{"id":"https://openalex.org/W2045314768","doi":"https://doi.org/10.1016/0014-5793(85)80731-6","title":"Appearance of an arachidonic acid 15\u2010lipoxygenase pathway upon differentiation of the human promyelocytic cell\u2010line HL\u201060","display_name":"Appearance of an arachidonic acid 15\u2010lipoxygenase pathway upon differentiation of the human promyelocytic cell\u2010line HL\u201060","publication_year":1985,"publication_date":"1985-06-03","ids":{"openalex":"https://openalex.org/W2045314768","doi":"https://doi.org/10.1016/0014-5793(85)80731-6","mag":"2045314768","pmid":"https://pubmed.ncbi.nlm.nih.gov/3922792"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(85)80731-6","doi":"https://doi.org/10.1016/0014-5793(85)80731-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(85)80731-6","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2885%2980731-6","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2885%2980731-6","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078574372","display_name":"Ulf Lundberg","orcid":"https://orcid.org/0000-0002-0232-5744","observed_orcids":["https://orcid.org/0000-0002-0232-5744"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ulf Lundberg","raw_affiliation_strings":["Department of Physiological Chemistry, Karolinska Institutet, S-104 01 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, Karolinska Institutet, S-104 01 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029525374","display_name":"Charles Nicholas Serhan","orcid":"https://orcid.org/0000-0003-4627-8545","observed_orcids":["https://orcid.org/0000-0003-4627-8545"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Charles N. Serhan","raw_affiliation_strings":["Department of Physiological Chemistry, Karolinska Institutet, S-104 01 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, Karolinska Institutet, S-104 01 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112759205","display_name":"Bengt O. Samuelsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bengt Samuelsson","raw_affiliation_strings":["Department of Physiological Chemistry, Karolinska Institutet, S-104 01 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, Karolinska Institutet, S-104 01 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":1.4841,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.78488138,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"185","issue":"1","first_page":"14","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.08399999886751175,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.8569999933242798},{"id":"https://openalex.org/keywords/15-lipoxygenase","display_name":"15-lipoxygenase","score":0.9850000143051147},{"id":"https://openalex.org/keywords/15-hydroperoxyeicosatetraenoic-acid","display_name":"15-hydroperoxyeicosatetraenoic acid","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/dmso-induced-differentiation","display_name":"DMSO-induced differentiation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/eicosanoid-metabolism","display_name":"eicosanoid metabolism","score":0.8130000233650208},{"id":"https://openalex.org/keywords/leukotriene-biosynthesis","display_name":"leukotriene biosynthesis","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C2780857362","wikidata":"https://www.wikidata.org/wiki/Q1827455","display_name":"Lipoxygenase","level":3,"score":0.8485889434814453},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.7519643306732178},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.560765266418457},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4626316428184509},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4577364921569824},{"id":"https://openalex.org/C90342290","wikidata":"https://www.wikidata.org/wiki/Q94234745","display_name":"Arachidonate 5-lipoxygenase","level":4,"score":0.4510936737060547},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3597699999809265},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.22175300121307373},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20138847827911377},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15559512376785278}],"mesh":[{"descriptor_ui":"D001091","descriptor_name":"Arachidonate Lipoxygenases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004121","descriptor_name":"Dimethyl Sulfoxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008054","descriptor_name":"Lipid Peroxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008084","descriptor_name":"Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015289","descriptor_name":"Leukotrienes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-5793(85)80731-6","doi":"https://doi.org/10.1016/0014-5793(85)80731-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(85)80731-6","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2885%2980731-6","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:3922792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3922792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/0014-5793(85)80731-6","doi":"https://doi.org/10.1016/0014-5793(85)80731-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(85)80731-6","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2885%2980731-6","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306237","display_name":"Arthritis Foundation","ror":"https://ror.org/04zk9fe75"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2045314768.pdf","grobid_xml":"https://content.openalex.org/works/W2045314768.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1497443731","https://openalex.org/W1531198291","https://openalex.org/W1631595783","https://openalex.org/W1968028322","https://openalex.org/W1968441176","https://openalex.org/W1989856248","https://openalex.org/W1995127270","https://openalex.org/W1995232506","https://openalex.org/W1998186108","https://openalex.org/W1998824673","https://openalex.org/W2004351423","https://openalex.org/W2019384900","https://openalex.org/W2026846570","https://openalex.org/W2027711342","https://openalex.org/W2029571242","https://openalex.org/W2033280809","https://openalex.org/W2048766409","https://openalex.org/W2067022078","https://openalex.org/W2090127336","https://openalex.org/W2108449184","https://openalex.org/W2125376694"],"related_works":["https://openalex.org/W2402129663","https://openalex.org/W2127988832","https://openalex.org/W639263071","https://openalex.org/W2075651066","https://openalex.org/W2007629880","https://openalex.org/W74591817","https://openalex.org/W1968441176","https://openalex.org/W2039207394","https://openalex.org/W1982181307","https://openalex.org/W1960356334"],"abstract_inverted_index":{"The":[0],"metabolism":[1],"of":[2,46,90],"arachidonic":[3,35,48],"acid":[4,36,49],"and":[5,24,57,82],"15-HPETE":[6,38,79],"was":[7],"studied":[8],"in":[9],"a":[10,26,69,98],"human":[11],"promyelocytic":[12],"cell":[13,100],"line":[14],"(HL-60).":[15],"Upon":[16],"exposure":[17],"to":[18,77,80],"DMSO,":[19],"HL-60":[20,66],"cells":[21,31,67],"undergo":[22],"differentiation":[23,65],"acquire":[25],"15-lipoxygenase":[27,50,70,92],"activity":[28,71],"while":[29],"undifferentiated":[30],"challenged":[32],"with":[33],"either":[34],"or":[37],"did":[39],"not":[40],"enzymatically":[41],"transform":[42,78],"these":[43,85],"precursors.":[44],"Products":[45],"the":[47,75,91],"pathway":[51],"were":[52],"identified":[53],"by":[54,97],"HPLC.":[55],"UV-absorption":[56],"gas":[58],"chromatography-mass":[59],"spectrometry.":[60],"Results":[61],"indicate":[62],"that":[63,88],"upon":[64],"express":[68],"as":[72,74],"well":[73],"ability":[76],"8,15-DHETEs":[81],"14,15-DHETE.":[83],"Moreover,":[84],"findings":[86],"suggest":[87],"products":[89],"cascade":[93],"may":[94],"be":[95],"generated":[96],"single":[99],"system.":[101]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}