{"id":"https://openalex.org/W2045807105","doi":"https://doi.org/10.1158/2159-8290.cd-13-0581","title":"New Connections between Old Pathways: PDK1 Signaling Promotes Cellular Transformation through PLK1-Dependent MYC Stabilization","display_name":"New Connections between Old Pathways: PDK1 Signaling Promotes Cellular Transformation through PLK1-Dependent MYC Stabilization","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W2045807105","doi":"https://doi.org/10.1158/2159-8290.cd-13-0581","mag":"2045807105","pmid":"https://pubmed.ncbi.nlm.nih.gov/24124229","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3857155"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.cd-13-0581","doi":"https://doi.org/10.1158/2159-8290.cd-13-0581","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2159-8290.cd-13-0581","pdf_url":null,"source":{"id":"https://openalex.org/S2486275289","display_name":"Cancer Discovery","issn_l":"2159-8274","issn":["2159-8274","2159-8290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Discovery","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3857155","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020458570","display_name":"John T. Cunningham","orcid":"https://orcid.org/0000-0001-6490-4533","observed_orcids":["https://orcid.org/0000-0001-6490-4533"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John T. Cunningham","raw_affiliation_strings":["Authors' Affiliation: Department of Urology, School of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Department of Urology, School of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023731504","display_name":"Davide Ruggero","orcid":"https://orcid.org/0000-0002-9444-5865","observed_orcids":["https://orcid.org/0000-0002-9444-5865"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Davide Ruggero","raw_affiliation_strings":["Authors' Affiliation: Department of Urology, School of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Department of Urology, School of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5023731504"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"10","first_page":"1099","last_page":"1102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pdk1","display_name":"PDK1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/plk1","display_name":"PLK1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/myc-stabilization","display_name":"MYC stabilization","score":0.9599999785423279},{"id":"https://openalex.org/keywords/phosphoinositide-3-kinase-signaling","display_name":"phosphoinositide 3-kinase signaling","score":0.8930000066757202},{"id":"https://openalex.org/keywords/oncogenic-signaling","display_name":"oncogenic signaling","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/tumor-cell-survival","display_name":"tumor cell survival","score":0.878000020980835},{"id":"https://openalex.org/keywords/tumor-formation","display_name":"tumor formation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/pdk1-inhibitors","display_name":"PDK1 inhibitors","score":0.8259999752044678},{"id":"https://openalex.org/keywords/plk1-inhibitors","display_name":"PLK1 inhibitors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/myc-oncoprotein","display_name":"Myc oncoprotein","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C146276462","wikidata":"https://www.wikidata.org/wiki/Q21131841","display_name":"PLK1","level":4,"score":0.7644931077957153},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6792412400245667},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6185606122016907},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6099621057510376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5649230480194092},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.49954748153686523},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.45540839433670044},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.36253073811531067},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3497788906097412},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.28830486536026},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21016281843185425}],"mesh":[{"descriptor_ui":"D000097869","descriptor_name":"Polo-Like Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D064413","descriptor_name":"3-Phosphoinositide-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1158/2159-8290.cd-13-0581","doi":"https://doi.org/10.1158/2159-8290.cd-13-0581","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2159-8290.cd-13-0581","pdf_url":null,"source":{"id":"https://openalex.org/S2486275289","display_name":"Cancer Discovery","issn_l":"2159-8274","issn":["2159-8274","2159-8290"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Discovery","raw_type":"journal-article"},{"id":"pmid:24124229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24124229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer discovery","raw_type":"Editorial"},{"id":"pmh:oai:europepmc.org:2951418","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3857155","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3857155","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3857155","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Discov","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7vj483c7","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7vj483c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Discovery, vol 3, iss 10","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2951418","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3857155","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3553584197","display_name":"Delineating the Mechanisms Responsible for Synthetic Lethality in MYC-induced Tumorigenesis Driven by Control of Protein Synthesis","funder_award_id":"R01CA140456","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G981350091","display_name":"Deciphering the role of the translational oncogenic program in Prostate Cancer","funder_award_id":"R01CA154916","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1588880778","https://openalex.org/W1999025078","https://openalex.org/W2009949436","https://openalex.org/W2038291983","https://openalex.org/W2038444072","https://openalex.org/W2039171339","https://openalex.org/W2041535798","https://openalex.org/W2042066283","https://openalex.org/W2110864471","https://openalex.org/W2112357436","https://openalex.org/W2120572492","https://openalex.org/W2129104457","https://openalex.org/W2135798683","https://openalex.org/W2145941456","https://openalex.org/W2146414563","https://openalex.org/W2146915309","https://openalex.org/W2151748280"],"related_works":["https://openalex.org/W1999025078","https://openalex.org/W2610740894","https://openalex.org/W7212119318","https://openalex.org/W2030373852","https://openalex.org/W4386189786","https://openalex.org/W2120643013","https://openalex.org/W2537873018","https://openalex.org/W2069232844","https://openalex.org/W3029082758","https://openalex.org/W4210813934"],"abstract_inverted_index":{"Limited":[0],"understanding":[1],"of":[2,18,39,80,97],"the":[3,15,62,77,89,98],"functional":[4,63],"link":[5],"between":[6],"multiple":[7],"oncogenic":[8,33,54],"pathways":[9],"is":[10],"a":[11,46],"major":[12],"barrier":[13],"in":[14,68,86],"ongoing":[16],"effort":[17],"cancer":[19,69],"biologists":[20],"to":[21,27],"design":[22],"an":[23],"effective":[24],"therapeutic":[25,78],"approach":[26],"treat":[28],"malignancies":[29],"characterized":[30],"by":[31,94],"driver":[32],"network":[34],"signals.":[35],"In":[36],"this":[37],"issue":[38],"Cancer":[40],"Discovery,":[41],"Tan":[42],"and":[43,58,72,75,83],"colleagues":[44],"elucidate":[45],"novel":[47],"PDK1-PLK1-MYC":[48,66],"signaling":[49,67],"pathway":[50],"connecting":[51],"two":[52],"fundamental":[53],"programs,":[55],"phosphoinositide":[56],"3-kinase":[57],"MYC.":[59],"They":[60],"define":[61],"role":[64],"for":[65],"cell":[70],"survival":[71],"tumor":[73],"formation":[74],"show":[76],"benefit":[79],"inhibiting":[81],"PDK1":[82],"PLK1":[84],"pharmacologically":[85],"cancer,":[87],"tackling":[88],"most":[90],"undruggable":[91],"tumors":[92],"defined":[93],"elevated":[95],"levels":[96],"MYC":[99],"oncoprotein.":[100]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}