{"id":"https://openalex.org/W2046167883","doi":"https://doi.org/10.1309/ajcp16ntxzlzfaib","title":"Soluble Transferrin Receptor (sTfR) and sTfR/log Ferritin Index for the Diagnosis of Iron-Deficiency Anemia A Meta-Analysis","display_name":"Soluble Transferrin Receptor (sTfR) and sTfR/log Ferritin Index for the Diagnosis of Iron-Deficiency Anemia A Meta-Analysis","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W2046167883","doi":"https://doi.org/10.1309/ajcp16ntxzlzfaib","mag":"2046167883","pmid":"https://pubmed.ncbi.nlm.nih.gov/23086764"},"language":"en","primary_location":{"id":"doi:10.1309/ajcp16ntxzlzfaib","doi":"https://doi.org/10.1309/ajcp16ntxzlzfaib","is_oa":false,"landing_page_url":"https://doi.org/10.1309/ajcp16ntxzlzfaib","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084122093","display_name":"Ilenia Infusino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210087773","display_name":"Luigi Sacco Hospital","ror":"https://ror.org/0025g8755","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087773","https://openalex.org/I4210156709"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilenia Infusino","raw_affiliation_strings":["Laboratorio Analisi, Ospedale Luigi Sacco, Via GB Grassi 74, 20157 Milano, Italy. infusino.ilenia@hsacco.it","Centre for Metrological Traceability in Laboratory Medicine (CIRME), University of Milan, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio Analisi, Ospedale Luigi Sacco, Via GB Grassi 74, 20157 Milano, Italy. infusino.ilenia@hsacco.it","institution_ids":["https://openalex.org/I4210087773"]},{"raw_affiliation_string":"Centre for Metrological Traceability in Laboratory Medicine (CIRME), University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035001679","display_name":"Federica Braga","orcid":"https://orcid.org/0000-0003-3562-7180","observed_orcids":["https://orcid.org/0000-0003-3562-7180"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Braga","raw_affiliation_strings":["Centre for Metrological Traceability in Laboratory Medicine (CIRME), University of Milan, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Metrological Traceability in Laboratory Medicine (CIRME), University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023614887","display_name":"Alberto Dolci","orcid":"https://orcid.org/0000-0002-9833-7538","observed_orcids":["https://orcid.org/0000-0002-9833-7538"]},"institutions":[{"id":"https://openalex.org/I4210087773","display_name":"Luigi Sacco Hospital","ror":"https://ror.org/0025g8755","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210087773","https://openalex.org/I4210156709"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Dolci","raw_affiliation_strings":["Clinical Biochemistry Laboratory, \u2018Luigi Sacco\u2019 University Hospital, Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Biochemistry Laboratory, \u2018Luigi Sacco\u2019 University Hospital, Milan","institution_ids":["https://openalex.org/I4210087773"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085613233","display_name":"Mauro Panteghini","orcid":"https://orcid.org/0000-0002-7147-3433","observed_orcids":["https://orcid.org/0000-0002-7147-3433"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mauro Panteghini","raw_affiliation_strings":["Centre for Metrological Traceability in Laboratory Medicine (CIRME), University of Milan, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Metrological Traceability in Laboratory Medicine (CIRME), University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4660,"currency":"USD","value_usd":4660},"apc_paid":null,"fwci":0.7465,"has_fulltext":false,"cited_by_count":144,"citation_normalized_percentile":{"value":0.64705882,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"138","issue":"5","first_page":"642","last_page":"649"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soluble-transferrin-receptor","display_name":"soluble transferrin receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/iron-deficiency-anemia","display_name":"iron deficiency anemia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/anemia-of-chronic-disease","display_name":"anemia of chronic disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.9589999914169312},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.7940000295639038},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.7919999957084656},{"id":"https://openalex.org/keywords/likelihood-ratios","display_name":"likelihood ratios","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C2776485076","wikidata":"https://www.wikidata.org/wiki/Q7558947","display_name":"Soluble transferrin receptor","level":5,"score":0.6649063229560852},{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.6105872392654419},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.5208702087402344},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5085893869400024},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5035013556480408},{"id":"https://openalex.org/C2776732101","wikidata":"https://www.wikidata.org/wiki/Q954674","display_name":"Iron-deficiency anemia","level":3,"score":0.48663458228111267},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.46300485730171204},{"id":"https://openalex.org/C157481446","wikidata":"https://www.wikidata.org/wiki/Q5270351","display_name":"Diagnostic odds ratio","level":3,"score":0.4524362087249756},{"id":"https://openalex.org/C2777417653","wikidata":"https://www.wikidata.org/wiki/Q1313081","display_name":"Iron deficiency","level":3,"score":0.4364449381828308},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42427805066108704},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.3754575550556183},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35648101568222046},{"id":"https://openalex.org/C3019673199","wikidata":"https://www.wikidata.org/wiki/Q6073056","display_name":"Iron status","level":4,"score":0.09574002027511597}],"mesh":[{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011990","descriptor_name":"Receptors, Transferrin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011990","descriptor_name":"Receptors, Transferrin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011990","descriptor_name":"Receptors, Transferrin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018798","descriptor_name":"Anemia, Iron-Deficiency","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018798","descriptor_name":"Anemia, Iron-Deficiency","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018798","descriptor_name":"Anemia, Iron-Deficiency","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018798","descriptor_name":"Anemia, Iron-Deficiency","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018798","descriptor_name":"Anemia, Iron-Deficiency","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018798","descriptor_name":"Anemia, Iron-Deficiency","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1309/ajcp16ntxzlzfaib","doi":"https://doi.org/10.1309/ajcp16ntxzlzfaib","is_oa":false,"landing_page_url":"https://doi.org/10.1309/ajcp16ntxzlzfaib","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},{"id":"pmid:23086764","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23086764","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of clinical pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W10000712","https://openalex.org/W55541686","https://openalex.org/W77594368","https://openalex.org/W100002005","https://openalex.org/W1507178887","https://openalex.org/W1854101460","https://openalex.org/W1924847619","https://openalex.org/W1930624773","https://openalex.org/W1978287414","https://openalex.org/W1982984964","https://openalex.org/W1989575132","https://openalex.org/W1990748933","https://openalex.org/W2006759478","https://openalex.org/W2014632439","https://openalex.org/W2048383325","https://openalex.org/W2060330790","https://openalex.org/W2062256364","https://openalex.org/W2077070367","https://openalex.org/W2077491701","https://openalex.org/W2080420991","https://openalex.org/W2081845103","https://openalex.org/W2084133634","https://openalex.org/W2091543383","https://openalex.org/W2099320317","https://openalex.org/W2101830214","https://openalex.org/W2101894389","https://openalex.org/W2114642256","https://openalex.org/W2121032725","https://openalex.org/W2126211916","https://openalex.org/W2128401740","https://openalex.org/W2131310817","https://openalex.org/W2140448780","https://openalex.org/W2144207984","https://openalex.org/W2153825320","https://openalex.org/W2160432438","https://openalex.org/W2169160087","https://openalex.org/W2171318711","https://openalex.org/W2172242653","https://openalex.org/W2415748475","https://openalex.org/W2475375124","https://openalex.org/W3022903699","https://openalex.org/W4253415737"],"related_works":["https://openalex.org/W2172242653","https://openalex.org/W2412528270","https://openalex.org/W1555621528","https://openalex.org/W2416887698","https://openalex.org/W1976827621","https://openalex.org/W2188798147","https://openalex.org/W2410232417","https://openalex.org/W2300959245","https://openalex.org/W2915326004","https://openalex.org/W3131004245"],"abstract_inverted_index":{"Determination":[0],"of":[1,16,24,32,82,98,127,142],"serum":[2],"soluble":[3],"transferrin":[4],"receptor":[5],"(sTfR)":[6],"is":[7],"proposed":[8],"to":[9,27,136],"distinguish":[10],"between":[11],"iron-deficiency":[12],"anemia":[13,15],"and":[14,34,43,71,88,106,108,115],"chronic":[17],"disease.":[18],"Here":[19],"we":[20],"conducted":[21],"a":[22,79,96],"meta-analysis":[23,39],"the":[25,29,138],"literature":[26],"evaluate":[28],"diagnostic":[30,140],"efficacy":[31],"sTfR":[33,42,45,49,64,72,100],"sTfR/log":[35],"ferritin":[36],"index.":[37],"The":[38,57,102],"included":[40],"18":[41],"10":[44,99],"index":[46,50,73],"studies.":[47,83,101],"Three":[48],"studies":[51,133],"were,":[52],"however,":[53],"eliminated":[54],"as":[55],"outliers.":[56],"odds":[58],"ratio":[59],"was":[60,92],"significant":[61],"for":[62,85],"both":[63],"(22.9,":[65],"95%":[66,75],"confidence":[67],"interval":[68],"[CI],":[69],"9.6-55.0)":[70],"(9.5,":[74],"CI,":[76],"5.0-18.1)":[77],"in":[78,95],"heterogeneous":[80],"set":[81],"Meta-analysis":[84],"sensitivity,":[86,104],"specificity,":[87,105],"likelihood":[89],"ratios":[90],"(LRs)":[91],"performed":[93],"only":[94],"subset":[97],"overall":[103,139],"positive":[107],"negative":[109],"LRs":[110],"were":[111],"86%,":[112],"75%,":[113],"3.85,":[114],"0.19,":[116],"respectively,":[117],"with":[118],"an":[119],"area":[120],"under":[121],"summary":[122],"receiver":[123],"operating":[124],"characteristic":[125],"curve":[126],"0.912":[128],"(standard":[129],"error,":[130],"0.039).":[131],"Additional":[132],"are":[134],"needed":[135],"define":[137],"accuracy":[141],"sTfR.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
