{"id":"https://openalex.org/W2045952978","doi":"https://doi.org/10.3892/ijo.14.2.281","title":"Clinicopathologic significance of protein induced vitamin K absence or antagonist II and alpha-fetoprotein in hepatocellular carcinoma.","display_name":"Clinicopathologic significance of protein induced vitamin K absence or antagonist II and alpha-fetoprotein in hepatocellular carcinoma.","publication_year":1999,"publication_date":"1999-02-01","ids":{"openalex":"https://openalex.org/W2045952978","doi":"https://doi.org/10.3892/ijo.14.2.281","mag":"2045952978","pmid":"https://pubmed.ncbi.nlm.nih.gov/9917503"},"language":"en","primary_location":{"id":"doi:10.3892/ijo.14.2.281","doi":"https://doi.org/10.3892/ijo.14.2.281","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijo.14.2.281","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109547735","display_name":"Taichi Nakagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Nakagawa","raw_affiliation_strings":["The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041576626","display_name":"Toshihito Seki","orcid":"https://orcid.org/0009-0003-6529-9998","observed_orcids":["https://orcid.org/0009-0003-6529-9998"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Seki","raw_affiliation_strings":["The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113538710","display_name":"T Shiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Shiro","raw_affiliation_strings":["The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002963782","display_name":"Masayuki Wakabayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Wakabayashi","raw_affiliation_strings":["The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034892457","display_name":"Masahiro Imamura","orcid":"https://orcid.org/0000-0002-5287-2770","observed_orcids":["https://orcid.org/0000-0002-5287-2770"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Imamura","raw_affiliation_strings":["The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T Itoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Itoh","raw_affiliation_strings":["The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016507040","display_name":"Toru Tamai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Tamai","raw_affiliation_strings":["The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103221579","display_name":"Akira Nishimura","orcid":"https://orcid.org/0000-0001-6085-6829","observed_orcids":["https://orcid.org/0000-0001-6085-6829"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A Nishimura","raw_affiliation_strings":["The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063407748","display_name":"Noriyo Yamashiki","orcid":"https://orcid.org/0000-0002-9274-0000","observed_orcids":["https://orcid.org/0000-0002-9274-0000"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Yamashiki","raw_affiliation_strings":["The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026534988","display_name":"Kazutaka Matsuzaki","orcid":"https://orcid.org/0000-0003-2337-2686","observed_orcids":["https://orcid.org/0000-0003-2337-2686"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Matsuzaki","raw_affiliation_strings":["The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021393907","display_name":"Noriko Sakaida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N Sakaida","raw_affiliation_strings":["The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109983952","display_name":"Kyoichi Inoue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Inoue","raw_affiliation_strings":["The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114115997","display_name":"\u00c1 Okamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"A Okamura","raw_affiliation_strings":["The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126884977"],"apc_list":null,"apc_paid":null,"fwci":1.2996,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.80011285,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"14","issue":"2","first_page":"281","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9300000071525574},{"id":"https://openalex.org/keywords/des-gamma-carboxy-prothrombin","display_name":"PIVKA-II","score":0.9010000228881836},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.824999988079071},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.8069999814033508},{"id":"https://openalex.org/keywords/histologic-grade","display_name":"histologic grade","score":0.7170000076293945},{"id":"https://openalex.org/keywords/satellite-nodules","display_name":"satellite nodules","score":0.9869999885559082},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/japanese-patients","display_name":"Japanese patients","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C2779314089","wikidata":"https://www.wikidata.org/wiki/Q18026830","display_name":"HCCS","level":3,"score":0.8866247534751892},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8303042054176331},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7559829950332642},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.5409646034240723},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5232906937599182},{"id":"https://openalex.org/C2779742787","wikidata":"https://www.wikidata.org/wiki/Q18026064","display_name":"Glypican 3","level":3,"score":0.5153595805168152},{"id":"https://openalex.org/C2780624289","wikidata":"https://www.wikidata.org/wiki/Q306076","display_name":"Alpha-fetoprotein","level":3,"score":0.463279664516449},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45868635177612305},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.44296640157699585},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44085195660591125},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.42043203115463257},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.35506463050842285},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30560100078582764}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011516","descriptor_name":"Prothrombin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3892/ijo.14.2.281","doi":"https://doi.org/10.3892/ijo.14.2.281","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijo.14.2.281","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},{"id":"pmid:9917503","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9917503","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oncology","raw_type":"Journal Article"},{"id":"mag:2259282310","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/500000196752","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2047027255","https://openalex.org/W2401761015","https://openalex.org/W3030449887","https://openalex.org/W3032288157","https://openalex.org/W3161034212","https://openalex.org/W2023920064","https://openalex.org/W2896860980","https://openalex.org/W4415412111","https://openalex.org/W2890926168","https://openalex.org/W7216938481"],"abstract_inverted_index":{"Protein":[0],"induced":[1],"vitamin":[2],"K":[3],"absence":[4],"or":[5],"antagonist":[6],"II":[7],"(PIVKA-II)":[8],"and":[9,43,56,73,76,86,90,100,122,127,173,186,224],"alpha-fetoprotein":[10],"(AFP)":[11],"have":[12],"been":[13],"considered":[14],"useful":[15],"serum":[16,41,54,71,104,140,191,216],"markers":[17,33],"of":[18,30,80,107,118,163,171,198,213,221],"hepatocellular":[19],"carcinoma":[20],"(HCC).":[21],"In":[22],"this":[23],"study,":[24],"we":[25],"examined":[26,67],"the":[27,68,153,159,219,225,233],"clinicopathologic":[28],"significance":[29],"these":[31],"tumour":[32,77,92],"in":[34,131,215],"patients":[35,50,108,119,133],"with":[36,51,109,120,134,218,232],"HCCs":[37,112,125,166,176],"by":[38,61,146,152,207],"measuring":[39],"their":[40],"levels":[42,58,75,106,142,162],"performing":[44],"immunohistochemistry.":[45],"We":[46,66],"studied":[47],"349":[48],"Japanese":[49],"HCCs.":[52],"Their":[53],"PIVKA-II":[55,72,99,105,160,192,214],"AFP":[57,74,101,141],"were":[59,113,129,143,167,181,184],"determined":[60],"enzyme":[62],"immunoassay":[63],"before":[64],"treatment.":[65],"correlations":[69],"between":[70],"size,":[78],"presence":[79,212,220],"satellite":[81,137,222],"nodules,":[82],"histologic":[83,226],"HCC":[84,132,179,199,227],"grade,":[85,228],"concomitant":[87,147,208],"liver":[88,148,209],"diseases":[89],"subjected":[91],"tissues":[93],"to":[94,97],"immunohistochemical":[95,234],"staining":[96,157],"detect":[98],"expression.":[102],"The":[103,139,190,211],"poorly":[110,164],"differentiated":[111,124,165,175],"significantly":[114,145],"higher":[115,130,168],"than":[116,135,169,200],"those":[117,170],"well":[121,172],"moderately":[123,174],"(p<0.05)":[126],"they":[128],"without":[136],"nodules.":[138],"influenced":[144,206],"diseases,":[149],"but":[150],"not":[151,205],"other":[154],"factors.":[155],"Immunohistochemical":[156],"revealed":[158],"expression":[161],"(p<0.05).":[177],"Some":[178],"cells":[180],"PIVKA-II-positive,":[182],"others":[183],"AFP-positive,":[185],"some":[187],"expressed":[188],"both.":[189],"concentration":[193],"was":[194,204],"a":[195,229],"better":[196],"indicator":[197],"AFP,":[201],"as":[202],"it":[203],"diseases.":[210],"correlated":[217],"nodules":[223],"result":[230],"concordant":[231],"findings.":[235]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}