{"id":"https://openalex.org/W2045784231","doi":"https://doi.org/10.1021/ac0301604","title":"Analytical Approaches to Improved Characterization of Substitution in Hydroxypropyl Cellulose","display_name":"Analytical Approaches to Improved Characterization of Substitution in Hydroxypropyl Cellulose","publication_year":2003,"publication_date":"2003-10-16","ids":{"openalex":"https://openalex.org/W2045784231","doi":"https://doi.org/10.1021/ac0301604","mag":"2045784231","pmid":"https://pubmed.ncbi.nlm.nih.gov/14615984"},"language":"en","primary_location":{"id":"doi:10.1021/ac0301604","doi":"https://doi.org/10.1021/ac0301604","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac0301604","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110029945","display_name":"Sara Richardson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Sara Richardson","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, SE-431 83 M\u00f6lndal, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, SE-431 83 M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080821830","display_name":"Thomas Andersson","orcid":"https://orcid.org/0000-0002-7777-5870","observed_orcids":["https://orcid.org/0000-0002-7777-5870"]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Thomas Andersson","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, SE-431 83 M\u00f6lndal, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, SE-431 83 M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012836642","display_name":"Gunnar Brinkmalm","orcid":"https://orcid.org/0000-0001-6958-2393","observed_orcids":["https://orcid.org/0000-0001-6958-2393"]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gunnar Brinkmalm","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, SE-431 83 M\u00f6lndal, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, SE-431 83 M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031945237","display_name":"Bengt Wittgren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bengt Wittgren","raw_affiliation_strings":["AstraZeneca R&D M\u00f6lndal, SE-431 83 M\u00f6lndal, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca R&D M\u00f6lndal, SE-431 83 M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110029945"],"corresponding_institution_ids":["https://openalex.org/I4210143795"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.8939,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.68884707,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"75","issue":"22","first_page":"6077","last_page":"6083"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10610","display_name":"Advanced Cellulose Research Studies","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10610","display_name":"Advanced Cellulose Research Studies","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.18320000171661377,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10869","display_name":"Polysaccharides and Plant Cell Walls","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxypropyl-cellulose","display_name":"hydroxypropyl cellulose","score":1.0},{"id":"https://openalex.org/keywords/cellulose-ethers","display_name":"cellulose ethers","score":0.878000020980835},{"id":"https://openalex.org/keywords/degree-of-substitution","display_name":"degree of substitution","score":0.7009999752044678},{"id":"https://openalex.org/keywords/nmr-spectroscopy","display_name":"NMR spectroscopy","score":0.703000009059906},{"id":"https://openalex.org/keywords/maldi-tof-mass-spectrometry","display_name":"MALDI-TOF mass spectrometry","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hpaec-pad","display_name":"HPAEC-PAD","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8898710012435913},{"id":"https://openalex.org/C2781218482","wikidata":"https://www.wikidata.org/wiki/Q724426","display_name":"Hydroxypropyl cellulose","level":3,"score":0.8027122020721436},{"id":"https://openalex.org/C2779251873","wikidata":"https://www.wikidata.org/wiki/Q80294","display_name":"Cellulose","level":2,"score":0.7960050702095032},{"id":"https://openalex.org/C2778220771","wikidata":"https://www.wikidata.org/wiki/Q1522579","display_name":"Substitution (logic)","level":2,"score":0.6664139032363892},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.6041111350059509},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.5331933498382568},{"id":"https://openalex.org/C2776174307","wikidata":"https://www.wikidata.org/wiki/Q416312","display_name":"Methyl cellulose","level":3,"score":0.530469536781311},{"id":"https://openalex.org/C2780407432","wikidata":"https://www.wikidata.org/wiki/Q103230","display_name":"Ether","level":2,"score":0.5263280272483826},{"id":"https://openalex.org/C39143791","wikidata":"https://www.wikidata.org/wiki/Q7632133","display_name":"Substitution method","level":2,"score":0.4691559076309204},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.45262664556503296},{"id":"https://openalex.org/C196503311","wikidata":"https://www.wikidata.org/wiki/Q145623","display_name":"Molar mass","level":3,"score":0.4341857433319092},{"id":"https://openalex.org/C175528265","wikidata":"https://www.wikidata.org/wiki/Q500256","display_name":"Chemical structure","level":2,"score":0.4278136193752289},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.38332879543304443},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.09284111857414246},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002240","descriptor_name":"Carbohydrate Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ac0301604","doi":"https://doi.org/10.1021/ac0301604","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac0301604","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:14615984","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14615984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1894951232","https://openalex.org/W1968906383","https://openalex.org/W1971731473","https://openalex.org/W1977645804","https://openalex.org/W1989401750","https://openalex.org/W2003535188","https://openalex.org/W2005879767","https://openalex.org/W2007049342","https://openalex.org/W2007787141","https://openalex.org/W2017466809","https://openalex.org/W2018057513","https://openalex.org/W2020604723","https://openalex.org/W2030593590","https://openalex.org/W2033017078","https://openalex.org/W2036642260","https://openalex.org/W2037387220","https://openalex.org/W2039141477","https://openalex.org/W2039187916","https://openalex.org/W2040880880","https://openalex.org/W2057088759","https://openalex.org/W2068629194","https://openalex.org/W2081322907","https://openalex.org/W2085481884","https://openalex.org/W2086179443","https://openalex.org/W2090798189","https://openalex.org/W2093448674","https://openalex.org/W2094364334","https://openalex.org/W2094591203","https://openalex.org/W2124558731","https://openalex.org/W2161419801","https://openalex.org/W3004921787","https://openalex.org/W3022942012","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2090798189","https://openalex.org/W1989401750","https://openalex.org/W2007787141","https://openalex.org/W3043208971","https://openalex.org/W2160010957","https://openalex.org/W7117549101","https://openalex.org/W2924455641","https://openalex.org/W4375815013","https://openalex.org/W2041337043","https://openalex.org/W2513970756"],"abstract_inverted_index":{"Chemical":[0],"characterization":[1],"of":[2,6,24,33,37,70,107,110,113,126,135,165,174,193],"cellulose":[3,60,182],"derivatives":[4,39],"is":[5],"high":[7],"importance":[8,173],"as":[9,96,187],"it":[10],"provides":[11,190],"information":[12,82,194],"about":[13],"the":[14,22,34,50,54,84,100,108,111,121,127,133,140,154,166,170,181,196],"often":[15],"inhomogeneous":[16],"substitution":[17,52,55,128,184],"that":[18,89,153],"may":[19],"seriously":[20],"affect":[21],"properties":[23],"these":[25,38],"polymers":[26],"in":[27,57,120,139,159],"various":[28],"applications.":[29],"A":[30],"detailed":[31],"mapping":[32],"chemical":[35,197],"structure":[36],"requires":[40],"several":[41,176],"advanced":[42],"techniques":[43],"to":[44],"be":[45,91],"employed.":[46],"In":[47,98],"this":[48],"study,":[49],"average":[51],"and":[53,75,78,163,172],"heterogeneity":[56,125],"two":[58,122,155],"hydroxypropyl":[59,114,167],"(HPC)":[61],"samples":[62,157],"from":[63],"different":[64,191],"suppliers":[65],"were":[66],"studied":[67,130],"by":[68,93,131,146],"means":[69],"NMR":[71,80],"spectroscopy,":[72],"MALDI-TOF":[73,94],"MS,":[74],"HPAEC-PAD.":[76],"(1)H":[77],"(13)C":[79],"provided":[81],"on":[83,195],"molar":[85],"substitution,":[86],"a":[87],"parameter":[88],"could":[90],"analyzed":[92],"MS":[95],"well.":[97],"addition,":[99],"latter":[101],"technique":[102],"was":[103,129,144],"used":[104],"for":[105],"determination":[106],"distribution":[109,164],"number":[112],"groups":[115],"per":[116],"glucose":[117,137],"unit":[118],"present":[119],"polymers.":[123],"The":[124,149],"determining":[132],"amount":[134],"unsubstituted":[136],"units":[138],"HPC":[141,156],"samples,":[142],"which":[143],"accomplished":[145],"HPAEC-PAD":[147],"analysis.":[148],"results":[150],"obtained":[151],"suggest":[152],"differ":[158],"both":[160],"hydroxypropoxy":[161],"content":[162],"groups.":[168],"Further,":[169],"benefits":[171],"employing":[175],"analytical":[177],"methods":[178],"when":[179],"investigating":[180],"ether":[183],"are":[185],"demonstrated,":[186],"each":[188],"method":[189],"kinds":[192],"content.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
