{"id":"https://openalex.org/W2046277604","doi":"https://doi.org/10.1159/000084871","title":"Hypothalamic Resistin Immunoreactivity Is Reduced b y Obesity in the Mouse: Co-Localization with \u03b1-Melanostimulating Hormone","display_name":"Hypothalamic Resistin Immunoreactivity Is Reduced b y Obesity in the Mouse: Co-Localization with \u03b1-Melanostimulating Hormone","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2046277604","doi":"https://doi.org/10.1159/000084871","mag":"2046277604","pmid":"https://pubmed.ncbi.nlm.nih.gov/15809509"},"language":"en","primary_location":{"id":"doi:10.1159/000084871","doi":"https://doi.org/10.1159/000084871","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000084871","pdf_url":null,"source":{"id":"https://openalex.org/S84102376","display_name":"Neuroendocrinology","issn_l":"0028-3835","issn":["0028-3835","1423-0194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081504667","display_name":"Michael Wilkinson","orcid":"https://orcid.org/0000-0002-4252-5097","observed_orcids":["https://orcid.org/0000-0002-4252-5097","https://orcid.org/0000-0001-6561-2145"]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael Wilkinson","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Faculty of Medicine, Dalhousie University, Halifax, Canada. mwilk@dal.ca","Department of Obstetrics and Gynaecology, Faculty of Medicine, Dalhousie University, Halifax, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Faculty of Medicine, Dalhousie University, Halifax, Canada. mwilk@dal.ca","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Faculty of Medicine, Dalhousie University, Halifax, Canada","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009422526","display_name":"Diane A. Wilkinson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diane Wilkinson","raw_affiliation_strings":["Obstetrics and Gynaecology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynaecology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075327981","display_name":"Glen Wiesner","orcid":"https://orcid.org/0000-0002-0071-130X","observed_orcids":["https://orcid.org/0000-0002-0071-130X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glen Wiesner","raw_affiliation_strings":["Human Neurotransmitter Laboratory, Baker Institute, Melbourne, Australia","Obstetrics and Gynaecology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Neurotransmitter Laboratory, Baker Institute, Melbourne, Australia","institution_ids":[]},{"raw_affiliation_string":"Obstetrics and Gynaecology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112902809","display_name":"Barbara A. Morash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Barbara Morash","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Faculty of Medicine, Dalhousie University, Halifax, Canada and","Obstetrics and Gynaecology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Faculty of Medicine, Dalhousie University, Halifax, Canada and","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Obstetrics and Gynaecology,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109927354","display_name":"Ehud Ur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ehud Ur","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Faculty of Medicine, Dalhousie University, Halifax, Canada and","Obstetrics and Gynaecology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Faculty of Medicine, Dalhousie University, Halifax, Canada and","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Obstetrics and Gynaecology,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9464,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.84853967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"81","issue":"1","first_page":"19","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.3034999966621399,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resistin","display_name":"resistin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9710000157356262},{"id":"https://openalex.org/keywords/proopiomelanocortin-neurons","display_name":"proopiomelanocortin neurons","score":0.9259999990463257},{"id":"https://openalex.org/keywords/arcuate-nucleus","display_name":"arcuate nucleus","score":0.8989999890327454},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6420000195503235},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.871999979019165},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.675000011920929},{"id":"https://openalex.org/keywords/hypothalamic-lesions","display_name":"hypothalamic lesions","score":0.49399998784065247},{"id":"https://openalex.org/keywords/monosodium-glutamate","display_name":"monosodium glutamate","score":0.8700000047683716},{"id":"https://openalex.org/keywords/gold-thioglucose","display_name":"gold thioglucose","score":0.9639999866485596},{"id":"https://openalex.org/keywords/lactation","display_name":"lactation","score":0.5950000286102295},{"id":"https://openalex.org/keywords/fasting","display_name":"fasting","score":0.4390000104904175},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.5849999785423279},{"id":"https://openalex.org/keywords/ob-ob-mice","display_name":"ob/ob mice","score":0.8370000123977661},{"id":"https://openalex.org/keywords/neuropeptide-co-localization","display_name":"neuropeptide co-localization","score":0.7419999837875366},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7310000061988831},{"id":"https://openalex.org/keywords/visceral-fat","display_name":"visceral fat","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C2779760629","wikidata":"https://www.wikidata.org/wiki/Q419499","display_name":"Resistin","level":5,"score":0.9542005062103271},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8800761103630066},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8729246258735657},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.7866411209106445},{"id":"https://openalex.org/C2778458369","wikidata":"https://www.wikidata.org/wiki/Q253246","display_name":"Arcuate nucleus","level":3,"score":0.55258709192276},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5193985104560852},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.457154244184494},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.4254220128059387},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.40244853496551514},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.39849013090133667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34806129336357117},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.25366994738578796}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000521","descriptor_name":"alpha-MSH","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006051","descriptor_name":"Aurothioglucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006729","descriptor_name":"Hormones, Ectopic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012970","descriptor_name":"Sodium Glutamate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052243","descriptor_name":"Resistin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1159/000084871","doi":"https://doi.org/10.1159/000084871","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000084871","pdf_url":null,"source":{"id":"https://openalex.org/S84102376","display_name":"Neuroendocrinology","issn_l":"0028-3835","issn":["0028-3835","1423-0194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"journal-article"},{"id":"pmid:15809509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15809509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroendocrinology","raw_type":"Comparative Study"},{"id":"pmh:oai:eprints.vu.edu.au:35251","doi":null,"is_oa":false,"landing_page_url":"https://vuir.vu.edu.au/35251/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400215","display_name":"Victoria University Research Repository (Victoria University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I41156924","host_organization_name":"Victoria University of Wellington","host_organization_lineage":["https://openalex.org/I41156924"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W32740597","https://openalex.org/W1516728464","https://openalex.org/W1569177428","https://openalex.org/W1963558079","https://openalex.org/W1964819028","https://openalex.org/W1969228109","https://openalex.org/W1969973773","https://openalex.org/W1972275518","https://openalex.org/W1972435690","https://openalex.org/W1986493673","https://openalex.org/W1986939620","https://openalex.org/W1990657409","https://openalex.org/W1999744765","https://openalex.org/W2001095683","https://openalex.org/W2022129879","https://openalex.org/W2027180375","https://openalex.org/W2028304496","https://openalex.org/W2030707377","https://openalex.org/W2034622046","https://openalex.org/W2035216298","https://openalex.org/W2039055221","https://openalex.org/W2045061550","https://openalex.org/W2053051844","https://openalex.org/W2062316965","https://openalex.org/W2070233031","https://openalex.org/W2074890095","https://openalex.org/W2078157159","https://openalex.org/W2085164095","https://openalex.org/W2088085350","https://openalex.org/W2093303185","https://openalex.org/W2095351701","https://openalex.org/W2100897987","https://openalex.org/W2103977562","https://openalex.org/W2107940713","https://openalex.org/W2109861165","https://openalex.org/W2109945170","https://openalex.org/W2110678596","https://openalex.org/W2116215072","https://openalex.org/W2125797489","https://openalex.org/W2132437711","https://openalex.org/W2141130683","https://openalex.org/W2158969119","https://openalex.org/W2163029508","https://openalex.org/W2169846033","https://openalex.org/W2417744539","https://openalex.org/W4212849655"],"related_works":["https://openalex.org/W2088085350","https://openalex.org/W2034622046","https://openalex.org/W150079931","https://openalex.org/W2157510059","https://openalex.org/W2120332366","https://openalex.org/W2023612431","https://openalex.org/W2351001160","https://openalex.org/W7096024949","https://openalex.org/W2992716892","https://openalex.org/W1506239129"],"abstract_inverted_index":{"Resistin":[0,13],"is":[1,28,64,351,359,367,375,388],"a":[2,57,109,139,158,309,323,331,389],"new":[3],"adipokine":[4],"expressed":[5,368],"in":[6,68,134,138,169,175,180,198,226,231,256,290,354,369],"mouse,":[7],"rat":[8],"and":[9,21,43,72,98,137,205,230,247,343],"human":[10,40],"adipose":[11],"tissue.":[12],"may":[14],"be":[15,236,288,300],"an":[16,282,327],"important":[17],"link":[18],"between":[19],"obesity":[20],"insulin":[22],"resistance,":[23],"though":[24,245],"this":[25],"controversial":[26],"view":[27],"complicated":[29],"by":[30,75,90,152,157,195,212,378],"the":[31,51,69,96,118,122,126,135,143,163,170,223,257,269,272,293,364,386],"discovery":[32],"of":[33,36,59,101,112,121,142,253,259,326],"multiple":[34],"sites":[35],"resistin":[37,60,63,86,103,147,349,365,374],"expression,":[38],"including":[39],"macrophages,":[41],"placenta":[42],"pancreas.":[44],"In":[45,243,318],"previous":[46],"studies":[47],"we":[48,107,264],"demonstrated":[49],"that":[50,84,222,266,285,307,337,348,385],"mouse":[52,71],"hypothalamo-pituitary":[53],"system":[54],"was":[55,83,150,166,314,339],"also":[56],"site":[58],"production.":[61],"Pituitary":[62],"developmentally":[65],"regulated,":[66],"reduced":[67],"ob/ob":[70,185],"severely":[73,232],"down-regulated":[74],"food":[76],"deprivation":[77],"(24":[78],"h).":[79],"An":[80],"unexpected":[81],"finding":[82],"hypothalamic":[85,102,209,332],"mRNA":[87,350],"remained":[88],"unaffected":[89,151],"fasting.":[91],"The":[92],"present":[93],"experiments":[94],"examined":[95],"localization":[97],"possible":[99],"regulation":[100],"protein.":[104],"Using":[105],"immunohistochemistry":[106],"observed":[108],"complex":[110],"network":[111],"resistin+":[113,176,273],"fibres":[114,177],"extending":[115],"rostrally":[116],"from":[117],"arcuate":[119],"nucleus":[120],"hypothalamus":[123,387],"(ARC)":[124],"to":[125,238,268,281,299,361],"preoptic":[127],"area.":[128],"Labelled":[129],"cell":[130,274],"bodies":[131],"occurred":[132],"only":[133],"ARC":[136,270],"periventricular":[140,164],"region":[141],"dorsal":[144],"hypothalamus.":[145],"Hypothalamic":[146],"immunoreactivity":[148],"(ir)":[149],"fasting":[153],"(48":[154],"h)":[155],"or":[156,216,240,372],"high":[159,251],"fat":[160,262],"diet,":[161],"but":[162,356],"staining":[165],"greatly":[167],"increased":[168],"lactating":[171],"mouse.":[172],"Marked":[173],"reductions":[174],"were":[178],"seen":[179],"brain":[181],"tissue":[182,391],"from:":[183],"(a)":[184],"mice,":[186,229,234],"(b)":[187],"young":[188],"mice":[189,207,249],"made":[190],"underweight":[191,233],"for":[192,311,392],"their":[193],"age":[194],"raising":[196],"them":[197],"large":[199],"litters":[200],"(20":[201],"pups":[202],"per":[203],"litter)":[204],"(c)":[206],"with":[208,316,330,341],"lesions":[210],"induced":[211],"monosodium":[213],"glutamate":[214],"(MSG)":[215],"gold":[217],"thioglucose":[218],"(GTG).":[219],"We":[220,334],"speculate":[221],"resistin-ir":[224,286],"deficit":[225],"genetically":[227],"obese":[228],"could":[235],"due":[237],"low":[239],"absent":[241],"leptin.":[242],"contrast,":[244],"MSG-":[246],"GTG-treated":[248],"have":[250],"levels":[252],"circulating":[254],"leptin,":[255],"presence":[258],"excessive":[260],"visceral":[261],"deposits,":[263],"hypothesize":[265],"damage":[267],"destroys":[271],"bodies.":[275],"This":[276,297],"latter":[277],"supposition":[278],"led":[279],"us":[280],"additional":[283],"hypothesis,":[284],"would":[287],"contained":[289],"neurons":[291,371],"expressing":[292],"proopiomelanocortin":[294],"(POMC)":[295],"gene.":[296],"proved":[298],"correct.":[301],"Double":[302],"label":[303],"immunofluorescence":[304],"histochemistry":[305],"revealed":[306],"alpha-MSH-ir,":[308],"marker":[310],"POMC":[312,370],"neurons,":[313],"co-localized":[315,329,340],"resistin-ir.":[317],"conclusion,":[319],"our":[320,382],"data":[321,383],"reveal":[322],"second":[324],"example":[325],"adipocytokine":[328],"neuropeptide.":[333],"reported":[335],"previously":[336],"leptin":[338],"oxytocin":[342],"vasopressin.":[344],"RT-PCR":[345],"analysis":[346],"confirmed":[347],"readily":[352],"detectable":[353],"ARC,":[355],"further":[357],"work":[358],"required":[360],"determine":[362],"whether":[363],"gene":[366],"if":[373],"specifically":[376],"accumulated":[377],"these":[379],"cells.":[380],"Nonetheless,":[381],"suggest":[384],"target":[390],"resistin.":[393]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}