{"id":"https://openalex.org/W2045936690","doi":"https://doi.org/10.1016/s0968-0896(02)00238-9","title":"Non-classical antifolates, 5-(N-phenylpyrrolidin-3-yl)-2,4,6-triaminopyrimidines and 2,4-Diamino-6(5H)-oxopyrimidines, synthesis and antitumor studies","display_name":"Non-classical antifolates, 5-(N-phenylpyrrolidin-3-yl)-2,4,6-triaminopyrimidines and 2,4-Diamino-6(5H)-oxopyrimidines, synthesis and antitumor studies","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2045936690","doi":"https://doi.org/10.1016/s0968-0896(02)00238-9","mag":"2045936690","pmid":"https://pubmed.ncbi.nlm.nih.gov/12467717"},"language":"en","primary_location":{"id":"doi:10.1016/s0968-0896(02)00238-9","doi":"https://doi.org/10.1016/s0968-0896(02)00238-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0968-0896(02)00238-9","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103476640","display_name":"Yen-Lin Huang","orcid":"https://orcid.org/0000-0003-1444-780X","observed_orcids":["https://orcid.org/0000-0003-1444-780X"]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yen-Lin Huang","raw_affiliation_strings":["Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, 115, Taipei, Taiwan","Department of Medicinal Chemistry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan","Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, 115, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"raw_affiliation_string":"Department of Medicinal Chemistry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078501585","display_name":"Chyun\u2010Feng Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chyun-Feng Lin","raw_affiliation_strings":["Department of Medicinal Chemistry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan","Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040461202","display_name":"Yi\u2010Jen Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Jen Lee","raw_affiliation_strings":["Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei-Wei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei-Wei Li","raw_affiliation_strings":["Molecular Pharmacology and Therapeutics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pharmacology and Therapeutics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064161599","display_name":"Ting-Chou Chao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ting-Chou Chao","raw_affiliation_strings":["Molecular Pharmacology and Therapeutics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pharmacology and Therapeutics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012458959","display_name":"Valeriy A. Bacherikov","orcid":"https://orcid.org/0000-0001-7399-7102","observed_orcids":["https://orcid.org/0000-0001-7399-7102"]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Valeriy A. Bacherikov","raw_affiliation_strings":["Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045558312","display_name":"Kuo\u2010Tung Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuo-Tung Chen","raw_affiliation_strings":["Department of Medicinal Chemistry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chin-Ming Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chin-Ming Chen","raw_affiliation_strings":["Department of Medicinal Chemistry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102249675","display_name":"Tsann\u2010Long Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Tsann-Long Su","raw_affiliation_strings":["Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5102249675"],"corresponding_institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"],"apc_list":{"value":3960,"currency":"USD","value_usd":3960},"apc_paid":null,"fwci":0.671,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.60722828,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"11","issue":"1","first_page":"145","last_page":"157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.7167999744415283,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.7167999744415283,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.26249998807907104,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/2-4-6-triaminopyrimidine","display_name":"2,4,6-triaminopyrimidine","score":0.9419999718666077},{"id":"https://openalex.org/keywords/pyrrolidone-derivatives","display_name":"pyrrolidinone derivatives","score":0.6779999732971191},{"id":"https://openalex.org/keywords/knoevenagel-condensation","display_name":"Knoevenagel condensation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/guanidine-condensation","display_name":"guanidine condensation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9599999785423279},{"id":"https://openalex.org/keywords/doxorubicin-resistance","display_name":"doxorubicin resistance","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9102344512939453},{"id":"https://openalex.org/C2780513484","wikidata":"https://www.wikidata.org/wiki/Q419572","display_name":"Malononitrile","level":3,"score":0.728739857673645},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6537855863571167},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6237450838088989},{"id":"https://openalex.org/C168395250","wikidata":"https://www.wikidata.org/wiki/Q898972","display_name":"Knoevenagel condensation","level":3,"score":0.533652126789093},{"id":"https://openalex.org/C2779244968","wikidata":"https://www.wikidata.org/wiki/Q186414","display_name":"Aniline","level":2,"score":0.504531741142273},{"id":"https://openalex.org/C2778689049","wikidata":"https://www.wikidata.org/wiki/Q898422","display_name":"Substituent","level":2,"score":0.46953925490379333},{"id":"https://openalex.org/C2779463914","wikidata":"https://www.wikidata.org/wiki/Q183309","display_name":"Guanidine","level":2,"score":0.4390127658843994},{"id":"https://openalex.org/C2777256644","wikidata":"https://www.wikidata.org/wiki/Q421348","display_name":"Isatin","level":2,"score":0.4309764802455902},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.29065948724746704},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.14535307884216309},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10651126503944397},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003857","descriptor_name":"Deoxyuridine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005493","descriptor_name":"Folic Acid Antagonists","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D005493","descriptor_name":"Folic Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013762","descriptor_name":"Tetrahydrofolate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/s0968-0896(02)00238-9","doi":"https://doi.org/10.1016/s0968-0896(02)00238-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0968-0896(02)00238-9","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:12467717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12467717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:libir.tmu.edu.tw:123456789/23210","doi":null,"is_oa":false,"landing_page_url":"https://libir.tmu.edu.tw/handle/123456789/23210","pdf_url":null,"source":{"id":"https://openalex.org/S4406923063","display_name":"Taipei Medical University Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:localhost:987654321/9415","doi":null,"is_oa":false,"landing_page_url":"http://libir.tmu.edu.tw/handle/987654321/9415","pdf_url":null,"source":{"id":"https://openalex.org/S4406923063","display_name":"Taipei Medical University Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W279678372","https://openalex.org/W565417519","https://openalex.org/W1482953594","https://openalex.org/W1524554356","https://openalex.org/W1530463449","https://openalex.org/W1532990229","https://openalex.org/W1649636917","https://openalex.org/W1880119188","https://openalex.org/W1971035689","https://openalex.org/W1973930215","https://openalex.org/W1978777640","https://openalex.org/W1982766841","https://openalex.org/W1988516441","https://openalex.org/W1995635516","https://openalex.org/W2004398073","https://openalex.org/W2005725046","https://openalex.org/W2007726988","https://openalex.org/W2011593151","https://openalex.org/W2011809539","https://openalex.org/W2016544327","https://openalex.org/W2018525495","https://openalex.org/W2025597999","https://openalex.org/W2028017747","https://openalex.org/W2033798598","https://openalex.org/W2040138819","https://openalex.org/W2042378550","https://openalex.org/W2060018176","https://openalex.org/W2065756476","https://openalex.org/W2067887295","https://openalex.org/W2073651191","https://openalex.org/W2077945404","https://openalex.org/W2079752673","https://openalex.org/W2080549249","https://openalex.org/W2093481319","https://openalex.org/W2094429937","https://openalex.org/W2109550151","https://openalex.org/W2143811153","https://openalex.org/W2149757864","https://openalex.org/W2169602887","https://openalex.org/W2271920406","https://openalex.org/W2316822650","https://openalex.org/W2320114424","https://openalex.org/W2340948639","https://openalex.org/W2400221128","https://openalex.org/W2409397985","https://openalex.org/W2949895788","https://openalex.org/W2950027239","https://openalex.org/W2950749613","https://openalex.org/W4230580706","https://openalex.org/W4242564283"],"related_works":["https://openalex.org/W7113256139","https://openalex.org/W2951200084","https://openalex.org/W2320243697","https://openalex.org/W2951441850","https://openalex.org/W2037013726","https://openalex.org/W2383795910","https://openalex.org/W1970637583","https://openalex.org/W1982669395","https://openalex.org/W2077945506","https://openalex.org/W2949244765"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
