{"id":"https://openalex.org/W2045929686","doi":"https://doi.org/10.1111/j.1476-5381.1980.tb07030.x","title":"HYDRALAZINE: EFFECT ON THE OUTFLOW OF NORADRENALINE AND MECHANICAL RESPONSES EVOKED BY SYMPATHETIC NERVE STIMULATION OF THE RAT TAIL ARTERY","display_name":"HYDRALAZINE: EFFECT ON THE OUTFLOW OF NORADRENALINE AND MECHANICAL RESPONSES EVOKED BY SYMPATHETIC NERVE STIMULATION OF THE RAT TAIL ARTERY","publication_year":1980,"publication_date":"1980-07-01","ids":{"openalex":"https://openalex.org/W2045929686","doi":"https://doi.org/10.1111/j.1476-5381.1980.tb07030.x","mag":"2045929686","pmid":"https://pubmed.ncbi.nlm.nih.gov/7397451","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2044289"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.1980.tb07030.x","doi":"https://doi.org/10.1111/j.1476-5381.1980.tb07030.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1980.tb07030.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1980.tb07030.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1980.tb07030.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108199876","display_name":"Claude Chevillard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210152567","display_name":"H\u00f4pital Saint Charles","ror":"https://ror.org/01e4pq116","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210152567"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. CHEVILLARD","raw_affiliation_strings":["INSERM FRA. 37 (Med. D), Ho\u030cpital St Charles, 34059 Montpellier, and INSERM U.7","INSERM FRA. 37 (Med. D), H\u01d2pital St Charles, 34059 Montpellier, and INSERM U.7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM FRA. 37 (Med. D), Ho\u030cpital St Charles, 34059 Montpellier, and INSERM U.7","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210152567"]},{"raw_affiliation_string":"INSERM FRA. 37 (Med. D), H\u01d2pital St Charles, 34059 Montpellier, and INSERM U.7","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210152567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109984143","display_name":"Maura Mathieu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210152567","display_name":"H\u00f4pital Saint Charles","ror":"https://ror.org/01e4pq116","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210152567"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M.N. MATHIEU","raw_affiliation_strings":["INSERM FRA. 37 (Med. D), Ho\u030cpital St Charles, 34059 Montpellier, and INSERM U.7","INSERM FRA. 37 (Med. D), H\u01d2pital St Charles, 34059 Montpellier, and INSERM U.7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM FRA. 37 (Med. D), Ho\u030cpital St Charles, 34059 Montpellier, and INSERM U.7","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210152567"]},{"raw_affiliation_string":"INSERM FRA. 37 (Med. D), H\u01d2pital St Charles, 34059 Montpellier, and INSERM U.7","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210152567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086686011","display_name":"Bernard Sa\u00efag","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210152567","display_name":"H\u00f4pital Saint Charles","ror":"https://ror.org/01e4pq116","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210152567"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"B. SAIAG","raw_affiliation_strings":["Ho\u030cpital Necker 75015, Paris, France","INSERM FRA. 37 (Med. D), H\u01d2pital St Charles, 34059 Montpellier, and INSERM U.7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ho\u030cpital Necker 75015, Paris, France","institution_ids":["https://openalex.org/I1288880153"]},{"raw_affiliation_string":"INSERM FRA. 37 (Med. D), H\u01d2pital St Charles, 34059 Montpellier, and INSERM U.7","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210152567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087503512","display_name":"Manuel Worcel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210152567","display_name":"H\u00f4pital Saint Charles","ror":"https://ror.org/01e4pq116","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210152567"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"M. WORCEL","raw_affiliation_strings":["Centre de Recherches ROUSSEL-UCLAF, 111, Route de Noisy, BP 9, 93230 Romainville, France","INSERM FRA. 37 (Med. D), H\u01d2pital St Charles, 34059 Montpellier, and INSERM U.7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherches ROUSSEL-UCLAF, 111, Route de Noisy, BP 9, 93230 Romainville, France","institution_ids":[]},{"raw_affiliation_string":"INSERM FRA. 37 (Med. D), H\u01d2pital St Charles, 34059 Montpellier, and INSERM U.7","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210152567"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5086686011","https://openalex.org/A5087503512"],"corresponding_institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488","https://openalex.org/I4210152567"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":10.6485,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.98293616,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"69","issue":"3","first_page":"415","last_page":"420"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.3296000063419342,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.3296000063419342,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.301800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.16820000112056732,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydralazine","display_name":"hydralazine","score":1.0},{"id":"https://openalex.org/keywords/noradrenaline-release","display_name":"noradrenaline release","score":0.8460000157356262},{"id":"https://openalex.org/keywords/sympathetic-activation","display_name":"sympathetic activation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/presynaptic-inhibition","display_name":"presynaptic inhibition","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tail-artery","display_name":"tail artery","score":0.6809999942779541},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.8970000147819519},{"id":"https://openalex.org/keywords/noradrenaline-efflux","display_name":"noradrenaline efflux","score":0.7160000205039978},{"id":"https://openalex.org/keywords/theophylline","display_name":"theophylline","score":0.871999979019165},{"id":"https://openalex.org/keywords/vascular-smooth-muscle","display_name":"vascular smooth muscle","score":0.7070000171661377},{"id":"https://openalex.org/keywords/sympathetic-nerve-terminals","display_name":"sympathetic nerve terminals","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2780521442","wikidata":"https://www.wikidata.org/wiki/Q419987","display_name":"Hydralazine","level":3,"score":0.9617376327514648},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.77889084815979},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.613264799118042},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5389716029167175},{"id":"https://openalex.org/C2778095195","wikidata":"https://www.wikidata.org/wiki/Q407308","display_name":"Theophylline","level":2,"score":0.5337575078010559},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5264347791671753},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.47983500361442566},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4551631212234497},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.41817498207092285},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2751989960670471},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.10438257455825806},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08988705277442932}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006830","descriptor_name":"Hydralazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013623","descriptor_name":"Tail","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1476-5381.1980.tb07030.x","doi":"https://doi.org/10.1111/j.1476-5381.1980.tb07030.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1980.tb07030.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1980.tb07030.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:7397451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7397451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2044289","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2044289/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/j.1476-5381.1980.tb07030.x","doi":"https://doi.org/10.1111/j.1476-5381.1980.tb07030.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1980.tb07030.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1980.tb07030.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2045929686.pdf","grobid_xml":"https://content.openalex.org/works/W2045929686.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1509341519","https://openalex.org/W1853177975","https://openalex.org/W1968467182","https://openalex.org/W1984460604","https://openalex.org/W1984774260","https://openalex.org/W1997633278","https://openalex.org/W2035962819","https://openalex.org/W2040123861","https://openalex.org/W2050411423","https://openalex.org/W2052442001","https://openalex.org/W2056983944","https://openalex.org/W2066181062","https://openalex.org/W2070727102","https://openalex.org/W2116431551","https://openalex.org/W2148037483","https://openalex.org/W2300671158","https://openalex.org/W2395034489","https://openalex.org/W2411913325","https://openalex.org/W2414789131","https://openalex.org/W2419592709"],"related_works":["https://openalex.org/W2255540431","https://openalex.org/W8172748","https://openalex.org/W2255566208","https://openalex.org/W2067832727","https://openalex.org/W2083713044","https://openalex.org/W2463968879","https://openalex.org/W3103554316","https://openalex.org/W2053523195","https://openalex.org/W2000257869","https://openalex.org/W1972039095"],"abstract_inverted_index":{"1":[0],"The":[1,47,125,149],"effects":[2],"of":[3,12,22,36,70,77,108,119,151,165,172,179],"hydralazine":[4,109,130],"on":[5,110,137,145],"the":[6,18,23,67,78,105,111,116,120,160,166,170,173,177],"vasoconstrictor":[7],"responses":[8,28],"to":[9,29,134,156],"field":[10],"stimulation":[11,31],"sympathetic":[13,146],"nerves":[14],"were":[15,32],"studied":[16],"in":[17,43,84,132,163],"isolated":[19],"proximal":[20,73],"segments":[21,76],"rat":[24,121],"tail":[25,79,122],"artery.":[26,123],"Vasoconstrictor":[27],"transmural":[30],"depressed":[33],"by":[34,56,96],"superfusion":[35],"hydrazine":[37],"(0.3,":[38],"3":[39,64,98],"and":[40,51,63,74,92,176],"30":[41],"muM)":[42,65],"a":[44,85,141],"concentration-dependent":[45,86],"manner.":[46,87],"inhibition":[48,154],"appeared":[49,90],"slowly":[50],"was":[52,93],"not":[53,103],"easily":[54,94],"reversed":[55,95],"washing.":[57,97],"2":[58],"Hydralazine":[59],"(30":[60],"nM,":[61],"0.3":[62],"reduced":[66],"stimulation-induced":[68,112],"overflow":[69],"tritium":[71,113],"from":[72,115,159],"distal":[75,117],"artery":[80],"labelled":[81],"with":[82,181],"[3H]-noradrenaline":[83],"This":[88],"phenomenon":[89],"rapidly":[91],"Theophylline":[99],"(0.5":[100],"mM)":[101],"did":[102],"affect":[104],"inhibitory":[106],"effect":[107,144],"efflux":[114],"segment":[118],"4":[124],"present":[126],"results":[127],"indicate":[128],"that":[129],"has,":[131],"addition":[133],"its":[135],"action":[136],"vascular":[138],"smooth":[139],"muscle,":[140],"very":[142],"marked":[143],"nerve":[147],"terminals.":[148],"mechanism":[150],"this":[152],"presynaptic":[153],"appears":[155],"be":[157],"different":[158],"postsynaptic":[161],"effect,":[162],"view":[164],"much":[167],"shorter":[168],"delay,":[169],"shape":[171],"dose-effect":[174],"curve,":[175],"lack":[178],"interaction":[180],"theophylline.":[182]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
