{"id":"https://openalex.org/W2045324074","doi":"https://doi.org/10.1002/cncr.20605","title":"Nuclear factor\u2010\u03baB and I\u03baB kinase are constitutively active in human pancreatic cells, and their down\u2010regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis","display_name":"Nuclear factor\u2010\u03baB and I\u03baB kinase are constitutively active in human pancreatic cells, and their down\u2010regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis","publication_year":2004,"publication_date":"2004-10-08","ids":{"openalex":"https://openalex.org/W2045324074","doi":"https://doi.org/10.1002/cncr.20605","mag":"2045324074","pmid":"https://pubmed.ncbi.nlm.nih.gov/15476283"},"language":"en","primary_location":{"id":"doi:10.1002/cncr.20605","doi":"https://doi.org/10.1002/cncr.20605","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cncr.20605","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lan Li","raw_affiliation_strings":["Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA","Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048675624","display_name":"Bharat Bhushan Aggarwal","orcid":"https://orcid.org/0000-0003-3534-2898","observed_orcids":["https://orcid.org/0000-0003-3534-2898"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bharat B. Aggarwal","raw_affiliation_strings":["Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085218671","display_name":"Shishir Shishodia","orcid":"https://orcid.org/0000-0001-8135-8757","observed_orcids":["https://orcid.org/0000-0001-8135-8757"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shishir Shishodia","raw_affiliation_strings":["Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087376683","display_name":"James L. Abbruzzese","orcid":"https://orcid.org/0000-0001-9223-2965","observed_orcids":["https://orcid.org/0000-0001-9223-2965"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Abbruzzese","raw_affiliation_strings":["Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053481267","display_name":"Razelle Kurzrock","orcid":"https://orcid.org/0000-0003-4110-1214","observed_orcids":["https://orcid.org/0000-0003-4110-1214"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Razelle Kurzrock","raw_affiliation_strings":["","Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","Phase 1 Program, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, Texas","Fax: (713) 745-2374"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Phase 1 Program, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Fax: (713) 745-2374","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053481267"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":9.6494,"has_fulltext":false,"cited_by_count":294,"citation_normalized_percentile":{"value":0.99459784,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"101","issue":"10","first_page":"2351","last_page":"2362"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.8899999856948853},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9210000038146973},{"id":"https://openalex.org/keywords/ikappab-kinase","display_name":"I\u03baB kinase","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9869999885559082},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.824999988079071},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.996999979019165},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":1.0},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.7429999709129333},{"id":"https://openalex.org/keywords/anticancer-phytochemicals","display_name":"anticancer phytochemicals","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.6071596741676331},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5569787621498108},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.5461668372154236},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5046399831771851},{"id":"https://openalex.org/C100175707","wikidata":"https://www.wikidata.org/wiki/Q6103519","display_name":"I\u03baB kinase","level":4,"score":0.48370128870010376},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4819723963737488},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4664575159549713},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.46329864859580994},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4201137125492096},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40136948227882385},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.37191134691238403},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34143900871276855},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33215153217315674},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2883240580558777},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1971493363380432},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16704526543617249},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1311994194984436}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051550","descriptor_name":"I-kappa B Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cncr.20605","doi":"https://doi.org/10.1002/cncr.20605","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cncr.20605","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:15476283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15476283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2688310964","display_name":"SPORE in Pancreatic Cancer","funder_award_id":"5p20ca101936-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7653826056","display_name":null,"funder_award_id":"1P20 CA101936-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W4952422","https://openalex.org/W74993898","https://openalex.org/W1506887248","https://openalex.org/W1508025216","https://openalex.org/W1547348954","https://openalex.org/W1931508686","https://openalex.org/W1940692058","https://openalex.org/W1972733003","https://openalex.org/W1997298413","https://openalex.org/W1997446186","https://openalex.org/W2001356850","https://openalex.org/W2001378177","https://openalex.org/W2011962940","https://openalex.org/W2013721608","https://openalex.org/W2020086727","https://openalex.org/W2021931700","https://openalex.org/W2035308484","https://openalex.org/W2038890616","https://openalex.org/W2038891714","https://openalex.org/W2044573147","https://openalex.org/W2053499907","https://openalex.org/W2056533846","https://openalex.org/W2058118671","https://openalex.org/W2058577077","https://openalex.org/W2059941306","https://openalex.org/W2063709509","https://openalex.org/W2066724323","https://openalex.org/W2082721745","https://openalex.org/W2098562843","https://openalex.org/W2099023764","https://openalex.org/W2100283599","https://openalex.org/W2106293055","https://openalex.org/W2111866285","https://openalex.org/W2116338963","https://openalex.org/W2116861117","https://openalex.org/W2130092087","https://openalex.org/W2137138278","https://openalex.org/W2138123574","https://openalex.org/W2145045978","https://openalex.org/W2147921405","https://openalex.org/W2147965104","https://openalex.org/W2163958696","https://openalex.org/W2166994863","https://openalex.org/W2169265798","https://openalex.org/W2303469300","https://openalex.org/W2318388129","https://openalex.org/W2999065750","https://openalex.org/W4313347802"],"related_works":["https://openalex.org/W2061981941","https://openalex.org/W1981657616","https://openalex.org/W2338276782","https://openalex.org/W2096685256","https://openalex.org/W2121411068","https://openalex.org/W2101470559","https://openalex.org/W2783761121","https://openalex.org/W2120024176","https://openalex.org/W2229924112","https://openalex.org/W2015311620"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pancreatic":[1],"carcinoma":[2,78,220],"is":[3,39,56],"a":[4,27,40,151,210],"lethal":[5],"malignancy,":[6],"with":[7,142,172,218],"the":[8,48,101,131,173,207,214],"best":[9],"available":[10],"therapeutic":[11,42],"option-gemcitabine-yielding":[12],"response":[13],"rates":[14],"of":[15,50,103,125,135,175,216],"<":[16],"10%.":[17],"Because":[18],"nuclear":[19],"factor-kappaB":[20],"(NF-kappaB)":[21],"has":[22],"been":[23,128],"determined":[24],"to":[25,61],"play":[26],"role":[28],"in":[29,32,59,74,130,190],"cell":[30,79,167],"survival/proliferation":[31],"human":[33,76,191],"pancreatic":[34,77,136,192,219],"carcinoma,":[35],"this":[36,222],"transcription":[37],"factor":[38],"potential":[41],"target.":[43],"METHODS:":[44],"The":[45],"authors":[46,208],"investigated":[47],"ability":[49],"curcumin":[51,83],"(diferuloylmethane),":[52],"an":[53,91,121],"agent":[54],"that":[55],"pharmacologically":[57],"safe":[58],"humans,":[60],"modulate":[62],"NF-kappaB":[63,66,86,182,189],"activity.":[64,98],"RESULTS:":[65],"and":[67,82,96,116,133,144,156,183,202],"IkappaB":[68],"kinase":[69],"(IKK)":[70],"were":[71,140,196],"constitutively":[72],"active":[73],"all":[75,124],"lines":[80],"examined,":[81],"consistently":[84],"suppressed":[85],"binding":[87],"(as":[88,109,118,148,159],"assessed":[89,110,119,149,160],"using":[90,111,120,150,221],"electrophoretic":[92],"mobility":[93],"gel-shift":[94],"assay)":[95,155],"IKK":[97],"Curcumin":[99,180],"decreased":[100],"expression":[102],"NF-kappaB-regulated":[104],"gene":[105],"products,":[106],"including":[107],"cyclooxygenase-2":[108],"immunoblot":[112],"analysis),":[113],"prostaglandin":[114],"E2,":[115],"interleukin-8":[117],"enzyme-linked":[122],"immunoassay),":[123],"which":[126],"have":[127],"implicated":[129],"growth":[132,184,200],"invasiveness":[134],"carcinoma.":[137],"These":[138,194],"changes":[139],"associated":[141],"concentration-":[143],"time-dependent":[145],"antiproliferative":[146],"activity":[147],"3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium":[152],"bromide":[153],"[MTT]":[154],"proapoptotic":[157],"effects":[158,195],"via":[161],"annexin":[162],"V/propidium":[163],"iodide":[164],"staining":[165],"[fluorescence-activated":[166],"sorting,":[168],"as":[169,171],"well":[170],"induction":[174],"polyadenosine-5'-diphosphate-ribose":[176],"polymerase":[177],"cleavage).":[178],"CONCLUSIONS:":[179],"down-regulated":[181],"control":[185],"molecules":[186],"induced":[187],"by":[188,198],"cells.":[193],"accompanied":[197],"marked":[199],"inhibition":[201],"apoptosis.":[203],"Through":[204],"these":[205],"findings,":[206],"provided":[209],"biologic":[211],"rationale":[212],"for":[213],"treatment":[215],"patients":[217],"nontoxic":[223],"phytochemical.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}