{"id":"https://openalex.org/W2045779019","doi":"https://doi.org/10.1016/0014-5793(93)81618-a","title":"Comparison of properties of mistletoe lectin I A\u2010chain and ricin B\u2010Chain conjugate with native toxins","display_name":"Comparison of properties of mistletoe lectin I A\u2010chain and ricin B\u2010Chain conjugate with native toxins","publication_year":1993,"publication_date":"1993-12-20","ids":{"openalex":"https://openalex.org/W2045779019","doi":"https://doi.org/10.1016/0014-5793(93)81618-a","mag":"2045779019","pmid":"https://pubmed.ncbi.nlm.nih.gov/8262189"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(93)81618-a","doi":"https://doi.org/10.1016/0014-5793(93)81618-a","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(93)81618-a","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2893%2981618-A","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2893%2981618-A","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078851169","display_name":"Alexander Tonevitsky","orcid":"https://orcid.org/0000-0002-7079-7145","observed_orcids":["https://orcid.org/0000-0002-7079-7145"]},"institutions":[{"id":"https://openalex.org/I4210163576","display_name":"Genetika","ror":"https://ror.org/05hr7qe62","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210163576"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A.G. Tonevitsky","raw_affiliation_strings":["Institute for Genetics of Microorganisms, Moscow, Russian Federation","Institute for Genetics of Microorganisms, 1-st Dorozhny Proezd 1, Moscow 113545, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genetics of Microorganisms, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210163576"]},{"raw_affiliation_string":"Institute for Genetics of Microorganisms, 1-st Dorozhny Proezd 1, Moscow 113545, Russian Federation","institution_ids":["https://openalex.org/I4210163576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111542828","display_name":"A.Yu. Toptygin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A.Yu. Toptygin","raw_affiliation_strings":["Institute of Immunology of Russian Federation, Kashirskoye Shosse 24/2, Moscow 115478, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology of Russian Federation, Kashirskoye Shosse 24/2, Moscow 115478, Russian Federation","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018100825","display_name":"Abdijapar T. Shamshiev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163576","display_name":"Genetika","ror":"https://ror.org/05hr7qe62","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210163576"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A.T. Shamshiev","raw_affiliation_strings":["Institute for Genetics of Microorganisms, 1-st Dorozhny Proezd 1, Moscow 113545, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genetics of Microorganisms, 1-st Dorozhny Proezd 1, Moscow 113545, Russian Federation","institution_ids":["https://openalex.org/I4210163576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055967653","display_name":"Igor I. Agapov","orcid":"https://orcid.org/0000-0002-0273-4601","observed_orcids":["https://orcid.org/0000-0002-0273-4601"]},"institutions":[{"id":"https://openalex.org/I4210163576","display_name":"Genetika","ror":"https://ror.org/05hr7qe62","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210163576"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I.I. Agapov","raw_affiliation_strings":["Institute for Genetics of Microorganisms, 1-st Dorozhny Proezd 1, Moscow 113545, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genetics of Microorganisms, 1-st Dorozhny Proezd 1, Moscow 113545, Russian Federation","institution_ids":["https://openalex.org/I4210163576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083765264","display_name":"E.V. Ershova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163576","display_name":"Genetika","ror":"https://ror.org/05hr7qe62","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210163576"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E.V. Ershova","raw_affiliation_strings":["Institute for Genetics of Microorganisms, 1-st Dorozhny Proezd 1, Moscow 113545, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Genetics of Microorganisms, 1-st Dorozhny Proezd 1, Moscow 113545, Russian Federation","institution_ids":["https://openalex.org/I4210163576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061419899","display_name":"Uwe Pf\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155976169","display_name":"Witten/Herdecke University","ror":"https://ror.org/00yq55g44","country_code":"DE","type":"education","lineage":["https://openalex.org/I155976169"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U. Pfuller","raw_affiliation_strings":["AG Phytochemistry, University Witten/Herdecke, Berliner Allee 317/321, Berlin 0-1120, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AG Phytochemistry, University Witten/Herdecke, Berliner Allee 317/321, Berlin 0-1120, Germany","institution_ids":["https://openalex.org/I155976169"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026428225","display_name":"Karola Pf\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155976169","display_name":"Witten/Herdecke University","ror":"https://ror.org/00yq55g44","country_code":"DE","type":"education","lineage":["https://openalex.org/I155976169"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Pfuller","raw_affiliation_strings":["AG Phytochemistry, University Witten/Herdecke, Berliner Allee 317/321, Berlin 0-1120, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AG Phytochemistry, University Witten/Herdecke, Berliner Allee 317/321, Berlin 0-1120, Germany","institution_ids":["https://openalex.org/I155976169"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":0.1402,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.3830662,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"336","issue":"1","first_page":"100","last_page":"102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ricin-b-chain","display_name":"ricin B chain","score":0.9940000176429749},{"id":"https://openalex.org/keywords/chimeric-toxin","display_name":"chimeric toxin","score":0.9290000200271606},{"id":"https://openalex.org/keywords/disulfide-exchange","display_name":"disulfide exchange","score":0.8259999752044678},{"id":"https://openalex.org/keywords/ricin","display_name":"ricin","score":0.7360000014305115},{"id":"https://openalex.org/keywords/immunotoxins","display_name":"immunotoxins","score":0.734000027179718},{"id":"https://openalex.org/keywords/jurkat-cells","display_name":"Jurkat cells","score":0.7279999852180481},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/ammonium-chloride","display_name":"ammonium chloride","score":0.8130000233650208},{"id":"https://openalex.org/keywords/toxin-translocation","display_name":"toxin translocation","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C2777200438","wikidata":"https://www.wikidata.org/wiki/Q408668","display_name":"Ricin","level":3,"score":0.9950846433639526},{"id":"https://openalex.org/C115085202","wikidata":"https://www.wikidata.org/wiki/Q425665","display_name":"Immunotoxin","level":4,"score":0.8740894198417664},{"id":"https://openalex.org/C2780306569","wikidata":"https://www.wikidata.org/wiki/Q144940","display_name":"Viscum album","level":2,"score":0.76802659034729},{"id":"https://openalex.org/C2780758401","wikidata":"https://www.wikidata.org/wiki/Q408693","display_name":"Lectin","level":2,"score":0.7561295032501221},{"id":"https://openalex.org/C2779275196","wikidata":"https://www.wikidata.org/wiki/Q156691","display_name":"Loranthaceae","level":2,"score":0.587574303150177},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.5723485946655273},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.48154667019844055},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.4677474796772003},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4501032531261444},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42743033170700073},{"id":"https://openalex.org/C2780128948","wikidata":"https://www.wikidata.org/wiki/Q24788543","display_name":"Ribosome-inactivating protein","level":5,"score":0.41804391145706177},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.412501722574234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3611072897911072},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.31887152791023254},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15476343035697937},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.11110162734985352},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012276","descriptor_name":"Ricin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D012276","descriptor_name":"Ricin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014118","descriptor_name":"Toxins, Biological","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014118","descriptor_name":"Toxins, Biological","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014784","descriptor_name":"Mistletoe","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D028321","descriptor_name":"Plant Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D037102","descriptor_name":"Lectins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D037102","descriptor_name":"Lectins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D037121","descriptor_name":"Plant Lectins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054790","descriptor_name":"Ribosome Inactivating Proteins, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-5793(93)81618-a","doi":"https://doi.org/10.1016/0014-5793(93)81618-a","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(93)81618-a","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2893%2981618-A","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:8262189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8262189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/0014-5793(93)81618-a","doi":"https://doi.org/10.1016/0014-5793(93)81618-a","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(93)81618-a","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2893%2981618-A","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2045779019.pdf","grobid_xml":"https://content.openalex.org/works/W2045779019.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W192079772","https://openalex.org/W1586747665","https://openalex.org/W1976910216","https://openalex.org/W2009986190","https://openalex.org/W2012470334","https://openalex.org/W2033022173","https://openalex.org/W2061699262","https://openalex.org/W2080580789","https://openalex.org/W2094957574","https://openalex.org/W2112995653","https://openalex.org/W2163531642"],"related_works":["https://openalex.org/W1554758240","https://openalex.org/W1584944278","https://openalex.org/W1530321233","https://openalex.org/W2402434193","https://openalex.org/W1995792125","https://openalex.org/W2074569079","https://openalex.org/W226290658","https://openalex.org/W1980239810","https://openalex.org/W1976766249","https://openalex.org/W2070881297"],"abstract_inverted_index":{"Chimeric":[0,33],"toxin":[1,77],"protein":[2,23,34],"was":[3,35],"prepared":[4],"from":[5,95,100],"the":[6,16,54,60,87,91,101,105,112],"mistletoe":[7,43],"lectin":[8,44],"I":[9],"A-chain":[10,93],"and":[11,21,65,75],"ricin":[12,71,74,88,92],"B-chain":[13,89],"by":[14],"using":[15],"disulfide":[17],"exchange":[18],"reaction.":[19],"Ricin":[20],"chimeric":[22,76],"were":[24],"indistinguishable":[25],"in":[26,31],"binding":[27],"to":[28,38,104],"immobilized":[29],"asialofetuin":[30],"ELISA.":[32],"more":[36],"toxic":[37],"Jurkat":[39],"cells":[40],"than":[41],"native":[42,51],"I,":[45],"but":[46,67],"not":[47,69],"so":[48],"effective":[49],"as":[50],"ricin.":[52],"In":[53],"presence":[55],"of":[56,62],"NH4Cl,":[57],"which":[58],"enhances":[59],"toxicity":[61],"some":[63],"toxins":[64],"immunotoxins,":[66],"does":[68],"influence":[70],"toxicity,":[72],"both":[73],"had":[78],"equal":[79],"cytotoxic":[80],"activity.":[81],"The":[82],"possibility":[83],"is":[84,109],"discussed":[85],"that":[86],"protects":[90],"(RTA)":[94],"degradation":[96],"during":[97],"delivering":[98],"RTA":[99,108],"cell":[102],"surface":[103],"place":[106],"where":[107],"translocated":[110],"into":[111],"cytosol.":[113]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
