{"id":"https://openalex.org/W2046117118","doi":"https://doi.org/10.1161/01.cir.0000052617.91920.fd","title":"C-Reactive Protein Increases Plasminogen Activator Inhibitor-1 Expression and Activity in Human Aortic Endothelial Cells","display_name":"C-Reactive Protein Increases Plasminogen Activator Inhibitor-1 Expression and Activity in Human Aortic Endothelial Cells","publication_year":2003,"publication_date":"2003-01-27","ids":{"openalex":"https://openalex.org/W2046117118","doi":"https://doi.org/10.1161/01.cir.0000052617.91920.fd","mag":"2046117118","pmid":"https://pubmed.ncbi.nlm.nih.gov/12551862"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.0000052617.91920.fd","doi":"https://doi.org/10.1161/01.cir.0000052617.91920.fd","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.0000052617.91920.fd","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011782005","display_name":"Sridevi Devaraj","orcid":"https://orcid.org/0000-0001-9189-7914","observed_orcids":["https://orcid.org/0000-0001-9189-7914"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sridevi Devaraj","raw_affiliation_strings":["From the Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, Calif","Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, Calif 95817, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, Calif","institution_ids":["https://openalex.org/I4210160527"]},{"raw_affiliation_string":"Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, Calif 95817, USA","institution_ids":["https://openalex.org/I4210160527"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dan Yan Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Yan Xu","raw_affiliation_strings":["From the Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, Calif","institution_ids":["https://openalex.org/I4210160527"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037796085","display_name":"Ishwarlal Jialal","orcid":"https://orcid.org/0000-0001-9113-2604","observed_orcids":["https://orcid.org/0000-0001-9113-2604"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ishwarlal Jialal","raw_affiliation_strings":["From the Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, Calif","institution_ids":["https://openalex.org/I4210160527"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210160527"],"apc_list":null,"apc_paid":null,"fwci":36.4335,"has_fulltext":true,"cited_by_count":644,"citation_normalized_percentile":{"value":0.99813162,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"107","issue":"3","first_page":"398","last_page":"404"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.44510000944137573,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.44510000944137573,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.266400009393692,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.19339999556541443,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":1.0},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":1.0},{"id":"https://openalex.org/keywords/human-aortic-endothelial-cells","display_name":"human aortic endothelial cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5130000114440918},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/atherothrombosis","display_name":"atherothrombosis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9480000138282776},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.597000002861023},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9010000228881836},{"id":"https://openalex.org/keywords/endothelin-1-receptor","display_name":"endothelin-1 receptor","score":0.7699999809265137},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9190000295639038}],"concepts":[{"id":"https://openalex.org/C2780675426","wikidata":"https://www.wikidata.org/wiki/Q410485","display_name":"Plasminogen activator inhibitor-1","level":3,"score":0.7602829933166504},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7125536203384399},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.643509566783905},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.615160346031189},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5609773397445679},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5339656472206116},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.4814552664756775},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.4469437599182129},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.42756593227386475},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4115055203437805},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.41111963987350464},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3405950665473938},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27109071612358093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19186121225357056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11588972806930542},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07374903559684753}],"mesh":[{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020871","descriptor_name":"RNA Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024821","descriptor_name":"Metabolic Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1161/01.cir.0000052617.91920.fd","doi":"https://doi.org/10.1161/01.cir.0000052617.91920.fd","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.0000052617.91920.fd","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:12551862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12551862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.973.2029","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.973.2029","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/circulationaha/107/3/398.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.980.3496","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.980.3496","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/circulationaha/early/2003/01/06/01.CIR.0000052617.91920.FD.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4436215188","display_name":null,"funder_award_id":"NIH K24","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7325421989","display_name":"Clinical Studies in Nutrition and Metabolism","funder_award_id":"K24AT000596","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W69884986","https://openalex.org/W151540657","https://openalex.org/W202019503","https://openalex.org/W281257934","https://openalex.org/W292647304","https://openalex.org/W1525306910","https://openalex.org/W1595391532","https://openalex.org/W1702576180","https://openalex.org/W1893939249","https://openalex.org/W1963536396","https://openalex.org/W1964393238","https://openalex.org/W1964560926","https://openalex.org/W1971456874","https://openalex.org/W1972440424","https://openalex.org/W1990590605","https://openalex.org/W1999939355","https://openalex.org/W2005110412","https://openalex.org/W2020386415","https://openalex.org/W2025062210","https://openalex.org/W2027208842","https://openalex.org/W2032602729","https://openalex.org/W2033538734","https://openalex.org/W2039420330","https://openalex.org/W2039831544","https://openalex.org/W2059279349","https://openalex.org/W2066275038","https://openalex.org/W2070627144","https://openalex.org/W2071073097","https://openalex.org/W2078291282","https://openalex.org/W2089865619","https://openalex.org/W2090772022","https://openalex.org/W2092362047","https://openalex.org/W2096157026","https://openalex.org/W2097796010","https://openalex.org/W2098657147","https://openalex.org/W2124312719","https://openalex.org/W2129149737","https://openalex.org/W2139203772","https://openalex.org/W2156744146","https://openalex.org/W2157586491","https://openalex.org/W2159087408","https://openalex.org/W2315575691","https://openalex.org/W2398217550","https://openalex.org/W2412829787","https://openalex.org/W2417843828","https://openalex.org/W2471368982","https://openalex.org/W3022958147","https://openalex.org/W4248852506","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7100709713","https://openalex.org/W2072423141","https://openalex.org/W2043458428","https://openalex.org/W2117950541","https://openalex.org/W2109520899","https://openalex.org/W2015685461","https://openalex.org/W150173255","https://openalex.org/W2121524077","https://openalex.org/W2077111421","https://openalex.org/W2018427248"],"abstract_inverted_index":{"BACKGROUND:":[0],"Inflammation":[1],"plays":[2],"a":[3,12,50,101],"pivotal":[4],"role":[5],"in":[6,57,62,85,100,106,166],"atherosclerosis.":[7],"In":[8],"addition":[9],"to":[10,129,137],"being":[11],"risk":[13],"marker":[14,51],"for":[15,172],"cardiovascular":[16],"disease,":[17],"much":[18],"recent":[19],"data":[20],"suggest":[21],"that":[22,159],"C-reactive":[23],"protein":[24],"(CRP)":[25],"promotes":[26],"atherogenesis":[27],"via":[28],"effects":[29],"on":[30,83,143],"monocytes":[31],"and":[32,61,64,103,115,131,164,168,177],"endothelial":[33,65,88,124],"cells.":[34],"The":[35],"metabolic":[36,59,175],"syndrome":[37,60,176],"is":[38,54],"associated":[39],"with":[40,97],"significantly":[41],"elevated":[42,56],"levels":[43],"of":[44,52,71,81,95,123,141],"CRP.":[45],"Plasminogen":[46],"activator":[47],"inhibitor-1":[48],"(PAI-1),":[49],"atherothrombosis,":[53],"also":[55],"the":[58,68,79,139,156,174],"diabetes,":[63],"cells":[66,89],"are":[67,75],"major":[69],"source":[70],"PAI-1.":[72,144],"However,":[73],"there":[74],"no":[76],"studies":[77],"examining":[78],"effect":[80,140],"CRP":[82,98,118,142,145,160],"PAI-1":[84,108,110,113,116,120,148,162],"human":[86],"aortic":[87],"(HAECs).":[90],"METHODS":[91],"AND":[92],"RESULTS:":[93],"Incubation":[94],"HAECs":[96,167],"results":[99],"time-":[102],"dose-dependent":[104],"increase":[105],"secreted":[107],"antigen,":[109],"activity,":[111],"intracellular":[112],"protein,":[114],"mRNA.":[117,121],"stabilizes":[119],"Inhibitors":[122],"NO":[125],"synthase,":[126],"blocking":[127],"antibodies":[128],"interleukin-6":[130],"an":[132],"endothelin-1":[133],"receptor":[134],"blocker,":[135],"fail":[136],"attenuate":[138],"additionally":[146],"increased":[147],"under":[149],"hyperglycemic":[150],"conditions.":[151],"CONCLUSIONS:":[152],"This":[153],"study":[154],"makes":[155],"novel":[157],"observation":[158],"induces":[161],"expression":[163],"activity":[165],"thus":[169],"has":[170],"implications":[171],"both":[173],"atherothrombosis.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":32}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}