{"id":"https://openalex.org/W2045769692","doi":"https://doi.org/10.1054/mehy.2000.1103","title":"Alpha lipoic acid: a novel treatment for depression","display_name":"Alpha lipoic acid: a novel treatment for depression","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W2045769692","doi":"https://doi.org/10.1054/mehy.2000.1103","mag":"2045769692","pmid":"https://pubmed.ncbi.nlm.nih.gov/11090300"},"language":"en","primary_location":{"id":"doi:10.1054/mehy.2000.1103","doi":"https://doi.org/10.1054/mehy.2000.1103","is_oa":false,"landing_page_url":"https://doi.org/10.1054/mehy.2000.1103","pdf_url":null,"source":{"id":"https://openalex.org/S27514295","display_name":"Medical Hypotheses","issn_l":"0306-9877","issn":["0306-9877","1532-2777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Hypotheses","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M.R. Salazar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177605424","display_name":"Amherst College","ror":"https://ror.org/028vqfs63","country_code":"US","type":"education","lineage":["https://openalex.org/I177605424"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M.R. Salazar","raw_affiliation_strings":["Amherst College, Amherst, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amherst College, Amherst, Massachusetts, USA","institution_ids":["https://openalex.org/I177605424"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I177605424"],"apc_list":{"value":2820,"currency":"USD","value_usd":2820},"apc_paid":null,"fwci":0.5415,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.70766773,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"55","issue":"6","first_page":"510","last_page":"512"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.7538999915122986,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.7538999915122986,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.12290000170469284,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.11429999768733978,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-lipoic-acid","display_name":"alpha-lipoic acid","score":0.9760000109672546},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9089999794960022},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9769999980926514},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.8333731889724731},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.7621606588363647},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.648154079914093},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6293720006942749},{"id":"https://openalex.org/C2910140794","wikidata":"https://www.wikidata.org/wiki/Q312229","display_name":"Alpha-Lipoic Acid","level":3,"score":0.5912883877754211},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5647355318069458},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.5641108751296997},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.552705705165863},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5459782481193542},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5298005938529968},{"id":"https://openalex.org/C3017594256","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin sensitivity","level":4,"score":0.5246877074241638},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44753479957580566},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2723340392112732},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16277864575386047},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.12590143084526062},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1062152087688446},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.09365406632423401},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008063","descriptor_name":"Thioctic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1054/mehy.2000.1103","doi":"https://doi.org/10.1054/mehy.2000.1103","is_oa":false,"landing_page_url":"https://doi.org/10.1054/mehy.2000.1103","pdf_url":null,"source":{"id":"https://openalex.org/S27514295","display_name":"Medical Hypotheses","issn_l":"0306-9877","issn":["0306-9877","1532-2777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Hypotheses","raw_type":"journal-article"},{"id":"pmid:11090300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11090300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical hypotheses","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W7872492","https://openalex.org/W157140528","https://openalex.org/W186166836","https://openalex.org/W197043901","https://openalex.org/W201058876","https://openalex.org/W253326700","https://openalex.org/W641490350","https://openalex.org/W1448990868","https://openalex.org/W1571697300","https://openalex.org/W1717129987","https://openalex.org/W1974307538","https://openalex.org/W2000168251","https://openalex.org/W2006770638","https://openalex.org/W2007212760","https://openalex.org/W2026009458","https://openalex.org/W2026167623","https://openalex.org/W2028860498","https://openalex.org/W2030396551","https://openalex.org/W2030998472","https://openalex.org/W2034890147","https://openalex.org/W2035223521","https://openalex.org/W2035467074","https://openalex.org/W2039579026","https://openalex.org/W2042328265","https://openalex.org/W2043567599","https://openalex.org/W2048834744","https://openalex.org/W2051541240","https://openalex.org/W2052152340","https://openalex.org/W2062815987","https://openalex.org/W2081300445","https://openalex.org/W2081317398","https://openalex.org/W2082800304","https://openalex.org/W2094812201","https://openalex.org/W2101288743","https://openalex.org/W2112886079","https://openalex.org/W2115326907","https://openalex.org/W2163132131","https://openalex.org/W2269159367","https://openalex.org/W2279813448","https://openalex.org/W2405149675","https://openalex.org/W2466386647","https://openalex.org/W2892067986","https://openalex.org/W4300456437"],"related_works":["https://openalex.org/W2062725752","https://openalex.org/W2007212760","https://openalex.org/W3088780152","https://openalex.org/W2165544678","https://openalex.org/W6945493330","https://openalex.org/W2794378602","https://openalex.org/W2058599021","https://openalex.org/W7010486673","https://openalex.org/W3016121734","https://openalex.org/W2385467376"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
