{"id":"https://openalex.org/W2045554667","doi":"https://doi.org/10.1111/j.1749-6632.1987.tb36215.x","title":"Alcoholism: Is It a Model for the Study of Disorders of Mood and Consummately Behavior?a","display_name":"Alcoholism: Is It a Model for the Study of Disorders of Mood and Consummately Behavior?a","publication_year":1987,"publication_date":"1987-06-01","ids":{"openalex":"https://openalex.org/W2045554667","doi":"https://doi.org/10.1111/j.1749-6632.1987.tb36215.x","mag":"2045554667","pmid":"https://pubmed.ncbi.nlm.nih.gov/3300484"},"language":"en","primary_location":{"id":"doi:10.1111/j.1749-6632.1987.tb36215.x","doi":"https://doi.org/10.1111/j.1749-6632.1987.tb36215.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1987.tb36215.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110097573","display_name":"Ting\u2010Kai Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"TING\u2010KAI LI","raw_affiliation_strings":["Indiana University School of Medicine and Veterans Administration Medical Center, Indianapolis, Indiana 46223"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine and Veterans Administration Medical Center, Indianapolis, Indiana 46223","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109992600","display_name":"Lawrence Lumeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LAWRENCE LUMENG","raw_affiliation_strings":["Indiana University School of Medicine and Veterans Administration Medical Center, Indianapolis, Indiana 46223"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine and Veterans Administration Medical Center, Indianapolis, Indiana 46223","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036789705","display_name":"William J. McBride","orcid":"https://orcid.org/0000-0001-8894-533X","observed_orcids":["https://orcid.org/0000-0001-8894-533X"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WILLIAM J. McBRIDE","raw_affiliation_strings":["Indiana University School of Medicine and Veterans Administration Medical Center, Indianapolis, Indiana 46223"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine and Veterans Administration Medical Center, Indianapolis, Indiana 46223","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054806565","display_name":"James M. Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JAMES M. MURPHY","raw_affiliation_strings":["Indiana University School of Medicine and Veterans Administration Medical Center, Indianapolis, Indiana 46223"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine and Veterans Administration Medical Center, Indianapolis, Indiana 46223","institution_ids":["https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4394709130"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.02020202,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"499","issue":"1","first_page":"239","last_page":"249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.9049999713897705},{"id":"https://openalex.org/keywords/animal-models-of-alcoholism","display_name":"animal models of alcoholism","score":0.9850000143051147},{"id":"https://openalex.org/keywords/alcohol-preference","display_name":"alcohol preference","score":0.5870000123977661},{"id":"https://openalex.org/keywords/selective-breeding","display_name":"selective breeding","score":0.6679999828338623},{"id":"https://openalex.org/keywords/voluntary-ethanol-consumption","display_name":"voluntary ethanol consumption","score":0.699999988079071},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.8790000081062317},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.824999988079071},{"id":"https://openalex.org/keywords/eating-disorders","display_name":"eating disorders","score":0.9660000205039978},{"id":"https://openalex.org/keywords/carbohydrate-craving","display_name":"carbohydrate craving","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":0.9750000238418579},{"id":"https://openalex.org/keywords/alcohol-seeking-behavior","display_name":"alcohol seeking","score":0.9070000052452087},{"id":"https://openalex.org/keywords/genetic-predisposition-to-alcoholism","display_name":"genetic predisposition to alcoholism","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C2779541405","wikidata":"https://www.wikidata.org/wiki/Q498902","display_name":"Craving","level":3,"score":0.6235225796699524},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.5665228366851807},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.5479391813278198},{"id":"https://openalex.org/C2777134132","wikidata":"https://www.wikidata.org/wiki/Q188638","display_name":"Mood disorders","level":3,"score":0.475860059261322},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.47020894289016724},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4658447504043579},{"id":"https://openalex.org/C2781249084","wikidata":"https://www.wikidata.org/wiki/Q908656","display_name":"Preference","level":2,"score":0.46195247769355774},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.4468051493167877},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.43152546882629395},{"id":"https://openalex.org/C3018449479","wikidata":"https://www.wikidata.org/wiki/Q4340209","display_name":"Depressed mood","level":3,"score":0.43150535225868225},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4285759925842285},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.41961079835891724},{"id":"https://openalex.org/C3019635848","wikidata":"https://www.wikidata.org/wiki/Q154","display_name":"Alcohol consumption","level":3,"score":0.41750386357307434},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.400847852230072},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.33846819400787354},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3360099196434021},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3147614300251007},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.2372061312198639},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.190562903881073},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16437938809394836},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.12924113869667053},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C175444787","wikidata":"https://www.wikidata.org/wiki/Q39072","display_name":"Microeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000435","descriptor_name":"Alcoholic Intoxication","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004040","descriptor_name":"Dietary Carbohydrates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019964","descriptor_name":"Mood Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1749-6632.1987.tb36215.x","doi":"https://doi.org/10.1111/j.1749-6632.1987.tb36215.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1987.tb36215.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:3300484","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3300484","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1793342749","display_name":null,"funder_award_id":"AA 03243","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W108542985","https://openalex.org/W1442042069","https://openalex.org/W1577233759","https://openalex.org/W1974686906","https://openalex.org/W1975711542","https://openalex.org/W1977498657","https://openalex.org/W1980714268","https://openalex.org/W1986444352","https://openalex.org/W1990114427","https://openalex.org/W1991839015","https://openalex.org/W1993807545","https://openalex.org/W1999063330","https://openalex.org/W1999723816","https://openalex.org/W2003568100","https://openalex.org/W2007215489","https://openalex.org/W2008536799","https://openalex.org/W2008646949","https://openalex.org/W2008944623","https://openalex.org/W2011627006","https://openalex.org/W2021489067","https://openalex.org/W2030516531","https://openalex.org/W2035469264","https://openalex.org/W2040981420","https://openalex.org/W2042373129","https://openalex.org/W2042552047","https://openalex.org/W2046038414","https://openalex.org/W2051105147","https://openalex.org/W2063692436","https://openalex.org/W2071274668","https://openalex.org/W2086466782","https://openalex.org/W2087786037","https://openalex.org/W2088049361","https://openalex.org/W2093119064","https://openalex.org/W2111666128","https://openalex.org/W2117967177","https://openalex.org/W2256826156","https://openalex.org/W2337436933","https://openalex.org/W2414236551","https://openalex.org/W2507030560","https://openalex.org/W2906318858","https://openalex.org/W3019801591"],"related_works":["https://openalex.org/W2472015507","https://openalex.org/W2408673722","https://openalex.org/W2442219175","https://openalex.org/W2161606831","https://openalex.org/W2046649514","https://openalex.org/W397681736","https://openalex.org/W1982694655","https://openalex.org/W7098401826","https://openalex.org/W2157759655","https://openalex.org/W2460239665"],"abstract_inverted_index":{"Depression,":[0],"eating":[1],"disorders,":[2],"and":[3,60,112],"carbohydrate":[4,143],"craving":[5],"are":[6,158,168],"frequently":[7],"seen":[8],"in":[9,82,122,141,160,171],"alcoholics":[10],"or":[11],"recovering":[12],"alcoholics.":[13],"Accordingly,":[14],"these":[15],"disorders":[16],"may":[17],"share":[18],"some":[19],"mediating":[20],"pathways.":[21],"It":[22],"is":[23,28,116],"now":[24,88],"well-established":[25],"that":[26,90],"there":[27],"a":[29,75,172],"genetic":[30,35],"predisposition":[31],"to":[32,163],"alcoholism.":[33,45,104],"Through":[34],"means,":[36],"our":[37],"laboratory":[38],"has":[39],"developed":[40],"an":[41,100],"animal":[42,101],"model":[43,102],"of":[44,55,70,78,99,103,120,126,136,145],"Free-fed":[46],"Wistar":[47],"rats":[48,157],"were":[49],"selectively":[50],"bred":[51],"for":[52],"the":[53,72,91,96,110,113,117,127,133,137,142,146,164,176],"traits":[54],"alcohol-preference":[56],"(the":[57,62],"P":[58,92,111,128,138,156],"line)":[59],"non-preference":[61],"NP":[63,114,165,177],"line).":[64],"After":[65],"more":[66,79,169],"than":[67,80,175],"20":[68],"generations":[69],"selection,":[71],"lines":[73],"show":[74],"stable":[76],"difference":[77,108],"six-fold":[81],"voluntary":[83,152],"ethanol":[84,153],"consumption.":[85],"We":[86],"have":[87],"shown":[89],"line":[93,115],"satisfies":[94],"all":[95],"perceived":[97],"requirements":[98],"One":[105],"major":[106],"discovered":[107],"between":[109],"lowered":[118],"content":[119,144],"serotonin":[121],"certain":[123],"brain":[124],"regions":[125],"rats.":[129,178],"Interestingly,":[130],"fluoxetine":[131],"curbs":[132],"alcohol-seeking":[134],"behavior":[135],"rats;":[139],"variation":[140],"diet,":[147],"however,":[148],"does":[149],"not":[150],"modify":[151],"intake.":[154],"The":[155],"similar":[159],"body":[161],"weight":[162],"rats,":[166],"but":[167],"active":[170],"novel":[173],"environment":[174]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}