{"id":"https://openalex.org/W2045376161","doi":"https://doi.org/10.1002/hep.23286","title":"Systematic Review of Randomized Trials on Vasoconstrictor Drugs for Hepatorenal Syndrome","display_name":"Systematic Review of Randomized Trials on Vasoconstrictor Drugs for Hepatorenal Syndrome","publication_year":2009,"publication_date":"2009-09-09","ids":{"openalex":"https://openalex.org/W2045376161","doi":"https://doi.org/10.1002/hep.23286","mag":"2045376161","pmid":"https://pubmed.ncbi.nlm.nih.gov/19885875"},"language":"en","primary_location":{"id":"doi:10.1002/hep.23286","doi":"https://doi.org/10.1002/hep.23286","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.23286","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2045376161"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114375523","display_name":"Lise Lotte Gluud","orcid":"https://orcid.org/0000-0002-9462-4468","observed_orcids":["https://orcid.org/0000-0002-9462-4468"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]},{"id":"https://openalex.org/I4210139775","display_name":"Cochrane","ror":"https://ror.org/048ztsn21","country_code":"DK","type":"other","lineage":["https://openalex.org/I4210139775"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Lise L. Gluud","raw_affiliation_strings":["Department of Internal Medicine, Copenhagen University Hospital Gentofte, Hellerup, Denmark. liselottegluud@yahoo.dk","Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen, Denmark","Department of Internal Medicine, Copenhagen University Hospital Gentofte, Hellerup, Denmark","fax: (45)-3545-7101"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Copenhagen University Hospital Gentofte, Hellerup, Denmark. liselottegluud@yahoo.dk","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]},{"raw_affiliation_string":"Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen, Denmark","institution_ids":["https://openalex.org/I4210139775"]},{"raw_affiliation_string":"Department of Internal Medicine, Copenhagen University Hospital Gentofte, Hellerup, Denmark","institution_ids":["https://openalex.org/I2802582725"]},{"raw_affiliation_string":"fax: (45)-3545-7101","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034563710","display_name":"Kurt Christensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139775","display_name":"Cochrane","ror":"https://ror.org/048ztsn21","country_code":"DK","type":"other","lineage":["https://openalex.org/I4210139775"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Kurt Christensen","raw_affiliation_strings":["Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen, Denmark","institution_ids":["https://openalex.org/I4210139775"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045441786","display_name":"Erik I. Christensen","orcid":"https://orcid.org/0000-0003-0684-5162","observed_orcids":["https://orcid.org/0000-0003-0684-5162"]},"institutions":[{"id":"https://openalex.org/I2801941904","display_name":"Bispebjerg Hospital","ror":"https://ror.org/00td68a17","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801941904","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I4210139775","display_name":"Cochrane","ror":"https://ror.org/048ztsn21","country_code":"DK","type":"other","lineage":["https://openalex.org/I4210139775"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Erik Christensen","raw_affiliation_strings":["Clinic of Internal Medicine, Bispebjerg University Hospital, Copenhagen, Denmark","Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic of Internal Medicine, Bispebjerg University Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2801941904"]},{"raw_affiliation_string":"Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen, Denmark","institution_ids":["https://openalex.org/I4210139775"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037909839","display_name":"Aleksander Ahm Krag","orcid":"https://orcid.org/0000-0002-9598-4932","observed_orcids":["https://orcid.org/0000-0002-9598-4932","https://orcid.org/0000-0002-1462-5920"]},"institutions":[{"id":"https://openalex.org/I2801942218","display_name":"Hvidovre Hospital","ror":"https://ror.org/00edrn755","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801942218","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Aleksander Krag","raw_affiliation_strings":["Department of Internal Medicine, Copenhagen University Hospital Gentofte, Hellerup, Denmark","Department of Medical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Copenhagen University Hospital Gentofte, Hellerup, Denmark","institution_ids":["https://openalex.org/I2802582725"]},{"raw_affiliation_string":"Department of Medical Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark","institution_ids":["https://openalex.org/I2801942218"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5114375523"],"corresponding_institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802582725","https://openalex.org/I4210139775"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":3.0693,"has_fulltext":false,"cited_by_count":297,"citation_normalized_percentile":{"value":0.95008606,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"51","issue":"2","first_page":"576","last_page":"584"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatorenal-syndrome","display_name":"hepatorenal syndrome","score":0.9869999885559082},{"id":"https://openalex.org/keywords/vasoconstrictor-drugs","display_name":"vasoconstrictor drugs","score":0.9449999928474426},{"id":"https://openalex.org/keywords/terlipressin","display_name":"terlipressin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.7699999809265137},{"id":"https://openalex.org/keywords/octreotide","display_name":"octreotide","score":0.9909999966621399},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.906000018119812},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.8970000147819519},{"id":"https://openalex.org/keywords/type-1-hepatorenal-syndrome","display_name":"hepatorenal syndrome type 1","score":0.9190000295639038},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.6100000143051147},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C2779393834","wikidata":"https://www.wikidata.org/wiki/Q324147","display_name":"Terlipressin","level":4,"score":0.9363768100738525},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8450652956962585},{"id":"https://openalex.org/C2776988256","wikidata":"https://www.wikidata.org/wiki/Q247131","display_name":"Hepatorenal syndrome","level":3,"score":0.7577849626541138},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.629357099533081},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.6109391450881958},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.6088882088661194},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.568490207195282},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5679052472114563},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.47619783878326416},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4639325737953186},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.42881470918655396},{"id":"https://openalex.org/C2780496750","wikidata":"https://www.wikidata.org/wiki/Q193889","display_name":"Ascites","level":2,"score":0.1715357005596161}],"mesh":[{"descriptor_ui":"D006530","descriptor_name":"Hepatorenal Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/hep.23286","doi":"https://doi.org/10.1002/hep.23286","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hep.23286","pdf_url":null,"source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:19885875","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19885875","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/3059e3e5-85f1-48f6-a994-da7dd7f2a176","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/3059e3e5-85f1-48f6-a994-da7dd7f2a176","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gluud, L L, Christensen, K, Christensen, E & Krag, A A 2010, 'Systematic review of randomized trials on vasoconstrictor drugs for hepatorenal syndrome', Hepatology, vol. 51, no. 2, pp. 576-84. https://doi.org/10.1002/hep.23286","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1967589221","https://openalex.org/W1970128129","https://openalex.org/W1971969855","https://openalex.org/W1972241537","https://openalex.org/W1979573742","https://openalex.org/W1984223131","https://openalex.org/W2029276570","https://openalex.org/W2036652612","https://openalex.org/W2036943696","https://openalex.org/W2045620941","https://openalex.org/W2061489021","https://openalex.org/W2071905444","https://openalex.org/W2074466817","https://openalex.org/W2075974527","https://openalex.org/W2078113157","https://openalex.org/W2094598763","https://openalex.org/W2099765590","https://openalex.org/W2104802633","https://openalex.org/W2110970000","https://openalex.org/W2120179295","https://openalex.org/W2123173269","https://openalex.org/W2125478133","https://openalex.org/W2127765911","https://openalex.org/W2131903288","https://openalex.org/W2133774931","https://openalex.org/W2142369257","https://openalex.org/W2152740900","https://openalex.org/W2160795579","https://openalex.org/W2164601307","https://openalex.org/W2164963279","https://openalex.org/W2186657631","https://openalex.org/W2214600008","https://openalex.org/W2599064878","https://openalex.org/W3191020455","https://openalex.org/W4251513966","https://openalex.org/W4255387568","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4401670028","https://openalex.org/W4317254427","https://openalex.org/W1598136470","https://openalex.org/W2736192950","https://openalex.org/W1883254629","https://openalex.org/W2568876760","https://openalex.org/W2411796982","https://openalex.org/W2021191128","https://openalex.org/W1585368434","https://openalex.org/W4386092141"],"abstract_inverted_index":{"UNLABELLED:":[0],"Vasoconstrictor":[1],"drugs":[2,31,87],"may":[3,209],"improve":[4],"renal":[5],"function":[6],"in":[7,178,213,230],"hepatorenal":[8],"syndrome":[9],"(HRS),":[10],"but":[11,127,184],"the":[12,41,113,156,202,220,231,238,244,259],"effect":[13,114,175],"on":[14,29,63,115],"mortality":[15,94,116,165],"has":[16],"not":[17,128,185,247],"been":[18],"established.":[19],"We":[20],"therefore":[21],"performed":[22],"a":[23],"systematic":[24],"review":[25],"of":[26,81,181,201,219,233,241,258],"randomized":[27,61],"trials":[28,46,62,191],"vasoconstrictor":[30,86],"for":[32,249],"type":[33,36,182,186,214,253],"1":[34,183,215],"or":[35,66,90,99,144,198,256],"2":[37,187,254],"HRS.":[38,188,216],"Mortality":[39],"was":[40,83,117,176],"primary":[42],"outcome":[43],"measure.":[44],"Eligible":[45],"were":[47,58,76,192],"identified":[48],"through":[49],"electronic":[50],"and":[51,72,194,229],"manual":[52],"searches.":[53],"Intention-to-treat":[54],"random":[55],"effects":[56,200],"meta-analyses":[57],"performed.":[59],"Ten":[60],"terlipressin":[64,161],"alone":[65,89],"with":[67,91,96,167],"albumin,":[68,71],"octreotide":[69],"plus":[70,74,162,207],"noradrenalin":[73],"albumin":[75,92,100,163,168,208],"included.":[77],"The":[78,174,189,217],"total":[79],"number":[80,240],"patients":[82,242],"376.":[84],"Overall,":[85],"used":[88],"reduced":[93,164],"compared":[95,166],"no":[97,196],"intervention":[98],"(relative":[101],"risk":[102],"[RR],":[103],"0.82;":[104],"95%":[105,124,134,141,149,171],"confidence":[106],"interval":[107],"[CI],":[108],"0.70-0.96).":[109],"In":[110],"subgroup":[111,179],"analyses,":[112],"seen":[118,177],"at":[119,129],"15":[120],"days":[121,131,138,146],"(RR,":[122,132,139,147,169],"0.60;":[123],"CI,":[125,135,142,150,172],"0.37-0.97)":[126],"30":[130],"0.74;":[133],"0.40-1.39),":[136],"90":[137],"0.89;":[140],"0.66-1.22),":[143],"180":[145],"0.83;":[148],"0.65-1.05).":[151],"Subgroup":[152],"analyses":[153,180],"stratified":[154],"by":[155],"treatments":[157,203],"assessed":[158],"showed":[159],"that":[160],"0.81;":[170],"0.68-0.97).":[173],"remaining":[190,260],"small":[193,239],"found":[195],"beneficial":[197],"harmful":[199],"assessed.":[204,263],"CONCLUSION:":[205],"Terlipressin":[206],"prolong":[210],"short-term":[211],"survival":[212],"duration":[218],"response":[221],"should":[222],"be":[223],"considered":[224],"when":[225],"making":[226],"treatment":[227,250,261],"decisions":[228],"timing":[232],"potential":[234],"liver":[235],"transplantations.":[236],"Considering":[237],"included,":[243],"evidence":[245],"does":[246],"allow":[248],"recommendations":[251],"regarding":[252],"HRS":[255],"any":[257],"comparisons":[262]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":33},{"year":2014,"cited_by_count":26},{"year":2013,"cited_by_count":39},{"year":2012,"cited_by_count":35}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
