{"id":"https://openalex.org/W2045645945","doi":"https://doi.org/10.1002/pros.21345","title":"G\u2010protein alpha\u2010s and \u201012 subunits are involved in androgen\u2010stimulated PI3K activation and androgen receptor transactivation in prostate cancer cells","display_name":"G\u2010protein alpha\u2010s and \u201012 subunits are involved in androgen\u2010stimulated PI3K activation and androgen receptor transactivation in prostate cancer cells","publication_year":2011,"publication_date":"2011-02-09","ids":{"openalex":"https://openalex.org/W2045645945","doi":"https://doi.org/10.1002/pros.21345","mag":"2045645945","pmid":"https://pubmed.ncbi.nlm.nih.gov/21308712","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3143312"},"language":"en","primary_location":{"id":"doi:10.1002/pros.21345","doi":"https://doi.org/10.1002/pros.21345","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pros.21345","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3143312","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073453429","display_name":"Jianjun Liu","orcid":"https://orcid.org/0000-0003-1880-9230","observed_orcids":["https://orcid.org/0000-0003-1880-9230"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]},{"id":"https://openalex.org/I4210158865","display_name":"Affiliated Hospital of Guangdong Medical College Hospital","ror":"https://ror.org/057p7h461","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianjun Liu","raw_affiliation_strings":["Department of Urology, the Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, the Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China","institution_ids":["https://openalex.org/I176834541","https://openalex.org/I4210158865"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069655482","display_name":"Hyewon Youn","orcid":"https://orcid.org/0000-0003-1006-2689","observed_orcids":["https://orcid.org/0000-0003-1006-2689"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Hyewon Youn","raw_affiliation_strings":["Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea","Department of Urology, the University of Kansas Medical Center, Kansas City, Kansas","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Department of Urology, the University of Kansas Medical Center, Kansas City, Kansas","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101846977","display_name":"Jun Yang","orcid":"https://orcid.org/0000-0003-3261-5774","observed_orcids":["https://orcid.org/0000-0003-3261-5774"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]},{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jun Yang","raw_affiliation_strings":["Department of Urology, Tongji Hospital, Huazhong University of Science & Technology, Wuhan, Hubei, China","Department of Urology, the University of Kansas Medical Center, Kansas City, Kansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Tongji Hospital, Huazhong University of Science & Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]},{"raw_affiliation_string":"Department of Urology, the University of Kansas Medical Center, Kansas City, Kansas","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006180330","display_name":"Ningchao Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]},{"id":"https://openalex.org/I4210158865","display_name":"Affiliated Hospital of Guangdong Medical College Hospital","ror":"https://ror.org/057p7h461","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ningchao Du","raw_affiliation_strings":["Department of Urology, the Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, the Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China","institution_ids":["https://openalex.org/I176834541","https://openalex.org/I4210158865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100422746","display_name":"Jihong Liu","orcid":"https://orcid.org/0000-0001-9711-2428","observed_orcids":["https://orcid.org/0000-0001-9711-2428"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]},{"id":"https://openalex.org/I4210158865","display_name":"Affiliated Hospital of Guangdong Medical College Hospital","ror":"https://ror.org/057p7h461","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158865"]},{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jihong Liu","raw_affiliation_strings":["Department of Urology, the Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China","Department of Urology, Tongji Hospital, Huazhong University of Science & Technology, Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, the Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China","institution_ids":["https://openalex.org/I176834541","https://openalex.org/I4210158865"]},{"raw_affiliation_string":"Department of Urology, Tongji Hospital, Huazhong University of Science & Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100411954","display_name":"Hongwei Liu","orcid":"https://orcid.org/0000-0002-6466-926X","observed_orcids":["https://orcid.org/0000-0002-6466-926X"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]},{"id":"https://openalex.org/I4210158865","display_name":"Affiliated Hospital of Guangdong Medical College Hospital","ror":"https://ror.org/057p7h461","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongwei Liu","raw_affiliation_strings":["Department of Urology, the Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, the Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China","institution_ids":["https://openalex.org/I176834541","https://openalex.org/I4210158865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084681260","display_name":"Benyi Li","orcid":"https://orcid.org/0000-0001-6242-5117","observed_orcids":["https://orcid.org/0000-0001-6242-5117"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]},{"id":"https://openalex.org/I4210158865","display_name":"Affiliated Hospital of Guangdong Medical College Hospital","ror":"https://ror.org/057p7h461","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158865"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Benyi Li","raw_affiliation_strings":["Department of Urology, the Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China","Department of Urology, the University of Kansas Medical Center, Kansas City, Kansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, the Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China","institution_ids":["https://openalex.org/I176834541","https://openalex.org/I4210158865"]},{"raw_affiliation_string":"Department of Urology, the University of Kansas Medical Center, Kansas City, Kansas","institution_ids":["https://openalex.org/I4210128618"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5084681260"],"corresponding_institution_ids":["https://openalex.org/I176834541","https://openalex.org/I4210128618","https://openalex.org/I4210158865"],"apc_list":{"value":4600,"currency":"USD","value_usd":4600},"apc_paid":null,"fwci":1.3596,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.82630364,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"71","issue":"12","first_page":"1276","last_page":"1286"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9480000138282776},{"id":"https://openalex.org/keywords/pi3k-p110beta","display_name":"PI3K p110\u03b2","score":0.921999990940094},{"id":"https://openalex.org/keywords/pi3k-activation","display_name":"PI3K activation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/androgen-receptor-transactivation","display_name":"androgen receptor transactivation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8790000081062317},{"id":"https://openalex.org/keywords/caveolae","display_name":"caveolae","score":0.9700000286102295},{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/caveolin-2","display_name":"caveolin-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/androgen-signaling","display_name":"androgen signaling","score":0.6880000233650208},{"id":"https://openalex.org/keywords/prostate-specific-antigen-promoter","display_name":"prostate-specific antigen promoter","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5839999914169312},{"id":"https://openalex.org/keywords/castration-resistance","display_name":"castration resistance","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.956483006477356},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.8280079364776611},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49832773208618164},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.49674588441848755},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4691668450832367},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.46878278255462646},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.42647719383239746},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39534732699394226},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.39221203327178955},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3597647547721863},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26456594467163086},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.2239849865436554},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.20326486229896545},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19242286682128906},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0822848379611969},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0768948495388031},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.060776352882385254},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.05535680055618286},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015741","descriptor_name":"Metribolone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019205","descriptor_name":"GTP-Binding Protein alpha Subunits, Gs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021941","descriptor_name":"Caveolae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044365","descriptor_name":"GTP-Binding Protein alpha Subunits, G12-G13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058543","descriptor_name":"Class Ia Phosphatidylinositol 3-Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/pros.21345","doi":"https://doi.org/10.1002/pros.21345","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pros.21345","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},{"id":"pmid:21308712","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21308712","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2433024","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3143312","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3143312","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3143312","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Prostate","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2433024","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3143312","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1330308381","display_name":null,"funder_award_id":"1-P20-RR15563","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G229183575","display_name":null,"funder_award_id":"P20-RR015563","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G343181842","display_name":"Center for Cancer Experimental Therapeutics","funder_award_id":"5p20rr015563-08","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306985","display_name":"Kansas Masonic Foundation","ror":"https://ror.org/018611e81"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1965865405","https://openalex.org/W1980006154","https://openalex.org/W1987950628","https://openalex.org/W1988679331","https://openalex.org/W1995375125","https://openalex.org/W1999640678","https://openalex.org/W2000337048","https://openalex.org/W2005614924","https://openalex.org/W2005658600","https://openalex.org/W2014031706","https://openalex.org/W2027239007","https://openalex.org/W2033031708","https://openalex.org/W2043223273","https://openalex.org/W2043236550","https://openalex.org/W2052307676","https://openalex.org/W2056287665","https://openalex.org/W2062164878","https://openalex.org/W2064059449","https://openalex.org/W2064293531","https://openalex.org/W2068319312","https://openalex.org/W2072891243","https://openalex.org/W2073101309","https://openalex.org/W2075657886","https://openalex.org/W2077863736","https://openalex.org/W2078400569","https://openalex.org/W2081365151","https://openalex.org/W2083451024","https://openalex.org/W2095480781","https://openalex.org/W2114481572","https://openalex.org/W2119207552","https://openalex.org/W2124245112","https://openalex.org/W2132869487","https://openalex.org/W2134454666","https://openalex.org/W2146352944","https://openalex.org/W2147110251","https://openalex.org/W2163021406","https://openalex.org/W2164858484","https://openalex.org/W2168609045","https://openalex.org/W2170913213","https://openalex.org/W2172223287"],"related_works":["https://openalex.org/W2027239007","https://openalex.org/W2083451024","https://openalex.org/W2083234838","https://openalex.org/W2143382696","https://openalex.org/W153660547","https://openalex.org/W2074338805","https://openalex.org/W80505981","https://openalex.org/W2189716845","https://openalex.org/W652928385","https://openalex.org/W2043236550"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,125],"androgen":[2,51,73,215],"receptor":[3],"(AR)":[4],"is":[5],"a":[6],"ligand-dependent":[7],"transcription":[8],"factor":[9],"that":[10,42,236,260],"mediates":[11],"androgenic":[12],"hormone":[13],"action":[14],"in":[15,28,121,244,267],"cells.":[16],"We":[17],"recently":[18],"demonstrated":[19],"the":[20,39,65,104,137,142,167,210,249,272],"involvement":[21],"of":[22,144,194,204,214,274],"phosphoinositide":[23],"3-OH":[24],"kinase":[25,115,123],"(PI3K)":[26],"p110beta":[27,230],"AR":[29,48,67,152,173,187,202,211,246,250,268],"transactivation":[30,49,68,153,188,269],"and":[31,47,58,86,109,154,178,189],"gene":[32,155,252],"expression.":[33,156],"In":[34],"this":[35],"study,":[36],"we":[37],"determined":[38,129],"upstream":[40],"signals":[41],"lead":[43],"to":[44,212],"PI3K/p110beta":[45],"activation":[46],"after":[50],"stimulation.":[52],"METHODS:":[53],"Human":[54],"prostate":[55],"cancer":[56],"LAPC-4":[57],"22Rv1":[59],"cell":[60,190],"lines":[61],"were":[62,91,117],"used":[63],"for":[64],"experiments.":[66],"was":[69,81,101,128],"assessed":[70],"using":[71,83,93,119,130],"an":[72],"responsive":[74],"element-driven":[75],"luciferase":[76],"(ARE-LUC)":[77],"assay.":[78,124,133],"Cell":[79],"proliferation":[80],"examined":[82],"BrdU":[84],"incorporation":[85],"MTT":[87],"assays.":[88],"Target":[89],"genes":[90,180],"silenced":[92],"small":[94],"interfering":[95],"RNA":[96],"(siRNA)":[97],"approach.":[98],"Gene":[99],"expression":[100],"evaluated":[102],"at":[103,136],"mRNA":[105],"level":[106,111],"(real-time":[107],"RT-PCR)":[108],"protein":[110],"(Western":[112],"blot).":[113],"PI3K":[114,229,276],"activities":[116,273],"measured":[118],"immunoprecipitation-based":[120],"vitro":[122],"AR-DNA-binding":[126],"activity":[127],"chromatin-immunoprecipitation":[131],"(ChIP)":[132],"RESULTS:":[134],"First,":[135],"cellular":[138],"plasma":[139],"membrane,":[140],"disrupting":[141],"integrity":[143],"caveolae":[145,160],"microdomain":[146],"with":[147,166,248],"methyl-\u03b2-cyclodextrin":[148],"(M-\u03b2-CD)":[149],"abolished":[150],"androgen-induced":[151,172,186,201,245],"Then,":[157],"knocking":[158,219],"down":[159,220],"structural":[161],"proteins":[162],"caveolin-1":[163],"or":[164,196,239],"-2":[165],"gene-specific":[168],"siRNAs":[169],"significantly":[170,226],"reduced":[171],"transactivation.":[174],"Next,":[175],"silencing":[176],"G\u03b1(s)":[177,195,206,221,238],"G\u03b1(12)":[179,197,224,240],"but":[181,222],"not":[182,223],"other":[183],"G-proteins":[184],"blocked":[185],"proliferation.":[191],"Consistently,":[192],"overexpression":[193],"active":[198,207],"mutants":[199],"enhanced":[200],"transactivation,":[203],"which":[205],"mutant":[208],"sensitized":[209],"castration-level":[213],"(R1881).":[216],"Most":[217],"interestingly,":[218],"subunit":[225],"suppressed":[227],"androgen-stimulated":[228],"activation.":[231],"However,":[232],"ChIP":[233],"analysis":[234],"revealed":[235],"both":[237],"subunits":[241,264],"are":[242,265],"involved":[243,266],"interaction":[247],"target":[251],"PSA":[253],"promoter":[254],"region.":[255],"CONCLUSION:":[256],"These":[257],"data":[258],"suggest":[259],"caveolae-associated":[261],"G-protein":[262],"alpha":[263],"by":[270],"modulating":[271],"different":[275],"isoforms.":[277]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}