{"id":"https://openalex.org/W2045709794","doi":"https://doi.org/10.1152/ajpregu.00576.2004","title":"Age-related differences in apoptosis with disuse atrophy in soleus muscle","display_name":"Age-related differences in apoptosis with disuse atrophy in soleus muscle","publication_year":2005,"publication_date":"2005-01-14","ids":{"openalex":"https://openalex.org/W2045709794","doi":"https://doi.org/10.1152/ajpregu.00576.2004","mag":"2045709794","pmid":"https://pubmed.ncbi.nlm.nih.gov/15650125"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.00576.2004","doi":"https://doi.org/10.1152/ajpregu.00576.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00576.2004","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028177578","display_name":"Christiaan Leeuwenburgh","orcid":"https://orcid.org/0000-0003-0826-4257","observed_orcids":["https://orcid.org/0000-0003-0826-4257"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christiaan Leeuwenburgh","raw_affiliation_strings":["Biochemistry of Aging Laboratory and Department of Aging and Geriatric Research, University of Florida, Gainesville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry of Aging Laboratory and Department of Aging and Geriatric Research, University of Florida, Gainesville, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026785684","display_name":"Cathy M. Gurley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cathy M. Gurley","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008460213","display_name":"Beau A. Strotman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beau A. Strotman","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050841546","display_name":"Esther E. Dupont\u2010Versteegden","orcid":"https://orcid.org/0000-0001-5576-9659","observed_orcids":["https://orcid.org/0000-0001-5576-9659"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Esther E. Dupont-Versteegden","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.4719,"has_fulltext":false,"cited_by_count":234,"citation_normalized_percentile":{"value":0.97407234,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"288","issue":"5","first_page":"R1288","last_page":"R1296"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.753000020980835},{"id":"https://openalex.org/keywords/disuse-muscle-atrophy","display_name":"disuse atrophy","score":0.871999979019165},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/soleus-muscle","display_name":"soleus muscle","score":0.875},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7689999938011169},{"id":"https://openalex.org/keywords/hindlimb-unloading","display_name":"hindlimb unloading","score":0.9760000109672546},{"id":"https://openalex.org/keywords/myonuclear-domain","display_name":"myonuclear domain","score":0.9509999752044678},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9179999828338623},{"id":"https://openalex.org/keywords/endonuclease-g","display_name":"endonuclease G","score":0.8669999837875366},{"id":"https://openalex.org/keywords/mitochondrial-translocation","display_name":"mitochondrial translocation","score":0.746999979019165},{"id":"https://openalex.org/keywords/subsarcolemmal-mitochondria","display_name":"subsarcolemmal mitochondria","score":0.8849999904632568},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.6010000109672546},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C2776104385","wikidata":"https://www.wikidata.org/wiki/Q1954164","display_name":"Soleus muscle","level":3,"score":0.7441805601119995},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7059954404830933},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6914073824882507},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.6845241785049438},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.6319577097892761},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6291553378105164},{"id":"https://openalex.org/C51738704","wikidata":"https://www.wikidata.org/wiki/Q5766112","display_name":"Hindlimb","level":2,"score":0.4815950095653534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47087275981903076},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.43703216314315796},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.41085392236709595},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3461993336677551},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22553303837776184},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10685691237449646},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004706","descriptor_name":"Endodeoxyribonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006614","descriptor_name":"Hindlimb","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011914","descriptor_name":"Rats, Inbred BN","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpregu.00576.2004","doi":"https://doi.org/10.1152/ajpregu.00576.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00576.2004","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmid:15650125","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15650125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Regulatory, integrative and comparative physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.321.3169","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.321.3169","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajpregu.physiology.org/content/early/2005/01/13/ajpregu.00576.2004.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1144019503","display_name":"Impaired Regulation of Muscle size with Aging","funder_award_id":"R03AG020407","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2943345296","display_name":"Muscle and Bone Maintenance in Hindlimb Suspended Rats","funder_award_id":"R01AR047577","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5672409827","display_name":"Apoptosis and Life-Long Caloric Restriction","funder_award_id":"R01AG021042","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W856233817","https://openalex.org/W1480948328","https://openalex.org/W1735876586","https://openalex.org/W1814652372","https://openalex.org/W1850312794","https://openalex.org/W1887455807","https://openalex.org/W1967912613","https://openalex.org/W1970295191","https://openalex.org/W1975884987","https://openalex.org/W1976166977","https://openalex.org/W1977724043","https://openalex.org/W1980417783","https://openalex.org/W1984419476","https://openalex.org/W1987892459","https://openalex.org/W1996177324","https://openalex.org/W1997546274","https://openalex.org/W1998826441","https://openalex.org/W2001425392","https://openalex.org/W2006520769","https://openalex.org/W2007604900","https://openalex.org/W2014582629","https://openalex.org/W2016762118","https://openalex.org/W2016952113","https://openalex.org/W2025104722","https://openalex.org/W2026711486","https://openalex.org/W2031405037","https://openalex.org/W2033652837","https://openalex.org/W2034114409","https://openalex.org/W2034728632","https://openalex.org/W2041991145","https://openalex.org/W2042533702","https://openalex.org/W2045846836","https://openalex.org/W2054836913","https://openalex.org/W2055130924","https://openalex.org/W2060725618","https://openalex.org/W2067511188","https://openalex.org/W2074595210","https://openalex.org/W2078593257","https://openalex.org/W2087261949","https://openalex.org/W2090232685","https://openalex.org/W2093355627","https://openalex.org/W2095468287","https://openalex.org/W2102010332","https://openalex.org/W2113701180","https://openalex.org/W2115596499","https://openalex.org/W2117324772","https://openalex.org/W2119227182","https://openalex.org/W2124358693","https://openalex.org/W2128635872","https://openalex.org/W2129228740","https://openalex.org/W2131565699","https://openalex.org/W2133944868","https://openalex.org/W2135817592","https://openalex.org/W2139267283","https://openalex.org/W2140913717","https://openalex.org/W2156265674","https://openalex.org/W2162539094","https://openalex.org/W2162595307","https://openalex.org/W2162808674","https://openalex.org/W2165534500","https://openalex.org/W2168607364","https://openalex.org/W2176966894","https://openalex.org/W2184471213","https://openalex.org/W2184656706","https://openalex.org/W2270230062","https://openalex.org/W2287505356","https://openalex.org/W4240654071","https://openalex.org/W4297573836"],"related_works":["https://openalex.org/W7097317198","https://openalex.org/W2099168858","https://openalex.org/W2135817592","https://openalex.org/W2086253350","https://openalex.org/W7097140945","https://openalex.org/W2021080095","https://openalex.org/W2085718517","https://openalex.org/W1992604738","https://openalex.org/W2088184393","https://openalex.org/W2254502980"],"abstract_inverted_index":{"Muscle":[0],"atrophy":[1,46,56],"is":[2,274],"associated":[3,65],"with":[4,66,99,134,141,157,167],"a":[5,83,187],"loss":[6,67],"of":[7,22,27,51,68,74,108,123,235,248],"muscle":[8,26,59,73,152,234,255,273],"fiber":[9],"nuclei,":[10],"most":[11],"likely":[12],"through":[13,281],"apoptosis.":[14],"We":[15],"investigated":[16],"age-related":[17],"differences":[18],"in":[19,24,58,71,82,86,94,104,120,136,145,150,173,192,196,205,221,232,252,261,265,271,287],"the":[20,87,142,182,193,202,258,278,285],"extent":[21],"apoptosis":[23,109,262],"soleus":[25,72,121,151,233],"young":[28,95,128,137,222,266],"(6":[29],"mo)":[30,34],"and":[31,61,96,115,138,199,223,256,267],"old":[32,97,105,124,139,146,224,253,268],"(32":[33],"male":[35],"Fischer":[36],"344":[37],"x":[38],"Brown":[39],"Norway":[40],"rats":[41,126,240],"subjected":[42],"to":[43,154,201,284,289],"acute":[44],"disuse":[45],"induced":[47],"by":[48,277],"14":[49],"days":[50],"hindlimb":[52],"suspension":[53],"(HS).":[54],"HS-induced":[55],"(reduction":[57],"weight":[60],"cross-sectional":[62],"area)":[63],"was":[64,190,213],"myofiber":[69],"nuclei":[70],"young,":[75,174,209,239],"but":[76,159,175,207,227,237],"not":[77,162,176,208,238],"old,":[78,177,206,236],"rats.":[79,178],"This":[80],"resulted":[81],"significant":[84,164],"decrease":[85],"myonuclear":[88,249],"domain":[89],"(cross-sectional":[90],"area":[91],"per":[92],"nucleus)":[93],"rats,":[98,140,226],"changes":[100,144,160],"being":[101],"more":[102],"pronounced":[103],"animals.":[106,129,147,211],"Levels":[107,130],"(TdT-mediated":[110],"dUTP":[111],"nick":[112],"end":[113],"labeling":[114],"DNA":[116],"fragmentation)":[117],"were":[118,131,161],"higher":[119],"muscles":[122],"control":[125,197,210,225],"than":[127],"significantly":[132,171],"increased":[133,156,172,229],"HS":[135],"greatest":[143],"Caspase-3":[148],"activity":[149,170],"tended":[153],"be":[155],"age,":[158],"statistically":[163],"(P=0.052).":[165],"However,":[166],"HS,":[168],"caspase-3":[169],"Immunohistochemistry":[179],"showed":[180],"that":[181,246,257],"proapoptotic":[183],"endonuclease":[184],"G":[185],"(EndoG,":[186],"mitochondrion-specific":[188],"nuclease)":[189],"localized":[191],"subsarcolemmal":[194,279],"mitochondria":[195,280],"muscles,":[198],"translocation":[200,283],"nucleus":[203,286],"occurred":[204],"There":[212],"no":[214],"difference":[215],"between":[216],"EndoG":[217,228,282],"total":[218],"protein":[219],"content":[220],"almost":[230],"fivefold":[231],"after":[241],"HS.":[242,290],"These":[243],"results":[244],"show":[245],"deregulation":[247],"number":[250],"occurs":[251],"skeletal":[254,272],"pathways":[259],"involved":[260],"are":[263],"distinct":[264],"muscles.":[269],"Apoptosis":[270],"partly":[275],"mediated":[276],"response":[288]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
