{"id":"https://openalex.org/W2045651986","doi":"https://doi.org/10.1016/j.biopsych.2005.04.026","title":"Studies of Humoral Immunity to Preprohypocretin in Human Leukocyte Antigen DQB1*0602\u2013Positive Narcoleptic Subjects with Cataplexy","display_name":"Studies of Humoral Immunity to Preprohypocretin in Human Leukocyte Antigen DQB1*0602\u2013Positive Narcoleptic Subjects with Cataplexy","publication_year":2005,"publication_date":"2005-07-26","ids":{"openalex":"https://openalex.org/W2045651986","doi":"https://doi.org/10.1016/j.biopsych.2005.04.026","mag":"2045651986","pmid":"https://pubmed.ncbi.nlm.nih.gov/16043129"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopsych.2005.04.026","doi":"https://doi.org/10.1016/j.biopsych.2005.04.026","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biopsych.2005.04.026","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062965638","display_name":"John Logan Black","orcid":"https://orcid.org/0000-0001-6726-7293","observed_orcids":["https://orcid.org/0000-0001-6726-7293"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John L. Black","raw_affiliation_strings":["Psychogenomics Laboratory, Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. black.john@mayo.edu","Psychogenomics Laboratory, Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychogenomics Laboratory, Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. black.john@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Psychogenomics Laboratory, Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062672802","display_name":"Michael H. Silber","orcid":"https://orcid.org/0000-0002-6529-5773","observed_orcids":["https://orcid.org/0000-0002-6529-5773"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael H. Silber","raw_affiliation_strings":["Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota","Mayo Sleep Disorders Center, Mayo Clinic College of Medicine, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Sleep Disorders Center, Mayo Clinic College of Medicine, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032351428","display_name":"Lois E. Krahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lois E. Krahn","raw_affiliation_strings":["Department of Psychiatry and Psychology and Mayo Sleep Disorders Laboratory, Mayo Clinic College of Medicine, Scottsdale, Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychology and Mayo Sleep Disorders Laboratory, Mayo Clinic College of Medicine, Scottsdale, Arizona","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079635965","display_name":"Rajeswari Avula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajeswari K. Avula","raw_affiliation_strings":["Psychogenomics Laboratory, Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychogenomics Laboratory, Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109808350","display_name":"Denise L. Walker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise L. Walker","raw_affiliation_strings":["Psychogenomics Laboratory, Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychogenomics Laboratory, Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088891117","display_name":"V. Shane Pankratz","orcid":"https://orcid.org/0000-0002-3742-040X","observed_orcids":["https://orcid.org/0000-0002-3742-040X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Shane Pankratz","raw_affiliation_strings":["Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070646800","display_name":"Paul A. Fredrickson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A. Fredrickson","raw_affiliation_strings":["Department of Psychiatry and Psychology and Mayo Sleep Disorders Laboratory, Mayo Clinic College of Medicine, Jacksonville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychology and Mayo Sleep Disorders Laboratory, Mayo Clinic College of Medicine, Jacksonville, Florida","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012662745","display_name":"Nancy L. Slocumb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy L. Slocumb","raw_affiliation_strings":["Mayo Sleep Disorders Center, Mayo Clinic College of Medicine, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Sleep Disorders Center, Mayo Clinic College of Medicine, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062965638"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":5489,"currency":"USD","value_usd":5489},"apc_paid":null,"fwci":2.3054,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.86589475,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"58","issue":"6","first_page":"504","last_page":"509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/narcolepsy-type-1","display_name":"narcolepsy type 1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/orexin","display_name":"orexin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hla-dqb1-0602","display_name":"HLA-DQB1*0602","score":0.9309999942779541},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.8949999809265137},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.8050000071525574},{"id":"https://openalex.org/keywords/hypocretin-receptor-2","display_name":"hypocretin receptor 2","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.824999988079071},{"id":"https://openalex.org/keywords/orexin-a","display_name":"orexin-A","score":0.8339999914169312},{"id":"https://openalex.org/keywords/hypocretin-2","display_name":"hypocretin-2","score":0.9879999756813049},{"id":"https://openalex.org/keywords/autoimmune-hypothesis","display_name":"autoimmune hypothesis","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C2780163352","wikidata":"https://www.wikidata.org/wiki/Q944473","display_name":"Cataplexy","level":4,"score":0.5964742302894592},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5621650218963623},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.5371599197387695},{"id":"https://openalex.org/C2779494582","wikidata":"https://www.wikidata.org/wiki/Q189561","display_name":"Narcolepsy","level":3,"score":0.5362064242362976},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4979403018951416},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4227331578731537},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4056370258331299},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35682129859924316},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.14673393964767456},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068797","descriptor_name":"Orexins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D002385","descriptor_name":"Cataplexy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002385","descriptor_name":"Cataplexy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002385","descriptor_name":"Cataplexy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006683","descriptor_name":"HLA-DQ Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006683","descriptor_name":"HLA-DQ Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009290","descriptor_name":"Narcolepsy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009290","descriptor_name":"Narcolepsy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009290","descriptor_name":"Narcolepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D059866","descriptor_name":"HLA-DQ beta-Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biopsych.2005.04.026","doi":"https://doi.org/10.1016/j.biopsych.2005.04.026","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biopsych.2005.04.026","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},{"id":"pmid:16043129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16043129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological psychiatry","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7099999785423279}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G653381835","display_name":"Hypocretin System Immune Diathesis in Human Narcolepsy","funder_award_id":"R01MH062599","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8988331127","display_name":null,"funder_award_id":"MH62599","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W167596909","https://openalex.org/W1154395573","https://openalex.org/W1519232679","https://openalex.org/W1569665048","https://openalex.org/W1831184030","https://openalex.org/W1893651774","https://openalex.org/W1983298714","https://openalex.org/W2012430463","https://openalex.org/W2013802173","https://openalex.org/W2036201159","https://openalex.org/W2037455416","https://openalex.org/W2040700968","https://openalex.org/W2047139729","https://openalex.org/W2049088920","https://openalex.org/W2072154498","https://openalex.org/W2093954030","https://openalex.org/W2119279851","https://openalex.org/W2120006319","https://openalex.org/W2159953069","https://openalex.org/W2166288538","https://openalex.org/W2166763835","https://openalex.org/W2168219052","https://openalex.org/W2169378022","https://openalex.org/W2412705706","https://openalex.org/W4299579025","https://openalex.org/W6603669592","https://openalex.org/W6677865079"],"related_works":["https://openalex.org/W2412705706","https://openalex.org/W1569665048","https://openalex.org/W2066390219","https://openalex.org/W167596909","https://openalex.org/W2329431982","https://openalex.org/W4239791223","https://openalex.org/W2914964760","https://openalex.org/W2086295255","https://openalex.org/W2183787133","https://openalex.org/W219972809"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}