{"id":"https://openalex.org/W2045802845","doi":"https://doi.org/10.1042/bj20111495","title":"Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient","display_name":"Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient","publication_year":2012,"publication_date":"2012-06-15","ids":{"openalex":"https://openalex.org/W2045802845","doi":"https://doi.org/10.1042/bj20111495","mag":"2045802845","pmid":"https://pubmed.ncbi.nlm.nih.gov/22694310"},"language":"en","primary_location":{"id":"doi:10.1042/bj20111495","doi":"https://doi.org/10.1042/bj20111495","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20111495","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/89714","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102973821","display_name":"Jung\u2010Il Chae","orcid":"https://orcid.org/0000-0003-2232-077X","observed_orcids":["https://orcid.org/0000-0003-2232-077X"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung-Il Chae","raw_affiliation_strings":["Department of Oral Pharmacology, School of Dentistry and Institute of Dental Bioscience, BK21 project, Chonbuk National University, Jeonju 651-756, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pharmacology, School of Dentistry and Institute of Dental Bioscience, BK21 project, Chonbuk National University, Jeonju 651-756, Korea","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359360","display_name":"Dong\u2010Wook Kim","orcid":"https://orcid.org/0000-0002-5025-1532","observed_orcids":["https://orcid.org/0000-0002-5025-1532","https://orcid.org/0000-0003-3419-0538"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Wook Kim","raw_affiliation_strings":["Department of Oral Pharmacology, School of Dentistry and Institute of Dental Bioscience, BK21 project, Chonbuk National University, Jeonju 651-756, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pharmacology, School of Dentistry and Institute of Dental Bioscience, BK21 project, Chonbuk National University, Jeonju 651-756, Korea","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101839368","display_name":"Nayeon Lee","orcid":"https://orcid.org/0000-0002-3377-2301","observed_orcids":["https://orcid.org/0000-0002-3377-2301"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Nayeon Lee","raw_affiliation_strings":["CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seoul 135-081, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seoul 135-081, Korea","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Young-Joo Jeon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young-Joo Jeon","raw_affiliation_strings":["Department of Oral Pharmacology, School of Dentistry and Institute of Dental Bioscience, BK21 project, Chonbuk National University, Jeonju 651-756, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pharmacology, School of Dentistry and Institute of Dental Bioscience, BK21 project, Chonbuk National University, Jeonju 651-756, Korea","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Iksoo Jeon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Iksoo Jeon","raw_affiliation_strings":["CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seoul 135-081, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seoul 135-081, Korea","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101856818","display_name":"Jihye Kwon","orcid":"https://orcid.org/0000-0002-0680-7716","observed_orcids":["https://orcid.org/0000-0002-0680-7716"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jihye Kwon","raw_affiliation_strings":["CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seoul 135-081, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seoul 135-081, Korea","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000774459","display_name":"Jumi Kim","orcid":"https://orcid.org/0000-0002-6095-2236","observed_orcids":["https://orcid.org/0000-0002-6095-2236","https://orcid.org/0009-0004-6859-5028","https://orcid.org/0009-0009-0339-9727"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jumi Kim","raw_affiliation_strings":["CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seoul 135-081, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seoul 135-081, Korea","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028241736","display_name":"Yunjo Soh","orcid":"https://orcid.org/0000-0001-9543-225X","observed_orcids":["https://orcid.org/0000-0001-9543-225X"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yunjo Soh","raw_affiliation_strings":["Department of Oral Pharmacology, School of Dentistry and Institute of Dental Bioscience, BK21 project, Chonbuk National University, Jeonju 651-756, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pharmacology, School of Dentistry and Institute of Dental Bioscience, BK21 project, Chonbuk National University, Jeonju 651-756, Korea","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026903916","display_name":"Dong\u2010Seok Lee","orcid":"https://orcid.org/0000-0001-6348-8937","observed_orcids":["https://orcid.org/0000-0001-6348-8937"]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Seok Lee","raw_affiliation_strings":["CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seoul 135-081, Korea","College of Natural Sciences, Kyungpook National University, Daegu 702-701, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seoul 135-081, Korea","institution_ids":["https://openalex.org/I4210148737"]},{"raw_affiliation_string":"College of Natural Sciences, Kyungpook National University, Daegu 702-701, Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042396721","display_name":"Kang-Seok Seo","orcid":"https://orcid.org/0000-0002-6116-6114","observed_orcids":["https://orcid.org/0000-0002-6116-6114"]},"institutions":[{"id":"https://openalex.org/I199143407","display_name":"Sunchon National University","ror":"https://ror.org/043jqrs76","country_code":"KR","type":"education","lineage":["https://openalex.org/I199143407"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kang\u00a0Seok Seo","raw_affiliation_strings":["Department of Animal Science and Technology, Sunchon National University, Suncheon 540-742, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science and Technology, Sunchon National University, Suncheon 540-742, Korea","institution_ids":["https://openalex.org/I199143407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100885398","display_name":"Nag-Jin Choi","orcid":"https://orcid.org/0000-0003-0145-8905","observed_orcids":["https://orcid.org/0000-0003-0145-8905"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Nag-Jin Choi","raw_affiliation_strings":["Department of Animal Science, College of Agricultural and Life Science, Chonbuk National University, Jeonju 651-756, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science, College of Agricultural and Life Science, Chonbuk National University, Jeonju 651-756, Korea","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071287957","display_name":"Byoung Chul Park","orcid":"https://orcid.org/0000-0002-8879-5551","observed_orcids":["https://orcid.org/0000-0002-8879-5551","https://orcid.org/0000-0002-1584-2644"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byoung\u00a0Chul Park","raw_affiliation_strings":["Medical Proteomics Research Center, KRIBB, Daejeon 305-333, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Proteomics Research Center, KRIBB, Daejeon 305-333, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110169438","display_name":"Sung Hyun Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung\u00a0Hyun Kang","raw_affiliation_strings":["Medical Proteomics Research Center, KRIBB, Daejeon 305-333, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Proteomics Research Center, KRIBB, Daejeon 305-333, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110872","display_name":"Joohyun Ryu","orcid":"https://orcid.org/0000-0002-8886-6006","observed_orcids":["https://orcid.org/0000-0002-8886-6006"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joohyun Ryu","raw_affiliation_strings":["Medical Proteomics Research Center, KRIBB, Daejeon 305-333, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Proteomics Research Center, KRIBB, Daejeon 305-333, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102389149","display_name":"Seung-Hun Oh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung-Hun Oh","raw_affiliation_strings":["CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seoul 135-081, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seoul 135-081, Korea","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070764607","display_name":"Dong Ah Shin","orcid":"https://orcid.org/0000-0002-5225-4083","observed_orcids":["https://orcid.org/0000-0002-5225-4083"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong\u00a0Ah Shin","raw_affiliation_strings":["Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047086305","display_name":"Dong Ryul Lee","orcid":"https://orcid.org/0000-0003-1534-4810","observed_orcids":["https://orcid.org/0000-0003-1534-4810","https://orcid.org/0000-0002-7117-2681"]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]},{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong\u00a0Ryul Lee","raw_affiliation_strings":["CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seoul 135-081, Korea","College of Natural Sciences, Kyungpook National University, Daegu 702-701, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seoul 135-081, Korea","institution_ids":["https://openalex.org/I4210148737"]},{"raw_affiliation_string":"College of Natural Sciences, Kyungpook National University, Daegu 702-701, Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jeong\u00a0Tae Do","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeong\u00a0Tae Do","raw_affiliation_strings":["CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seoul 135-081, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seoul 135-081, Korea","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053522703","display_name":"In\u2010Hyun Park","orcid":"https://orcid.org/0000-0001-7748-1293","observed_orcids":["https://orcid.org/0000-0001-7748-1293"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"In-Hyun Park","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, U.S.A","Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, U.S.A","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, U.S.A","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059348374","display_name":"George Q. Daley","orcid":"https://orcid.org/0000-0002-6346-5919","observed_orcids":["https://orcid.org/0000-0002-6346-5919"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George\u00a0Q. Daley","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, U.S.A","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013799594","display_name":"Jihwan Song","orcid":"https://orcid.org/0000-0002-6597-8208","observed_orcids":["https://orcid.org/0000-0002-6597-8208"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jihwan Song","raw_affiliation_strings":["CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seoul 135-081, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHA Stem Cell Institute, Department of Biomedical Science, CHA University, Seoul 135-081, Korea","institution_ids":["https://openalex.org/I4210148737"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5028241736"],"corresponding_institution_ids":["https://openalex.org/I80611190"],"apc_list":null,"apc_paid":null,"fwci":3.7769,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.94941932,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"446","issue":"3","first_page":"359","last_page":"371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":1.0},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/proteomic-profiling","display_name":"proteomic profiling","score":0.6570000052452087},{"id":"https://openalex.org/keywords/cag-repeat-expansion","display_name":"CAG repeat expansion","score":0.8140000104904175},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7570000290870667},{"id":"https://openalex.org/keywords/superoxide-dismutase-1","display_name":"superoxide dismutase 1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/peroxiredoxin","display_name":"peroxiredoxin","score":0.9290000200271606},{"id":"https://openalex.org/keywords/btf3","display_name":"BTF3","score":0.921999990940094},{"id":"https://openalex.org/keywords/atm","display_name":"ATM","score":0.8429999947547913},{"id":"https://openalex.org/keywords/p53-dependent-apoptosis","display_name":"p53-dependent apoptosis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cytoskeletal-proteins","display_name":"cytoskeletal proteins","score":0.8690000176429749},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/disease-models","display_name":"disease models","score":0.5569999814033508},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.8790907859802246},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.7564983367919922},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7002478241920471},{"id":"https://openalex.org/C2780647506","wikidata":"https://www.wikidata.org/wiki/Q190564","display_name":"Huntington's disease","level":3,"score":0.6682052612304688},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5600472688674927},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5543227195739746},{"id":"https://openalex.org/C2781427258","wikidata":"https://www.wikidata.org/wiki/Q2620886","display_name":"Huntingtin","level":4,"score":0.5503765344619751},{"id":"https://openalex.org/C2777615887","wikidata":"https://www.wikidata.org/wiki/Q15328137","display_name":"SOD1","level":4,"score":0.47675713896751404},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.43149858713150024},{"id":"https://openalex.org/C2780416994","wikidata":"https://www.wikidata.org/wiki/Q419462","display_name":"Peroxiredoxin","level":4,"score":0.43115097284317017},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3472074270248413},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3243129551410675},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.280262291431427},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22428864240646362},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14840537309646606},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.13232961297035217},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08666735887527466},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07655587792396545},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071058","descriptor_name":"Huntingtin Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019680","descriptor_name":"Trinucleotide Repeat Expansion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1042/bj20111495","doi":"https://doi.org/10.1042/bj20111495","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20111495","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:22694310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22694310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:http://repository.kribb.re.kr:8080/:201005/10906","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1042/BJ20111495","pdf_url":null,"source":{"id":"https://openalex.org/S4406922719","display_name":"KRIBB Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"/dspace/upload/original/10944.pdf","raw_type":"Article"},{"id":"pmh:oai:https://repository.kribb.re.kr:201005/10906","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1042/BJ20111495","pdf_url":null,"source":{"id":"https://openalex.org/S4406922719","display_name":"KRIBB Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"/dspace/upload/original/10944.pdf","raw_type":"Article"},{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/89714","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/89714","pdf_url":null,"source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:ir.ymlib.yonsei.ac.kr:22282913/89714","doi":null,"is_oa":true,"landing_page_url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/89714","pdf_url":null,"source":{"id":"https://openalex.org/S4306400691","display_name":"YUHSpace (Yonsei University Medical Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193775966","host_organization_name":"Yonsei University","host_organization_lineage":["https://openalex.org/I193775966"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W286273192","https://openalex.org/W426097930","https://openalex.org/W1499711091","https://openalex.org/W1591312627","https://openalex.org/W1853857034","https://openalex.org/W1966476278","https://openalex.org/W1967972793","https://openalex.org/W1970965314","https://openalex.org/W1973044543","https://openalex.org/W1977721212","https://openalex.org/W1978138384","https://openalex.org/W1978902744","https://openalex.org/W1979715288","https://openalex.org/W1985493919","https://openalex.org/W1993638375","https://openalex.org/W1998826441","https://openalex.org/W1998946448","https://openalex.org/W2002612012","https://openalex.org/W2003126320","https://openalex.org/W2003906576","https://openalex.org/W2006806309","https://openalex.org/W2012654654","https://openalex.org/W2014803841","https://openalex.org/W2017726167","https://openalex.org/W2020609260","https://openalex.org/W2028939491","https://openalex.org/W2031840568","https://openalex.org/W2042343467","https://openalex.org/W2043671423","https://openalex.org/W2044695362","https://openalex.org/W2045086385","https://openalex.org/W2050445860","https://openalex.org/W2056144728","https://openalex.org/W2074918942","https://openalex.org/W2078116784","https://openalex.org/W2080632801","https://openalex.org/W2088144746","https://openalex.org/W2111185320","https://openalex.org/W2112250073","https://openalex.org/W2112360818","https://openalex.org/W2112810459","https://openalex.org/W2113695502","https://openalex.org/W2113780833","https://openalex.org/W2118546680","https://openalex.org/W2121642311","https://openalex.org/W2129129493","https://openalex.org/W2155488504","https://openalex.org/W2156251255","https://openalex.org/W2157645703","https://openalex.org/W2158496331","https://openalex.org/W2160834780","https://openalex.org/W6682539277"],"related_works":["https://openalex.org/W4295261767","https://openalex.org/W2320957378","https://openalex.org/W2286755989","https://openalex.org/W4295260288","https://openalex.org/W1497938915","https://openalex.org/W4319593636","https://openalex.org/W7160845079","https://openalex.org/W2996518554","https://openalex.org/W2335878205","https://openalex.org/W7135804698"],"abstract_inverted_index":{"HD":[0,35,229],"(Huntington's":[1],"disease)":[2],"is":[3,145],"a":[4,34,198],"devastating":[5],"neurodegenerative":[6],"genetic":[7],"disorder":[8],"caused":[9],"by":[10,160],"abnormal":[11],"expansion":[12],"of":[13,49,154,162,174],"CAG":[14,39],"repeats":[15,40],"in":[16,89,125,147,180,211],"the":[17,46,152,163,172,206,214,218],"HTT":[18],"(huntingtin)":[19],"gene.":[20],"We":[21,136],"have":[22,52],"recently":[23],"established":[24],"two":[25],"iPSC":[26],"(induced":[27],"pluripotent":[28],"stem":[29,62],"cell)":[30],"lines":[31],"derived":[32],"from":[33,217],"patient":[36],"carrying":[37],"72":[38],"(HD-iPSC).":[41],"In":[42,167],"order":[43],"to":[44,86,133,151,204],"understand":[45,205],"proteomic":[47,55],"profiles":[48],"HD-iPSCs,":[50,126,148,181],"we":[51,106,169],"performed":[53],"comparative":[54],"analysis":[56],"among":[57],"normal":[58],"hESCs":[59],"(human":[60],"embryonic":[61],"cells;":[63],"H9),":[64],"iPSCs":[65],"(551-8)":[66],"and":[67,72,76,100,118,208,213],"HD-iPSCs":[68,129,195],"at":[69],"undifferentiated":[70],"stages,":[71],"identified":[73,215],"26":[74],"up-":[75],"down-regulated":[77],"proteins.":[78,103],"Interestingly,":[79],"these":[80,191],"differentially":[81],"expressed":[82],"proteins":[83,176,216],"are":[84,122,130],"known":[85],"be":[87],"involved":[88],"different":[90],"biological":[91],"processes,":[92],"such":[93,112],"as":[94,113,223],"oxidative":[95,109,134],"stress,":[96],"programmed":[97],"cell":[98],"death":[99],"cellular":[101,200],"oxygen-associated":[102],"Among":[104],"them,":[105],"found":[107,138],"that":[108,128,139,171,183,194],"stress-related":[110],"proteins,":[111],"SOD1":[114],"(superoxide":[115],"dismutase":[116],"1)":[117],"Prx":[119],"(peroxiredoxin)":[120],"families":[121],"particularly":[123],"affected":[124],"implying":[127,182],"highly":[131],"susceptible":[132],"stress.":[135],"also":[137,187],"BTF3":[140],"(basic":[141],"transcription":[142],"factor":[143],"3)":[144],"up-regulated":[146],"which":[149],"leads":[150],"induction":[153],"ATM":[155],"(ataxia":[156],"telangiectasia":[157],"mutated),":[158],"followed":[159],"activation":[161],"p53-mediated":[164],"apoptotic":[165],"pathway.":[166],"addition,":[168],"observed":[170],"expression":[173],"cytoskeleton-associated":[175],"was":[177,186],"significantly":[178],"reduced":[179],"neuronal":[184],"differentiation":[185],"affected.":[188],"Taken":[189],"together,":[190],"results":[192],"demonstrate":[193],"can":[196],"provide":[197],"unique":[199],"disease":[201],"model":[202],"system":[203],"pathogenesis":[207],"neurodegeneration":[209],"mechanisms":[210],"HD,":[212],"present":[219],"study":[220],"may":[221],"serve":[222],"potential":[224],"targets":[225],"for":[226],"developing":[227],"future":[228],"therapeutics.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}