{"id":"https://openalex.org/W2045554373","doi":"https://doi.org/10.2337/diacare.26.3.784","title":"Pramlintide as an Adjunct to Insulin Therapy Improves Long-Term Glycemic and Weight Control in Patients With Type 2 Diabetes","display_name":"Pramlintide as an Adjunct to Insulin Therapy Improves Long-Term Glycemic and Weight Control in Patients With Type 2 Diabetes","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W2045554373","doi":"https://doi.org/10.2337/diacare.26.3.784","mag":"2045554373","pmid":"https://pubmed.ncbi.nlm.nih.gov/12610038"},"language":"en","primary_location":{"id":"doi:10.2337/diacare.26.3.784","doi":"https://doi.org/10.2337/diacare.26.3.784","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diacare.26.3.784","pdf_url":"https://diabetesjournals.org/care/article-pdf/26/3/784/665362/dc0303000784.pdf","source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://diabetesjournals.org/care/article-pdf/26/3/784/665362/dc0303000784.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048198396","display_name":"Priscilla A. Hollander","orcid":"https://orcid.org/0000-0003-2072-632X","observed_orcids":["https://orcid.org/0000-0003-2072-632X"]},"institutions":[{"id":"https://openalex.org/I2802366037","display_name":"Baylor University Medical Center","ror":"https://ror.org/03nxfhe13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802366037","https://openalex.org/I4210160418"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priscilla A. Hollander","raw_affiliation_strings":["Baylor University Medical Center, Dallas, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor University Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I2802366037"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Philip Levy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip Levy","raw_affiliation_strings":["Phoenix Endocrinology Clinic, Phoenix, Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Phoenix Endocrinology Clinic, Phoenix, Arizona","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083503351","display_name":"Mark S. Fineman","orcid":"https://orcid.org/0000-0002-9883-6847","observed_orcids":["https://orcid.org/0000-0002-9883-6847"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark S. Fineman","raw_affiliation_strings":["Amylin Pharmaceuticals, Inc., San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amylin Pharmaceuticals, Inc., San Diego, California","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062921481","display_name":"David G. Maggs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David G. Maggs","raw_affiliation_strings":["Amylin Pharmaceuticals, Inc., San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amylin Pharmaceuticals, Inc., San Diego, California","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113725447","display_name":"Larry Zaiqian Shen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Larry Z. Shen","raw_affiliation_strings":["Amylin Pharmaceuticals, Inc., San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amylin Pharmaceuticals, Inc., San Diego, California","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004232298","display_name":"Susan A. Strobel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan A. Strobel","raw_affiliation_strings":["Amylin Pharmaceuticals, Inc., San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amylin Pharmaceuticals, Inc., San Diego, California","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109131952","display_name":"Christian Weyer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Weyer","raw_affiliation_strings":["Amylin Pharmaceuticals, Inc., San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amylin Pharmaceuticals, Inc., San Diego, California","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019395960","display_name":"Orville Kolterman","orcid":"https://orcid.org/0000-0002-9306-1288","observed_orcids":["https://orcid.org/0000-0002-9306-1288"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Orville G. Kolterman","raw_affiliation_strings":["Amylin Pharmaceuticals, Inc., San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amylin Pharmaceuticals, Inc., San Diego, California","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.4322,"has_fulltext":true,"cited_by_count":308,"citation_normalized_percentile":{"value":0.98323645,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"26","issue":"3","first_page":"784","last_page":"790"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pramlintide","display_name":"pramlintide","score":1.0},{"id":"https://openalex.org/keywords/amylin-analogues","display_name":"amylin analogues","score":0.902999997138977},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.984000027179718},{"id":"https://openalex.org/keywords/insulin-therapy","display_name":"insulin therapy","score":0.8690000176429749},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.8690000176429749},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9509999752044678},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.8920000195503235},{"id":"https://openalex.org/keywords/nausea","display_name":"nausea","score":0.6819999814033508},{"id":"https://openalex.org/keywords/long-term-efficacy-and-safety","display_name":"long-term efficacy and safety","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9334510564804077},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6377352476119995},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6295709013938904},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.6093738675117493},{"id":"https://openalex.org/C2780705028","wikidata":"https://www.wikidata.org/wiki/Q424643","display_name":"Amylin","level":4,"score":0.5870695114135742},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5851259231567383},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.5560681223869324},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5203268527984619},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.49955081939697266},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.4642845690250397},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.45582541823387146},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45474573969841003},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.4416746497154236},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42975467443466187},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4134323000907898},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3789516091346741},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058228","descriptor_name":"Islet Amyloid Polypeptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2337/diacare.26.3.784","doi":"https://doi.org/10.2337/diacare.26.3.784","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diacare.26.3.784","pdf_url":"https://diabetesjournals.org/care/article-pdf/26/3/784/665362/dc0303000784.pdf","source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},{"id":"pmid:12610038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12610038","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes care","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.615.9026","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.615.9026","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://care.diabetesjournals.org/content/26/3/784.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.2337/diacare.26.3.784","doi":"https://doi.org/10.2337/diacare.26.3.784","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diacare.26.3.784","pdf_url":"https://diabetesjournals.org/care/article-pdf/26/3/784/665362/dc0303000784.pdf","source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2045554373.pdf","grobid_xml":"https://content.openalex.org/works/W2045554373.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1535088540","https://openalex.org/W1977761436","https://openalex.org/W1982298257","https://openalex.org/W1994056464","https://openalex.org/W2001910224","https://openalex.org/W2007561446","https://openalex.org/W2027804378","https://openalex.org/W2029563448","https://openalex.org/W2038951352","https://openalex.org/W2048083913","https://openalex.org/W2060927585","https://openalex.org/W2068095214","https://openalex.org/W2074118400","https://openalex.org/W2076531509","https://openalex.org/W2080065474","https://openalex.org/W2090172582","https://openalex.org/W2107706963","https://openalex.org/W2134775254","https://openalex.org/W2139075957","https://openalex.org/W2156516527","https://openalex.org/W2159173770","https://openalex.org/W2173663152","https://openalex.org/W2174004839","https://openalex.org/W2337454357","https://openalex.org/W2415356562","https://openalex.org/W2512485408","https://openalex.org/W2752336761","https://openalex.org/W4213149640","https://openalex.org/W4231349462","https://openalex.org/W4238603950","https://openalex.org/W4252759459"],"related_works":["https://openalex.org/W1982298257","https://openalex.org/W2139075957","https://openalex.org/W2065786925","https://openalex.org/W2080088997","https://openalex.org/W49611480","https://openalex.org/W2114626270","https://openalex.org/W2082090081","https://openalex.org/W2094113642","https://openalex.org/W2001085877","https://openalex.org/W2074118400"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Mealtime":[1,242],"amylin":[2,7,243],"replacement":[3,244],"with":[4,23,61,89,95,125,156,173,179,190,208,234,245,264],"the":[5,30,36,223],"human":[6],"analog":[8],"pramlintide,":[9],"as":[10,250],"an":[11,166,219,251],"adjunct":[12,252],"to":[13,34,101,132,253],"mealtime":[14],"insulin":[15,90,254],"replacement,":[16],"reduces":[17],"postprandial":[18],"glucose":[19],"excursions":[20],"in":[21,43,93,138,222,262],"patients":[22,60,164,263],"type":[24,62,265],"2":[25,63,266],"diabetes.":[26,267],"The":[27,161,187,228],"aim":[28],"of":[29,41,107,163],"present":[31],"study":[32],"was":[33,150,169,196,237],"assess":[35],"long-term":[37,257],"efficacy":[38],"and":[39,141,146,216,259],"safety":[40],"pramlintide":[42,111,126,174,191,235,246],"this":[44],"patient":[45],"population.":[46],"RESEARCH":[47],"DESIGN":[48],"AND":[49],"METHODS:":[50],"In":[51],"a":[52,133,199],"52-week,":[53],"double-blind,":[54],"placebo-controlled,":[55],"parallel-group,":[56],"multicenter":[57],"study,":[58],"656":[59],"diabetes":[64,70],"(age":[65],"57":[66],"+/-":[67,73,78,83,86],"10":[68],"years,":[69,75],"duration":[71],"12":[72],"7":[74],"BMI":[76],"34.0":[77],"7.0":[79],"kg/m(2),":[80],"HbA(1c)":[81,139,167],"9.1":[82],"1.2%,":[84],"mean":[85,200],"SD)":[87],"treated":[88],"(alone":[91],"or":[92,110,119],"combination":[94],"sulfonylureas":[96],"and/or":[97],"metformin)":[98],"were":[99],"randomized":[100],"receive":[102],"additional":[103],"preprandial":[104],"subcutaneous":[105],"injections":[106],"either":[108],"placebo":[109,157,180,209],"(60":[112],"micro":[113,128,193],"g":[114,129,194],"TID,":[115],"90":[116],"microg":[117,121,176,248],"BID,":[118,249],"120":[120,127,192,247],"BID).":[122],"RESULTS:":[123],"Treatment":[124],"BID":[130,195],"led":[131],"sustained":[134],"reduction":[135],"from":[136],"baseline":[137],"(-0.68":[140],"-0.62%":[142],"at":[143,210],"weeks":[144],"26":[145],"52,":[147,212],"respectively),":[148],"which":[149],"significantly":[151],"greater":[152,172],"than":[153,178],"that":[154],"seen":[155],"(P":[158],"<":[159,185,214],"0.05).":[160,186],"proportion":[162],"achieving":[165],"<8%":[168],"approximately":[170],"twofold":[171],"(120":[175],"BID)":[177],"(46":[181],"vs.":[182,205],"28%,":[183],"P":[184,213],"glycemic":[188,258],"improvement":[189],"accompanied":[197],"by":[198],"weight":[201,260],"loss":[202],"(-1.4":[203],"kg":[204,207],"+0.7":[206],"week":[211],"0.05)":[215],"occurred":[217],"without":[218],"overall":[220],"increase":[221],"severe":[224],"hypoglycemia":[225],"event":[226,232],"rate.":[227],"most":[229],"common":[230],"adverse":[231],"associated":[233],"use":[236],"transient,":[238],"mild-to-moderate":[239],"nausea.":[240],"CONCLUSIONS:":[241],"therapy,":[255],"improves":[256],"control":[261]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}