{"id":"https://openalex.org/W2045458696","doi":"https://doi.org/10.1159/000122599","title":"A New Prognostic Staging System for Hepatocellular Carcinoma: Value of the Biomarker Combined Japan Integrated Staging Score","display_name":"A New Prognostic Staging System for Hepatocellular Carcinoma: Value of the Biomarker Combined Japan Integrated Staging Score","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2045458696","doi":"https://doi.org/10.1159/000122599","mag":"2045458696","pmid":"https://pubmed.ncbi.nlm.nih.gov/18544953"},"language":"en","primary_location":{"id":"doi:10.1159/000122599","doi":"https://doi.org/10.1159/000122599","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000122599","pdf_url":null,"source":{"id":"https://openalex.org/S64836871","display_name":"Intervirology","issn_l":"0300-5526","issn":["0300-5526","1423-0100"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intervirology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033358909","display_name":"Satoshi Kitai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I916559398","display_name":"Kindai University","ror":"https://ror.org/05kt9ap64","country_code":"JP","type":"education","lineage":["https://openalex.org/I916559398"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Kitai","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Osaka-Sayama, Japan. m-kudo@med.kindai.ac.jp","Division of Gastroenterology and Hepatology, Department of Internal Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kinki University School of Medicine, Osaka-Sayama, Japan. m-kudo@med.kindai.ac.jp","institution_ids":["https://openalex.org/I916559398"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032900701","display_name":"Masatoshi Kudo","orcid":"https://orcid.org/0000-0002-4102-3474","observed_orcids":["https://orcid.org/0000-0002-4102-3474"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masatoshi Kudo","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063658372","display_name":"Yasunori Minami","orcid":"https://orcid.org/0000-0001-7146-5954","observed_orcids":["https://orcid.org/0000-0001-7146-5954"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasunori Minami","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076725199","display_name":"Kazuomi Ueshima","orcid":"https://orcid.org/0000-0002-7577-5789","observed_orcids":["https://orcid.org/0000-0002-7577-5789"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuomi Ueshima","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024807041","display_name":"Hobyung Chung","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hobyung Chung","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021075691","display_name":"Satoru Hagiwara","orcid":"https://orcid.org/0000-0002-3412-4701","observed_orcids":["https://orcid.org/0000-0002-3412-4701"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoru Hagiwara","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100877809","display_name":"Tatsuo Inoue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tatsuo Inoue","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108478763","display_name":"Emi Ishikawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emi Ishikawa","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038455694","display_name":"Shunsuke Takahashi","orcid":"https://orcid.org/0000-0002-4186-8119","observed_orcids":["https://orcid.org/0000-0002-4186-8119"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shunsuke Takahashi","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064543009","display_name":"Yutaka Asakuma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yutaka Asakuma","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Internal Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110155777","display_name":"Seiji Haji","orcid":"https://orcid.org/0000-0001-8320-3257","observed_orcids":["https://orcid.org/0000-0001-8320-3257"]},"institutions":[{"id":"https://openalex.org/I916559398","display_name":"Kindai University","ror":"https://ror.org/05kt9ap64","country_code":"JP","type":"education","lineage":["https://openalex.org/I916559398"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiji Haji","raw_affiliation_strings":["Department of Surgery, Kinki University School of Medicine, Departments of Gastroenterology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kinki University School of Medicine, Departments of Gastroenterology,","institution_ids":["https://openalex.org/I916559398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112442872","display_name":"Yukio Osaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151887","display_name":"Osaka Red Cross Hospital","ror":"https://ror.org/05h4q5j46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4210151887"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukio Osaki","raw_affiliation_strings":["Osaka Red Cross Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka Red Cross Hospital and","institution_ids":["https://openalex.org/I4210151887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113534971","display_name":"Hiroko Oka","orcid":"https://orcid.org/0000-0002-6887-8456","observed_orcids":["https://orcid.org/0000-0002-6887-8456"]},"institutions":[{"id":"https://openalex.org/I4210099064","display_name":"Osaka City General Hospital","ror":"https://ror.org/00v053551","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099064","https://openalex.org/I4405284496"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroko Oka","raw_affiliation_strings":["Osaka City General Hospital,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka City General Hospital,","institution_ids":["https://openalex.org/I4210099064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041576626","display_name":"Toshihito Seki","orcid":"https://orcid.org/0009-0003-6529-9998","observed_orcids":["https://orcid.org/0009-0003-6529-9998"]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihito Seki","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Kansai Medical University, and Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Kansai Medical University, and Departments of","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110417358","display_name":"Hiroshi Kasugai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Kasugai","raw_affiliation_strings":["Gastroenterology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080639400","display_name":"Yo Sasaki","orcid":"https://orcid.org/0000-0003-0024-0031","observed_orcids":["https://orcid.org/0000-0003-0024-0031"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yo Sasaki","raw_affiliation_strings":["Surgery and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087443447","display_name":"Takashi Matsunaga","orcid":"https://orcid.org/0000-0003-0960-0427","observed_orcids":["https://orcid.org/0000-0003-0960-0427","https://orcid.org/0009-0003-9815-1156"]},"institutions":[{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Matsunaga","raw_affiliation_strings":["Clinical Laboratory and Medical Informatics, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory and Medical Informatics, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1250,"currency":"CHF","value_usd":1250},"apc_paid":null,"fwci":1.9547,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.8643819,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"51","issue":"Suppl. 1","first_page":"86","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/prognostic-staging","display_name":"prognostic staging","score":0.796999990940094},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.8709999918937683},{"id":"https://openalex.org/keywords/des-gamma-carboxy-prothrombin","display_name":"PIVKA-II","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.8600000143051147},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.878000020980835},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.7319999933242798},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"prognostic model","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7799999117851257},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6682813763618469},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.616274356842041},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6136031150817871},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5766134262084961},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4104636311531067},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40080341696739197},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.1917649507522583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12377101182937622},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011516","descriptor_name":"Prothrombin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027806","descriptor_name":"Lens Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000122599","doi":"https://doi.org/10.1159/000122599","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000122599","pdf_url":null,"source":{"id":"https://openalex.org/S64836871","display_name":"Intervirology","issn_l":"0300-5526","issn":["0300-5526","1423-0100"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intervirology","raw_type":"journal-article"},{"id":"pmid:18544953","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18544953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intervirology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1511848366","https://openalex.org/W1534957296","https://openalex.org/W1539891810","https://openalex.org/W1974402264","https://openalex.org/W1979300931","https://openalex.org/W1982770627","https://openalex.org/W1988148746","https://openalex.org/W1989711166","https://openalex.org/W1989739623","https://openalex.org/W1994454529","https://openalex.org/W2008206360","https://openalex.org/W2009624493","https://openalex.org/W2011043511","https://openalex.org/W2019413523","https://openalex.org/W2021761439","https://openalex.org/W2025732411","https://openalex.org/W2037480346","https://openalex.org/W2055499437","https://openalex.org/W2055702442","https://openalex.org/W2058719417","https://openalex.org/W2060123467","https://openalex.org/W2078207502","https://openalex.org/W2082382028","https://openalex.org/W2086737714","https://openalex.org/W2089114108","https://openalex.org/W2101746249","https://openalex.org/W2142635246","https://openalex.org/W2147172608","https://openalex.org/W2148436793","https://openalex.org/W2163486683","https://openalex.org/W2171662722","https://openalex.org/W2330134488","https://openalex.org/W2334978547","https://openalex.org/W2395539198","https://openalex.org/W2410782603","https://openalex.org/W2591170673","https://openalex.org/W3041047318","https://openalex.org/W4298434897"],"related_works":["https://openalex.org/W1975200650","https://openalex.org/W2060003767","https://openalex.org/W2011043511","https://openalex.org/W1968039618","https://openalex.org/W2009624493","https://openalex.org/W2019846668","https://openalex.org/W2095440967","https://openalex.org/W2061873656","https://openalex.org/W2036926413","https://openalex.org/W1976091842"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,32,144,192],"Japan":[2],"Integrated":[3],"Staging":[4],"(JIS)":[5],"score":[6,24,101,140,155,159,176,187,194],"has":[7],"been":[8],"reported":[9],"to":[10,38,98,137,177,203],"have":[11,178],"good":[12,221],"stratification":[13,89,150,197],"ability":[14,90,147,198],"in":[15,80],"patients":[16,77,219],"with":[17,66,220],"hepatocellular":[18],"carcinoma":[19],"(HCC).":[20],"However,":[21],"the":[22,40,47,67,88,99,103,113,121,131,138,149,153,157,162,167,174,185,209,212,218],"JIS":[23,50,69,105,123,154,186,214],"could":[25],"not":[26],"estimate":[27],"malignant":[28],"grade":[29],"of":[30,34,42,74,125,152,208],"HCC.":[31],"aim":[33],"this":[35,81],"study":[36],"was":[37,201],"evaluate":[39],"performance":[41],"a":[43,94,179,205],"new":[44],"staging":[45],"system:":[46],"biomarker":[48],"combined":[49],"(bm-JIS)":[51],"which":[52],"includes":[53],"three":[54],"tumor":[55],"markers:":[56],"alpha-fetoprotein":[57],"(AFP),":[58],"Lens":[59],"culinaris":[60],"agglutinin-reactive":[61],"AFP":[62],"and":[63,91,102,129,148,156,199],"des-gamma-carboxy":[64],"prothrombin":[65],"conventional":[68,104,122,213],"score.":[70,106],"METHODS:":[71],"A":[72],"total":[73],"1,924":[75],"HCC":[76],"were":[78,109],"included":[79],"study.":[82],"We":[83],"compared":[84],"their":[85],"overall":[86],"survival,":[87],"suitability":[92],"as":[93],"prognostic":[95],"model":[96,172],"according":[97,136],"bm-JIS":[100,118,139,158,175,193],"RESULTS:":[107],"There":[108],"significant":[110],"differences":[111],"between":[112],"survival":[114,132],"curves":[115,133],"for":[116,217],"all":[117],"scores.":[119],"For":[120],"scores":[124],"0,":[126],"1,":[127],"2":[128],"3,":[130],"differed":[134],"greatly":[135],"(p":[141],"<":[142],"0.0001).":[143],"independent":[145],"homogenizing":[146],"value":[151],"determined":[160],"by":[161],"likelihood":[163],"ratio":[164],"test":[165],"using":[166],"Cox":[168],"proportional":[169],"hazard":[170],"regression":[171],"showed":[173,195],"higher":[180],"value(chi2":[181],"=":[182,189],"717.348)":[183],"than":[184,211],"(chi2":[188],"668.91).":[190],"CONCLUSIONS:":[191],"superior":[196],"thus":[200],"found":[202],"be":[204],"better":[206],"predictor":[207],"prognosis":[210],"score,":[215],"especially":[216],"prognosis.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}