{"id":"https://openalex.org/W2045488347","doi":"https://doi.org/10.1097/00045391-199605000-00006","title":"SINGLE-AND MULTIPLE-DOSE PHARMACOKINETICS OF REDUCED METABOLITE (MDL 74,156) FOLLOWING ORAL ADMINISTRATION OF DOLASETRON MESYLATE TO NORMAL MALE SUBJECTS","display_name":"SINGLE-AND MULTIPLE-DOSE PHARMACOKINETICS OF REDUCED METABOLITE (MDL 74,156) FOLLOWING ORAL ADMINISTRATION OF DOLASETRON MESYLATE TO NORMAL MALE SUBJECTS","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W2045488347","doi":"https://doi.org/10.1097/00045391-199605000-00006","mag":"2045488347","pmid":"https://pubmed.ncbi.nlm.nih.gov/11862273"},"language":"en","primary_location":{"id":"doi:10.1097/00045391-199605000-00006","doi":"https://doi.org/10.1097/00045391-199605000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00045391-199605000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S67118044","display_name":"American Journal of Therapeutics","issn_l":"1075-2765","issn":["1075-2765","1536-3686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ajit Shah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ajit Shah","raw_affiliation_strings":["Marion Merrell Dow, Inc., Kansas City, MO, USA","Marion Merrell Dote, Inc., Kansas City, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marion Merrell Dow, Inc., Kansas City, MO, USA","institution_ids":[]},{"raw_affiliation_string":"Marion Merrell Dote, Inc., Kansas City, MO, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110233674","display_name":"Robert C. Lanman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Lanman","raw_affiliation_strings":["Kansas City Analytical Services, Shawenee, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kansas City Analytical Services, Shawenee, KS, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023954017","display_name":"Vijay O. Bhargava","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vijay Bhargava","raw_affiliation_strings":["Marion Merrell Dote, Inc., Kansas City, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marion Merrell Dote, Inc., Kansas City, MO, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002299630","display_name":"Scott James Weir","orcid":"https://orcid.org/0000-0002-8020-434X","observed_orcids":["https://orcid.org/0000-0002-8020-434X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott Weir","raw_affiliation_strings":["Marion Merrell Dote, Inc., Kansas City, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marion Merrell Dote, Inc., Kansas City, MO, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110162975","display_name":"William F. Hahne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William Hahne","raw_affiliation_strings":["Marion Merrell Dote, Inc., Kansas City, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marion Merrell Dote, Inc., Kansas City, MO, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18084769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"5","first_page":"364","last_page":"370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.8291000127792358,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.8291000127792358,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.16300000250339508,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dolasetron","display_name":"dolasetron","score":0.8870000243186951},{"id":"https://openalex.org/keywords/reduced-metabolites","display_name":"reduced metabolites","score":0.7609999775886536},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9440000057220459},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.8579999804496765},{"id":"https://openalex.org/keywords/antiemetic-activity","display_name":"antiemetic activity","score":0.8740000128746033},{"id":"https://openalex.org/keywords/chemotherapy-induced-nausea-and-vomiting","display_name":"chemotherapy-induced nausea and vomiting","score":0.9599999785423279},{"id":"https://openalex.org/keywords/dose-proportionality","display_name":"dose proportionality","score":0.75},{"id":"https://openalex.org/keywords/renal-clearance","display_name":"renal clearance","score":0.722000002861023},{"id":"https://openalex.org/keywords/half-life","display_name":"half-life","score":0.4869999885559082},{"id":"https://openalex.org/keywords/healthy-men","display_name":"healthy men","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8510062098503113},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7985363602638245},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7442793250083923},{"id":"https://openalex.org/C149151106","wikidata":"https://www.wikidata.org/wiki/Q4677569","display_name":"Active metabolite","level":3,"score":0.7375958561897278},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6755375862121582},{"id":"https://openalex.org/C2780884295","wikidata":"https://www.wikidata.org/wiki/Q575136","display_name":"Antiemetic","level":3,"score":0.6565550565719604},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.5520315170288086},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4640950560569763},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.4477503299713135},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.43580162525177},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.4138856530189514},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2622334659099579},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/00045391-199605000-00006","doi":"https://doi.org/10.1097/00045391-199605000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00045391-199605000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S67118044","display_name":"American Journal of Therapeutics","issn_l":"1075-2765","issn":["1075-2765","1536-3686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Therapeutics","raw_type":"journal-article"},{"id":"pmid:11862273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11862273","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2132691174","https://openalex.org/W2122796503","https://openalex.org/W2078029775","https://openalex.org/W2040155790","https://openalex.org/W1998535329","https://openalex.org/W2040742226","https://openalex.org/W2141760638","https://openalex.org/W2044174574","https://openalex.org/W2092727952","https://openalex.org/W7096310946"],"abstract_inverted_index":{"Dolasetron,":[0],"a":[1,120],"5-hydroxytryptamine(3)":[2],"receptor":[3],"antagonist,":[4],"is":[5,29],"under":[6,134],"investigation":[7],"for":[8,32],"prevention":[9],"of":[10,20,44,51,64,70,102,171,192],"nausea":[11],"and":[12,28,40,84,99,118,132,169,185,202],"vomiting":[13],"due":[14],"to":[15,76,140,151,163,178,187,196],"chemotherapy.":[16],"The":[17,110,128,143,158,190],"keto-reduced":[18],"metabolite":[19,47,112,194],"dolasetron":[21,52,71,95],"has":[22],"been":[23],"identified":[24],"in":[25,54,115,124,174],"human":[26],"plasma":[27,94,117,122,130,135],"likely":[30],"responsible":[31],"the":[33,45,103,116,141],"antiemetic":[34],"activity.":[35],"This":[36],"study":[37],"evaluated":[38],"single":[39,201],"multiple":[41,203],"dose":[42,172,198],"pharmacokinetics":[43,101,191],"reduced":[46,111,193],"following":[48],"oral":[49,68,146],"administration":[50],"mesylate":[53,72],"healthy":[55],"male":[56],"subjects.":[57],"Five":[58],"groups":[59],"(six":[60],"active/two":[61],"placebo":[62,80],"each)":[63],"subjects":[65],"received":[66],"either":[67],"doses":[69],"ranging":[73],"from":[74,149,161],"25":[75],"200":[77],"mg":[78],"or":[79],"on":[81,88],"day":[82],"1":[83,126],"every":[85],"12":[86],"h":[87],"days":[89],"2":[90],"through":[91],"9.":[92],"Because":[93],"concentrations":[96,131],"were":[97,138,176],"low":[98],"sporadic,":[100],"parent":[104],"compound":[105],"could":[106],"not":[107],"be":[108,197],"determined.":[109],"appeared":[113],"rapidly":[114],"reached":[119],"maximal":[121,129],"concentration":[123],"about":[125],"h.":[127,165],"areas":[133],"concentration--time":[136],"curves":[137],"proportional":[139],"dose.":[142],"mean":[144],"apparent":[145],"clearance":[147,168],"ranged":[148,160],"9.89":[150],"23.10":[152],"ml":[153,180],"min(minus":[154,181],"sign1)":[155,182,184],"kg(minus":[156,183],"sign1).":[157],"half-life":[159],"5.20":[162],"10.80":[164],"Mean":[166],"renal":[167],"fraction":[170],"excreted":[173],"urine":[175],"0.97":[177],"3.97":[179],"7.47":[186],"31.9%,":[188],"respectively.":[189],"appears":[195],"independent":[199],"after":[200],"dosing.":[204]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
