{"id":"https://openalex.org/W2046008239","doi":"https://doi.org/10.1517/17460441.2014.924923","title":"The preclinical development of regorafenib for the treatment of colorectal cancer","display_name":"The preclinical development of regorafenib for the treatment of colorectal cancer","publication_year":2014,"publication_date":"2014-06-04","ids":{"openalex":"https://openalex.org/W2046008239","doi":"https://doi.org/10.1517/17460441.2014.924923","mag":"2046008239","pmid":"https://pubmed.ncbi.nlm.nih.gov/24896071"},"language":"en","primary_location":{"id":"doi:10.1517/17460441.2014.924923","doi":"https://doi.org/10.1517/17460441.2014.924923","is_oa":false,"landing_page_url":"https://doi.org/10.1517/17460441.2014.924923","pdf_url":null,"source":{"id":"https://openalex.org/S142541038","display_name":"Expert Opinion on Drug Discovery","issn_l":"1746-0441","issn":["1746-0441","1746-045X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Discovery","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035321896","display_name":"Koh Miura","orcid":"https://orcid.org/0000-0001-7303-9430","observed_orcids":["https://orcid.org/0000-0001-7303-9430"]},"institutions":[{"id":"https://openalex.org/I4210107389","display_name":"Miyagi Prefectural Hospital Organization","ror":"https://ror.org/01qt7mp11","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210107389"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koh Miura","raw_affiliation_strings":["Miyagi Cancer Center, Department of Surgery,\r47-1 Nodayama, Natori 981-1293, Japan ; ; ,","+81 22 381 1168","Miyagi Cancer Center, Department of Surgery,\n47-1 Nodayama, Natori 981-1293, Japan +81 22 384 3151"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miyagi Cancer Center, Department of Surgery,\r47-1 Nodayama, Natori 981-1293, Japan ; ; ,","institution_ids":["https://openalex.org/I4210107389"]},{"raw_affiliation_string":"+81 22 381 1168","institution_ids":[]},{"raw_affiliation_string":"Miyagi Cancer Center, Department of Surgery,\n47-1 Nodayama, Natori 981-1293, Japan +81 22 384 3151","institution_ids":["https://openalex.org/I4210107389"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masayuki Satoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107389","display_name":"Miyagi Prefectural Hospital Organization","ror":"https://ror.org/01qt7mp11","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210107389"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Satoh","raw_affiliation_strings":["Miyagi Cancer Center, Department of Surgery,\r47-1 Nodayama, Natori 981-1293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miyagi Cancer Center, Department of Surgery,\r47-1 Nodayama, Natori 981-1293, Japan","institution_ids":["https://openalex.org/I4210107389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104534615","display_name":"Makoto Kinouchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107389","display_name":"Miyagi Prefectural Hospital Organization","ror":"https://ror.org/01qt7mp11","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210107389"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Kinouchi","raw_affiliation_strings":["Miyagi Cancer Center, Department of Surgery,\r47-1 Nodayama, Natori 981-1293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miyagi Cancer Center, Department of Surgery,\r47-1 Nodayama, Natori 981-1293, Japan","institution_ids":["https://openalex.org/I4210107389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109095497","display_name":"Kuniharu Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107389","display_name":"Miyagi Prefectural Hospital Organization","ror":"https://ror.org/01qt7mp11","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210107389"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kuniharu Yamamoto","raw_affiliation_strings":["Miyagi Cancer Center, Department of Surgery,\r47-1 Nodayama, Natori 981-1293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miyagi Cancer Center, Department of Surgery,\r47-1 Nodayama, Natori 981-1293, Japan","institution_ids":["https://openalex.org/I4210107389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044920749","display_name":"Yasuhiro Hasegawa","orcid":"https://orcid.org/0000-0002-8714-5485","observed_orcids":["https://orcid.org/0000-0002-8714-5485","https://orcid.org/0000-0002-9766-8503"]},"institutions":[{"id":"https://openalex.org/I4210107389","display_name":"Miyagi Prefectural Hospital Organization","ror":"https://ror.org/01qt7mp11","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210107389"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Hasegawa","raw_affiliation_strings":["Miyagi Cancer Center, Department of Surgery,\r47-1 Nodayama, Natori 981-1293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miyagi Cancer Center, Department of Surgery,\r47-1 Nodayama, Natori 981-1293, Japan","institution_ids":["https://openalex.org/I4210107389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077319617","display_name":"Alex A. Philchenkov","orcid":"https://orcid.org/0000-0001-5315-4490","observed_orcids":["https://orcid.org/0000-0001-5315-4490"]},"institutions":[{"id":"https://openalex.org/I4210113428","display_name":"R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology","ror":"https://ror.org/02ff7k505","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210113428"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Alex Philchenkov","raw_affiliation_strings":["R.E. Kavetsky Institute of Experimental Pathology, Oncology & Radiobiology, 45 Vasylkivska Street, Kyiv 03022, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R.E. Kavetsky Institute of Experimental Pathology, Oncology & Radiobiology, 45 Vasylkivska Street, Kyiv 03022, Ukraine","institution_ids":["https://openalex.org/I4210113428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108234649","display_name":"Yoichiro Kakugawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107389","display_name":"Miyagi Prefectural Hospital Organization","ror":"https://ror.org/01qt7mp11","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210107389"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoichiro Kakugawa","raw_affiliation_strings":["Miyagi Cancer Center, Department of Surgery,\r47-1 Nodayama, Natori 981-1293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miyagi Cancer Center, Department of Surgery,\r47-1 Nodayama, Natori 981-1293, Japan","institution_ids":["https://openalex.org/I4210107389"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112095405","display_name":"Tsuneaki Fujiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107389","display_name":"Miyagi Prefectural Hospital Organization","ror":"https://ror.org/01qt7mp11","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210107389"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuneaki Fujiya","raw_affiliation_strings":["Miyagi Cancer Center, Department of Surgery,\r47-1 Nodayama, Natori 981-1293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miyagi Cancer Center, Department of Surgery,\r47-1 Nodayama, Natori 981-1293, Japan","institution_ids":["https://openalex.org/I4210107389"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2943,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.26170799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"9","first_page":"1087","last_page":"1101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regorafenib","display_name":"regorafenib","score":1.0},{"id":"https://openalex.org/keywords/sorafenib","display_name":"sorafenib","score":0.9409999847412109},{"id":"https://openalex.org/keywords/multikinase-inhibitor","display_name":"multikinase inhibitor","score":0.9139999747276306},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9100000262260437},{"id":"https://openalex.org/keywords/ras-mapk-pathway","display_name":"RAS/MAPK pathway","score":0.9900000095367432},{"id":"https://openalex.org/keywords/history-of-drug-discovery","display_name":"history of drug discovery","score":0.6850000023841858},{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.8299999833106995},{"id":"https://openalex.org/keywords/kinase-profiling","display_name":"kinase profiling","score":0.656000018119812},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9359999895095825},{"id":"https://openalex.org/keywords/drug-toxicology","display_name":"drug toxicology","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C2776248978","wikidata":"https://www.wikidata.org/wiki/Q3891664","display_name":"Regorafenib","level":4,"score":0.9801727533340454},{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.7640935182571411},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.654174268245697},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6444023251533508},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5896254181861877},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5088039040565491},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.41051185131073},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3924700915813446},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38030463457107544},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3753466308116913},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2826020419597626},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1782105267047882},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12422797083854675},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077157","descriptor_name":"Sorafenib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1517/17460441.2014.924923","doi":"https://doi.org/10.1517/17460441.2014.924923","is_oa":false,"landing_page_url":"https://doi.org/10.1517/17460441.2014.924923","pdf_url":null,"source":{"id":"https://openalex.org/S142541038","display_name":"Expert Opinion on Drug Discovery","issn_l":"1746-0441","issn":["1746-0441","1746-045X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Discovery","raw_type":"journal-article"},{"id":"pmid:24896071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24896071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on drug discovery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2487853464","display_name":"Identification of novel therapeutic targets on alternative pre-mRNA splicing in digestive malignancy","funder_award_id":"26461967","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1491779959","https://openalex.org/W1502320764","https://openalex.org/W1504814099","https://openalex.org/W1582646314","https://openalex.org/W1884736998","https://openalex.org/W1927527067","https://openalex.org/W1964935829","https://openalex.org/W1968046158","https://openalex.org/W1968209756","https://openalex.org/W1969825132","https://openalex.org/W1981989535","https://openalex.org/W1990095055","https://openalex.org/W1995416161","https://openalex.org/W1997533142","https://openalex.org/W2002784910","https://openalex.org/W2004295816","https://openalex.org/W2012708129","https://openalex.org/W2019687915","https://openalex.org/W2027362487","https://openalex.org/W2033987292","https://openalex.org/W2043489227","https://openalex.org/W2047113040","https://openalex.org/W2061345986","https://openalex.org/W2065455574","https://openalex.org/W2070396671","https://openalex.org/W2077804275","https://openalex.org/W2079398727","https://openalex.org/W2094159326","https://openalex.org/W2095162893","https://openalex.org/W2095692554","https://openalex.org/W2097409998","https://openalex.org/W2102646127","https://openalex.org/W2111358509","https://openalex.org/W2115363065","https://openalex.org/W2121368761","https://openalex.org/W2124662474","https://openalex.org/W2125763124","https://openalex.org/W2133190197","https://openalex.org/W2133627716","https://openalex.org/W2139241036","https://openalex.org/W2140765540","https://openalex.org/W2146949992","https://openalex.org/W2147834058","https://openalex.org/W2149026055","https://openalex.org/W2149662085","https://openalex.org/W2150577094","https://openalex.org/W2150813121","https://openalex.org/W2157416388","https://openalex.org/W2157769714","https://openalex.org/W2163188200","https://openalex.org/W2164865375","https://openalex.org/W2169961966","https://openalex.org/W2314927739"],"related_works":["https://openalex.org/W2332019204","https://openalex.org/W2368349579","https://openalex.org/W2097409998","https://openalex.org/W2790124402","https://openalex.org/W4238246462","https://openalex.org/W1994936777","https://openalex.org/W2060625959","https://openalex.org/W1983873711","https://openalex.org/W1968209756","https://openalex.org/W4231066336"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1],"RAS-RAF-MEK-ERK":[2],"pathway":[3],"is":[4,98,110],"one":[5],"of":[6,15,143,185,196,224,244,252],"the":[7,13,45,51,79,82,91,95,107,135,138,151,154,157,183,199,213,217,222,241,245,253],"best":[8],"characterized":[9],"kinase":[10,118,186,202],"cascades.":[11],"During":[12],"exploration":[14],"small":[16],"molecules":[17],"that":[18,216,227],"inhibit":[19],"RAF1":[20],"kinase,":[21],"regorafenib":[22,55,145],"(BAY":[23,71],"73-4506)":[24],"was":[25,43,56],"discovered":[26,49],"as":[27,60,84,116,120,122,163,165,249],"a":[28,61,85,111,117,250],"multikinase":[29,47,62,86],"inhibitor":[30,48,63,87,119],"which":[31],"demonstrated":[32],"anti-cancer,":[33],"anti-angiogenic,":[34],"and":[35,141,146,160,170,188,204],"apoptotic":[36],"activities":[37],"in":[38,68,81,123,150],"metastatic":[39,65],"colorectal":[40,66],"cancer.":[41],"This":[42],"not":[44],"first":[46,80],"for":[50,64,88,201,207],"disease;":[52],"indeed,":[53],"before":[54],"approved":[57],"by":[58],"FDA":[59,174],"cancer":[67],"2012,":[69],"sorafenib":[70,147],"43-9006)":[72],"had":[73],"already":[74],"been":[75],"developed":[76,248,255],"to":[77,101,180,189,231],"be":[78,229],"world":[83],"malignancy.":[89],"Indeed,":[90,212],"only":[92],"difference":[93],"between":[94],"two":[96],"compounds":[97],"fluorine":[99],"bound":[100],"its":[102,124,166],"proximal":[103],"phenyl":[104],"ring":[105],"although":[106],"end":[108],"result":[109],"considerably":[112],"different":[113],"profile,":[114],"both":[115,144],"well":[121,164],"clinical":[125],"application.":[126],"AREAS":[127],"COVERED:":[128],"In":[129,178],"this":[130],"drug":[131,197],"discovery":[132],"case":[133],"history,":[134],"authors":[136,155,214],"review":[137],"design,":[139],"discovery,":[140,198],"development":[142,209],"from":[148],"back":[149],"1990s.":[152],"Furthermore,":[153],"highlight":[156],"drug's":[158],"anti-cancer":[159],"anti-angiogenic":[161],"properties":[162],"efficacy,":[167],"safety":[168],"pharmacology":[169],"toxicology":[171],"based":[172],"on":[173],"documents.":[175],"EXPERT":[176],"OPINION:":[177],"order":[179],"better":[181,220,232],"predict":[182],"efficacy":[184],"inhibitors":[187],"utilize":[190],"them":[191],"more":[192],"efficiently,":[193],"our":[194],"understanding":[195],"approaches":[200],"profiling,":[203],"technologies":[205],"needed":[206],"their":[208],"are":[210,256],"paramount.":[211],"believe":[215],"field":[218],"should":[219],"explore":[221],"use":[223],"predictive":[225],"biomarkers":[226],"might":[228],"able":[230],"assess":[233],"these":[234],"therapeutics.":[235],"Pharmaceutical":[236],"scientists":[237],"must":[238],"also":[239],"consider":[240],"cost":[242],"effectiveness":[243],"targeted":[246],"agents":[247],"number":[251],"drugs":[254],"very":[257],"expensive.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}