{"id":"https://openalex.org/W2045731806","doi":"https://doi.org/10.4155/cli.14.106","title":"Application of biomarkers in oncology clinical trials","display_name":"Application of biomarkers in oncology clinical trials","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2045731806","doi":"https://doi.org/10.4155/cli.14.106","mag":"2045731806"},"language":"en","primary_location":{"id":"doi:10.4155/cli.14.106","doi":"https://doi.org/10.4155/cli.14.106","is_oa":false,"landing_page_url":"https://doi.org/10.4155/cli.14.106","pdf_url":null,"source":{"id":"https://openalex.org/S2765044866","display_name":"Clinical Investigation","issn_l":"2041-6792","issn":["2041-6792","2041-6806"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060056480","display_name":"Naveen K. Dakappagari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naveen Dakappagari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050365976","display_name":"Hua C. Gong","orcid":"https://orcid.org/0000-0002-5853-1950","observed_orcids":["https://orcid.org/0000-0002-5853-1950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Gong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001779249","display_name":"Reinhold Pollner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reinhold Pollner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111686301","display_name":"Amara C. Siva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amara Siva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039685591","display_name":"Shabnam Tangri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shabnam Tangri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005645056","display_name":"Jelveh Lameh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jelveh Lameh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.05115132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"5","issue":"1","first_page":"61","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.053599998354911804,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.02319999970495701,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cancer-clinical-trials","display_name":"cancer clinical trials","score":0.9860000014305115},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.9509999752044678},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.7200000286102295},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.6000000238418579},{"id":"https://openalex.org/keywords/genetic-assays","display_name":"genetic assays","score":0.7850000262260437},{"id":"https://openalex.org/keywords/protein-biomarkers","display_name":"protein biomarkers","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cancer-therapeutics","display_name":"cancer therapeutics","score":0.8989999890327454},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.5519999861717224},{"id":"https://openalex.org/keywords/biomarker-monitoring","display_name":"biomarker monitoring","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8698190450668335},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.552070677280426},{"id":"https://openalex.org/C2776598537","wikidata":"https://www.wikidata.org/wiki/Q1812651","display_name":"Clinical Oncology","level":3,"score":0.49695995450019836},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.49317115545272827},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4221465587615967},{"id":"https://openalex.org/C3020497934","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision oncology","level":3,"score":0.41718846559524536},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.40822768211364746},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2563830018043518}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4155/cli.14.106","doi":"https://doi.org/10.4155/cli.14.106","is_oa":false,"landing_page_url":"https://doi.org/10.4155/cli.14.106","pdf_url":null,"source":{"id":"https://openalex.org/S2765044866","display_name":"Clinical Investigation","issn_l":"2041-6792","issn":["2041-6792","2041-6806"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Investigation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W1638379","https://openalex.org/W183254587","https://openalex.org/W1503621113","https://openalex.org/W1527161131","https://openalex.org/W1543099628","https://openalex.org/W1557439734","https://openalex.org/W1652033010","https://openalex.org/W1808567889","https://openalex.org/W1964044574","https://openalex.org/W1965277715","https://openalex.org/W1966420013","https://openalex.org/W1966581896","https://openalex.org/W1966956946","https://openalex.org/W1969216373","https://openalex.org/W1980004701","https://openalex.org/W1987009448","https://openalex.org/W1995830102","https://openalex.org/W1996409634","https://openalex.org/W1999403469","https://openalex.org/W2002937040","https://openalex.org/W2003984225","https://openalex.org/W2015162631","https://openalex.org/W2017270259","https://openalex.org/W2017350973","https://openalex.org/W2017952818","https://openalex.org/W2019931839","https://openalex.org/W2026125236","https://openalex.org/W2031510245","https://openalex.org/W2033560619","https://openalex.org/W2043071900","https://openalex.org/W2043696829","https://openalex.org/W2046911066","https://openalex.org/W2049426761","https://openalex.org/W2056979759","https://openalex.org/W2057353356","https://openalex.org/W2065799563","https://openalex.org/W2072010297","https://openalex.org/W2074651601","https://openalex.org/W2079216025","https://openalex.org/W2082927057","https://openalex.org/W2092784580","https://openalex.org/W2093613683","https://openalex.org/W2098223440","https://openalex.org/W2099200814","https://openalex.org/W2099385154","https://openalex.org/W2099871686","https://openalex.org/W2100302724","https://openalex.org/W2102792851","https://openalex.org/W2104696401","https://openalex.org/W2104830962","https://openalex.org/W2106789440","https://openalex.org/W2110278085","https://openalex.org/W2111609050","https://openalex.org/W2116343277","https://openalex.org/W2120018526","https://openalex.org/W2120326191","https://openalex.org/W2120490763","https://openalex.org/W2121158863","https://openalex.org/W2121389354","https://openalex.org/W2128542677","https://openalex.org/W2128792706","https://openalex.org/W2130488043","https://openalex.org/W2133105825","https://openalex.org/W2138604360","https://openalex.org/W2138709799","https://openalex.org/W2138713106","https://openalex.org/W2139236349","https://openalex.org/W2139260559","https://openalex.org/W2141149378","https://openalex.org/W2143047270","https://openalex.org/W2146968545","https://openalex.org/W2148332636","https://openalex.org/W2148377031","https://openalex.org/W2153520524","https://openalex.org/W2156824251","https://openalex.org/W2157694607","https://openalex.org/W2160363302","https://openalex.org/W2161821474","https://openalex.org/W2164837623","https://openalex.org/W2165574508","https://openalex.org/W2167550136","https://openalex.org/W2169816570","https://openalex.org/W2170302964","https://openalex.org/W2171237493","https://openalex.org/W2275311108","https://openalex.org/W2407901362","https://openalex.org/W2579829632","https://openalex.org/W2943433104"],"related_works":["https://openalex.org/W2035275576","https://openalex.org/W3096007184","https://openalex.org/W2101768284","https://openalex.org/W1846328250","https://openalex.org/W4287009981","https://openalex.org/W4392709614","https://openalex.org/W2996141946","https://openalex.org/W2299795119","https://openalex.org/W2143119140","https://openalex.org/W7118071041"],"abstract_inverted_index":{"Technological":[0,66],"advancement":[1],"and":[2,49,80,96,102],"the":[3,23,30,41,57,74,83,92,100,121],"discovery":[4],"of":[5,25,32,43,77,85,94,104,123],"various":[6],"biomarkers":[7,105],"have":[8,17],"made":[9],"personalized/precision":[10],"medicine":[11,34],"a":[12,35],"reality.":[13],"Thus,":[14],"pharmaceutical":[15],"companies":[16],"targeted":[18],"many":[19],"deregulated":[20],"pathways":[21],"for":[22,37,62,99,120],"development":[24,122],"specific":[26,86],"cancer":[27,38,45,125],"therapeutics,":[28],"making":[29],"practice":[31],"precision":[33],"reality":[36],"patients.":[39],"With":[40],"exploration":[42],"novel":[44],"therapies,":[46],"advanced":[47],"genetic-":[48,95],"protein-based":[50,97],"assays":[51],"are":[52,60,68],"used":[53],"to":[54,72],"ensure":[55],"that":[56],"correct":[58],"patients":[59],"selected":[61],"each":[63,78],"clinical":[64,108],"trial.":[65],"tools":[67,119],"applied":[69],"in":[70,82,106],"order":[71],"assess":[73],"genetic":[75],"makeup":[76],"patient":[79],"changes":[81],"expression":[84],"protein":[87],"biomarkers.":[88],"Here,":[89],"we":[90,111],"describe":[91],"utility":[93],"technologies":[98],"identification":[101],"monitoring":[103],"oncology":[107],"trials.":[109],"Moreover,":[110],"discuss":[112],"how":[113],"technological":[114],"advances":[115],"may":[116],"serve":[117],"as":[118],"future":[124],"therapeutics.":[126]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
