{"id":"https://openalex.org/W2045373134","doi":"https://doi.org/10.1038/nature09204","title":"Network organization of the human autophagy system","display_name":"Network organization of the human autophagy system","publication_year":2010,"publication_date":"2010-06-20","ids":{"openalex":"https://openalex.org/W2045373134","doi":"https://doi.org/10.1038/nature09204","mag":"2045373134","pmid":"https://pubmed.ncbi.nlm.nih.gov/20562859","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2901998"},"language":"en","primary_location":{"id":"doi:10.1038/nature09204","doi":"https://doi.org/10.1038/nature09204","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature09204","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2901998","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070758909","display_name":"Christian Behrends","orcid":"https://orcid.org/0000-0002-9184-7607","observed_orcids":["https://orcid.org/0000-0002-9184-7607"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Behrends","raw_affiliation_strings":["Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050980507","display_name":"Mathew E. Sowa","orcid":"https://orcid.org/0000-0003-0155-696X","observed_orcids":["https://orcid.org/0000-0003-0155-696X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mathew E. Sowa","raw_affiliation_strings":["Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079793809","display_name":"Steven P. Gygi","orcid":"https://orcid.org/0000-0001-7626-0034","observed_orcids":["https://orcid.org/0000-0001-7626-0034"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven P. Gygi","raw_affiliation_strings":["Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047746208","display_name":"J. Wade Harper","orcid":"https://orcid.org/0000-0002-6944-7236","observed_orcids":["https://orcid.org/0000-0002-6944-7236"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. Wade Harper","raw_affiliation_strings":["Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA,","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047746208"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":40.3246,"has_fulltext":false,"cited_by_count":1593,"citation_normalized_percentile":{"value":0.99985985,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"466","issue":"7302","first_page":"68","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":1.0},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.734000027179718},{"id":"https://openalex.org/keywords/lc3","display_name":"LC3","score":0.8920000195503235},{"id":"https://openalex.org/keywords/gabarap","display_name":"GABARAP","score":0.8809999823570251},{"id":"https://openalex.org/keywords/lc3-interacting-region","display_name":"LC3-interacting region","score":0.8939999938011169},{"id":"https://openalex.org/keywords/autophagosome-biogenesis","display_name":"autophagosome formation","score":0.925000011920929},{"id":"https://openalex.org/keywords/cargo-recruitment","display_name":"cargo recruitment","score":0.7760000228881836},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.7910000085830688},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/lipid-phosphorylation","display_name":"lipid phosphorylation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.9559999704360962},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2780042272","wikidata":"https://www.wikidata.org/wiki/Q27548992","display_name":"ATG8","level":4,"score":0.9281646013259888},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8373070955276489},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7336665391921997},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6368503570556641},{"id":"https://openalex.org/C168296220","wikidata":"https://www.wikidata.org/wiki/Q14882441","display_name":"Autophagosome","level":4,"score":0.5703376531600952},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.5315057635307312},{"id":"https://openalex.org/C99089365","wikidata":"https://www.wikidata.org/wiki/Q18034356","display_name":"BAG3","level":4,"score":0.5086263418197632},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.44802623987197876},{"id":"https://openalex.org/C171896709","wikidata":"https://www.wikidata.org/wiki/Q18034663","display_name":"Autophagy-related protein 13","level":5,"score":0.4403122663497925},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3165143132209778},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.2569088041782379},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2052498757839203},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.1850316822528839},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1823103427886963},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071190","descriptor_name":"Autophagy-Related Protein 8 Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010588","descriptor_name":"Phagosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/nature09204","doi":"https://doi.org/10.1038/nature09204","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature09204","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:20562859","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20562859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2901998","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2901998","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nature","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.818.4587","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.818.4587","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/27/16/nihms-208952.PMC2901998.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:nat:nature:v:466:y:2010:i:7302:d:10.1038_nature09204","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/nature09204","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2901998","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2901998","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nature","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G419760055","display_name":"Mechanisms of Selective Autophagy","funder_award_id":"R01GM095567","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7642108499","display_name":"SYSTEMATIC ANALYSIS OF THE DUB PROTEOME","funder_award_id":"R01GM054137","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7759553031","display_name":"SYSTEMATIC ANALYSIS OF PROTEOLYSIS PATHWAYS FOR CULLIN TARGETS","funder_award_id":"R01GM070565","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000904569","display_name":"Ubiquitin\u2010mediated proteolysis and cell cycle control","funder_award_id":"R01AG011085","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306710","display_name":"Glenn Foundation for Medical Research","ror":"https://ror.org/02ebg5q27"},{"id":"https://openalex.org/F4320333265","display_name":"Takeda Oncology","ror":"https://ror.org/05vm7p871"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1521172306","https://openalex.org/W1541181512","https://openalex.org/W1963521777","https://openalex.org/W1972256263","https://openalex.org/W1973638222","https://openalex.org/W1983831622","https://openalex.org/W1991841644","https://openalex.org/W1994823455","https://openalex.org/W1999032458","https://openalex.org/W1999477136","https://openalex.org/W1999857522","https://openalex.org/W2002288000","https://openalex.org/W2018636808","https://openalex.org/W2023680182","https://openalex.org/W2025665129","https://openalex.org/W2035244376","https://openalex.org/W2040157483","https://openalex.org/W2049864784","https://openalex.org/W2055243017","https://openalex.org/W2063650222","https://openalex.org/W2064381459","https://openalex.org/W2065592028","https://openalex.org/W2068784898","https://openalex.org/W2070461863","https://openalex.org/W2089483770","https://openalex.org/W2098912234","https://openalex.org/W2105056758","https://openalex.org/W2106969933","https://openalex.org/W2109034822","https://openalex.org/W2113038168","https://openalex.org/W2113432343","https://openalex.org/W2113892331","https://openalex.org/W2127440157","https://openalex.org/W2140809728","https://openalex.org/W2148340793","https://openalex.org/W2154993563","https://openalex.org/W2165218453","https://openalex.org/W2167141338"],"related_works":["https://openalex.org/W2067709083","https://openalex.org/W2128162080","https://openalex.org/W3100326425","https://openalex.org/W2888605402","https://openalex.org/W2046567882","https://openalex.org/W7132948252","https://openalex.org/W4360797483","https://openalex.org/W2139834969","https://openalex.org/W2581669044","https://openalex.org/W4385897884"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":34},{"year":2025,"cited_by_count":53},{"year":2024,"cited_by_count":78},{"year":2023,"cited_by_count":62},{"year":2022,"cited_by_count":88},{"year":2021,"cited_by_count":96},{"year":2020,"cited_by_count":94},{"year":2019,"cited_by_count":98},{"year":2018,"cited_by_count":85},{"year":2017,"cited_by_count":103},{"year":2016,"cited_by_count":128},{"year":2015,"cited_by_count":135},{"year":2014,"cited_by_count":106},{"year":2013,"cited_by_count":142},{"year":2012,"cited_by_count":152}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}