{"id":"https://openalex.org/W2045948069","doi":"https://doi.org/10.1159/000092765","title":"Adventitial Neuronal Somata","display_name":"Adventitial Neuronal Somata","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2045948069","doi":"https://doi.org/10.1159/000092765","mag":"2045948069","pmid":"https://pubmed.ncbi.nlm.nih.gov/16636576"},"language":"en","primary_location":{"id":"doi:10.1159/000092765","doi":"https://doi.org/10.1159/000092765","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000092765","pdf_url":null,"source":{"id":"https://openalex.org/S150425866","display_name":"Journal of Vascular Research","issn_l":"1018-1172","issn":["1018-1172","1423-0135"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Vascular Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033759162","display_name":"Chandra Somasundaram","orcid":"https://orcid.org/0000-0001-5669-8469","observed_orcids":["https://orcid.org/0000-0001-5669-8469"]},"institutions":[{"id":"https://openalex.org/I123127086","display_name":"North Carolina Central University","ror":"https://ror.org/051r3tx83","country_code":"US","type":"education","lineage":["https://openalex.org/I123127086"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandra Somasundaram","raw_affiliation_strings":["Cardiovascular Disease Research Program, Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA. csomasundaram@nccu.edu","Cardiovascular Disease Research Program, Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, N.C., and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Research Program, Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA. csomasundaram@nccu.edu","institution_ids":["https://openalex.org/I123127086"]},{"raw_affiliation_string":"Cardiovascular Disease Research Program, Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, N.C., and","institution_ids":["https://openalex.org/I123127086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034603627","display_name":"Debra I. Diz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debra I. Diz","raw_affiliation_strings":["Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, N.C., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, N.C., USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Timothy Coleman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123127086","display_name":"North Carolina Central University","ror":"https://ror.org/051r3tx83","country_code":"US","type":"education","lineage":["https://openalex.org/I123127086"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Coleman","raw_affiliation_strings":["Cardiovascular Disease Research Program, Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, N.C., and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Research Program, Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, N.C., and","institution_ids":["https://openalex.org/I123127086"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112091674","display_name":"Richard D. Bukoski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123127086","display_name":"North Carolina Central University","ror":"https://ror.org/051r3tx83","country_code":"US","type":"education","lineage":["https://openalex.org/I123127086"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D. Bukoski","raw_affiliation_strings":["Cardiovascular Disease Research Program, Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, N.C., and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Research Program, Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, N.C., and","institution_ids":["https://openalex.org/I123127086"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1266,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.43755801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"43","issue":"3","first_page":"278","last_page":"288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.04349999874830246,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.03790000081062317,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcitonin-gene-related-peptide","display_name":"calcitonin gene-related peptide","score":0.8759999871253967},{"id":"https://openalex.org/keywords/beta-cgrp","display_name":"beta-CGRP","score":0.8069999814033508},{"id":"https://openalex.org/keywords/mesenteric-arteries","display_name":"mesenteric arteries","score":0.875},{"id":"https://openalex.org/keywords/sensory-nerves","display_name":"sensory nerves","score":0.5289999842643738},{"id":"https://openalex.org/keywords/neuronal-somata","display_name":"neuronal somata","score":0.4230000078678131},{"id":"https://openalex.org/keywords/collagenase-digestion","display_name":"collagenase digestion","score":0.5820000171661377},{"id":"https://openalex.org/keywords/neuronal-cell-adhesion-molecule","display_name":"neuronal cell adhesion molecule","score":0.7129999995231628},{"id":"https://openalex.org/keywords/small-arteries","display_name":"small arteries","score":0.3070000112056732},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4332504868507385},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3696483373641968},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.34791046380996704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3379804491996765},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27695077657699585}],"mesh":[{"descriptor_ui":"D000098902","descriptor_name":"CD163 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003239","descriptor_name":"Connective Tissue Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008638","descriptor_name":"Mesenteric Arteries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015214","descriptor_name":"Antigens, Differentiation, Myelomonocytic","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015740","descriptor_name":"Calcitonin Gene-Related Peptide","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015740","descriptor_name":"Calcitonin Gene-Related Peptide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019006","descriptor_name":"Neural Cell Adhesion Molecules","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000092765","doi":"https://doi.org/10.1159/000092765","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000092765","pdf_url":null,"source":{"id":"https://openalex.org/S150425866","display_name":"Journal of Vascular Research","issn_l":"1018-1172","issn":["1018-1172","1423-0135"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Vascular Research","raw_type":"journal-article"},{"id":"pmid:16636576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16636576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of vascular research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3457932693","display_name":"Mechanisms Linking Ca2+ Homeostasis & Vascular Tone","funder_award_id":"R01HL064761","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G534303546","display_name":null,"funder_award_id":"HL64761","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1511198581","https://openalex.org/W1549505695","https://openalex.org/W1552730840","https://openalex.org/W1893676782","https://openalex.org/W1960225347","https://openalex.org/W1978082894","https://openalex.org/W1984941270","https://openalex.org/W1999281703","https://openalex.org/W2012629338","https://openalex.org/W2022400183","https://openalex.org/W2029627774","https://openalex.org/W2039728399","https://openalex.org/W2050781058","https://openalex.org/W2051221829","https://openalex.org/W2064438027","https://openalex.org/W2076859714","https://openalex.org/W2076982071","https://openalex.org/W2077062443","https://openalex.org/W2079277054","https://openalex.org/W2086727023","https://openalex.org/W2094907236","https://openalex.org/W2107247243","https://openalex.org/W2139878437","https://openalex.org/W2146989155","https://openalex.org/W2160584330","https://openalex.org/W2184481089","https://openalex.org/W2410711964"],"related_works":["https://openalex.org/W2076461774","https://openalex.org/W7098032052","https://openalex.org/W2021244751","https://openalex.org/W2030059572","https://openalex.org/W3174105591","https://openalex.org/W2394305909","https://openalex.org/W2067333902","https://openalex.org/W2017310749","https://openalex.org/W3119253378","https://openalex.org/W4389608568"],"abstract_inverted_index":{"Confocal":[0],"analysis":[1,106],"of":[2,78,84,92,107,138,146,187,192,199,236,243],"the":[3,26,54,65,79,93,100,108,114,125,136,151,230],"whole-mount":[4],"rat":[5,55],"mesenteric":[6,66,251],"branch":[7],"arteries":[8],"(MBA)":[9],"revealed":[10],"nucleated":[11],"structures":[12],"with":[13,42,113,158,173,223],"axonal":[14],"processes":[15],"which":[16,96],"immunostained":[17,205],"for":[18,207,229],"calcitonin":[19],"gene-related":[20],"peptide":[21],"(CGRP).":[22],"Immunocytochemistry":[23],"ruled":[24],"out":[25],"possibility":[27],"that":[28,49,118,201,233],"these":[29,224],"were":[30],"immune":[31],"elements":[32],"(macrophages":[33],"and":[34,69,81,149,196,204,212,216],"mast":[35],"or":[36],"dendritic":[37],"cells)":[38],"in":[39,53,124,135,154,183,249],"close":[40],"proximity":[41],"nerve":[43,245],"fibers.":[44],"To":[45,127],"test":[46],"our":[47],"hypothesis":[48],"beta-CGRP":[50,80,115,121],"is":[51,122,247],"expressed":[52,123],"MBA,":[56,139],"we":[57,140],"performed":[58,141],"RT-PCR":[59],"using":[60],"total":[61],"RNA":[62],"isolated":[63,147],"from":[64],"artery":[67],"arcade":[68],"intron":[70],"spanning":[71],"primers":[72],"designed":[73],"to":[74],"amplify":[75],"188":[76],"bp":[77,83],"333":[82],"alpha-CGRP":[85],"cDNA.":[86],"The":[87,166],"PCR":[88],"yielded":[89],"an":[90],"amplicon":[91],"predicted":[94],"size":[95],"was":[97,168],"cloned":[98],"into":[99],"pCR":[101],"3.1":[102],"vector.":[103],"DNA":[104],"sequence":[105],"insert":[109],"showed":[110],"100%":[111],"homology":[112],"cDNA,":[116],"indicating":[117],"mRNA":[119],"encoding":[120],"vessel.":[126],"learn":[128],"whether":[129],"neuronal":[130,208,238],"cell":[131,209],"bodies":[132],"are":[133],"located":[134,248],"adventitia":[137],"a":[142,184,189,197,234],"limited":[143],"collagenase":[144],"digestion":[145],"segments":[148],"plated":[150],"resulting":[152],"cells":[153,195,200,219],"Ham's":[155,174],"F12":[156,175],"medium":[157,167],"10%":[159],"horse":[160],"serum":[161],"on":[162],"polyornithine-coated":[163],"cover":[164],"glasses.":[165],"replaced":[169],"after":[170],"48":[171],"h":[172],"nutrient":[176],"mixture":[177],"containing":[178],"N2":[179],"supplement.":[180],"This":[181],"resulted":[182],"mixed":[185],"population":[186,235],"fibroblasts,":[188],"small":[190,250],"number":[191],"smooth":[193,217],"muscle":[194,218],"subset":[198],"sprouted":[202],"axons":[203],"positively":[206],"adhesion":[210],"molecule":[211],"CGRP":[213],"antigens.":[214],"Fibroblasts":[215],"did":[220],"not":[221],"label":[222],"antibodies.":[225],"These":[226],"data":[227],"demonstrate,":[228],"first":[231],"time,":[232],"adventitial":[237],"somata":[239],"(termed":[240],"ANNIES),":[241],"possibly":[242],"sensory":[244],"origin,":[246],"arteries.":[252]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}