf":[302],"Ruprecht":[303],"Wiedemeyer.":[304],"Targeting":[305],"[abstract].":[311],"In:":[312],"Proceedings":[313],"AACR":[316],"Special":[317],"Conference":[318],"Advances":[320],"Ovarian":[322],"Research:":[324],"From":[325],"Concept":[326],"Clinic;":[328],"Sep":[329],"18-21,":[330],"2013;":[331],"Miami,":[332],"FL.":[333],"Philadelphia":[334],"(PA):":[335],"AACR;":[336],"Clin":[337],"Res":[339],"2013;19(19":[340],"Suppl):Abstract":[341],"nr":[342],"B48.":[343]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}