{"id":"https://openalex.org/W2045596191","doi":"https://doi.org/10.1126/science.173.3998.738","title":"Origin of 5-Hydroxyindoleacetic Acid in the Spinal Fluid","display_name":"Origin of 5-Hydroxyindoleacetic Acid in the Spinal Fluid","publication_year":1971,"publication_date":"1971-08-20","ids":{"openalex":"https://openalex.org/W2045596191","doi":"https://doi.org/10.1126/science.173.3998.738","mag":"2045596191","pmid":"https://pubmed.ncbi.nlm.nih.gov/5109594"},"language":"en","primary_location":{"id":"doi:10.1126/science.173.3998.738","doi":"https://doi.org/10.1126/science.173.3998.738","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.173.3998.738","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111787763","display_name":"Marin Bulat","orcid":"https://orcid.org/0009-0008-1062-8631","observed_orcids":["https://orcid.org/0009-0008-1062-8631"]},"institutions":[{"id":"https://openalex.org/I4210123216","display_name":"Ru\u0111er Bo\u0161kovi\u0107 Institute","ror":"https://ror.org/02mw21745","country_code":"HR","type":"facility","lineage":["https://openalex.org/I4210123216"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"M. Bulat","raw_affiliation_strings":["Institute Ruder Bo\u0161kovi\u0107, Bijeni\u010dka 54, 41000 Zagreb, Yugoslavia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute Ruder Bo\u0161kovi\u0107, Bijeni\u010dka 54, 41000 Zagreb, Yugoslavia","institution_ids":["https://openalex.org/I4210123216"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109202727","display_name":"B. \u017divkovi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123216","display_name":"Ru\u0111er Bo\u0161kovi\u0107 Institute","ror":"https://ror.org/02mw21745","country_code":"HR","type":"facility","lineage":["https://openalex.org/I4210123216"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"B. \u017divkovi\u0107","raw_affiliation_strings":["Institute Ruder Bo\u0161kovi\u0107, Bijeni\u010dka 54, 41000 Zagreb, Yugoslavia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute Ruder Bo\u0161kovi\u0107, Bijeni\u010dka 54, 41000 Zagreb, Yugoslavia","institution_ids":["https://openalex.org/I4210123216"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210123216"],"apc_list":null,"apc_paid":null,"fwci":23.8073,"has_fulltext":false,"cited_by_count":118,"citation_normalized_percentile":{"value":0.99846248,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"173","issue":"3998","first_page":"738","last_page":"740"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.301800012588501,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.301800012588501,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.29319998621940613,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.1460999995470047,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-hydroxyindoleacetic-acid","display_name":"5-hydroxyindoleacetic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8460000157356262},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.7260000109672546},{"id":"https://openalex.org/keywords/subarachnoid-space","display_name":"subarachnoid space","score":0.8709999918937683},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9039999842643738},{"id":"https://openalex.org/keywords/serotonin-metabolism","display_name":"serotonin metabolism","score":0.9369999766349792},{"id":"https://openalex.org/keywords/intracisternal-administration","display_name":"intracisternal administration","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C2779164789","wikidata":"https://www.wikidata.org/wiki/Q238532","display_name":"5-Hydroxyindoleacetic acid","level":4,"score":0.9547231793403625},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.8115946650505066},{"id":"https://openalex.org/C2780813603","wikidata":"https://www.wikidata.org/wiki/Q268930","display_name":"Subarachnoid space","level":3,"score":0.7428622245788574},{"id":"https://openalex.org/C2779904517","wikidata":"https://www.wikidata.org/wiki/Q5008900","display_name":"CATS","level":2,"score":0.6702814698219299},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.5299345850944519},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3838021159172058},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3474400043487549},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3440888524055481},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23228636384010315},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.19305911660194397},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18578007817268372},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.09822037816047668},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006897","descriptor_name":"Hydroxyindoleacetic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006897","descriptor_name":"Hydroxyindoleacetic Acid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006897","descriptor_name":"Hydroxyindoleacetic Acid","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006897","descriptor_name":"Hydroxyindoleacetic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006897","descriptor_name":"Hydroxyindoleacetic Acid","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D007278","descriptor_name":"Injections, Spinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013346","descriptor_name":"Subarachnoid Space","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.173.3998.738","doi":"https://doi.org/10.1126/science.173.3998.738","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.173.3998.738","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:5109594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5109594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1964008167","https://openalex.org/W1966134332","https://openalex.org/W1968160865","https://openalex.org/W1978457748","https://openalex.org/W1978773368","https://openalex.org/W1980772143","https://openalex.org/W1981824196","https://openalex.org/W1989142203","https://openalex.org/W1995444708","https://openalex.org/W1997755756","https://openalex.org/W1998745278","https://openalex.org/W2004899124","https://openalex.org/W2012775663","https://openalex.org/W2033769442","https://openalex.org/W2035152097","https://openalex.org/W2057850934","https://openalex.org/W2115768579","https://openalex.org/W2163612179","https://openalex.org/W2247301355","https://openalex.org/W2586182948","https://openalex.org/W4366064379","https://openalex.org/W4406989240"],"related_works":["https://openalex.org/W2049927175","https://openalex.org/W1982048459","https://openalex.org/W2011373887","https://openalex.org/W2136236393","https://openalex.org/W2418575770","https://openalex.org/W1998745278","https://openalex.org/W1966134332","https://openalex.org/W2408990284","https://openalex.org/W2029658909","https://openalex.org/W2080819749"],"abstract_inverted_index":{"5-Hydroxyindoleacetic":[0],"acid":[1,15,34],"applied":[2],"intracisternally":[3],"in":[4,9,17,24,35,50,57],"cats":[5],"does":[6],"not":[7,55],"appear":[8],"spinal":[10,19,29,37,42,52],"fluid.":[11],"Changes":[12],"of":[13,27,48],"5-hydroxyindoleacetic":[14,33],"concentration":[16],"the":[18,25,28,36,41,51,58],"cord":[20,43],"are":[21],"clearly":[22],"reflected":[23],"perfusate":[26],"subarachnoid":[30],"space.":[31],"Thus,":[32],"fluid":[38],"originates":[39],"from":[40],"and":[44],"reflects":[45],"metabolic":[46],"changes":[47],"5-hydroxytryptamine":[49],"tissue,":[53],"but":[54],"those":[56],"brain.":[59]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
