{"id":"https://openalex.org/W2045551237","doi":"https://doi.org/10.1038/nature03113","title":"Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA","display_name":"Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W2045551237","doi":"https://doi.org/10.1038/nature03113","mag":"2045551237","pmid":"https://pubmed.ncbi.nlm.nih.gov/15592417"},"language":"en","primary_location":{"id":"doi:10.1038/nature03113","doi":"https://doi.org/10.1038/nature03113","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature03113","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085152597","display_name":"Photini Kiepiela","orcid":"https://orcid.org/0000-0003-2563-7617","observed_orcids":["https://orcid.org/0000-0003-2563-7617"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Photini Kiepiela","raw_affiliation_strings":["HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, Durban 4015, South Africa","HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, Durban 4015, South Africa","institution_ids":["https://openalex.org/I95023434"]},{"raw_affiliation_string":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073126768","display_name":"Alasdair J. Leslie","orcid":"https://orcid.org/0000-0003-2538-6467","observed_orcids":["https://orcid.org/0000-0003-2538-6467"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210100268","display_name":"Medawar Building for Pathogen Research","ror":"https://ror.org/017g85521","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alasdair J. Leslie","raw_affiliation_strings":["Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, OX1 3SY, Oxford, UK","Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, OX1 3SY, Oxford, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]},{"raw_affiliation_string":"Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014813162","display_name":"Isobella Honeyborne","orcid":"https://orcid.org/0000-0003-0596-758X","observed_orcids":["https://orcid.org/0000-0003-0596-758X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210100268","display_name":"Medawar Building for Pathogen Research","ror":"https://ror.org/017g85521","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["GB","ZA"],"is_corresponding":false,"raw_author_name":"Isobella Honeyborne","raw_affiliation_strings":["Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, OX1 3SY, Oxford, UK","HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, 4015, Durban, South Africa","Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, UK","HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, OX1 3SY, Oxford, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]},{"raw_affiliation_string":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, 4015, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]},{"raw_affiliation_string":"Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]},{"raw_affiliation_string":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024469055","display_name":"Danni Ramduth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Danni Ramduth","raw_affiliation_strings":["HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, 4015, Durban, South Africa","HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, 4015, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]},{"raw_affiliation_string":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081656476","display_name":"Christina Thobakgale","orcid":"https://orcid.org/0000-0001-5619-8894","observed_orcids":["https://orcid.org/0000-0001-5619-8894"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Christina Thobakgale","raw_affiliation_strings":["HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, 4015, Durban, South Africa","HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, 4015, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]},{"raw_affiliation_string":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059261770","display_name":"Senica Chetty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Senica Chetty","raw_affiliation_strings":["HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, 4015, Durban, South Africa","HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, 4015, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]},{"raw_affiliation_string":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091675129","display_name":"Prinisha Rathnavalu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Prinisha Rathnavalu","raw_affiliation_strings":["HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, 4015, Durban, South Africa","HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, 4015, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]},{"raw_affiliation_string":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066677003","display_name":"Corey Moore","orcid":"https://orcid.org/0000-0002-0089-5356","observed_orcids":["https://orcid.org/0000-0002-0089-5356"]},"institutions":[{"id":"https://openalex.org/I176790772","display_name":"Murdoch University","ror":"https://ror.org/00r4sry34","country_code":"AU","type":"education","lineage":["https://openalex.org/I176790772"]},{"id":"https://openalex.org/I2799740997","display_name":"Royal Perth Hospital","ror":"https://ror.org/00zc2xc51","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2799740997","https://openalex.org/I2800882159","https://openalex.org/I4388446364","https://openalex.org/I4405257575"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Corey Moore","raw_affiliation_strings":["Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Wellington Street, Western Australia, 6000, Australia","Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Wellington Street, Western Australia, 6000, Australia","institution_ids":["https://openalex.org/I176790772","https://openalex.org/I2799740997"]},{"raw_affiliation_string":"Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Australia","institution_ids":["https://openalex.org/I176790772","https://openalex.org/I2799740997"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065065049","display_name":"Katja J. Pfafferott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210100268","display_name":"Medawar Building for Pathogen Research","ror":"https://ror.org/017g85521","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katja J. Pfafferott","raw_affiliation_strings":["Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, OX1 3SY, Oxford, UK","Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, OX1 3SY, Oxford, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]},{"raw_affiliation_string":"Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067279317","display_name":"Louise S. Hilton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210100268","display_name":"Medawar Building for Pathogen Research","ror":"https://ror.org/017g85521","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Louise Hilton","raw_affiliation_strings":["Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, OX1 3SY, Oxford, UK","Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, OX1 3SY, Oxford, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]},{"raw_affiliation_string":"Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089364098","display_name":"Peter Zimbwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210100268","display_name":"Medawar Building for Pathogen Research","ror":"https://ror.org/017g85521","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter Zimbwa","raw_affiliation_strings":["Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, OX1 3SY, Oxford, UK","Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, OX1 3SY, Oxford, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]},{"raw_affiliation_string":"Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035764838","display_name":"Sarah W. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Moore","raw_affiliation_strings":["Department of Microbiology, University of Washington, Seattle, Washington, 98195-8070, USA","Department of Microbiology, University of Washington, Seattle, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Washington, Seattle, Washington, 98195-8070, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Microbiology, University of Washington, Seattle, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027975124","display_name":"Todd M. Allen","orcid":"https://orcid.org/0000-0002-6609-1318","observed_orcids":["https://orcid.org/0000-0002-6609-1318"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Allen","raw_affiliation_strings":["Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts, 02129, USA","Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts, 02129, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090367243","display_name":"Christian Brander","orcid":"https://orcid.org/0000-0002-0548-5778","observed_orcids":["https://orcid.org/0000-0002-0548-5778"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Brander","raw_affiliation_strings":["Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts, 02129, USA","Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts, 02129, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044802324","display_name":"Marylyn M. Addo","orcid":"https://orcid.org/0000-0003-2836-9224","observed_orcids":["https://orcid.org/0000-0003-2836-9224"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marylyn M. Addo","raw_affiliation_strings":["Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts, 02129, USA","Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts, 02129, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042817775","display_name":"Marcus A. Altfeld","orcid":"https://orcid.org/0000-0001-5972-2997","observed_orcids":["https://orcid.org/0000-0001-5972-2997"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus Altfeld","raw_affiliation_strings":["Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts, 02129, USA","Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts, 02129, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086087903","display_name":"IAN R. JAMES","orcid":"https://orcid.org/0009-0008-7533-2751","observed_orcids":["https://orcid.org/0009-0008-7533-2751"]},"institutions":[{"id":"https://openalex.org/I176790772","display_name":"Murdoch University","ror":"https://ror.org/00r4sry34","country_code":"AU","type":"education","lineage":["https://openalex.org/I176790772"]},{"id":"https://openalex.org/I2799740997","display_name":"Royal Perth Hospital","ror":"https://ror.org/00zc2xc51","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2799740997","https://openalex.org/I2800882159","https://openalex.org/I4388446364","https://openalex.org/I4405257575"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ian James","raw_affiliation_strings":["Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Wellington Street, Western Australia, 6000, Australia","Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Wellington Street, Western Australia, 6000, Australia","institution_ids":["https://openalex.org/I176790772","https://openalex.org/I2799740997"]},{"raw_affiliation_string":"Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Australia","institution_ids":["https://openalex.org/I176790772","https://openalex.org/I2799740997"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070165631","display_name":"Simon Alexander Mallal","orcid":"https://orcid.org/0000-0002-7036-1309","observed_orcids":["https://orcid.org/0000-0002-7036-1309"]},"institutions":[{"id":"https://openalex.org/I176790772","display_name":"Murdoch University","ror":"https://ror.org/00r4sry34","country_code":"AU","type":"education","lineage":["https://openalex.org/I176790772"]},{"id":"https://openalex.org/I2799740997","display_name":"Royal Perth Hospital","ror":"https://ror.org/00zc2xc51","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2799740997","https://openalex.org/I2800882159","https://openalex.org/I4388446364","https://openalex.org/I4405257575"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Simon Mallal","raw_affiliation_strings":["Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Wellington Street, Western Australia, 6000, Australia","Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Wellington Street, Western Australia, 6000, Australia","institution_ids":["https://openalex.org/I176790772","https://openalex.org/I2799740997"]},{"raw_affiliation_string":"Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Level 2 North Block, Royal Perth Hospital, Australia","institution_ids":["https://openalex.org/I176790772","https://openalex.org/I2799740997"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Bunce","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Bunce","raw_affiliation_strings":["Dynal Biotech Ltd, 11 Bassendale Road, Wirral, CH62 3QL, UK","Dynal Biotech Ltd, Wirral, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dynal Biotech Ltd, 11 Bassendale Road, Wirral, CH62 3QL, UK","institution_ids":[]},{"raw_affiliation_string":"Dynal Biotech Ltd, Wirral, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113373807","display_name":"L D Barber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800598996","display_name":"Anthony Nolan","ror":"https://ror.org/043bfms20","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800598996"]},{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Linda D. Barber","raw_affiliation_strings":["Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, NW3 2QG, London, UK","Anthony Nolan Research Institute, Royal Free Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, NW3 2QG, London, UK","institution_ids":["https://openalex.org/I2800598996","https://openalex.org/I2801138448"]},{"raw_affiliation_string":"Anthony Nolan Research Institute, Royal Free Hospital, London, UK","institution_ids":["https://openalex.org/I2800598996","https://openalex.org/I2801138448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006205918","display_name":"James J. Szinger","orcid":"https://orcid.org/0000-0002-6605-9940","observed_orcids":["https://orcid.org/0000-0002-6605-9940"]},"institutions":[{"id":"https://openalex.org/I1308548392","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35","country_code":"US","type":"funder","lineage":["https://openalex.org/I1308548392"]},{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Szinger","raw_affiliation_strings":["Los Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA","Santa Fe Institute, Santa Fe, New Mexico, 87501, USA","Los Alamos National Laboratory, Los Alamos, USA","Santa Fe Institute, Santa Fe, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Los Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA","institution_ids":["https://openalex.org/I1343871089"]},{"raw_affiliation_string":"Santa Fe Institute, Santa Fe, New Mexico, 87501, USA","institution_ids":["https://openalex.org/I1308548392"]},{"raw_affiliation_string":"Los Alamos National Laboratory, Los Alamos, USA","institution_ids":["https://openalex.org/I1343871089"]},{"raw_affiliation_string":"Santa Fe Institute, Santa Fe, USA","institution_ids":["https://openalex.org/I1308548392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031165744","display_name":"Cheryl L. Day","orcid":"https://orcid.org/0000-0002-6497-4846","observed_orcids":["https://orcid.org/0000-0002-6497-4846"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210100268","display_name":"Medawar Building for Pathogen Research","ror":"https://ror.org/017g85521","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cheryl Day","raw_affiliation_strings":["Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, OX1 3SY, Oxford, UK","Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, OX1 3SY, Oxford, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]},{"raw_affiliation_string":"Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029546143","display_name":"Paul Klenerman","orcid":"https://orcid.org/0000-0003-4307-9161","observed_orcids":["https://orcid.org/0000-0003-4307-9161"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210100268","display_name":"Medawar Building for Pathogen Research","ror":"https://ror.org/017g85521","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Klenerman","raw_affiliation_strings":["Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, OX1 3SY, Oxford, UK","Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, OX1 3SY, Oxford, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]},{"raw_affiliation_string":"Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028336562","display_name":"James I. Mullins","orcid":"https://orcid.org/0000-0002-4461-8158","observed_orcids":["https://orcid.org/0000-0002-4461-8158"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Mullins","raw_affiliation_strings":["Department of Microbiology, University of Washington, Seattle, Washington, 98195-8070, USA","Department of Microbiology, University of Washington, Seattle, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Washington, Seattle, Washington, 98195-8070, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Microbiology, University of Washington, Seattle, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022985881","display_name":"Bette Korber","orcid":"https://orcid.org/0000-0002-2026-5757","observed_orcids":["https://orcid.org/0000-0002-2026-5757"]},"institutions":[{"id":"https://openalex.org/I1308548392","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35","country_code":"US","type":"funder","lineage":["https://openalex.org/I1308548392"]},{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bette Korber","raw_affiliation_strings":["Los Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA","Santa Fe Institute, Santa Fe, New Mexico, 87501, USA","Los Alamos National Laboratory, Los Alamos, USA","Santa Fe Institute, Santa Fe, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Los Alamos National Laboratory, Los Alamos, New Mexico, 87545, USA","institution_ids":["https://openalex.org/I1343871089"]},{"raw_affiliation_string":"Santa Fe Institute, Santa Fe, New Mexico, 87501, USA","institution_ids":["https://openalex.org/I1308548392"]},{"raw_affiliation_string":"Los Alamos National Laboratory, Los Alamos, USA","institution_ids":["https://openalex.org/I1343871089"]},{"raw_affiliation_string":"Santa Fe Institute, Santa Fe, USA","institution_ids":["https://openalex.org/I1308548392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088400921","display_name":"Hoosen Mahomed Coovadia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Hoosen M. Coovadia","raw_affiliation_strings":["HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, 4015, Durban, South Africa","HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, 4015, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]},{"raw_affiliation_string":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016518899","display_name":"Bruce D. Walker","orcid":"https://orcid.org/0000-0001-6122-9245","observed_orcids":["https://orcid.org/0000-0001-6122-9245","https://orcid.org/0000-0002-8506-6740"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["US","ZA"],"is_corresponding":false,"raw_author_name":"Bruce D. Walker","raw_affiliation_strings":["HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, 4015, Durban, South Africa","Howard Hughes Medical Institute, Chevy Chase, Maryland, 20815, USA","Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts, 02129, USA","HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa","Howard Hughes Medical Institute, Chevy Chase, USA","Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, 4015, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Chevy Chase, Maryland, 20815, USA","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts, 02129, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Chevy Chase, USA","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043346206","display_name":"Philip Goulder","orcid":"https://orcid.org/0000-0002-9842-4674","observed_orcids":["https://orcid.org/0000-0002-9842-4674"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210100268","display_name":"Medawar Building for Pathogen Research","ror":"https://ror.org/017g85521","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["GB","US","ZA"],"is_corresponding":true,"raw_author_name":"Philip J. R. Goulder","raw_affiliation_strings":["Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, OX1 3SY, Oxford, UK","HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, 4015, Durban, South Africa","Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts, 02129, USA","Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, UK","HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa","Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, OX1 3SY, Oxford, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]},{"raw_affiliation_string":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, 4015, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]},{"raw_affiliation_string":"Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts, 02129, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, UK","institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210100268"]},{"raw_affiliation_string":"HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]},{"raw_affiliation_string":"Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, USA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5043346206"],"corresponding_institution_ids":["https://openalex.org/I40120149","https://openalex.org/I4210087915","https://openalex.org/I4210100268","https://openalex.org/I95023434"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":16.9705,"has_fulltext":false,"cited_by_count":845,"citation_normalized_percentile":{"value":0.99868074,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"432","issue":"7018","first_page":"769","last_page":"775"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-b","display_name":"HLA-B","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hla-a","display_name":"HLA-A","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cd8-t-cell-responses","display_name":"CD8+ T cell responses","score":0.8730000257492065},{"id":"https://openalex.org/keywords/hla-class-i-restriction","display_name":"HLA class I restriction","score":0.7850000262260437},{"id":"https://openalex.org/keywords/viral-set-point","display_name":"viral set point","score":0.6290000081062317},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.8299999833106995},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hla-polymorphism","display_name":"HLA polymorphism","score":0.75},{"id":"https://openalex.org/keywords/hiv-vaccine-design","display_name":"HIV vaccine design","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.8462539911270142},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6837233304977417},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6633697748184204},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6553488969802856},{"id":"https://openalex.org/C2910492473","wikidata":"https://www.wikidata.org/wiki/Q18026920","display_name":"HLA-B Antigens","level":4,"score":0.5789297223091125},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5593541860580444},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.523292601108551},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.510674774646759},{"id":"https://openalex.org/C2775866039","wikidata":"https://www.wikidata.org/wiki/Q14906952","display_name":"HLA-A","level":4,"score":0.43765097856521606},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4200846552848816},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4194064140319824},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.39721184968948364},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3961692452430725},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3219475746154785},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11431452631950378},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000353","descriptor_name":"Africa, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000353","descriptor_name":"Africa, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000353","descriptor_name":"Africa, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015234","descriptor_name":"HLA-A Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015234","descriptor_name":"HLA-A Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015234","descriptor_name":"HLA-A Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015234","descriptor_name":"HLA-A Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015234","descriptor_name":"HLA-A Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015234","descriptor_name":"HLA-A Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015235","descriptor_name":"HLA-B Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015235","descriptor_name":"HLA-B Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015235","descriptor_name":"HLA-B Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015235","descriptor_name":"HLA-B Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015235","descriptor_name":"HLA-B Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015235","descriptor_name":"HLA-B Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015693","descriptor_name":"Gene Products, nef","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015693","descriptor_name":"Gene Products, nef","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015693","descriptor_name":"Gene Products, nef","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054311","descriptor_name":"nef Gene Products, Human Immunodeficiency Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054311","descriptor_name":"nef Gene Products, Human Immunodeficiency Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054311","descriptor_name":"nef Gene Products, Human Immunodeficiency Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/nature03113","doi":"https://doi.org/10.1038/nature03113","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature03113","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:15592417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15592417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"},{"id":"pmh:oai:researchrepository.murdoch.edu.au:5149","doi":null,"is_oa":false,"landing_page_url":"http://researchrepository.murdoch.edu.au/id/eprint/5149/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:nature:v:432:y:2004:i:7018:d:10.1038_nature03113","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/nature03113","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:181942","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/181942/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NATURE , 432 (7018) pp. 769-774. (2004)","raw_type":"Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/f92a8166-a284-44dd-8049-7b5ada581c40","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/f92a8166-a284-44dd-8049-7b5ada581c40","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5699999928474426}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1928067986","https://openalex.org/W1963813930","https://openalex.org/W1964867999","https://openalex.org/W1966710345","https://openalex.org/W1971877271","https://openalex.org/W1975101865","https://openalex.org/W1985058594","https://openalex.org/W1995453338","https://openalex.org/W1997145350","https://openalex.org/W2009102382","https://openalex.org/W2009444355","https://openalex.org/W2012139740","https://openalex.org/W2014569071","https://openalex.org/W2035555649","https://openalex.org/W2038599188","https://openalex.org/W2058321555","https://openalex.org/W2060764856","https://openalex.org/W2063485002","https://openalex.org/W2068428266","https://openalex.org/W2078708274","https://openalex.org/W2087484510","https://openalex.org/W2097150100","https://openalex.org/W2099182602","https://openalex.org/W2099618881","https://openalex.org/W2142405752","https://openalex.org/W2151651155","https://openalex.org/W2157824753"],"related_works":["https://openalex.org/W4241627343","https://openalex.org/W2408599910","https://openalex.org/W2169978372","https://openalex.org/W2011936762","https://openalex.org/W2006475088","https://openalex.org/W2601749131","https://openalex.org/W2205639878","https://openalex.org/W2002647387","https://openalex.org/W4281745084","https://openalex.org/W2050042904"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":29},{"year":2018,"cited_by_count":30},{"year":2017,"cited_by_count":30},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":38},{"year":2014,"cited_by_count":38},{"year":2013,"cited_by_count":49},{"year":2012,"cited_by_count":68}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}