{"id":"https://openalex.org/W2045576452","doi":"https://doi.org/10.1159/000056369","title":"Chemoprevention of Basal Cell Carcinomas in the ptc1+/\u2013 Mouse \u2013 Green and Black Tea","display_name":"Chemoprevention of Basal Cell Carcinomas in the ptc1+/\u2013 Mouse \u2013 Green and Black Tea","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2045576452","doi":"https://doi.org/10.1159/000056369","mag":"2045576452","pmid":"https://pubmed.ncbi.nlm.nih.gov/11598435"},"language":"en","primary_location":{"id":"doi:10.1159/000056369","doi":"https://doi.org/10.1159/000056369","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000056369","pdf_url":null,"source":{"id":"https://openalex.org/S2715032","display_name":"Skin Pharmacology and Physiology","issn_l":"1422-2868","issn":["1422-2868","1422-2906","1660-5527","1660-5535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Skin Pharmacology and Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079103689","display_name":"Jennifer L. Hebert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L. Hebert","raw_affiliation_strings":["Department of Dermatology, University of California, San Francisco, Calif, USA","Departments of Dermatology,University of California, San Francisco, Calif.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of California, San Francisco, Calif, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Departments of Dermatology,University of California, San Francisco, Calif.,","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044181824","display_name":"Farishta Khugyani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farishta Khugyani","raw_affiliation_strings":["Departments of Dermatology,University of California, San Francisco, Calif.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology,University of California, San Francisco, Calif.,","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079917691","display_name":"Mohammad Athar","orcid":"https://orcid.org/0000-0001-5829-7992","observed_orcids":["https://orcid.org/0000-0001-5829-7992"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad Athar","raw_affiliation_strings":["Columbia University, New York, N.Y., and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York, N.Y., and","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051957313","display_name":"Levy Kopelovich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Levy Kopelovich","raw_affiliation_strings":["National Cancer Institute, Division of Cancer Prevention, Bethesda, Md., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Division of Cancer Prevention, Bethesda, Md., USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110942683","display_name":"Ervin H. Epstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ervin H. Epstein Jr.","raw_affiliation_strings":["Departments of Dermatology,University of California, San Francisco, Calif.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology,University of California, San Francisco, Calif.,","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068087553","display_name":"Michelle Aszterbaum","orcid":"https://orcid.org/0000-0002-6126-7644","observed_orcids":["https://orcid.org/0000-0002-6126-7644"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Aszterbaum","raw_affiliation_strings":["Departments of Dermatology,University of California, San Francisco, Calif.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Dermatology,University of California, San Francisco, Calif.,","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9878,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.85544685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"14","issue":"6","first_page":"358","last_page":"362"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.8871999979019165,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.8871999979019165,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.09749999642372131,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9100000262260437},{"id":"https://openalex.org/keywords/basal-cell-carcinoma","display_name":"basal cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/green-tea","display_name":"green tea","score":0.8240000009536743},{"id":"https://openalex.org/keywords/black-tea","display_name":"black tea","score":1.0},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.7549999952316284},{"id":"https://openalex.org/keywords/tea-polyphenols","display_name":"tea polyphenols","score":0.6869999766349792},{"id":"https://openalex.org/keywords/sun-exposure","display_name":"sun exposure","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6660764813423157},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.6193163394927979},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.608350932598114},{"id":"https://openalex.org/C2778804307","wikidata":"https://www.wikidata.org/wiki/Q809758","display_name":"Basal cell carcinoma","level":3,"score":0.6064808964729309},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.46159836649894714},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4517310857772827},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.4373369812965393},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43029534816741943},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4290008842945099},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.41217660903930664},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3470688462257385},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34345099329948425},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33786439895629883},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28891026973724365},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12815558910369873},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013662","descriptor_name":"Tea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000056369","doi":"https://doi.org/10.1159/000056369","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000056369","pdf_url":null,"source":{"id":"https://openalex.org/S2715032","display_name":"Skin Pharmacology and Physiology","issn_l":"1422-2868","issn":["1422-2868","1422-2906","1660-5527","1660-5535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Skin Pharmacology and Physiology","raw_type":"journal-article"},{"id":"pmid:11598435","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11598435","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Skin pharmacology and applied skin physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5958317235","display_name":"BASAL CELL CARCINOMA CHEMOPREVENTION IN BCNS PATIENTS","funder_award_id":"U19CA081888","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1806370804","https://openalex.org/W1967936513","https://openalex.org/W1968322588","https://openalex.org/W1972002448","https://openalex.org/W1976534669","https://openalex.org/W1980429742","https://openalex.org/W1983341583","https://openalex.org/W1998921522","https://openalex.org/W2001155940","https://openalex.org/W2010466320","https://openalex.org/W2023518603","https://openalex.org/W2033479028","https://openalex.org/W2050217208","https://openalex.org/W2082851306","https://openalex.org/W2088938515","https://openalex.org/W2100251566","https://openalex.org/W2107357322","https://openalex.org/W2134188156","https://openalex.org/W2162636527","https://openalex.org/W2165229464","https://openalex.org/W2171156752","https://openalex.org/W2347245015"],"related_works":["https://openalex.org/W2107357322","https://openalex.org/W2134188156","https://openalex.org/W2010466320","https://openalex.org/W2075480222","https://openalex.org/W2096686046","https://openalex.org/W2166581740","https://openalex.org/W1998921522","https://openalex.org/W2091658328","https://openalex.org/W2110430784","https://openalex.org/W2039498286"],"abstract_inverted_index":{"Skin":[0],"cancers":[1],"are":[2],"a":[3,101],"rising":[4],"menace":[5],"as":[6],"their":[7],"incidence":[8],"increases,":[9],"attributed":[10],"in":[11,81,115,137,145],"part":[12],"to":[13,24,34,39,45,131,140],"increasing":[14,19],"ultraviolet":[15],"radiation":[16],"exposure.":[17],"This":[18],"problem":[20],"has":[21],"stimulated":[22],"efforts":[23],"devise":[25],"useful":[26],"preventive":[27],"approaches.":[28,158],"The":[29],"uncertain":[30],"efficacy":[31],"of":[32,54,68,71,78,93,104,111,151],"exhortations":[33],"avoid":[35],"sun":[36],"exposure":[37],"and":[38,43,60,66,70,97],"use":[40],"protective":[41],"clothing":[42],"sunscreens":[44],"reduce":[46],"damage":[47],"when":[48],"exposed":[49],"argue":[50],"for":[51],"the":[52,64,91,109],"development":[53,110],"an":[55],"oral":[56,94],"chemopreventive":[57],"agent.":[58],"Bickers":[59],"others":[61,128],"have":[62,89,122,129],"studied":[63,90],"effects":[65,92],"mechanisms":[67],"tea":[69,96,99,125],"its":[72],"putative":[73],"active":[74],"components":[75],"on":[76,100],"inhibition":[77],"skin":[79,106],"cancer":[80,153],"experimental":[82],"models.":[83],"To":[84,118],"continue":[85],"this":[86,152],"work,":[87],"we":[88,121],"green":[95],"black":[98],"new":[102],"model":[103],"ultraviolet-induced":[105],"carcinogenesis":[107,144],"-":[108],"basal":[112,142],"cell":[113,134,143],"carcinomas":[114],"ptc1+/-":[116],"mice.":[117],"our":[119,146],"surprise,":[120],"found":[123],"that":[124,149],"preparations":[126],"which":[127],"used":[130],"prevent":[132],"squamous":[133],"carcinoma":[135],"formation":[136],"mice":[138],"fail":[139],"inhibit":[141],"model,":[147],"suggesting":[148],"prevention":[150],"may":[154],"require":[155],"special,":[156],"tumor-specific":[157]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}