{"id":"https://openalex.org/W2045870522","doi":"https://doi.org/10.1002/ijc.2910640104","title":"Analysis and clinical implications of k\u2010ras gene mutations and infection with human papillomavirus types 16 and 18 in primary adenocarcinoma of the uterine cervix","display_name":"Analysis and clinical implications of k\u2010ras gene mutations and infection with human papillomavirus types 16 and 18 in primary adenocarcinoma of the uterine cervix","publication_year":1995,"publication_date":"1995-02-20","ids":{"openalex":"https://openalex.org/W2045870522","doi":"https://doi.org/10.1002/ijc.2910640104","mag":"2045870522","pmid":"https://pubmed.ncbi.nlm.nih.gov/7665253"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.2910640104","doi":"https://doi.org/10.1002/ijc.2910640104","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910640104","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113560724","display_name":"Patrizia Tenti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Patrizia Tenti","raw_affiliation_strings":["Department of Human Pathology, University of Pavia, Italy","Department of Human Pathology, University of Pavia, via Forlanini 14, 27100 Pavia, Italy. Fax: 382 525866"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Pathology, University of Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"Department of Human Pathology, University of Pavia, via Forlanini 14, 27100 Pavia, Italy. Fax: 382 525866","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019434935","display_name":"Solange Romagnoli","orcid":"https://orcid.org/0000-0001-5465-661X","observed_orcids":["https://orcid.org/0000-0001-5465-661X"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Solange Romagnoli","raw_affiliation_strings":["Department of Human Pathology, University of Pavia, and Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Pathology, University of Pavia, and Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004507388","display_name":"Enrico Maria Silini","orcid":"https://orcid.org/0000-0003-2578-3059","observed_orcids":["https://orcid.org/0000-0003-2578-3059"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico Silini","raw_affiliation_strings":["Department of Human Pathology, University of Pavia, and Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Pathology, University of Pavia, and Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001450937","display_name":"Natalia Simona Pellegata","orcid":"https://orcid.org/0000-0002-8000-7784","observed_orcids":["https://orcid.org/0000-0002-8000-7784"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Natalia S. Pellegata","raw_affiliation_strings":["Department of Genetics and Microbiology, University of Pavia, Italy","Department of Genetics & Microbiology, University of Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Microbiology, University of Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"Department of Genetics & Microbiology, University of Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073504029","display_name":"Rita Zappatore","orcid":"https://orcid.org/0000-0002-5467-3740","observed_orcids":["https://orcid.org/0000-0002-5467-3740"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rita Zappatore","raw_affiliation_strings":["Department of Human Pathology, University of Pavia, and Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Pathology, University of Pavia, and Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050955593","display_name":"Arsenio Spinillo","orcid":"https://orcid.org/0000-0002-7755-1084","observed_orcids":["https://orcid.org/0000-0002-7755-1084"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Arsenio Spinillo","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Pavia and IRCCS Policlinico San Matteo, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Pavia and IRCCS Policlinico San Matteo, Pavia, Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083208491","display_name":"Carlo Zara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Zara","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Pavia and IRCCS Policlinico San Matteo, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Pavia and IRCCS Policlinico San Matteo, Pavia, Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069735756","display_name":"Guglielmina Nadia Ranzani","orcid":"https://orcid.org/0000-0002-3080-6473","observed_orcids":["https://orcid.org/0000-0002-3080-6473"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Guglielmina N. Ranzani","raw_affiliation_strings":["Department of Genetics and Microbiology, University of Pavia, Italy","Department of Genetics & Microbiology, University of Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Microbiology, University of Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]},{"raw_affiliation_string":"Department of Genetics & Microbiology, University of Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111741373","display_name":"LUCIANO CARNEVALI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luciano Carnevali","raw_affiliation_strings":["Department of Human Pathology, University of Pavia, and Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Pathology, University of Pavia, and Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113560724"],"corresponding_institution_ids":["https://openalex.org/I25217355"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":1.1441,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.76419064,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"64","issue":"1","first_page":"9","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hpv-16","display_name":"HPV16","score":0.9279999732971191},{"id":"https://openalex.org/keywords/hpv-18","display_name":"HPV 18","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cervical-adenocarcinoma","display_name":"cervical adenocarcinoma","score":0.9369999766349792},{"id":"https://openalex.org/keywords/codon-12-mutation","display_name":"codon 12 mutation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.6819999814033508},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/clear-cell-histology","display_name":"clear cell histology","score":0.8460000157356262},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.6420000195503235},{"id":"https://openalex.org/keywords/oncogenic-cooperation","display_name":"oncogene cooperation","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7118080258369446},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5896106958389282},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5424450635910034},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.5041753053665161},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.4725758135318756},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45587390661239624},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.45090144872665405},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.45041486620903015},{"id":"https://openalex.org/C2778580637","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"HPV infection","level":4,"score":0.41812601685523987},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4142743647098541},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38527733087539673},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.252177357673645},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21903017163276672},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.1520771086215973},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14481264352798462},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12583649158477783},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014412","descriptor_name":"Tumor Virus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D014412","descriptor_name":"Tumor Virus Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.2910640104","doi":"https://doi.org/10.1002/ijc.2910640104","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910640104","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:7665253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7665253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W174152414","https://openalex.org/W1485038850","https://openalex.org/W1512997946","https://openalex.org/W1553224996","https://openalex.org/W1778855518","https://openalex.org/W1779915872","https://openalex.org/W1893545268","https://openalex.org/W1968251254","https://openalex.org/W1972216767","https://openalex.org/W2001376740","https://openalex.org/W2004204418","https://openalex.org/W2014356229","https://openalex.org/W2071697240","https://openalex.org/W2130058543","https://openalex.org/W2145815762","https://openalex.org/W2159594827","https://openalex.org/W2164034599","https://openalex.org/W2165677391","https://openalex.org/W2416142365","https://openalex.org/W2419669285","https://openalex.org/W3139983201","https://openalex.org/W4229610456"],"related_works":["https://openalex.org/W2041953245","https://openalex.org/W2048943178","https://openalex.org/W2004907020","https://openalex.org/W4237645384","https://openalex.org/W2020177654","https://openalex.org/W2161794912","https://openalex.org/W2023711868","https://openalex.org/W1819331759","https://openalex.org/W1968251254","https://openalex.org/W2369710645"],"abstract_inverted_index":{"Experimental":[0],"models":[1],"indicate":[2],"that":[3],"activated":[4],"ras":[5],"genes":[6],"and":[7,28,31,56,64,73,95,104,132,166,174,184,187,194,208],"HPV":[8,29,81,118,135],"oncogenic":[9,119,136],"sequences":[10,33,51,120,137],"may":[11],"cooperate":[12],"in":[13,19,34,87,112,115,123,142,145,154],"inducing":[14],"a":[15],"completely":[16],"transformed":[17],"phenotype":[18],"epithelial":[20],"cells.":[21],"We":[22,83],"searched":[23],"for":[24,66,77,216],"K-ras":[25,70,182],"gene":[26,71],"mutations":[27,72,86,183],"type-16":[30],"-18":[32,188],"67":[35],"primary":[36],"adenocarcinomas":[37],"of":[38,69,80,157,161,171,181,185,200,211],"the":[39,67,78,172,175],"uterine":[40],"cervix":[41],"by":[42,54,58,74,192],"analyzing":[43],"DNAs":[44],"from":[45],"formalin-fixed,":[46],"paraffin-embedded":[47],"tissue":[48],"samples.":[49],"Target":[50],"were":[52,91,101,106,109,121,138,151,179,213],"amplified":[53],"PCR":[55],"analyzed":[57],"denaturing":[59],"gradient":[60],"gel":[61],"electrophoresis":[62],"(DGGE)":[63],"sequencing":[65],"detection":[68,79],"Southern":[75],"blotting":[76],"infection.":[82],"found":[84],"16":[85],"15":[88],"cases;":[89],"14":[90],"at":[92,97],"codon":[93,98],"12":[94],"2":[96],"13;":[99],"11":[100],"base":[102],"transitions":[103],"5":[105],"transversions.":[107],"Mutations":[108],"more":[110,140],"frequent":[111,141],"mucin-secreting":[113,143],"than":[114,144],"non-mucinous":[116,146],"tumors.":[117,134,147,168],"detected":[122],"58":[124,158],"cases":[125],"with":[126],"no":[127],"significant":[128],"difference":[129],"between":[130],"K-ras-mutated":[131],"wild-type":[133],"also":[139],"Both":[148],"molecular":[149],"events":[150],"present":[152],"simultaneously":[153],"13":[155],"out":[156],"cases,":[159],"all":[160],"which":[162],"had":[163],"histologically":[164],"grade-2":[165],"grade-3":[167],"Clinico-pathological":[169],"parameters":[170],"disease":[173],"overall":[176],"survival,":[177],"however,":[178],"independent":[180],"HPV-16":[186],"infection,":[189],"as":[190],"shown":[191],"univariate":[193],"multivariate":[195],"analysis.":[196],"In":[197],"contrast,":[198],"stage":[199],"disease,":[201],"lymph-node":[202],"metastases,":[203],"deep":[204],"infiltration,":[205],"clear-cell":[206],"histology":[207],"low":[209],"grade":[210],"differentiation":[212],"risk":[214],"factors":[215],"tumor-related":[217],"death.":[218]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}