{"id":"https://openalex.org/W2045603286","doi":"https://doi.org/10.1111/j.1365-2265.1994.tb02478.x","title":"Longitudinal study of maternal plasma bioavailable testosterone and androstanediol glucuronide levels during pregnancy","display_name":"Longitudinal study of maternal plasma bioavailable testosterone and androstanediol glucuronide levels during pregnancy","publication_year":1994,"publication_date":"1994-02-01","ids":{"openalex":"https://openalex.org/W2045603286","doi":"https://doi.org/10.1111/j.1365-2265.1994.tb02478.x","mag":"2045603286","pmid":"https://pubmed.ncbi.nlm.nih.gov/8137527"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2265.1994.tb02478.x","doi":"https://doi.org/10.1111/j.1365-2265.1994.tb02478.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2265.1994.tb02478.x","pdf_url":null,"source":{"id":"https://openalex.org/S182143151","display_name":"Clinical Endocrinology","issn_l":"0300-0664","issn":["0300-0664","1365-2265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039178481","display_name":"V. Kerlan","orcid":"https://orcid.org/0000-0001-8105-6628","observed_orcids":["https://orcid.org/0000-0001-8105-6628"]},"institutions":[{"id":"https://openalex.org/I161929037","display_name":"Universit\u00e9 de Bretagne Occidentale","ror":"https://ror.org/01b8h3982","country_code":"FR","type":"education","lineage":["https://openalex.org/I161929037","https://openalex.org/I4405260085"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"V\u00e9ronique Kerlan","raw_affiliation_strings":["Department of Endocrinology, University Bretagne Occidentale, Brest, France","Department of Endocrinology, University Bretagne Occidentale, Brest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, University Bretagne Occidentale, Brest, France","institution_ids":["https://openalex.org/I161929037"]},{"raw_affiliation_string":"Department of Endocrinology, University Bretagne Occidentale, Brest","institution_ids":["https://openalex.org/I161929037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006768717","display_name":"KHALIL NAHOUL","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khalil Nahoul","raw_affiliation_strings":["Fondation de Recherche en Hormonologie Fresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fondation de Recherche en Hormonologie Fresnes, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079657029","display_name":"Marie\u2010Th\u00e9r\u00e8se Le Martelot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie\u2010Th\u00e9r\u00e8se Le Martelot","raw_affiliation_strings":["Department of Gynecology, Brest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Brest","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058181878","display_name":"J P Bercovici","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161929037","display_name":"Universit\u00e9 de Bretagne Occidentale","ror":"https://ror.org/01b8h3982","country_code":"FR","type":"education","lineage":["https://openalex.org/I161929037","https://openalex.org/I4405260085"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean\u2010Pierre Bercovici","raw_affiliation_strings":["Department of Endocrinology, University Bretagne Occidentale, Brest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, University Bretagne Occidentale, Brest","institution_ids":["https://openalex.org/I161929037"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039178481"],"corresponding_institution_ids":["https://openalex.org/I161929037"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":0.2663,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.53633911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"40","issue":"2","first_page":"263","last_page":"267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.05040000006556511,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.03920000046491623,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioavailable-testosterone","display_name":"bioavailable testosterone","score":0.9610000252723694},{"id":"https://openalex.org/keywords/androstanediol-glucuronide","display_name":"androstanediol glucuronide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.7250000238418579},{"id":"https://openalex.org/keywords/sex-hormone-binding-globulin","display_name":"sex hormone-binding globulin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.7099999785423279},{"id":"https://openalex.org/keywords/estriol","display_name":"estriol","score":0.9800000190734863},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.8450000286102295},{"id":"https://openalex.org/keywords/17-hydroxyprogesterone","display_name":"17-hydroxyprogesterone","score":0.890999972820282},{"id":"https://openalex.org/keywords/delta-4-androstenedione","display_name":"\u03944-androstenedione","score":0.906000018119812},{"id":"https://openalex.org/keywords/testosterone-metabolism","display_name":"testosterone metabolism","score":0.5540000200271606},{"id":"https://openalex.org/keywords/5alpha-reductase-inhibition","display_name":"5\u03b1-reductase inhibition","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.7934439182281494},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.792741060256958},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7731700539588928},{"id":"https://openalex.org/C2776683971","wikidata":"https://www.wikidata.org/wiki/Q411064","display_name":"Androstenedione","level":4,"score":0.6256833672523499},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5685226917266846},{"id":"https://openalex.org/C30092816","wikidata":"https://www.wikidata.org/wiki/Q419613","display_name":"Sex hormone-binding globulin","level":4,"score":0.5241891741752625},{"id":"https://openalex.org/C2779186261","wikidata":"https://www.wikidata.org/wiki/Q137786","display_name":"Glucuronide","level":3,"score":0.519238293170929},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.4407353401184082},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.429823637008667},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2534407377243042},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18144726753234863},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.12301084399223328},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.07165807485580444}],"mesh":[{"descriptor_ui":"D000735","descriptor_name":"Androstenedione","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004964","descriptor_name":"Estriol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006908","descriptor_name":"Hydroxyprogesterones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012738","descriptor_name":"Sex Hormone-Binding Globulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015113","descriptor_name":"Androstane-3,17-diol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015113","descriptor_name":"Androstane-3,17-diol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019326","descriptor_name":"17-alpha-Hydroxyprogesterone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2265.1994.tb02478.x","doi":"https://doi.org/10.1111/j.1365-2265.1994.tb02478.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2265.1994.tb02478.x","pdf_url":null,"source":{"id":"https://openalex.org/S182143151","display_name":"Clinical Endocrinology","issn_l":"0300-0664","issn":["0300-0664","1365-2265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Endocrinology","raw_type":"journal-article"},{"id":"pmid:8137527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8137527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1490850016","https://openalex.org/W1744003469","https://openalex.org/W1900839667","https://openalex.org/W1963561957","https://openalex.org/W1990325333","https://openalex.org/W2015813771","https://openalex.org/W2020047576","https://openalex.org/W2029075686","https://openalex.org/W2032292657","https://openalex.org/W2036612573","https://openalex.org/W2051278310","https://openalex.org/W2082662520","https://openalex.org/W2091414980","https://openalex.org/W2143147694","https://openalex.org/W2155815182","https://openalex.org/W2163118201","https://openalex.org/W2400835419","https://openalex.org/W2411617451"],"related_works":["https://openalex.org/W1982611296","https://openalex.org/W2155815182","https://openalex.org/W1490850016","https://openalex.org/W2411617451","https://openalex.org/W2033375709","https://openalex.org/W2143147694","https://openalex.org/W12069601","https://openalex.org/W2943789434","https://openalex.org/W2022947371","https://openalex.org/W2116995571"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,55,135],"aim":[2],"of":[3,64,128,151,180,184],"this":[4],"study":[5],"to":[6,34],"evaluate":[7],"during":[8,144],"normal":[9,39],"pregnancy":[10],"plasma":[11,45],"bioavailable":[12,57],"testosterone":[13,58,121,130,138,152],"and":[14,23,52,81,92,105,115,165],"androstanediol":[15,21,113,163,174],"glucuronide":[16,22,75,114,164,175],"levels.":[17],"MEASUREMENTS:":[18],"Bioavailable":[19,120],"testosterone,":[20,103],"SHBG":[24,98],"levels":[25,59,143],"were":[26,60],"evaluated":[27],"every":[28],"4":[29],"weeks":[30,79],"from":[31],"week":[32,35,85,90,96],"6":[33,80],"38":[36],"in":[37,137,162,167,173],"10":[38],"pregnant":[40],"women.":[41],"We":[42],"also":[43],"measured":[44],"oestradiol,":[46],"oestriol,":[47],"delta":[48],"4-androstenedione,":[49],"17-hydroxyprogesterone,":[50],"progesterone":[51,185],"testosterone.":[53,134],"RESULTS:":[54],"mean":[56],"within":[61],"the":[62,126,160,171,181],"range":[63],"non-pregnant":[65],"women":[66],"but":[67],"with":[68,102,140],"an":[69],"increasing":[70],"trend":[71],"until":[72],"delivery.":[73],"Androstanediol":[74],"had":[76],"increased":[77,93],"at":[78,84,89,95],"8,":[82],"decreased":[83,141],"14,":[86],"remained":[87],"low":[88],"30,":[91],"again":[94],"34.":[97],"was":[99,157],"significantly":[100],"correlated":[101],"oestradiol":[104],"oestriol.":[106],"No":[107,155],"correlation":[108,156],"could":[109,146],"be":[110],"established":[111,158],"between":[112,159],"any":[116],"other":[117],"parameter.":[118],"DISCUSSION:":[119],"(non-SHBG":[122],"bound":[123,133],"testosterone)":[124],"represents":[125],"sum":[127],"free":[129],"plus":[131],"albumin":[132,142],"increase":[136,166],"concentrations":[139],"pregnancy,":[145],"suggest":[147],"reduced":[148],"metabolic":[149],"clearance":[150],"throughout":[153],"pregnancy.":[154],"decrease":[161,172],"progesterone,":[168],"suggesting":[169],"that":[170],"is":[176],"not":[177],"a":[178],"consequence":[179],"inhibitory":[182],"effect":[183],"on":[186],"5":[187],"alpha-reductase":[188],"activity.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
