{"id":"https://openalex.org/W2045913016","doi":"https://doi.org/10.1021/ja910942v","title":"Design of Single-Stranded Nucleic Acid Binding Peptides Based on Nucleocapsid CCHC-Box Zinc-Binding Domains","display_name":"Design of Single-Stranded Nucleic Acid Binding Peptides Based on Nucleocapsid CCHC-Box Zinc-Binding Domains","publication_year":2010,"publication_date":"2010-06-29","ids":{"openalex":"https://openalex.org/W2045913016","doi":"https://doi.org/10.1021/ja910942v","mag":"2045913016","pmid":"https://pubmed.ncbi.nlm.nih.gov/20586464","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2990226"},"language":"en","primary_location":{"id":"doi:10.1021/ja910942v","doi":"https://doi.org/10.1021/ja910942v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja910942v","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2990226","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083301870","display_name":"Anthony L. Guerrerio","orcid":"https://orcid.org/0000-0003-2458-7160","observed_orcids":["https://orcid.org/0000-0003-2458-7160"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony L. Guerrerio","raw_affiliation_strings":["Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, and National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, and National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210090567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088629060","display_name":"Jeremy M Berg","orcid":"https://orcid.org/0000-0003-3022-0963","observed_orcids":["https://orcid.org/0000-0003-3022-0963"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeremy M. Berg","raw_affiliation_strings":["Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, and National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, and National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088629060"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210090567"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.3905,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.58954386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"132","issue":"28","first_page":"9638","last_page":"9643"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.5536999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.5536999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.13660000264644623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.13439999520778656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleocapsid-protein","display_name":"nucleocapsid protein","score":0.8859999775886536},{"id":"https://openalex.org/keywords/peptide-design","display_name":"peptide design","score":0.8220000267028809},{"id":"https://openalex.org/keywords/linker-length","display_name":"linker length","score":0.6899999976158142},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.6349999904632568},{"id":"https://openalex.org/keywords/zinc-binding-proteins","display_name":"zinc-binding proteins","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8676080703735352},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.7632027864456177},{"id":"https://openalex.org/C2777995097","wikidata":"https://www.wikidata.org/wiki/Q422462","display_name":"Guanosine","level":2,"score":0.7549188733100891},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.5586788058280945},{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.532223105430603},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.5169443488121033},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46163415908813477},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.4102192521095276},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.11647692322731018},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06698313355445862},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.05301591753959656},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019251","descriptor_name":"Nucleocapsid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/ja910942v","doi":"https://doi.org/10.1021/ja910942v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja910942v","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:20586464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20586464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2990226","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2990226","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2990226","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2990226","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Chem Soc","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5895531413","display_name":"Protein structural mediation of molecular recognition processes","funder_award_id":"Z01DK036172","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7746302765","display_name":"Protein structural mediation of molecular recognition processes","funder_award_id":"ZIADK036172","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1554955915","https://openalex.org/W1824346003","https://openalex.org/W1963931542","https://openalex.org/W1965602008","https://openalex.org/W1977744062","https://openalex.org/W1983943439","https://openalex.org/W1986479935","https://openalex.org/W1998007775","https://openalex.org/W1999241312","https://openalex.org/W2000549843","https://openalex.org/W2022704908","https://openalex.org/W2028137906","https://openalex.org/W2030009910","https://openalex.org/W2030333654","https://openalex.org/W2042881412","https://openalex.org/W2043920788","https://openalex.org/W2044741494","https://openalex.org/W2048547641","https://openalex.org/W2057390170","https://openalex.org/W2061731390","https://openalex.org/W2063643370","https://openalex.org/W2070055731","https://openalex.org/W2074275888","https://openalex.org/W2076324807","https://openalex.org/W2078157295","https://openalex.org/W2080030061","https://openalex.org/W2081075139","https://openalex.org/W2084803012","https://openalex.org/W2091475535","https://openalex.org/W2093050056","https://openalex.org/W2095914498","https://openalex.org/W2096985241","https://openalex.org/W2100433487","https://openalex.org/W2103247555","https://openalex.org/W2104422107","https://openalex.org/W2106183011","https://openalex.org/W2119059712","https://openalex.org/W2124100270","https://openalex.org/W2132256310","https://openalex.org/W2132291850","https://openalex.org/W2144177887","https://openalex.org/W2150476056","https://openalex.org/W2150700027","https://openalex.org/W2158977548","https://openalex.org/W2290569355","https://openalex.org/W2399638523","https://openalex.org/W2414196289","https://openalex.org/W2949840759"],"related_works":["https://openalex.org/W2088514958","https://openalex.org/W2944509081","https://openalex.org/W2016207945","https://openalex.org/W2259770428","https://openalex.org/W281715270","https://openalex.org/W2091475535","https://openalex.org/W2087876626","https://openalex.org/W2030333654","https://openalex.org/W7217966290","https://openalex.org/W1991522409"],"abstract_inverted_index":{"The":[0,50,66],"solution":[1],"structures":[2],"of":[3,36,60,68,76,90],"nucleocapsid":[4],"(NC)-like":[5],"CCHC":[6,38,61,94],"zinc-binding":[7,39,95],"domains":[8,18,40,62,72,96],"bound":[9],"to":[10,43],"nucleic":[11,24,46,110],"acid":[12,47,111],"targets":[13],"have":[14,28],"revealed":[15],"that":[16,81,92,106],"these":[17],"bind":[19,107],"guanosine":[20,77],"residues":[21,78],"within":[22],"single-stranded":[23,45,54,109],"acids.":[25],"Here,":[26],"we":[27],"performed":[29],"initial":[30],"studies":[31,86],"examining":[32],"the":[33,58,64,69,74],"potential":[34],"use":[35],"NC-like":[37,93],"as":[41,100],"modules":[42],"construct":[44],"binding":[48],"peptides.":[49],"affinity":[51],"for":[52,103],"guanosine-containing":[53],"deoxyribooligonucleotides":[55],"increases":[56],"with":[57],"number":[59],"in":[63,79],"peptide.":[65],"length":[67],"linker":[70],"between":[71],"affects":[73],"spacing":[75],"oligonucleotides":[80],"are":[82],"preferentially":[83],"bound.":[84],"These":[85],"provide":[87],"a":[88,101],"proof":[89],"principle":[91],"can":[97],"be":[98],"utilized":[99],"basis":[102],"designing":[104],"peptides":[105],"specific":[108],"sequences.":[112]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
