{"id":"https://openalex.org/W2045347259","doi":"https://doi.org/10.7164/antibiotics.46.1101","title":"Antifungal macrocyclic polylactones from Penicillium verruculosum.","display_name":"Antifungal macrocyclic polylactones from Penicillium verruculosum.","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2045347259","doi":"https://doi.org/10.7164/antibiotics.46.1101","mag":"2045347259","pmid":"https://pubmed.ncbi.nlm.nih.gov/8360106"},"language":"en","primary_location":{"id":"doi:10.7164/antibiotics.46.1101","doi":"https://doi.org/10.7164/antibiotics.46.1101","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.46.1101","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/46/7/46_7_1101/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/46/7/46_7_1101/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113870933","display_name":"Jens Breinholt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"JENS BREINHOLT","raw_affiliation_strings":["Novo Nordisk A/S, Plant Protection Division, Bagsvaerd, Denmark","Novo Nordisk A/S, Plant Protection Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, Plant Protection Division, Bagsvaerd, Denmark","institution_ids":["https://openalex.org/I189090001"]},{"raw_affiliation_string":"Novo Nordisk A/S, Plant Protection Division","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035124052","display_name":"Georg W. Jensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"GEORG W. JENSEN","raw_affiliation_strings":["Novo Nordisk A/S, Plant Protection Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, Plant Protection Division","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112447227","display_name":"Ruby I. Nielsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"RUBY I. NIELSEN","raw_affiliation_strings":["Novo Nordisk A/S, Plant Protection Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, Plant Protection Division","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020341109","display_name":"Carl Erik Olsen","orcid":"https://orcid.org/0000-0002-2275-0596","observed_orcids":["https://orcid.org/0000-0002-2275-0596"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CARL E. OLSEN","raw_affiliation_strings":["Royal Veterinary and Agricultural University, Chemistry Department"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Veterinary and Agricultural University, Chemistry Department","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021559678","display_name":"Jens C. Frisvad","orcid":"https://orcid.org/0000-0002-0573-4340","observed_orcids":["https://orcid.org/0000-0002-0573-4340","https://orcid.org/0000-0002-6522-9987"]},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"JENS C. FRISVAD","raw_affiliation_strings":["The Technical University of Denmark, Department of Biotechnology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Technical University of Denmark, Department of Biotechnology","institution_ids":["https://openalex.org/I96673099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.15012407,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"46","issue":"7","first_page":"1101","last_page":"1108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/penicillium-verruculosum","display_name":"Penicillium verruculosum","score":0.9869999885559082},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.7950000166893005},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.6690000295639038},{"id":"https://openalex.org/keywords/fungal-secondary-metabolites","display_name":"fungal secondary metabolites","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.8052842617034912},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5110782384872437},{"id":"https://openalex.org/C2777484150","wikidata":"https://www.wikidata.org/wiki/Q843136","display_name":"Penicillium","level":2,"score":0.48175978660583496},{"id":"https://openalex.org/C2778394675","wikidata":"https://www.wikidata.org/wiki/Q648056","display_name":"Fungi imperfecti","level":2,"score":0.4233383536338806},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.3310977816581726},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.326352596282959},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.32282280921936035},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.20782670378684998},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19071239233016968},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1489662230014801}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007783","descriptor_name":"Lactones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010407","descriptor_name":"Penicillium","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D010407","descriptor_name":"Penicillium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.7164/antibiotics.46.1101","doi":"https://doi.org/10.7164/antibiotics.46.1101","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.46.1101","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/46/7/46_7_1101/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},{"id":"pmid:8360106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8360106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antibiotics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7164/antibiotics.46.1101","doi":"https://doi.org/10.7164/antibiotics.46.1101","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.46.1101","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/46/7/46_7_1101/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2045347259.pdf","grobid_xml":"https://content.openalex.org/works/W2045347259.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W618354635","https://openalex.org/W2032269112","https://openalex.org/W2045441636","https://openalex.org/W2063475148","https://openalex.org/W2139829924","https://openalex.org/W2329499411"],"related_works":["https://openalex.org/W1975089543","https://openalex.org/W1051329226","https://openalex.org/W1965109648","https://openalex.org/W2416570833","https://openalex.org/W4310857503","https://openalex.org/W2146057763","https://openalex.org/W2009102494","https://openalex.org/W2602707390","https://openalex.org/W1964300889","https://openalex.org/W2010929749"],"abstract_inverted_index":{"Three":[0],"macrocyclic":[1],"polylactones":[2],"have":[3],"been":[4],"isolated":[5],"from":[6],"Penicillium":[7],"verruculosum.":[8],"Two":[9],"were":[10,25],"found":[11],"to":[12,18],"be":[13,19],"novel":[14],"and":[15,29,37],"the":[16],"third":[17],"identical":[20],"with":[21],"NG-012(1).":[22],"Their":[23],"structures":[24],"elucidated":[26],"by":[27],"spectroscopic":[28],"chemical":[30],"methods.":[31],"A":[32],"full":[33],"assignment":[34],"of":[35],"1H-":[36],"13C-resonances":[38],"in":[39],"acetone-d6":[40],"are":[41],"given":[42],"for":[43],"all":[44],"three":[45],"compounds.":[46],"The":[47],"compounds":[48],"show":[49],"antifungal":[50],"activity.":[51]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}