{"id":"https://openalex.org/W2045360710","doi":"https://doi.org/10.1196/annals.1345.068","title":"Does Heterozygous \u03b2\u2010Thalassemia Confer a Protection against Coronary Artery Disease?","display_name":"Does Heterozygous \u03b2\u2010Thalassemia Confer a Protection against Coronary Artery Disease?","publication_year":2005,"publication_date":"2005-11-01","ids":{"openalex":"https://openalex.org/W2045360710","doi":"https://doi.org/10.1196/annals.1345.068","mag":"2045360710","pmid":"https://pubmed.ncbi.nlm.nih.gov/16339699"},"language":"en","primary_location":{"id":"doi:10.1196/annals.1345.068","doi":"https://doi.org/10.1196/annals.1345.068","is_oa":false,"landing_page_url":"https://doi.org/10.1196/annals.1345.068","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004923591","display_name":"Stergios T. Tassiopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"STERGIOS TASSIOPOULOS","raw_affiliation_strings":["First Department of Internal Medicine, University of Athens, Medical School, Laiko Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, University of Athens, Medical School, Laiko Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210114623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058712982","display_name":"Spyros Deftereos","orcid":"https://orcid.org/0000-0001-6757-543X","observed_orcids":["https://orcid.org/0000-0001-6757-543X"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"SPYROS DEFTEREOS","raw_affiliation_strings":["First Department of Internal Medicine, University of Athens, Medical School, Laiko Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, University of Athens, Medical School, Laiko Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210114623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077649402","display_name":"Kostas Konstantopoulos","orcid":"https://orcid.org/0000-0002-3801-7903","observed_orcids":["https://orcid.org/0000-0002-3801-7903"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"KOSTAS KONSTANTOPOULOS","raw_affiliation_strings":["First Department of Internal Medicine, University of Athens, Medical School, Laiko Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, University of Athens, Medical School, Laiko Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210114623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062238016","display_name":"Dimitrios T. Farmakis","orcid":"https://orcid.org/0000-0001-8364-3447","observed_orcids":["https://orcid.org/0000-0001-8364-3447"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"DIMITRIS FARMAKIS","raw_affiliation_strings":["First Department of Internal Medicine, University of Athens, Medical School, Laiko Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, University of Athens, Medical School, Laiko Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210114623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070595532","display_name":"Maria Tsironi","orcid":"https://orcid.org/0000-0002-0569-6217","observed_orcids":["https://orcid.org/0000-0002-0569-6217"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"MARIA TSIRONI","raw_affiliation_strings":["First Department of Internal Medicine, University of Athens, Medical School, Laiko Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, University of Athens, Medical School, Laiko Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210114623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111696341","display_name":"Michalis Kyriakidis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"MICHALIS KYRIAKIDIS","raw_affiliation_strings":["Department of Cardiology, \u201cLaiko\u201d Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, \u201cLaiko\u201d Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210114623"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111635250","display_name":"Athanassios Aessopos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210114623","display_name":"Laiko General Hospital of Athens","ror":"https://ror.org/02dvs1389","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210114623"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"ATHANASSIOS AESSOPOS","raw_affiliation_strings":["First Department of Internal Medicine, University of Athens, Medical School, Laiko Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, University of Athens, Medical School, Laiko Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210114623"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058712982"],"corresponding_institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210114623"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.6703,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.66284257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"1054","issue":"1","first_page":"467","last_page":"470"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-thalassemia-trait","display_name":"beta-thalassemia trait","score":0.902999997138977},{"id":"https://openalex.org/keywords/heterozygosity","display_name":"heterozygosity","score":0.8529999852180481},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9879999756813049},{"id":"https://openalex.org/keywords/stable-angina","display_name":"stable angina","score":0.9440000057220459},{"id":"https://openalex.org/keywords/coronary-stenosis","display_name":"coronary artery stenosis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/atherosclerotic-plaque","display_name":"atherosclerotic plaque","score":0.7160000205039978},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.6919999718666077},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.5960000157356262},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":1.0},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hemoglobin-electrophoresis","display_name":"hemoglobin electrophoresis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/lipoproteins","display_name":"lipoproteins","score":0.8019999861717224},{"id":"https://openalex.org/keywords/hemorheology","display_name":"hemorheology","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8814196586608887},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7028031945228577},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.702222466468811},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.669594407081604},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6521771550178528},{"id":"https://openalex.org/C2778425758","wikidata":"https://www.wikidata.org/wiki/Q180762","display_name":"Angina","level":3,"score":0.651220977306366},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.6208468079566956},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6074016690254211},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5904538631439209},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.462878942489624},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.4411919116973877},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.250710129737854},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21410655975341797}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000787","descriptor_name":"Angina Pectoris","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D000787","descriptor_name":"Angina Pectoris","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000787","descriptor_name":"Angina Pectoris","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D001797","descriptor_name":"Blood Protein Electrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006115","descriptor_name":"Greece","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017023","descriptor_name":"Coronary Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D018056","descriptor_name":"Hemorheology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1196/annals.1345.068","doi":"https://doi.org/10.1196/annals.1345.068","is_oa":false,"landing_page_url":"https://doi.org/10.1196/annals.1345.068","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:16339699","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16339699","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W217090552","https://openalex.org/W2044793646","https://openalex.org/W2087563743","https://openalex.org/W2089390501","https://openalex.org/W2152436391","https://openalex.org/W2312193316","https://openalex.org/W2396255647","https://openalex.org/W2415338967","https://openalex.org/W2606467290","https://openalex.org/W4248227905"],"related_works":["https://openalex.org/W142507698","https://openalex.org/W1977038865","https://openalex.org/W2140219750","https://openalex.org/W2300984990","https://openalex.org/W2604672860","https://openalex.org/W2064862595","https://openalex.org/W2416463243","https://openalex.org/W2345975122","https://openalex.org/W2920704069","https://openalex.org/W2127376555"],"abstract_inverted_index":{"Six":[0],"hundred":[1],"and":[2,90,125],"thirty-eight":[3],"patients":[4,33],"who":[5],"presented":[6],"with":[7,110],"clinical":[8],"symptoms":[9],"and/or":[10],"electrocardiographic":[11],"findings":[12],"suggestive":[13],"of":[14,38,68,81,129,137],"stable":[15],"angina":[16],"pectoris":[17],"were":[18,21,43,95],"studied;":[19],"they":[20],"also":[22],"investigated":[23],"by":[24,45],"coronary":[25,60,71],"arteriography.":[26],"Hemoglobin":[27],"electrophoresis":[28],"was":[29,103],"performed":[30],"on":[31],"all":[32],"to":[34,49],"detect":[35],"the":[36,39,52,66,82,99,134],"presence":[37,67],"beta-thalassemia":[40,106],"trait.":[41],"Results":[42],"analyzed":[44],"logistic":[46],"regression":[47],"analysis":[48],"determine":[50],"whether":[51],"latter":[53],"confers":[54],"any":[55],"protective":[56,139],"effect":[57],"against":[58,114],"advanced":[59],"artery":[61],"disease":[62],"(aCAD;":[63],"defined":[64],"as":[65],"atheromas":[69],"in":[70,74,92],"arteries,":[72],"resulting":[73],"stenosis":[75],"at":[76,98],"least":[77],"70%).":[78],"The":[79,123],"role":[80],"currently":[83],"accepted":[84],"risk":[85,113],"factors":[86],"(smoking,":[87],"hypertension,":[88],"hypercholesterolemia,":[89],"diabetes)":[91],"developing":[93],"aCAD":[94,115],"reconfirmed,":[96],"while":[97],"same":[100],"time":[101],"it":[102],"found":[104],"that":[105],"heterozygosity":[107],"is":[108],"associated":[109],"a":[111],"reduced":[112],"(odds":[116],"ratio":[117],"0.39,":[118],"95%":[119],"confidence":[120],"interval":[121],"0.16-0.98).":[122],"lipoprotein":[124],"blood":[126],"rheology":[127],"profile":[128],"these":[130],"individuals":[131],"may":[132],"be":[133],"underlying":[135],"causes":[136],"this":[138],"effect.":[140]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}