{"id":"https://openalex.org/W2045428587","doi":"https://doi.org/10.1016/j.media.2014.11.007","title":"A novel method for identifying a graph-based representation of 3-D microvascular networks from fluorescence microscopy image stacks","display_name":"A novel method for identifying a graph-based representation of 3-D microvascular networks from fluorescence microscopy image stacks","publication_year":2014,"publication_date":"2014-11-30","ids":{"openalex":"https://openalex.org/W2045428587","doi":"https://doi.org/10.1016/j.media.2014.11.007","mag":"2045428587","pmid":"https://pubmed.ncbi.nlm.nih.gov/25515433","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4955560"},"language":"en","primary_location":{"id":"doi:10.1016/j.media.2014.11.007","doi":"https://doi.org/10.1016/j.media.2014.11.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.media.2014.11.007","pdf_url":null,"source":{"id":"https://openalex.org/S116571295","display_name":"Medical Image Analysis","issn_l":"1361-8415","issn":["1361-8415","1361-8423","1361-8431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["ccf-c","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Image Analysis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4955560","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020456403","display_name":"Sepideh Almasi","orcid":"https://orcid.org/0000-0001-7684-438X","observed_orcids":["https://orcid.org/0000-0001-7684-438X"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sepideh Almasi","raw_affiliation_strings":["Dept. Electrical and Computer Engineering, Tufts University, Medford, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Electrical and Computer Engineering, Tufts University, Medford, MA, USA","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073577367","display_name":"Xiaoyin Xu","orcid":"https://orcid.org/0000-0003-0813-7979","observed_orcids":["https://orcid.org/0000-0003-0813-7979"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoyin Xu","raw_affiliation_strings":["Dept. Radiology, Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Radiology, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066671374","display_name":"Ayal Ben\u2010Zvi","orcid":"https://orcid.org/0000-0003-4012-7789","observed_orcids":["https://orcid.org/0000-0003-4012-7789"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayal Ben-Zvi","raw_affiliation_strings":["Dept. Neurobiology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Neurobiology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058142112","display_name":"Baptiste Lacoste","orcid":"https://orcid.org/0000-0002-1922-8801","observed_orcids":["https://orcid.org/0000-0002-1922-8801"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baptiste Lacoste","raw_affiliation_strings":["Dept. Neurobiology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Neurobiology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028273617","display_name":"Chenghua Gu","orcid":"https://orcid.org/0000-0002-4212-7232","observed_orcids":["https://orcid.org/0000-0002-4212-7232","https://orcid.org/0000-0003-4465-9125","https://orcid.org/0009-0003-1740-161X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenghua Gu","raw_affiliation_strings":["Dept. Neurobiology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Neurobiology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073127824","display_name":"Eric L. Miller","orcid":"https://orcid.org/0000-0002-3156-6002","observed_orcids":["https://orcid.org/0000-0002-3156-6002"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric L. Miller","raw_affiliation_strings":["Dept. Electrical and Computer Engineering, Tufts University, Medford, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. Electrical and Computer Engineering, Tufts University, Medford, MA, USA","institution_ids":["https://openalex.org/I121934306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020456403"],"corresponding_institution_ids":["https://openalex.org/I121934306"],"apc_list":{"value":4170,"currency":"USD","value_usd":4170},"apc_paid":null,"fwci":0.7912,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.7235667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"20","issue":"1","first_page":"208","last_page":"223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.6211000084877014,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.6211000084877014,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.23389999568462372,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.10580000281333923,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microvascular-networks","display_name":"microvascular networks","score":0.7829999923706055},{"id":"https://openalex.org/keywords/graph-representation","display_name":"graph representation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/critical-point-detection","display_name":"critical point detection","score":0.8619999885559082},{"id":"https://openalex.org/keywords/0-1-integer-programming","display_name":"0-1 integer programming","score":0.765999972820282},{"id":"https://openalex.org/keywords/graph-connectivity","display_name":"graph connectivity","score":0.6100000143051147},{"id":"https://openalex.org/keywords/vessel-curvature","display_name":"vessel curvature","score":0.4519999921321869},{"id":"https://openalex.org/keywords/network-topology","display_name":"network topology","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C185250623","wikidata":"https://www.wikidata.org/wiki/Q2301683","display_name":"Tortuosity","level":3,"score":0.637022852897644},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.618374764919281},{"id":"https://openalex.org/C195065555","wikidata":"https://www.wikidata.org/wiki/Q214881","display_name":"Curvature","level":2,"score":0.5136858820915222},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.4972057640552521},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.49689820408821106},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.446042001247406},{"id":"https://openalex.org/C17095337","wikidata":"https://www.wikidata.org/wiki/Q2375229","display_name":"Piecewise linear function","level":2,"score":0.43802115321159363},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.42353370785713196},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.41665640473365784},{"id":"https://openalex.org/C164660894","wikidata":"https://www.wikidata.org/wiki/Q2037833","display_name":"Piecewise","level":2,"score":0.41506439447402954},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3606570363044739},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3589407503604889},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.1832852065563202},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.17007344961166382},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11671629548072815},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.media.2014.11.007","doi":"https://doi.org/10.1016/j.media.2014.11.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.media.2014.11.007","pdf_url":null,"source":{"id":"https://openalex.org/S116571295","display_name":"Medical Image Analysis","issn_l":"1361-8415","issn":["1361-8415","1361-8423","1361-8431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["ccf-c","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Image Analysis","raw_type":"journal-article"},{"id":"pmid:25515433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25515433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical image analysis","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4955560","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4955560","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Med Image Anal","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4955560","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4955560","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Med Image Anal","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1121181511","display_name":"A novel informatics approach to understanding complex muscle fiber phenotypes","funder_award_id":"R01LM011415","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306369","display_name":"Harvard NeuroDiscovery Center","ror":"https://ror.org/000cs1t14"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1486444678","https://openalex.org/W1544290427","https://openalex.org/W1554799555","https://openalex.org/W1576682652","https://openalex.org/W1787237374","https://openalex.org/W1803535201","https://openalex.org/W1899587360","https://openalex.org/W1974954013","https://openalex.org/W1981329364","https://openalex.org/W1981689827","https://openalex.org/W1986141983","https://openalex.org/W1991605728","https://openalex.org/W2032128798","https://openalex.org/W2033695022","https://openalex.org/W2035890032","https://openalex.org/W2066283316","https://openalex.org/W2078261317","https://openalex.org/W2095049733","https://openalex.org/W2097062636","https://openalex.org/W2104460869","https://openalex.org/W2108855378","https://openalex.org/W2109294083","https://openalex.org/W2111528968","https://openalex.org/W2116040950","https://openalex.org/W2118842458","https://openalex.org/W2120666298","https://openalex.org/W2125241439","https://openalex.org/W2125577934","https://openalex.org/W2129534965","https://openalex.org/W2129600117","https://openalex.org/W2133059825","https://openalex.org/W2134756983","https://openalex.org/W2139719599","https://openalex.org/W2151114449","https://openalex.org/W2157709655","https://openalex.org/W2167439109","https://openalex.org/W2167685945","https://openalex.org/W2168005337","https://openalex.org/W2169118010","https://openalex.org/W2171330332","https://openalex.org/W2341512478","https://openalex.org/W2523062016","https://openalex.org/W2798566347","https://openalex.org/W4206727213","https://openalex.org/W4211084250","https://openalex.org/W4238015413","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2066283316","https://openalex.org/W2071511348","https://openalex.org/W3026760178","https://openalex.org/W7160040761","https://openalex.org/W2090985592","https://openalex.org/W2249416532","https://openalex.org/W2751865213","https://openalex.org/W2179112708","https://openalex.org/W2903564834","https://openalex.org/W4392025069"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
