{"id":"https://openalex.org/W2045899126","doi":"https://doi.org/10.1016/0014-5793(85)80348-3","title":"Effects of GTP,GDP[\u03b2S] and glucose on adenylate cyclase activity of E. coli B","display_name":"Effects of GTP,GDP[\u03b2S] and glucose on adenylate cyclase activity of E. coli B","publication_year":1985,"publication_date":"1985-03-25","ids":{"openalex":"https://openalex.org/W2045899126","doi":"https://doi.org/10.1016/0014-5793(85)80348-3","mag":"2045899126","pmid":"https://pubmed.ncbi.nlm.nih.gov/3884374"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(85)80348-3","doi":"https://doi.org/10.1016/0014-5793(85)80348-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-5793(85)80348-3","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103678757","display_name":"Janet M. Stein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Janet M. Stein","raw_affiliation_strings":["Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, England","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112623148","display_name":"Hans Leo Kornberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H.L. Kornberg","raw_affiliation_strings":["Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, England","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":null,"display_name":"B.R. Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B.R. Martin","raw_affiliation_strings":["Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, England","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":0.2508,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.55411722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"182","issue":"2","first_page":"429","last_page":"434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.3131999969482422,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.3131999969482422,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.2969000041484833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.18629999458789825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/escherichia-coli-b","display_name":"Escherichia coli B","score":0.9259999990463257},{"id":"https://openalex.org/keywords/guanosine-triphosphate","display_name":"GTP","score":0.9110000133514404},{"id":"https://openalex.org/keywords/gdp-beta-s","display_name":"GDP beta S","score":0.5860000252723694},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.7509999871253967},{"id":"https://openalex.org/keywords/enzyme-activation","display_name":"enzyme activation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.9409999847412109},{"id":"https://openalex.org/keywords/non-competitive-inhibition","display_name":"non-competitive inhibition","score":0.7139999866485596},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.956291675567627},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.9364380836486816},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.886354923248291},{"id":"https://openalex.org/C2779817904","wikidata":"https://www.wikidata.org/wiki/Q422582","display_name":"Guanosine diphosphate","level":5,"score":0.5967909693717957},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5599791407585144},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.4844772517681122},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44924044609069824},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4141496419906616},{"id":"https://openalex.org/C2776638253","wikidata":"https://www.wikidata.org/wiki/Q392227","display_name":"Guanosine triphosphate","level":4,"score":0.3514038920402527}],"mesh":[{"descriptor_ui":"D000067956","descriptor_name":"Adenylyl Cyclase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006150","descriptor_name":"Guanine Nucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006153","descriptor_name":"Guanosine Diphosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006153","descriptor_name":"Guanosine Diphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013873","descriptor_name":"Thionucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014050","descriptor_name":"Toluene","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016244","descriptor_name":"Guanosine 5'-O-(3-Thiotriphosphate)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-5793(85)80348-3","doi":"https://doi.org/10.1016/0014-5793(85)80348-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-5793(85)80348-3","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:3884374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3884374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W269806918","https://openalex.org/W1479913622","https://openalex.org/W1497081127","https://openalex.org/W1505544453","https://openalex.org/W1533750627","https://openalex.org/W1551266724","https://openalex.org/W1559081557","https://openalex.org/W1643374090","https://openalex.org/W1679885037","https://openalex.org/W1775749144","https://openalex.org/W1879712221","https://openalex.org/W1957985727","https://openalex.org/W1980430044","https://openalex.org/W1996446016","https://openalex.org/W2024296404","https://openalex.org/W2046244942","https://openalex.org/W2046363787","https://openalex.org/W2161928549","https://openalex.org/W2169503005","https://openalex.org/W2418662542","https://openalex.org/W4235608950"],"related_works":["https://openalex.org/W1975907010","https://openalex.org/W2025720131","https://openalex.org/W2230177212","https://openalex.org/W2001303891","https://openalex.org/W1497081127","https://openalex.org/W1643374090","https://openalex.org/W2124584607","https://openalex.org/W1516804153","https://openalex.org/W2054375619","https://openalex.org/W269806918"],"abstract_inverted_index":{"Adenylate":[0],"cyclase":[1,73],"activity":[2],"was":[3,16,50],"measured":[4],"in":[5,18],"suspensions":[6],"of":[7,40,46,55,70],"E.coli":[8,71],"B,":[9],"rendered":[10],"permeable":[11],"with":[12,34],"toluene.":[13],"The":[14],"enzyme":[15],"activated":[17],"a":[19,37,43],"dose-dependent":[20],"manner":[21],"by":[22,25,53,74],"GTP":[23,57],"and":[24,61,67],"its":[26],"non-hydrolysable":[27],"analogue,":[28],"GTP[gamma":[29],"S].":[30],"In":[31],"contrast,":[32],"incubation":[33],"GDP[beta":[35,62],"S],":[36],"non-phosphorylatable":[38],"analogue":[39],"GDP,":[41],"caused":[42],"dose-related":[44,68],"inhibition":[45,69],"adenylate":[47,72],"cyclase;":[48],"this":[49],"partially":[51],"overcome":[52],"addition":[54],"GTP.":[56],"did":[58],"not":[59],"relieve,":[60],"S]":[63],"augmented,":[64],"the":[65],"non-competitive":[66],"glucose.":[75]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}